JPWO2021092476A5 - - Google Patents
Download PDFInfo
- Publication number
- JPWO2021092476A5 JPWO2021092476A5 JP2022526119A JP2022526119A JPWO2021092476A5 JP WO2021092476 A5 JPWO2021092476 A5 JP WO2021092476A5 JP 2022526119 A JP2022526119 A JP 2022526119A JP 2022526119 A JP2022526119 A JP 2022526119A JP WO2021092476 A5 JPWO2021092476 A5 JP WO2021092476A5
- Authority
- JP
- Japan
- Prior art keywords
- cell
- nucleic acid
- subject
- acid molecules
- variants
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023208448A JP7807089B2 (ja) | 2019-11-06 | 2023-12-11 | 核酸分子を分析するための方法およびシステム |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962931688P | 2019-11-06 | 2019-11-06 | |
| US62/931,688 | 2019-11-06 | ||
| PCT/US2020/059526 WO2021092476A1 (en) | 2019-11-06 | 2020-11-06 | Methods and systems for analyzing nucleic acid molecules |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023208448A Division JP7807089B2 (ja) | 2019-11-06 | 2023-12-11 | 核酸分子を分析するための方法およびシステム |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2023501376A JP2023501376A (ja) | 2023-01-18 |
| JP2023501376A5 JP2023501376A5 (https=) | 2023-12-20 |
| JPWO2021092476A5 true JPWO2021092476A5 (https=) | 2023-12-20 |
| JP7825272B2 JP7825272B2 (ja) | 2026-03-06 |
Family
ID=75848071
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022526119A Active JP7825272B2 (ja) | 2019-11-06 | 2020-11-06 | 核酸分子を分析するための方法およびシステム |
| JP2023208448A Active JP7807089B2 (ja) | 2019-11-06 | 2023-12-11 | 核酸分子を分析するための方法およびシステム |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023208448A Active JP7807089B2 (ja) | 2019-11-06 | 2023-12-11 | 核酸分子を分析するための方法およびシステム |
Country Status (14)
| Country | Link |
|---|---|
| US (14) | US20210172022A1 (https=) |
| EP (3) | EP4527945A3 (https=) |
| JP (2) | JP7825272B2 (https=) |
| KR (1) | KR20220094218A (https=) |
| CN (3) | CN118374597A (https=) |
| AU (1) | AU2020378435A1 (https=) |
| BR (1) | BR112022008752A2 (https=) |
| CA (1) | CA3156589A1 (https=) |
| DE (1) | DE112020005433T5 (https=) |
| DK (1) | DK4055187T3 (https=) |
| ES (1) | ES3041276T3 (https=) |
| GB (4) | GB2613427B (https=) |
| MX (1) | MX2022005588A (https=) |
| WO (1) | WO2021092476A1 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2970916C (en) | 2014-03-14 | 2025-02-04 | Caredx, Inc. | METHODS FOR MONITORING IMMUNOSUPPRESSIVE THERAPIES IN A TRANSPLANT RECIPIENT |
| WO2021092476A1 (en) | 2019-11-06 | 2021-05-14 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and systems for analyzing nucleic acid molecules |
| US11783912B2 (en) | 2021-05-05 | 2023-10-10 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and systems for analyzing nucleic acid molecules |
| KR20230064172A (ko) * | 2021-11-03 | 2023-05-10 | 주식회사 지씨지놈 | 세포유리 핵산단편 위치별 서열 빈도 및 크기를 이용한 암 진단 방법 |
| MX2024006820A (es) * | 2021-12-15 | 2024-08-15 | Univ Johns Hopkins | Mutacion del genoma completo de molecula unica y perfiles de fragmentacion de acido desoxirribonucleico (adn) libre de celula. |
| CN114974421B (zh) * | 2022-05-20 | 2024-04-30 | 南开大学 | 基于扩散-降噪的单细胞转录组测序数据补插方法及系统 |
| KR20230172174A (ko) * | 2022-06-15 | 2023-12-22 | 주식회사 지씨지놈 | 무세포 핵산의 단일염기변이를 이용한 암 진단 및 암 종 예측방법 |
| CN115181800B (zh) * | 2022-07-11 | 2025-06-13 | 南京世和基因生物技术股份有限公司 | 基因标志物在非小细胞肺癌预后效果预测中的应用、预测装置以及计算机可读取介质 |
| GB202212094D0 (en) * | 2022-08-19 | 2022-10-05 | Inivata Ltd | Method of detecting cancer DNA in a sample |
| CN116466085A (zh) * | 2022-11-28 | 2023-07-21 | 中国人民解放军海军军医大学第三附属医院 | 一种四基因的生物标志物组合及其在肝癌治疗中的应用 |
| KR102630597B1 (ko) * | 2023-08-22 | 2024-01-29 | 주식회사 지놈인사이트테크놀로지 | 종양 정보를 활용한 미세 잔존 질환 탐지 방법 및 장치 |
| US20250140343A1 (en) * | 2023-10-30 | 2025-05-01 | Myriad Women's Health, Inc. | Methods for improving minimal residual disease assays |
| WO2025245136A1 (en) * | 2024-05-22 | 2025-11-27 | Foresight Diagnostics Inc. | Methods and systems for adjuvant therapy |
| WO2026019737A1 (en) * | 2024-07-16 | 2026-01-22 | Myriad Women's Health, Inc. | Targeted depletion sequencing for use in minimum residual disease assays |
| WO2026072949A1 (en) * | 2024-09-27 | 2026-04-02 | Roche Sequencing Solutions, Inc. | Multi-modal risk stratification of minimum residual disease |
Family Cites Families (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA241076A (en) | 1924-06-24 | Carter Formby King Otis | Calculating apparatus | |
| CA233975A (en) | 1923-09-04 | Rightmire Franklin | Anti-skid chain tightener | |
| CA188298A (en) | 1918-04-08 | 1919-01-14 | William H. Bot | Grain separator |
| US5804396A (en) | 1994-10-12 | 1998-09-08 | Sugen, Inc. | Assay for agents active in proliferative disorders |
| US6171856B1 (en) | 1997-07-30 | 2001-01-09 | Board Of Regents, The University Of Texas System | Methods and compositions relating to no-mediated cytotoxicity |
| DE10032165A1 (de) | 2000-07-01 | 2002-01-10 | Beiersdorf Ag | Verwendung von physiologisch verträglichen Sulfinsäuren als Antioxidans oder Radikalfänger in kosmetischen oder dermatologischen Zubereitungen |
| NZ532780A (en) | 2001-12-21 | 2006-10-27 | Wellcome Trust | Isolated naturally occurring mutant human B-Raf polypeptides and nucleic acids encoding them |
| CN101501211A (zh) | 2004-03-31 | 2009-08-05 | 综合医院公司 | 测定癌症对表皮生长因子受体靶向性治疗反应性的方法 |
| US7393665B2 (en) | 2005-02-10 | 2008-07-01 | Population Genetics Technologies Ltd | Methods and compositions for tagging and identifying polynucleotides |
| US8835358B2 (en) | 2009-12-15 | 2014-09-16 | Cellular Research, Inc. | Digital counting of individual molecules by stochastic attachment of diverse labels |
| WO2011103236A2 (en) | 2010-02-18 | 2011-08-25 | The Johns Hopkins University | Personalized tumor biomarkers |
| US20190010543A1 (en) | 2010-05-18 | 2019-01-10 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| CA2811185C (en) | 2010-09-21 | 2020-09-22 | Population Genetics Technologies Ltd. | Increasing confidence of allele calls with molecular counting |
| KR20190002733A (ko) | 2010-12-30 | 2019-01-08 | 파운데이션 메디신 인코포레이티드 | 종양 샘플의 다유전자 분석의 최적화 |
| ES2625288T3 (es) | 2011-04-15 | 2017-07-19 | The Johns Hopkins University | Sistema de secuenciación segura |
| DK2814959T3 (en) | 2012-02-17 | 2018-04-23 | Hutchinson Fred Cancer Res | COMPOSITIONS AND PROCEDURES FOR EXACTLY IDENTIFYING MUTATIONS |
| EP3744857A1 (en) | 2012-03-20 | 2020-12-02 | University Of Washington Through Its Center For Commercialization | Methods of lowering the error rate of massively parallel dna sequencing using duplex consensus sequencing |
| US20160040229A1 (en) | 2013-08-16 | 2016-02-11 | Guardant Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
| GB2533006B (en) | 2012-09-04 | 2017-06-07 | Guardant Health Inc | Systems and methods to detect copy number variation |
| US10876152B2 (en) | 2012-09-04 | 2020-12-29 | Guardant Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
| CN105190656B (zh) | 2013-01-17 | 2018-01-16 | 佩索纳里斯公司 | 用于遗传分析的方法和系统 |
| EP3885446A1 (en) | 2013-02-01 | 2021-09-29 | The Regents of The University of California | Methods for genome assembly and haplotype phasing |
| CN113337604A (zh) | 2013-03-15 | 2021-09-03 | 莱兰斯坦福初级大学评议会 | 循环核酸肿瘤标志物的鉴别和用途 |
| ES2660989T3 (es) | 2013-12-28 | 2018-03-27 | Guardant Health, Inc. | Métodos y sistemas para detectar variantes genéticas |
| EP3957749A1 (en) | 2014-04-21 | 2022-02-23 | Natera, Inc. | Detecting tumour specific mutations in biopsies with whole exome sequencing and in cell-free samples |
| WO2015169947A1 (en) * | 2014-05-09 | 2015-11-12 | Lifecodexx Ag | Detection of dna that originates from a specific cell-type and related methods |
| AU2015269103B2 (en) * | 2014-06-06 | 2021-12-23 | Cornell University | Method for identification and enumeration of nucleic acid sequence, expression, copy, or DNA methylation changes, using combined nuclease, ligase, polymerase, and sequencing reactions |
| MX2016016904A (es) * | 2014-06-26 | 2017-03-27 | 10X Genomics Inc | Analisis de secuencias de acidos nucleicos. |
| EP3191628B1 (en) | 2014-09-12 | 2022-05-25 | The Board of Trustees of the Leland Stanford Junior University | Identification and use of circulating nucleic acids |
| WO2016049878A1 (zh) * | 2014-09-30 | 2016-04-07 | 深圳华大基因科技有限公司 | 一种基于snp分型的亲子鉴定方法及应用 |
| CN107002131B (zh) | 2014-11-12 | 2022-04-29 | 尼欧基因组学实验室股份有限公司 | 作为确认骨髓增生异常综合征诊断的可靠测试的外周血血浆dna深度测序 |
| WO2016130578A1 (en) | 2015-02-09 | 2016-08-18 | 10X Genomics, Inc. | Systems and methods for determining structural variation and phasing using variant call data |
| ES2969767T3 (es) | 2015-05-01 | 2024-05-22 | Guardant Health Inc | Métodos de diagnóstico |
| CA3002740A1 (en) | 2015-10-19 | 2017-04-27 | Dovetail Genomics, Llc | Methods for genome assembly, haplotype phasing, and target independent nucleic acid detection |
| WO2017075436A1 (en) | 2015-10-30 | 2017-05-04 | New England Biolabs, Inc. | Compositions and methods for determining modified cytosines by sequencing |
| US10260088B2 (en) | 2015-10-30 | 2019-04-16 | New England Biolabs, Inc. | Compositions and methods for analyzing modified nucleotides |
| EP3384050A4 (en) | 2015-12-03 | 2019-07-31 | Alfred Health | MONITORING THE TREATMENT OR PROGRESSION OF MYELOMA |
| PL3387152T3 (pl) | 2015-12-08 | 2022-05-09 | Twinstrand Biosciences, Inc. | Ulepszone adaptory, sposoby i kompozycje do sekwencjonowania dupleksowego |
| CN109072309B (zh) | 2016-02-02 | 2023-05-16 | 夸登特健康公司 | 癌症进化检测和诊断 |
| US11479878B2 (en) * | 2016-03-16 | 2022-10-25 | Dana-Farber Cancer Institute, Inc. | Methods for genome characterization |
| US11299783B2 (en) | 2016-05-27 | 2022-04-12 | Personalis, Inc. | Methods and systems for genetic analysis |
| GB2600627B (en) | 2016-05-27 | 2022-12-07 | Personalis Inc | Personalized genetic testing |
| US9850523B1 (en) | 2016-09-30 | 2017-12-26 | Guardant Health, Inc. | Methods for multi-resolution analysis of cell-free nucleic acids |
| WO2018081161A1 (en) | 2016-10-24 | 2018-05-03 | Biomatrica, Inc. | Stabilization of nucleic acids on paper |
| EP4134444B1 (en) | 2017-03-23 | 2024-10-02 | University of Washington | Methods for targeted nucleic acid sequence enrichment with applications to error corrected nucleic acid sequencing |
| US11342047B2 (en) * | 2017-04-21 | 2022-05-24 | Illumina, Inc. | Using cell-free DNA fragment size to detect tumor-associated variant |
| US11542540B2 (en) | 2017-06-16 | 2023-01-03 | Life Technologies Corporation | Control nucleic acids, and compositions, kits, and uses thereof |
| EP3654763A4 (en) | 2017-06-28 | 2021-06-09 | Dow Agrosciences LLC | PLANT PROMOTER FOR TRANSGENIC EXPRESSION |
| EP3685386A1 (en) | 2017-09-20 | 2020-07-29 | Guardant Health, Inc. | Methods and systems for differentiating somatic and germline variants |
| EP3762512A1 (en) | 2018-03-06 | 2021-01-13 | Cancer Research Technology Limited | Improvements in variant detection |
| CN109337983A (zh) * | 2018-11-29 | 2019-02-15 | 优葆优保健康科技(宁波)有限公司 | 检测人甲状腺癌循环肿瘤dna的探针组合及其捕获测序系统 |
| EP3914736B1 (en) * | 2019-01-25 | 2023-12-20 | Grail, LLC | Detecting cancer, cancer tissue of origin, and/or a cancer cell type |
| KR102526916B1 (ko) * | 2019-04-05 | 2023-05-02 | 주식회사 제놉시 | Cfdna를 이용한 위암 진단방법 |
| CN110055312B (zh) * | 2019-04-09 | 2022-11-15 | 嘉兴雅康博医学检验所有限公司 | 用于检测egfr基因c797s和t790m顺反式突变的引物、探针及试剂盒 |
| WO2021003485A1 (en) | 2019-07-03 | 2021-01-07 | The Board Of Trustees Of The Leland Stanford Junior University | Methods to assess clinical outcome based upon updated probabilities and treatments thereof |
| WO2021092476A1 (en) | 2019-11-06 | 2021-05-14 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and systems for analyzing nucleic acid molecules |
| AU2021225854A1 (en) | 2020-02-24 | 2022-10-13 | The Board Of Trustees Of The Leland Stanford Junior University | Systems and methods for protecting nucleic-acid molecules |
| JP2024519501A (ja) | 2021-05-05 | 2024-05-14 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | 核酸分子を分析するための方法およびシステム |
| US11783912B2 (en) | 2021-05-05 | 2023-10-10 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and systems for analyzing nucleic acid molecules |
-
2020
- 2020-11-06 WO PCT/US2020/059526 patent/WO2021092476A1/en not_active Ceased
- 2020-11-06 ES ES20885631T patent/ES3041276T3/es active Active
- 2020-11-06 EP EP25155049.7A patent/EP4527945A3/en active Pending
- 2020-11-06 CN CN202410331875.3A patent/CN118374597A/zh active Pending
- 2020-11-06 GB GB2212061.2A patent/GB2613427B/en active Active
- 2020-11-06 DK DK20885631.0T patent/DK4055187T3/da active
- 2020-11-06 CN CN202410331007.5A patent/CN118834950A/zh active Pending
- 2020-11-06 JP JP2022526119A patent/JP7825272B2/ja active Active
- 2020-11-06 GB GB2112217.1A patent/GB2595193B/en active Active
- 2020-11-06 DE DE112020005433.0T patent/DE112020005433T5/de active Pending
- 2020-11-06 GB GB2404419.0A patent/GB2627085B/en active Active
- 2020-11-06 GB GB2318607.5A patent/GB2623904B/en active Active
- 2020-11-06 EP EP24161425.4A patent/EP4365309A3/en active Pending
- 2020-11-06 BR BR112022008752A patent/BR112022008752A2/pt unknown
- 2020-11-06 MX MX2022005588A patent/MX2022005588A/es unknown
- 2020-11-06 AU AU2020378435A patent/AU2020378435A1/en active Pending
- 2020-11-06 KR KR1020227019037A patent/KR20220094218A/ko active Pending
- 2020-11-06 CA CA3156589A patent/CA3156589A1/en active Pending
- 2020-11-06 CN CN202080007503.5A patent/CN113383085A/zh active Pending
- 2020-11-06 EP EP20885631.0A patent/EP4055187B1/en active Active
- 2020-11-30 US US17/107,668 patent/US20210172022A1/en not_active Abandoned
-
2021
- 2021-05-05 US US17/308,958 patent/US12492434B2/en active Active
- 2021-11-16 US US17/455,209 patent/US11447833B2/en active Active
- 2021-12-29 US US17/646,473 patent/US11613787B2/en active Active
- 2021-12-29 US US17/646,472 patent/US20220251664A1/en not_active Abandoned
-
2022
- 2022-05-02 US US17/661,730 patent/US11634779B2/en active Active
- 2022-08-16 US US17/820,200 patent/US20220389518A1/en not_active Abandoned
- 2022-11-17 US US18/056,652 patent/US11851716B2/en active Active
- 2022-11-17 US US18/056,656 patent/US20230124070A1/en not_active Abandoned
-
2023
- 2023-02-10 US US18/167,803 patent/US20230250485A1/en not_active Abandoned
- 2023-02-10 US US18/167,804 patent/US11965215B2/en active Active
- 2023-02-22 US US18/172,957 patent/US20230183816A1/en not_active Abandoned
- 2023-10-04 US US18/481,092 patent/US20240035095A1/en active Pending
- 2023-12-11 JP JP2023208448A patent/JP7807089B2/ja active Active
-
2024
- 2024-02-07 US US18/435,880 patent/US20240175088A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB2595193A (en) | Methods and systems for analyzing nucleic acid molecules | |
| US20210065842A1 (en) | Systems and methods for determining tumor fraction | |
| US10457988B2 (en) | MiRNAs as diagnostic markers | |
| JPWO2021092476A5 (https=) | ||
| US20190338362A1 (en) | Methods for non-invasive prenatal determination of aneuploidy using targeted next generation sequencing of biallelic snps | |
| CN110117652A (zh) | 肝癌早期诊断方法 | |
| CN119546780A (zh) | 用于治疗监测的甲基化无细胞dna的分子计数 | |
| US10161004B2 (en) | Diagnostic miRNA profiles in multiple sclerosis | |
| CN108300787A (zh) | 特异甲基化位点作为乳腺癌早期诊断标志物的应用 | |
| JP2024530154A (ja) | 体細胞変異と異常にメチル化された断片との同時発生 | |
| KR20240015624A (ko) | 게놈 전체 cfdna 단편화 프로파일을 이용한 암을 검출하는 방법 | |
| EP4464792A1 (en) | Non-invasive in-vitro method of diagnosis | |
| KR20260011755A (ko) | 체세포 돌연변이 검출을 위한 비침습적 시험관 내 방법 | |
| WO2020194057A1 (en) | Biomarkers for disease detection | |
| US20230099193A1 (en) | Personalized cancer liquid biopsies using primers from a primer bank | |
| WO2023147445A2 (en) | Cell-free rna biomarkers for the detection of cancer or predisposition to cancer | |
| CN108531593A (zh) | 特异甲基化位点作为乳腺癌复发诊断标志物的应用 | |
| CN113584171A (zh) | 基因突变位点的用途及突变位点检测方法 | |
| KR102152893B1 (ko) | 간세포암종 특이 mlh1 유전자에 대한 순환 종양 dna 변이 검출 용도 | |
| CN115772566B (zh) | 用于辅助检测肺癌体细胞erbb2基因突变的甲基化生物标记物及其应用 | |
| EP4628598A1 (en) | Dna methylation marker for determination of t-status of cancer | |
| HK40064341A (en) | Methods and systems for analyzing nucleic acid molecules | |
| EP3790995B1 (en) | Method of cancer prognosis by assessing tumor variant diversity by means of establishing diversity indices | |
| WO2022188776A1 (zh) | 可用于胃癌her2伴随诊断的基因甲基化标记物或其组合和应用 | |
| HK40080902A (en) | Gene methylation markers or combinations thereof for concomitant diagnosis of her2 in gastric carcinoma, and use thereof |