JPWO2021123192A5 - - Google Patents
Download PDFInfo
- Publication number
- JPWO2021123192A5 JPWO2021123192A5 JP2022537578A JP2022537578A JPWO2021123192A5 JP WO2021123192 A5 JPWO2021123192 A5 JP WO2021123192A5 JP 2022537578 A JP2022537578 A JP 2022537578A JP 2022537578 A JP2022537578 A JP 2022537578A JP WO2021123192 A5 JPWO2021123192 A5 JP WO2021123192A5
- Authority
- JP
- Japan
- Prior art keywords
- tablet
- starch
- lactose
- weight
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims 10
- 239000000203 mixture Substances 0.000 claims 9
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims 8
- 229920002472 Starch Polymers 0.000 claims 8
- 229960001375 lactose Drugs 0.000 claims 8
- 239000008101 lactose Substances 0.000 claims 8
- 239000008107 starch Substances 0.000 claims 8
- 229940032147 starch Drugs 0.000 claims 8
- 235000019698 starch Nutrition 0.000 claims 8
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims 6
- 239000011230 binding agent Substances 0.000 claims 5
- 239000007884 disintegrant Substances 0.000 claims 5
- WSVLPVUVIUVCRA-KPKNDVKVSA-N Alpha-lactose monohydrate Chemical compound O.O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O WSVLPVUVIUVCRA-KPKNDVKVSA-N 0.000 claims 3
- HGVDHZBSSITLCT-JLJPHGGASA-N Edoxaban Chemical compound N([C@H]1CC[C@@H](C[C@H]1NC(=O)C=1SC=2CN(C)CCC=2N=1)C(=O)N(C)C)C(=O)C(=O)NC1=CC=C(Cl)C=N1 HGVDHZBSSITLCT-JLJPHGGASA-N 0.000 claims 3
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 3
- 229920000881 Modified starch Polymers 0.000 claims 3
- 239000003085 diluting agent Substances 0.000 claims 3
- 229960000622 edoxaban Drugs 0.000 claims 3
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 3
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 3
- 229960001021 lactose monohydrate Drugs 0.000 claims 3
- 239000000314 lubricant Substances 0.000 claims 3
- 235000019359 magnesium stearate Nutrition 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 239000008109 sodium starch glycolate Substances 0.000 claims 3
- 229920003109 sodium starch glycolate Polymers 0.000 claims 3
- 229940079832 sodium starch glycolate Drugs 0.000 claims 3
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims 2
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims 2
- OKMWKBLSFKFYGZ-UHFFFAOYSA-N 1-behenoylglycerol Chemical compound CCCCCCCCCCCCCCCCCCCCCC(=O)OCC(O)CO OKMWKBLSFKFYGZ-UHFFFAOYSA-N 0.000 claims 1
- GUBGYTABKSRVRQ-DCSYEGIMSA-N Beta-Lactose Chemical compound OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-DCSYEGIMSA-N 0.000 claims 1
- 229920002261 Corn starch Polymers 0.000 claims 1
- 229920002785 Croscarmellose sodium Polymers 0.000 claims 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims 1
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims 1
- 235000021355 Stearic acid Nutrition 0.000 claims 1
- 229960004977 anhydrous lactose Drugs 0.000 claims 1
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 claims 1
- 239000001506 calcium phosphate Substances 0.000 claims 1
- 229910000389 calcium phosphate Inorganic materials 0.000 claims 1
- 235000011010 calcium phosphates Nutrition 0.000 claims 1
- 239000000378 calcium silicate Substances 0.000 claims 1
- 229910052918 calcium silicate Inorganic materials 0.000 claims 1
- 229960003340 calcium silicate Drugs 0.000 claims 1
- CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 claims 1
- 239000008116 calcium stearate Substances 0.000 claims 1
- 235000013539 calcium stearate Nutrition 0.000 claims 1
- OYACROKNLOSFPA-UHFFFAOYSA-N calcium;dioxido(oxo)silane Chemical compound [Ca+2].[O-][Si]([O-])=O OYACROKNLOSFPA-UHFFFAOYSA-N 0.000 claims 1
- 239000001768 carboxy methyl cellulose Substances 0.000 claims 1
- 229920003090 carboxymethyl hydroxyethyl cellulose Polymers 0.000 claims 1
- 239000003086 colorant Substances 0.000 claims 1
- 239000008120 corn starch Substances 0.000 claims 1
- 229960001681 croscarmellose sodium Drugs 0.000 claims 1
- 235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 claims 1
- 235000019700 dicalcium phosphate Nutrition 0.000 claims 1
- CGMRCMMOCQYHAD-UHFFFAOYSA-K dicalcium;phosphate;hydrate Chemical compound O.[Ca+2].[Ca+2].[O-]P([O-])([O-])=O CGMRCMMOCQYHAD-UHFFFAOYSA-K 0.000 claims 1
- 238000007908 dry granulation Methods 0.000 claims 1
- MVPICKVDHDWCJQ-UHFFFAOYSA-N ethyl 3-pyrrolidin-1-ylpropanoate Chemical compound CCOC(=O)CCN1CCCC1 MVPICKVDHDWCJQ-UHFFFAOYSA-N 0.000 claims 1
- 239000000796 flavoring agent Substances 0.000 claims 1
- 235000019634 flavors Nutrition 0.000 claims 1
- 235000003599 food sweetener Nutrition 0.000 claims 1
- 229940049654 glyceryl behenate Drugs 0.000 claims 1
- 229940075507 glyceryl monostearate Drugs 0.000 claims 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 1
- 229940071676 hydroxypropylcellulose Drugs 0.000 claims 1
- 229940057948 magnesium stearate Drugs 0.000 claims 1
- 239000008108 microcrystalline cellulose Substances 0.000 claims 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims 1
- 229940016286 microcrystalline cellulose Drugs 0.000 claims 1
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 claims 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 229920001592 potato starch Polymers 0.000 claims 1
- -1 rice starch Polymers 0.000 claims 1
- 229940100486 rice starch Drugs 0.000 claims 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims 1
- 235000010234 sodium benzoate Nutrition 0.000 claims 1
- 239000004299 sodium benzoate Substances 0.000 claims 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims 1
- 229940045902 sodium stearyl fumarate Drugs 0.000 claims 1
- 239000008117 stearic acid Substances 0.000 claims 1
- 150000005846 sugar alcohols Chemical class 0.000 claims 1
- 239000003765 sweetening agent Substances 0.000 claims 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims 1
- 238000005550 wet granulation Methods 0.000 claims 1
- XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical compound [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 claims 1
- 229930195727 α-lactose Natural products 0.000 claims 1
- 229930195724 β-lactose Natural products 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP19383144.3A EP3838267A1 (en) | 2019-12-19 | 2019-12-19 | Edoxaban tablets |
| EP19383144.3 | 2019-12-19 | ||
| PCT/EP2020/087055 WO2021123192A1 (en) | 2019-12-19 | 2020-12-18 | Edoxaban tablets |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023506991A JP2023506991A (ja) | 2023-02-20 |
| JPWO2021123192A5 true JPWO2021123192A5 (enrdf_load_stackoverflow) | 2023-12-21 |
Family
ID=69411195
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022537578A Withdrawn JP2023506991A (ja) | 2019-12-19 | 2020-12-18 | エドキサバン錠剤 |
Country Status (8)
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4262760A1 (en) | 2020-12-18 | 2023-10-25 | KRKA, d.d., Novo mesto | Edoxaban formulation containing no sugar alcohols |
| JP2023056113A (ja) * | 2021-10-07 | 2023-04-19 | 日医工株式会社 | エドキサバン含有医薬組成物 |
| CN114469881A (zh) * | 2022-03-14 | 2022-05-13 | 河北坤安药业有限公司 | 一种硝酸甘油片及其制备方法 |
| AU2023390819A1 (en) * | 2022-12-09 | 2025-07-03 | Synthon B.V. | Formulation comprising edoxaban and preparation thereof |
| CN115980214A (zh) * | 2022-12-21 | 2023-04-18 | 中国医学科学院北京协和医院 | 利用液相色谱-串联质谱同时定量分析利伐沙班、阿哌沙班、艾多沙班和贝曲沙班的方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2002346300C1 (en) | 2001-06-20 | 2014-03-06 | Daiichi Sankyo Company, Limited | Diamine derivatives |
| PT2140867T (pt) | 2007-03-29 | 2017-10-04 | Daiichi Sankyo Co Ltd | Composição farmacêutica |
| EP2548556B1 (en) | 2010-03-19 | 2016-08-10 | Daiichi Sankyo Company, Limited | Method for improving dissolvability of anticoagulant |
| CN103919746A (zh) * | 2014-04-17 | 2014-07-16 | 山东省医药工业研究所 | 依度沙班缓释片及其制备方法 |
| WO2016020080A1 (en) | 2014-08-06 | 2016-02-11 | Sandoz Ag | Pharmaceutical compositions of edoxaban |
| CN108743556A (zh) * | 2018-02-02 | 2018-11-06 | 重庆植恩药业有限公司 | 一种依度沙班片剂及其制备方法 |
| EP3744320A1 (en) * | 2019-05-29 | 2020-12-02 | Alfred E. Tiefenbacher (GmbH & Co. KG) | Pharmaceutical tablet composition comprising edoxaban |
-
2019
- 2019-12-19 EP EP19383144.3A patent/EP3838267A1/en not_active Withdrawn
-
2020
- 2020-12-18 BR BR112022012063A patent/BR112022012063A2/pt not_active Application Discontinuation
- 2020-12-18 CA CA3165090A patent/CA3165090A1/en active Pending
- 2020-12-18 KR KR1020227024909A patent/KR20220118510A/ko active Pending
- 2020-12-18 EP EP20838009.7A patent/EP4076406A1/en not_active Withdrawn
- 2020-12-18 WO PCT/EP2020/087055 patent/WO2021123192A1/en not_active Application Discontinuation
- 2020-12-18 JP JP2022537578A patent/JP2023506991A/ja not_active Withdrawn
- 2020-12-18 MX MX2022007707A patent/MX2022007707A/es unknown
- 2020-12-18 CN CN202080088448.7A patent/CN114845703A/zh active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2013530952A5 (enrdf_load_stackoverflow) | ||
| US20130344150A1 (en) | Direct compression tablets of otilonium | |
| JPWO2019152940A5 (enrdf_load_stackoverflow) | ||
| JP6073543B2 (ja) | ロラタジン含有口腔内崩壊錠の製造方法 | |
| HRP20190687T1 (hr) | N-acetilcisteinske tablete za gutanje | |
| KR20180066039A (ko) | 아파티닙을 포함하는 약학적 조성물 | |
| TW202336015A (zh) | 唑－４－羧酸結晶之製備方法及包含彼之醫藥組成物 | |
| JPWO2021123192A5 (enrdf_load_stackoverflow) | ||
| RU2003126177A (ru) | Способ приготовления негигроскопичной композиции вальпроата натрия | |
| JPH10279476A (ja) | ロキソプロフェンナトリウム含有錠剤 | |
| CA2987850A1 (en) | Alogliptin formulation | |
| EP1179342B1 (en) | Immediate release medicinal compositions for oral use | |
| JP4063386B2 (ja) | 速放性経口医薬品組成物 | |
| JP7226697B2 (ja) | ブロナンセリン含有錠剤 | |
| KR20160145904A (ko) | 안정성이 개선된 플로로글루시놀 무수물 함유 속용성 정제의 제조방법 | |
| US12221440B2 (en) | Process for the preparation of trametinib acetic acid solvate | |
| JP2018127417A (ja) | フェブキソスタット含有口腔内崩壊錠 | |
| JP2018184381A (ja) | エゼチミブ含有錠剤およびその製法 | |
| CN113521024A (zh) | 一种碳酸锂缓释片 | |
| JP2016124861A (ja) | オルメサルタンメドキソミル含有口腔内崩壊錠 | |
| JP2018127416A (ja) | フェブキソスタット含有錠剤の製造方法 | |
| JP2017014151A (ja) | 光安定性を向上した、シロドシンを含有する有核錠 | |
| WO2004045584A1 (en) | Bupropion hydrochloride solid dosage forms | |
| JPWO2022031666A5 (enrdf_load_stackoverflow) | ||
| JP7362302B2 (ja) | レベチラセタムを含有する錠剤とその製造方法 |