JPWO2021081375A5 - - Google Patents
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- Publication number
- JPWO2021081375A5 JPWO2021081375A5 JP2022523904A JP2022523904A JPWO2021081375A5 JP WO2021081375 A5 JPWO2021081375 A5 JP WO2021081375A5 JP 2022523904 A JP2022523904 A JP 2022523904A JP 2022523904 A JP2022523904 A JP 2022523904A JP WO2021081375 A5 JPWO2021081375 A5 JP WO2021081375A5
- Authority
- JP
- Japan
- Prior art keywords
- carboxamide
- pyrrolidine
- trifluoroethyl
- methylphenyl
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962925596P | 2019-10-24 | 2019-10-24 | |
| US62/925,596 | 2019-10-24 | ||
| US202063044898P | 2020-06-26 | 2020-06-26 | |
| US63/044,898 | 2020-06-26 | ||
| PCT/US2020/057132 WO2021081375A1 (en) | 2019-10-24 | 2020-10-23 | Inhibitors of raf kinases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022554169A JP2022554169A (ja) | 2022-12-28 |
| JPWO2021081375A5 true JPWO2021081375A5 (de) | 2023-10-30 |
Family
ID=75619376
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022523904A Pending JP2022554169A (ja) | 2019-10-24 | 2020-10-23 | Ｒａｆキナーゼの阻害剤 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US11098031B1 (de) |
| EP (1) | EP4048259A4 (de) |
| JP (1) | JP2022554169A (de) |
| KR (1) | KR20220104702A (de) |
| CN (1) | CN114845711A (de) |
| AU (1) | AU2020371727A1 (de) |
| BR (1) | BR112022007612A2 (de) |
| CA (1) | CA3158530A1 (de) |
| CL (1) | CL2022000998A1 (de) |
| CO (1) | CO2022006712A2 (de) |
| IL (1) | IL292424A (de) |
| MX (1) | MX2022004937A (de) |
| TW (1) | TW202128680A (de) |
| WO (1) | WO2021081375A1 (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR118826A1 (es) | 2019-05-03 | 2021-11-03 | Kinnate Biopharma Inc | Inhibidores de cinasas raf |
| CN114746417B (zh) * | 2019-12-06 | 2023-12-08 | 齐鲁制药有限公司 | Pan-RAF激酶抑制剂的联芳基化合物 |
| WO2022060996A1 (en) | 2020-09-18 | 2022-03-24 | Kinnate Biopharma Inc. | Inhibitors of raf kinases |
| US11377431B2 (en) | 2020-10-12 | 2022-07-05 | Kinnate Biopharma Inc. | Inhibitors of RAF kinases |
| EP4326256A1 (de) * | 2021-04-23 | 2024-02-28 | Kinnate Biopharma Inc. | Behandlung von krebs mit einem raf-hemmer |
| JP2024517431A (ja) * | 2021-04-23 | 2024-04-22 | キネート バイオファーマ インク． | （ｓ）－ｎ－（３－（２－（（（ｒ）－１－ヒドロキシプロパン－２－イル）アミノ）－６－モルホリノピリジン－４－イル）－４－メチルフェニル）－３－（２，２，２－トリフルオロエチル）ピロリジン－１－カルボキサミドおよびその塩の固体状態での形態 |
| CN115974851A (zh) * | 2021-10-14 | 2023-04-18 | 华领医药技术（上海）有限公司 | 2-氧代-3-氮杂双环[3.1.0]己烷衍生物 |
| WO2023070053A1 (en) * | 2021-10-21 | 2023-04-27 | Kinnate Biopharma Inc. | Inhibitors of raf kinases |
| US20230357179A1 (en) * | 2021-12-09 | 2023-11-09 | Deciphera Pharmaceuticals, Llc | Raf kinase inhibitors and methods of use thereof |
| US11814384B2 (en) | 2022-02-03 | 2023-11-14 | Kinnate Biopharma Inc. | Inhibtors of Raf kinases |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6334997B1 (en) | 1994-03-25 | 2002-01-01 | Isotechnika, Inc. | Method of using deuterated calcium channel blockers |
| BR9507200A (pt) | 1994-03-25 | 1997-09-16 | Isotechnika Inc | Melhora da eficácia de drogas por deuteração |
| US6187799B1 (en) | 1997-05-23 | 2001-02-13 | Onyx Pharmaceuticals | Inhibition of raf kinase activity using aryl ureas |
| US20070244120A1 (en) | 2000-08-18 | 2007-10-18 | Jacques Dumas | Inhibition of raf kinase using substituted heterocyclic ureas |
| GB9823873D0 (en) | 1998-10-30 | 1998-12-30 | Pharmacia & Upjohn Spa | 2-ureido-thiazole derivatives,process for their preparation,and their use as antitumour agents |
| AU2003209119A1 (en) | 2002-02-11 | 2003-09-04 | Bayer Pharmaceuticals Corporation | Pyridine, quinoline, and isoquinoline n-oxides as kinase inhibitors |
| CA2592118C (en) | 2004-12-23 | 2015-11-17 | Deciphera Pharmaceuticals, Llc | Urea derivatives as enzyme modulators |
| US8188113B2 (en) | 2006-09-14 | 2012-05-29 | Deciphera Pharmaceuticals, Inc. | Dihydropyridopyrimidinyl, dihydronaphthyidinyl and related compounds useful as kinase inhibitors for the treatment of proliferative diseases |
| CL2008001933A1 (es) | 2007-06-29 | 2009-09-25 | Millennium Pharm Inc | Compuestos derivados de pirimidina, inhibidores de la raf quinasa; compuestos intermediarios; procedimiento de preparacion; composicion farmaceutica; y su uso para tratar trastornos proliferativos, cardiacos, neurodegenerativos, inflamatorios, oseos, inmunologicos enfermedad viral, entre otros. |
| BRPI0908849A2 (pt) | 2008-02-22 | 2015-08-25 | Irm Llc | Composto e composições como c-kit e inibidores de pdgfr quinase |
| AU2009334997A1 (en) * | 2008-12-30 | 2011-08-04 | Millennium Pharmaceuticals, Inc. | Heteroaryl compounds useful as Raf kinase inhibitors |
| MX2014015024A (es) | 2012-06-07 | 2015-07-06 | Deciphera Pharmaceuticals Llc | Dihidronaftiridinas y compuestos relacionados útiles como inhibidores de cinasas para el tratamiento de enfermedades proliferativas. |
| US9242969B2 (en) | 2013-03-14 | 2016-01-26 | Novartis Ag | Biaryl amide compounds as kinase inhibitors |
| WO2016038582A1 (en) * | 2014-09-12 | 2016-03-17 | Novartis Ag | Compounds and compositions as raf kinase inhibitors |
| UY36294A (es) | 2014-09-12 | 2016-04-29 | Novartis Ag | Compuestos y composiciones como inhibidores de quinasa |
| JP2022525885A (ja) * | 2019-03-22 | 2022-05-20 | キネート バイオファーマ インク． | Ｒａｆキナーゼの阻害剤 |
| AR118826A1 (es) | 2019-05-03 | 2021-11-03 | Kinnate Biopharma Inc | Inhibidores de cinasas raf |
-
2020
- 2020-10-23 BR BR112022007612A patent/BR112022007612A2/pt unknown
- 2020-10-23 AU AU2020371727A patent/AU2020371727A1/en active Pending
- 2020-10-23 WO PCT/US2020/057132 patent/WO2021081375A1/en active Application Filing
- 2020-10-23 CN CN202080090257.4A patent/CN114845711A/zh active Pending
- 2020-10-23 KR KR1020227016515A patent/KR20220104702A/ko unknown
- 2020-10-23 CA CA3158530A patent/CA3158530A1/en active Pending
- 2020-10-23 TW TW109136965A patent/TW202128680A/zh unknown
- 2020-10-23 MX MX2022004937A patent/MX2022004937A/es unknown
- 2020-10-23 IL IL292424A patent/IL292424A/en unknown
- 2020-10-23 JP JP2022523904A patent/JP2022554169A/ja active Pending
- 2020-10-23 US US17/079,152 patent/US11098031B1/en active Active
- 2020-10-23 EP EP20878472.8A patent/EP4048259A4/de active Pending
-
2021
- 2021-03-25 US US17/213,036 patent/US20210300904A1/en active Pending
-
2022
- 2022-04-21 CL CL2022000998A patent/CL2022000998A1/es unknown
- 2022-05-20 CO CONC2022/0006712A patent/CO2022006712A2/es unknown
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