JPWO2021170071A5 - - Google Patents
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- JPWO2021170071A5 JPWO2021170071A5 JP2022551596A JP2022551596A JPWO2021170071A5 JP WO2021170071 A5 JPWO2021170071 A5 JP WO2021170071A5 JP 2022551596 A JP2022551596 A JP 2022551596A JP 2022551596 A JP2022551596 A JP 2022551596A JP WO2021170071 A5 JPWO2021170071 A5 JP WO2021170071A5
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- amino acid
- acid sequence
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- 125000003275 alpha amino acid group Chemical group 0.000 claims description 587
- 150000001413 amino acids Chemical class 0.000 claims description 77
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims description 35
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims description 35
- 206010028980 Neoplasm Diseases 0.000 claims description 16
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims description 14
- 238000000034 method Methods 0.000 claims description 14
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims description 13
- 229940127121 immunoconjugate Drugs 0.000 claims description 12
- 239000003814 drug Substances 0.000 claims description 11
- 230000035772 mutation Effects 0.000 claims description 10
- 229940079593 drug Drugs 0.000 claims description 9
- 101000851370 Homo sapiens Tumor necrosis factor receptor superfamily member 9 Proteins 0.000 claims description 8
- 201000011510 cancer Diseases 0.000 claims description 8
- 108020004707 nucleic acids Proteins 0.000 claims description 8
- 150000007523 nucleic acids Chemical class 0.000 claims description 8
- 102000039446 nucleic acids Human genes 0.000 claims description 8
- 239000000203 mixture Substances 0.000 claims description 7
- 230000004927 fusion Effects 0.000 claims description 6
- 206010006187 Breast cancer Diseases 0.000 claims description 4
- 208000026310 Breast neoplasm Diseases 0.000 claims description 4
- 208000005718 Stomach Neoplasms Diseases 0.000 claims description 4
- 239000012634 fragment Substances 0.000 claims description 4
- 206010017758 gastric cancer Diseases 0.000 claims description 4
- 239000003550 marker Substances 0.000 claims description 4
- 201000011549 stomach cancer Diseases 0.000 claims description 4
- 206010005003 Bladder cancer Diseases 0.000 claims description 3
- 208000003174 Brain Neoplasms Diseases 0.000 claims description 3
- 206010008342 Cervix carcinoma Diseases 0.000 claims description 3
- 206010009944 Colon cancer Diseases 0.000 claims description 3
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims description 3
- 206010014733 Endometrial cancer Diseases 0.000 claims description 3
- 206010014759 Endometrial neoplasm Diseases 0.000 claims description 3
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims description 3
- 208000008839 Kidney Neoplasms Diseases 0.000 claims description 3
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 3
- 206010027406 Mesothelioma Diseases 0.000 claims description 3
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims description 3
- 206010033128 Ovarian cancer Diseases 0.000 claims description 3
- 206010061535 Ovarian neoplasm Diseases 0.000 claims description 3
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims description 3
- 206010035226 Plasma cell myeloma Diseases 0.000 claims description 3
- 206010038389 Renal cancer Diseases 0.000 claims description 3
- 208000004337 Salivary Gland Neoplasms Diseases 0.000 claims description 3
- 206010061934 Salivary gland cancer Diseases 0.000 claims description 3
- 206010039491 Sarcoma Diseases 0.000 claims description 3
- 208000000453 Skin Neoplasms Diseases 0.000 claims description 3
- 208000024313 Testicular Neoplasms Diseases 0.000 claims description 3
- 206010057644 Testis cancer Diseases 0.000 claims description 3
- 208000000728 Thymus Neoplasms Diseases 0.000 claims description 3
- 208000024770 Thyroid neoplasm Diseases 0.000 claims description 3
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims description 3
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims description 3
- 201000005188 adrenal gland cancer Diseases 0.000 claims description 3
- 208000024447 adrenal gland neoplasm Diseases 0.000 claims description 3
- 201000010881 cervical cancer Diseases 0.000 claims description 3
- 201000004101 esophageal cancer Diseases 0.000 claims description 3
- 201000010536 head and neck cancer Diseases 0.000 claims description 3
- 208000014829 head and neck neoplasm Diseases 0.000 claims description 3
- 201000010982 kidney cancer Diseases 0.000 claims description 3
- 208000032839 leukemia Diseases 0.000 claims description 3
- 201000007270 liver cancer Diseases 0.000 claims description 3
- 208000014018 liver neoplasm Diseases 0.000 claims description 3
- 201000005202 lung cancer Diseases 0.000 claims description 3
- 208000020816 lung neoplasm Diseases 0.000 claims description 3
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims description 3
- 201000000050 myeloid neoplasm Diseases 0.000 claims description 3
- 201000002528 pancreatic cancer Diseases 0.000 claims description 3
- 208000008443 pancreatic carcinoma Diseases 0.000 claims description 3
- 201000000849 skin cancer Diseases 0.000 claims description 3
- 201000003120 testicular cancer Diseases 0.000 claims description 3
- 201000002510 thyroid cancer Diseases 0.000 claims description 3
- 201000005112 urinary bladder cancer Diseases 0.000 claims description 3
- 229940116741 CD137 agonist Drugs 0.000 claims description 2
- 102000004190 Enzymes Human genes 0.000 claims description 2
- 108090000790 Enzymes Proteins 0.000 claims description 2
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims description 2
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims description 2
- 239000000427 antigen Substances 0.000 claims description 2
- 102000036639 antigens Human genes 0.000 claims description 2
- 108091007433 antigens Proteins 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 238000012258 culturing Methods 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 239000007850 fluorescent dye Substances 0.000 claims description 2
- 229940124597 therapeutic agent Drugs 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 description 12
- 108090000765 processed proteins & peptides Proteins 0.000 description 6
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 229910052698 phosphorus Inorganic materials 0.000 description 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 1
- 241000282693 Cercopithecidae Species 0.000 description 1
- 108060003951 Immunoglobulin Proteins 0.000 description 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 description 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 description 1
- 102000051957 human ERBB2 Human genes 0.000 description 1
- 102000050327 human TNFRSF9 Human genes 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2020077146 | 2020-02-28 | ||
| CNPCT/CN2020/077146 | 2020-02-28 | ||
| PCT/CN2021/078055 WO2021170071A1 (en) | 2020-02-28 | 2021-02-26 | Anti-cd137 constructs, multispecific antibody and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023516941A JP2023516941A (ja) | 2023-04-21 |
| JPWO2021170071A5 true JPWO2021170071A5 (enrdf_load_stackoverflow) | 2024-02-22 |
Family
ID=77490694
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022551596A Pending JP2023516941A (ja) | 2020-02-28 | 2021-02-26 | 抗ｃｄ１３７コンストラクト、多重特異性抗体及びその使用 |
Country Status (9)
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4326780A4 (en) * | 2021-04-23 | 2025-02-26 | Shanghai Henlius Biotech, Inc. | Anti-gpc3 antibodies, multispecific antibodies and methods of use |
| EP4345113A1 (en) | 2022-09-30 | 2024-04-03 | SDS Optic Spolka Akcyjna | Anti-her2 antibody, a nucleic acid molecule encoding the variable region of said antibody, a method of detecting her2 in a biological sample, an immuno-enzymatic elisa assay and use of said anti-her2 antibody or fragments therefof |
| WO2025149667A1 (en) | 2024-01-12 | 2025-07-17 | Pheon Therapeutics Ltd | Antibody drug conjugates and uses thereof |
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-
2021
- 2021-02-26 EP EP21760950.2A patent/EP4110826A4/en active Pending
- 2021-02-26 CA CA3169910A patent/CA3169910A1/en active Pending
- 2021-02-26 AU AU2021228078A patent/AU2021228078A1/en active Pending
- 2021-02-26 JP JP2022551596A patent/JP2023516941A/ja active Pending
- 2021-02-26 CN CN202180015562.1A patent/CN115151573A/zh active Pending
- 2021-02-26 WO PCT/CN2021/078055 patent/WO2021170071A1/en unknown
- 2021-02-26 KR KR1020227032417A patent/KR20220145859A/ko active Pending
-
2022
- 2022-08-26 US US17/822,750 patent/US20220403040A1/en active Pending
- 2022-09-08 ZA ZA2022/10030A patent/ZA202210030B/en unknown