CN114728015A - 用于平衡肠中胆汁酸谱的合成组合物 - Google Patents

用于平衡肠中胆汁酸谱的合成组合物 Download PDF

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Publication number
CN114728015A
CN114728015A CN202080078561.7A CN202080078561A CN114728015A CN 114728015 A CN114728015 A CN 114728015A CN 202080078561 A CN202080078561 A CN 202080078561A CN 114728015 A CN114728015 A CN 114728015A
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CN
China
Prior art keywords
human
human milk
ibs
milk oligosaccharides
bile acid
Prior art date
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Pending
Application number
CN202080078561.7A
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English (en)
Chinese (zh)
Inventor
L·K·比格斯奈斯
B·麦康奈尔
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Glycom AS
Original Assignee
Glycom AS
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Filing date
Publication date
Application filed by Glycom AS filed Critical Glycom AS
Publication of CN114728015A publication Critical patent/CN114728015A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/745—Bifidobacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1611—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816—Wall or shell material
    • A61K9/4825—Proteins, e.g. gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Steroid Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CN202080078561.7A 2019-11-14 2020-11-13 用于平衡肠中胆汁酸谱的合成组合物 Pending CN114728015A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA201901337 2019-11-14
DKPA201901337 2019-11-14
PCT/IB2020/060692 WO2021094993A1 (en) 2019-11-14 2020-11-13 Synthetic composition for balancing the bile acid profile in the intestine

Publications (1)

Publication Number Publication Date
CN114728015A true CN114728015A (zh) 2022-07-08

Family

ID=75912919

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202080078561.7A Pending CN114728015A (zh) 2019-11-14 2020-11-13 用于平衡肠中胆汁酸谱的合成组合物

Country Status (8)

Country Link
US (1) US20220378809A1 (https=)
EP (1) EP4058031A4 (https=)
JP (1) JP2023501111A (https=)
KR (1) KR20220101131A (https=)
CN (1) CN114728015A (https=)
BR (1) BR112022009214A2 (https=)
CA (1) CA3160629A1 (https=)
WO (1) WO2021094993A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG10201903823QA (en) 2014-10-31 2019-05-30 Whole Biome Inc Methods and compositions relating to microbial treatment and diagnosis of disorders
CN111372596A (zh) 2017-08-30 2020-07-03 潘德勒姆治疗公司 用于治疗微生物组相关病症的方法和组合物
CA3106315A1 (en) 2018-07-19 2020-01-23 Pendulum Therapeutics, Inc. Methods and compositions for microbial engraftment
TW202126317A (zh) 2019-09-24 2021-07-16 美商普拉塔生技公司 用於治療發炎和免疫疾病之組成物和方法
WO2022026415A1 (en) * 2020-07-31 2022-02-03 Abbott Laboratories Method of preventing, reducing or delaying fatty liver disease
WO2022271729A1 (en) * 2021-06-21 2022-12-29 Pendulum Therapeutics, Inc. Compositions comprising microbes and methods of use and making thereof
CN115948273B (zh) * 2022-06-21 2023-07-18 合肥瀚微生物科技有限公司 治疗糖尿病及相关病症的两歧双歧杆菌
WO2024126578A1 (en) * 2022-12-13 2024-06-20 Dsm Ip Assets B.V. Synthetic composition comprising a human milk oligosaccharide for microbiota modulation

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160287619A1 (en) * 2014-12-08 2016-10-06 Glycom A/S Synthetic composition for preventing or treating CVD
CN107073021A (zh) * 2014-10-29 2017-08-18 格礼卡姆股份公司 合成组合物以及用于治疗肠易激综合症的方法
WO2017215721A1 (en) * 2016-06-15 2017-12-21 Glycom A/S Synthetic compositions comprising human milk oligosaccharides for use γν the prevention and treatment of disorders
CN108348536A (zh) * 2015-11-17 2018-07-31 格礼卡姆股份公司 治疗抗生素相关性并发症的合成组合物
WO2019106620A1 (en) * 2017-11-30 2019-06-06 Glycom A/S Human milk oligosaccharides and synthetic compositions thereof for microbiota modulation

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2735108B1 (en) * 2011-07-22 2016-12-21 Telefonaktiebolaget LM Ericsson (publ) Radio base station, radio network node and methods therein for detecting a faulty antenna
AT515152B1 (de) * 2013-11-26 2015-12-15 Chemiefaser Lenzing Ag Verfahren zum Vorbehandeln von rückgewonnenen Baumwollfasern zur Verwendung bei der Herstellung von Formkörpern aus regenerierter Cellulose
US11040049B2 (en) * 2014-10-29 2021-06-22 Glycom A/S Composition comprising HMSs/HMOs and use thereof
US10751354B2 (en) * 2015-09-14 2020-08-25 Glycom A/S Synthetic composition for microbiota modulation
US11278558B2 (en) * 2017-03-01 2022-03-22 Glycom A/S Synthetic composition for microbiota modulation
AU2018250337B2 (en) * 2017-04-07 2024-02-15 Children's Hospital Medical Center Treatment of inflammatory bowel diseases with 2'-fucosyllactose compounds
CN111587376A (zh) * 2017-09-13 2020-08-25 进化生物系统股份有限公司 哺乳动物婴儿的代谢组学修正

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107073021A (zh) * 2014-10-29 2017-08-18 格礼卡姆股份公司 合成组合物以及用于治疗肠易激综合症的方法
US20160287619A1 (en) * 2014-12-08 2016-10-06 Glycom A/S Synthetic composition for preventing or treating CVD
CN108348536A (zh) * 2015-11-17 2018-07-31 格礼卡姆股份公司 治疗抗生素相关性并发症的合成组合物
WO2017215721A1 (en) * 2016-06-15 2017-12-21 Glycom A/S Synthetic compositions comprising human milk oligosaccharides for use γν the prevention and treatment of disorders
WO2019106620A1 (en) * 2017-11-30 2019-06-06 Glycom A/S Human milk oligosaccharides and synthetic compositions thereof for microbiota modulation

Also Published As

Publication number Publication date
EP4058031A4 (en) 2023-11-08
KR20220101131A (ko) 2022-07-19
WO2021094993A1 (en) 2021-05-20
JP2023501111A (ja) 2023-01-18
CA3160629A1 (en) 2021-05-20
BR112022009214A2 (pt) 2022-08-02
US20220378809A1 (en) 2022-12-01
EP4058031A1 (en) 2022-09-21

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Application publication date: 20220708