JPWO2021076805A5 - - Google Patents
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- Publication number
- JPWO2021076805A5 JPWO2021076805A5 JP2022522628A JP2022522628A JPWO2021076805A5 JP WO2021076805 A5 JPWO2021076805 A5 JP WO2021076805A5 JP 2022522628 A JP2022522628 A JP 2022522628A JP 2022522628 A JP2022522628 A JP 2022522628A JP WO2021076805 A5 JPWO2021076805 A5 JP WO2021076805A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- amino acid
- molecule
- lnp
- cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962915304P | 2019-10-15 | 2019-10-15 | |
| US62/915,304 | 2019-10-15 | ||
| US202062959716P | 2020-01-10 | 2020-01-10 | |
| US62/959,716 | 2020-01-10 | ||
| US202063017040P | 2020-04-29 | 2020-04-29 | |
| US63/017,040 | 2020-04-29 | ||
| PCT/US2020/055844 WO2021076805A1 (en) | 2019-10-15 | 2020-10-15 | Mrnas encoding immune modulating polypeptides and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022552371A JP2022552371A (ja) | 2022-12-15 |
| JP2022552371A5 JP2022552371A5 (https=) | 2023-10-24 |
| JPWO2021076805A5 true JPWO2021076805A5 (https=) | 2023-10-24 |
Family
ID=73402111
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022522628A Pending JP2022552371A (ja) | 2019-10-15 | 2020-10-15 | 免疫調節ポリペプチドをコードするｍＲＮＡ及びその使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20240158458A1 (https=) |
| EP (1) | EP4045527A1 (https=) |
| JP (1) | JP2022552371A (https=) |
| AU (1) | AU2020368447A1 (https=) |
| CA (1) | CA3157859A1 (https=) |
| WO (1) | WO2021076805A1 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20240042015A1 (en) | 2020-05-19 | 2024-02-08 | Orna Therapeutics, Inc. | Circular rna compositions and methods |
| IL303195A (en) | 2020-11-25 | 2023-07-01 | Akagera Medicines Inc | Lipid nanoparticles for delivery of nucleic acids and related methods of use |
| AU2022273530A1 (en) * | 2021-05-12 | 2023-11-23 | Massachusetts Institute Of Technology | Modified mrna, modified non-coding rna, and uses thereof |
| CN118302435A (zh) * | 2022-02-18 | 2024-07-05 | 江苏众红生物工程创药研究院有限公司 | 一种实现生物活性分子其活性控释和缓释的方法及药物应用 |
| WO2023215498A2 (en) * | 2022-05-05 | 2023-11-09 | Modernatx, Inc. | Compositions and methods for cd28 antagonism |
| EP4531819A2 (en) | 2022-05-25 | 2025-04-09 | Akagera Medicines, Inc. | Lipid nanoparticles for delivery of nucleic acids and methods of use thereof |
| WO2024129826A2 (en) * | 2022-12-14 | 2024-06-20 | Grann Pharmaceuticals Inc. | Compositions and methods for modulating hsp70 activity |
| EP4680728A1 (en) * | 2023-03-17 | 2026-01-21 | Quell Therapeutics Limited | Treg therapy |
| WO2024240962A1 (en) * | 2023-05-25 | 2024-11-28 | Ethris Gmbh | Gm-csf-encoding nucleic acids, pharmaceutical compositions, methods and uses thereof |
| WO2025024674A2 (en) * | 2023-07-26 | 2025-01-30 | Promab Biotechnologies, Inc. | Method for treating local and distant tumors |
| WO2025264765A1 (en) * | 2024-06-18 | 2025-12-26 | Grann Pharmaceuticals Inc. | Compositions and methods for modulating heat shock protein 70 activity for treatment of inflammatory diseases |
| CN120041511B (zh) * | 2025-04-24 | 2025-09-02 | 浙江大学 | IL-4受体激活剂或M-CSF受体激活剂在增强mRNA编辑巨噬细胞效率中的应用 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8613481D0 (en) | 1986-06-04 | 1986-07-09 | Diatech Ltd | Translation of mrna |
| JPH09505474A (ja) | 1993-11-26 | 1997-06-03 | ブリテイツシユ・テクノロジー・グループ・リミテツド | 翻訳エンハンサーｄｎａ |
| US5824497A (en) | 1995-02-10 | 1998-10-20 | Mcmaster University | High efficiency translation of mRNA molecules |
| EP2261250B1 (en) * | 2001-12-21 | 2015-07-01 | Human Genome Sciences, Inc. | GCSF-Albumin fusion proteins |
| WO2009061853A2 (en) * | 2007-11-05 | 2009-05-14 | Massachusetts Institute Of Technology | Mutant interleukin-2 (il-2) polypeptides |
| SMT202200502T1 (it) | 2014-06-25 | 2023-01-13 | Acuitas Therapeutics Inc | Nuovi lipidi e formulazioni di nanoparticelle lipidiche per l'erogazione di acidi nucleici |
| RU2749113C2 (ru) * | 2015-04-22 | 2021-06-04 | Куревак Аг | Содержащая рнк композиция для лечения опухолевых заболеваний |
| WO2017070620A2 (en) * | 2015-10-22 | 2017-04-27 | Modernatx, Inc. | Broad spectrum influenza virus vaccine |
| EP3364949A4 (en) * | 2015-10-22 | 2019-07-31 | ModernaTX, Inc. | CANCER VACCINES |
| IL307179A (en) | 2015-10-28 | 2023-11-01 | Acuitas Therapeutics Inc | Novel lipids and lipid nanoparticle formulations for delivery of nucleic acids |
| JP2020514321A (ja) * | 2017-02-01 | 2020-05-21 | モデルナティーエックス， インコーポレイテッド | 活性化がん遺伝子変異ペプチドをコードする免疫調節治療ｍＲＮＡ組成物 |
| EP3720470A4 (en) | 2017-12-06 | 2021-09-15 | Pandion Operations, Inc. | IL-2 MUTEINS AND THEIR USES |
| WO2019144309A1 (en) * | 2018-01-24 | 2019-08-01 | Beijing Percans Oncology Co. Ltd. | Cytokine Fusion Proteins |
| JP2021512090A (ja) * | 2018-01-30 | 2021-05-13 | モデルナティーエックス， インコーポレイテッド | 免疫細胞に薬剤を送達するための組成物及び方法 |
-
2020
- 2020-10-15 WO PCT/US2020/055844 patent/WO2021076805A1/en not_active Ceased
- 2020-10-15 JP JP2022522628A patent/JP2022552371A/ja active Pending
- 2020-10-15 EP EP20807153.0A patent/EP4045527A1/en not_active Withdrawn
- 2020-10-15 CA CA3157859A patent/CA3157859A1/en active Pending
- 2020-10-15 US US17/768,513 patent/US20240158458A1/en not_active Abandoned
- 2020-10-15 AU AU2020368447A patent/AU2020368447A1/en not_active Abandoned
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