JPWO2021065980A5 - - Google Patents
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- JPWO2021065980A5 JPWO2021065980A5 JP2021551352A JP2021551352A JPWO2021065980A5 JP WO2021065980 A5 JPWO2021065980 A5 JP WO2021065980A5 JP 2021551352 A JP2021551352 A JP 2021551352A JP 2021551352 A JP2021551352 A JP 2021551352A JP WO2021065980 A5 JPWO2021065980 A5 JP WO2021065980A5
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- Prior art keywords
- hydrogen atom
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019180349 | 2019-09-30 | ||
| JP2019180349 | 2019-09-30 | ||
| PCT/JP2020/037074 WO2021065980A1 (ja) | 2019-09-30 | 2020-09-30 | Ｂｅｔ分解剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JPWO2021065980A1 JPWO2021065980A1 (https=) | 2021-04-08 |
| JPWO2021065980A5 true JPWO2021065980A5 (https=) | 2023-10-10 |
| JP7642552B2 JP7642552B2 (ja) | 2025-03-10 |
Family
ID=75336978
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021551352A Active JP7642552B2 (ja) | 2019-09-30 | 2020-09-30 | Ｂｅｔ分解剤 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20220378923A1 (https=) |
| EP (1) | EP4039333A4 (https=) |
| JP (1) | JP7642552B2 (https=) |
| KR (1) | KR20220077138A (https=) |
| CN (2) | CN120623106A (https=) |
| CA (1) | CA3152923A1 (https=) |
| TW (1) | TW202126638A (https=) |
| WO (1) | WO2021065980A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL312013A (en) * | 2021-10-14 | 2024-06-01 | Cullgen Shanghai Inc | Modified proteins and protein degraders |
| WO2025127150A1 (ja) * | 2023-12-15 | 2025-06-19 | 協和キリン株式会社 | ２価ｂｅｔ分解薬およびターゲティング分子－薬物複合体 |
| WO2025155642A1 (en) * | 2024-01-21 | 2025-07-24 | The Regents Of The University Of California | Dcaf16-based covalent handle for the rational design of monovalent degraders |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3849458A (en) | 1966-01-21 | 1974-11-19 | Incentive Res & Dev Ab | Method for deuterating organic compounds |
| JPS61148141A (ja) | 1984-12-21 | 1986-07-05 | Mitsubishi Rayon Co Ltd | 重水素化アクリル酸メチルまたは重水素化メタクリル酸メチルの製造法 |
| JPS61277648A (ja) | 1985-06-03 | 1986-12-08 | Mitsubishi Rayon Co Ltd | 重水素化アクリル酸又は重水素化メタクリル酸の製造方法 |
| JPS61275241A (ja) | 1985-05-29 | 1986-12-05 | Mitsubishi Rayon Co Ltd | 重水素化アクリル酸又は重水素化メタクリル酸の製造方法 |
| DE3701302A1 (de) | 1987-01-17 | 1988-07-28 | Hoechst Ag | Verfahren zur herstellung von deuterierten organischen verbindungen |
| WO2013033268A2 (en) | 2011-08-29 | 2013-03-07 | Coferon, Inc. | Bivalent bromodomain ligands, and methods of using same |
| US9266891B2 (en) | 2012-11-16 | 2016-02-23 | Boehringer Ingelheim International Gmbh | Substituted [1,2,4]triazolo[4,3-A]pyrazines that are BRD4 inhibitors |
| SG11201505979UA (en) | 2013-02-19 | 2015-09-29 | Bayer Pharma AG | Bicyclo 2,3-benzodiazepines and spirocyclically substituted 2,3-benzodiazepines |
| MX2015012158A (es) | 2013-03-11 | 2015-12-01 | Abbvie Inc | Inhibidores de bomodominio tetraciclicos fusionados. |
| HUE043568T2 (hu) | 2013-03-14 | 2019-08-28 | Glaxosmithkline Ip No 2 Ltd | 2,3-diszubsztituált 1-acil-4-amino-1,2,3,4-tetrahidrokinolin származékok és bromodomén inhibitorokkénti felhasználásuk |
| JP6370368B2 (ja) | 2013-03-27 | 2018-08-08 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｂｒｄ４阻害剤としてのインドリノン類似体 |
| JP6453845B2 (ja) | 2013-03-27 | 2019-01-16 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｂｒｄ４阻害薬としてのジヒドロキナゾリノン類似体 |
| TWI530499B (zh) | 2013-03-28 | 2016-04-21 | 吉李德科學股份有限公司 | 作為溴結構域（ｂｒｏｍｏｄｏｍａｉｎ）抑制劑之苯並咪唑酮衍生物類 |
| US8975417B2 (en) | 2013-05-27 | 2015-03-10 | Novartis Ag | Pyrazolopyrrolidine derivatives and their use in the treatment of disease |
| WO2014206150A1 (en) | 2013-06-28 | 2014-12-31 | Abbvie Inc. | Bromodomain inhibitors |
| ES2635003T3 (es) | 2013-07-09 | 2017-10-02 | Bayer Pharma Aktiengesellschaft | Dihidroquinoxalinonas y dihidropiridopirazinonas modificadas inhibidoras de proteína BET |
| US20150051208A1 (en) | 2013-08-14 | 2015-02-19 | Boehringer Ingelheim International Gmbh | Pyridinones |
| CN110627770A (zh) | 2013-11-18 | 2019-12-31 | 福马疗法公司 | 作为bet溴域抑制剂的四氢喹啉组成物 |
| EA029269B1 (ru) | 2013-11-21 | 2018-02-28 | Новартис Аг | Производные пирролопирролона и их применение для лечения заболеваний |
| WO2015081284A1 (en) | 2013-11-26 | 2015-06-04 | Coferon, Inc. | Bivalent bromodomain ligands, and methods of using same |
| EP3089970B1 (en) | 2013-12-09 | 2018-10-17 | AbbVie Inc. | Dihydropyridinone and dihydropyridazinone derivatives useful as bromodomain inhibitors |
| CN105980392A (zh) | 2013-12-10 | 2016-09-28 | 艾伯维公司 | 溴区结构域抑制剂 |
| KR102457145B1 (ko) | 2013-12-24 | 2022-10-19 | 브리스톨-마이어스 스큅 컴퍼니 | 항암제로서의 트리시클릭 화합물 |
| US9428515B2 (en) | 2014-05-09 | 2016-08-30 | Boehringer Ingelheim International Gmbh | Benzimidazole derivatives |
| WO2016105518A1 (en) * | 2014-12-23 | 2016-06-30 | Dana-Farber Cancer Institute, Inc. | Methods to induce targeted protein degradation through bifunctional molecules |
| US10259809B2 (en) | 2015-02-03 | 2019-04-16 | Trillium Therapeutics Inc. | Fluorinated imidazo[4,5-C]quinoline derivatives as inhibitors of bromodomain containing proteins |
| EP3319944A4 (en) * | 2015-07-10 | 2019-04-24 | Arvinas, Inc. | MDM2-BASED MODULATORS OF PROTEOLYSIS AND RELATED USE METHODS |
| MX2018006499A (es) | 2015-11-25 | 2018-08-01 | Dana Farber Cancer Inst Inc | Inhibidores de bromodominio bivalentes y usos de los mismos. |
| KR20180132861A (ko) | 2016-04-12 | 2018-12-12 | 더 리젠츠 오브 더 유니버시티 오브 미시간 | Bet 단백질 분해제 |
| WO2018064589A1 (en) * | 2016-09-29 | 2018-04-05 | Dana-Farber Cancer Institute, Inc. | Targeted protein degradation using a mutant e3 ubiquitin ligase |
| EP3758753A1 (en) * | 2018-02-27 | 2021-01-06 | Pfizer Inc | Combination of a cyclin dependent kinase inhibitor and a bet-bromodomain inhibitor |
| US11629152B2 (en) * | 2018-03-30 | 2023-04-18 | Kyowa Kirin Co., Ltd. | Compound with anticancer activity |
| EP3819305A4 (en) * | 2018-07-04 | 2022-04-06 | Mitsubishi Tanabe Pharma Corporation | AMIDE COMPOUND WITH BET PROTEOLYSIS-INDUCING ACTIVITY AND MEDICAL USE THEREOF |
-
2020
- 2020-09-30 CN CN202510130550.3A patent/CN120623106A/zh active Pending
- 2020-09-30 CN CN202080068724.3A patent/CN114502534A/zh active Pending
- 2020-09-30 WO PCT/JP2020/037074 patent/WO2021065980A1/ja not_active Ceased
- 2020-09-30 JP JP2021551352A patent/JP7642552B2/ja active Active
- 2020-09-30 TW TW109134098A patent/TW202126638A/zh unknown
- 2020-09-30 CA CA3152923A patent/CA3152923A1/en active Pending
- 2020-09-30 EP EP20873126.5A patent/EP4039333A4/en active Pending
- 2020-09-30 KR KR1020227014225A patent/KR20220077138A/ko active Pending
- 2020-09-30 US US17/764,883 patent/US20220378923A1/en active Pending
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