JPWO2021094993A5 - - Google Patents

Info

Publication number

JPWO2021094993A5

JPWO2021094993A5 JP2022523315A JP2022523315A JPWO2021094993A5 JP WO2021094993 A5 JPWO2021094993 A5 JP WO2021094993A5 JP 2022523315 A JP2022523315 A JP 2022523315A JP 2022523315 A JP2022523315 A JP 2022523315A JP WO2021094993 A5 JPWO2021094993 A5 JP WO2021094993A5

Authority

JP

Japan

Prior art keywords

human milk

milk oligosaccharides

human

hmos

synthetic

Prior art date

2023-11-07

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 235000020256 human milk Nutrition 0.000 claims 23
• 210000004251 human milk Anatomy 0.000 claims 23
• 229920001542 oligosaccharide Polymers 0.000 claims 23
• 150000002482 oligosaccharides Chemical class 0.000 claims 23
• 239000000203 mixture Substances 0.000 claims 20
• 239000003613 bile acid Substances 0.000 claims 7
• 208000002551 irritable bowel syndrome Diseases 0.000 claims 5
• 230000007935 neutral effect Effects 0.000 claims 4
• 208000008338 non-alcoholic fatty liver disease Diseases 0.000 claims 4
• 210000001035 gastrointestinal tract Anatomy 0.000 claims 3
• 241000186000 Bifidobacterium Species 0.000 claims 2
• 241000193163 Clostridioides difficile Species 0.000 claims 2
• 208000022559 Inflammatory bowel disease Diseases 0.000 claims 2
• 230000003115 biocidal effect Effects 0.000 claims 2
• KXGVEGMKQFWNSR-LLQZFEROSA-N deoxycholic acid Chemical compound C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 KXGVEGMKQFWNSR-LLQZFEROSA-N 0.000 claims 2
• 229960003964 deoxycholic acid Drugs 0.000 claims 2
• KXGVEGMKQFWNSR-UHFFFAOYSA-N deoxycholic acid Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)C(O)C2 KXGVEGMKQFWNSR-UHFFFAOYSA-N 0.000 claims 2
• 208000015181 infectious disease Diseases 0.000 claims 2
• 208000019423 liver disease Diseases 0.000 claims 2
• 208000030159 metabolic disease Diseases 0.000 claims 2
• 206010053219 non-alcoholic steatohepatitis Diseases 0.000 claims 2
• 241000186016 Bifidobacterium bifidum Species 0.000 claims 1
• 241001608472 Bifidobacterium longum Species 0.000 claims 1
• 241000186015 Bifidobacterium longum subsp. infantis Species 0.000 claims 1
• 206010008609 Cholangitis sclerosing Diseases 0.000 claims 1
• 206010009900 Colitis ulcerative Diseases 0.000 claims 1
• 208000011231 Crohn disease Diseases 0.000 claims 1
• 206010012735 Diarrhoea Diseases 0.000 claims 1
• 206010016654 Fibrosis Diseases 0.000 claims 1
• 241000282412 Homo Species 0.000 claims 1
• 208000008589 Obesity Diseases 0.000 claims 1
• 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
• FZIVHOUANIQOMU-YIHIYSSUSA-N alpha-L-Fucp-(1->2)-beta-D-Galp-(1->3)-beta-D-GlcpNAc-(1->3)-beta-D-Galp-(1->4)-D-Glcp Chemical compound O[C@H]1[C@H](O)[C@H](O)[C@H](C)O[C@H]1O[C@H]1[C@H](O[C@@H]2[C@H]([C@H](O[C@@H]3[C@H]([C@H](O[C@@H]4[C@H](OC(O)[C@H](O)[C@H]4O)CO)O[C@H](CO)[C@@H]3O)O)O[C@H](CO)[C@H]2O)NC(C)=O)O[C@H](CO)[C@H](O)[C@@H]1O FZIVHOUANIQOMU-YIHIYSSUSA-N 0.000 claims 1
• IEQCXFNWPAHHQR-YKLSGRGUSA-N beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc Chemical group O([C@H]1[C@H](O)[C@H]([C@@H](O[C@@H]1CO)O[C@@H]1[C@H]([C@H](O[C@@H]2[C@H](OC(O)[C@H](O)[C@H]2O)CO)O[C@H](CO)[C@@H]1O)O)NC(=O)C)[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O IEQCXFNWPAHHQR-YKLSGRGUSA-N 0.000 claims 1
• 229940002008 bifidobacterium bifidum Drugs 0.000 claims 1
• 229940004120 bifidobacterium infantis Drugs 0.000 claims 1
• 229940009291 bifidobacterium longum Drugs 0.000 claims 1
• 201000001883 cholelithiasis Diseases 0.000 claims 1
• 230000007882 cirrhosis Effects 0.000 claims 1
• 208000019425 cirrhosis of liver Diseases 0.000 claims 1
• FZIVHOUANIQOMU-UHFFFAOYSA-N lacto-N-fucopentaose I Natural products OC1C(O)C(O)C(C)OC1OC1C(OC2C(C(OC3C(C(OC4C(OC(O)C(O)C4O)CO)OC(CO)C3O)O)OC(CO)C2O)NC(C)=O)OC(CO)C(O)C1O FZIVHOUANIQOMU-UHFFFAOYSA-N 0.000 claims 1
• IEQCXFNWPAHHQR-UHFFFAOYSA-N lacto-N-neotetraose Natural products OCC1OC(OC2C(C(OC3C(OC(O)C(O)C3O)CO)OC(CO)C2O)O)C(NC(=O)C)C(O)C1OC1OC(CO)C(O)C(O)C1O IEQCXFNWPAHHQR-UHFFFAOYSA-N 0.000 claims 1
• 235000020824 obesity Nutrition 0.000 claims 1
• 208000010157 sclerosing cholangitis Diseases 0.000 claims 1
• 241000894007 species Species 0.000 claims 1
• 208000011580 syndromic disease Diseases 0.000 claims 1
• 238000002560 therapeutic procedure Methods 0.000 claims 1
• 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1
• 208000019206 urinary tract infection Diseases 0.000 claims 1