JPWO2021054448A5 - - Google Patents
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- JPWO2021054448A5 JPWO2021054448A5 JP2021546983A JP2021546983A JPWO2021054448A5 JP WO2021054448 A5 JPWO2021054448 A5 JP WO2021054448A5 JP 2021546983 A JP2021546983 A JP 2021546983A JP 2021546983 A JP2021546983 A JP 2021546983A JP WO2021054448 A5 JPWO2021054448 A5 JP WO2021054448A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- thr
- ala
- peptide
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 201000011510 cancer Diseases 0.000 description 5
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- -1 9-fluorenylmethoxycarbonyl (Fmoc) Chemical class 0.000 description 3
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 3
- OBMZMSLWNNWEJA-XNCRXQDQSA-N C1=CC=2C(C[C@@H]3NC(=O)[C@@H](NC(=O)[C@H](NC(=O)N(CC#CCN(CCCC[C@H](NC(=O)[C@@H](CC4=CC=CC=C4)NC3=O)C(=O)N)CC=C)NC(=O)[C@@H](N)C)CC3=CNC4=C3C=CC=C4)C)=CNC=2C=C1 Chemical compound C1=CC=2C(C[C@@H]3NC(=O)[C@@H](NC(=O)[C@H](NC(=O)N(CC#CCN(CCCC[C@H](NC(=O)[C@@H](CC4=CC=CC=C4)NC3=O)C(=O)N)CC=C)NC(=O)[C@@H](N)C)CC3=CNC4=C3C=CC=C4)C)=CNC=2C=C1 OBMZMSLWNNWEJA-XNCRXQDQSA-N 0.000 description 3
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- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- JGFZNNIVVJXRND-UHFFFAOYSA-N N,N-Diisopropylethylamine (DIPEA) Chemical compound CCN(C(C)C)C(C)C JGFZNNIVVJXRND-UHFFFAOYSA-N 0.000 description 2
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- VZQHRKZCAZCACO-PYJNHQTQSA-N (2s)-2-[[(2s)-2-[2-[[(2s)-2-[[(2s)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]propanoyl]amino]prop-2-enoylamino]-3-methylbutanoyl]amino]propanoic acid Chemical compound OC(=O)[C@H](C)NC(=O)[C@H](C(C)C)NC(=O)C(=C)NC(=O)[C@H](C)NC(=O)[C@@H](N)CCCNC(N)=N VZQHRKZCAZCACO-PYJNHQTQSA-N 0.000 description 1
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- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 1
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- 208000008839 Kidney Neoplasms Diseases 0.000 description 1
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- 206010027406 Mesothelioma Diseases 0.000 description 1
- 206010063569 Metastatic squamous cell carcinoma Diseases 0.000 description 1
- 208000035489 Monocytic Acute Leukemia Diseases 0.000 description 1
- 208000034578 Multiple myelomas Diseases 0.000 description 1
- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 description 1
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 description 1
- 208000033835 Myelomonocytic Acute Leukemia Diseases 0.000 description 1
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- 208000009565 Pharyngeal Neoplasms Diseases 0.000 description 1
- 206010034811 Pharyngeal cancer Diseases 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 206010035226 Plasma cell myeloma Diseases 0.000 description 1
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 description 1
- 206010060862 Prostate cancer Diseases 0.000 description 1
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- 206010038389 Renal cancer Diseases 0.000 description 1
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- 208000034254 Squamous cell carcinoma of the cervix uteri Diseases 0.000 description 1
- 208000024313 Testicular Neoplasms Diseases 0.000 description 1
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 description 1
- 239000004473 Threonine Substances 0.000 description 1
- 208000024770 Thyroid neoplasm Diseases 0.000 description 1
- 206010062129 Tongue neoplasm Diseases 0.000 description 1
- 206010046770 Uterine carcinoma in situ Diseases 0.000 description 1
- 208000033559 Waldenström macroglobulinemia Diseases 0.000 description 1
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- 230000001154 acute effect Effects 0.000 description 1
- 208000011912 acute myelomonocytic leukemia M4 Diseases 0.000 description 1
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- 208000027202 mammary Paget disease Diseases 0.000 description 1
- 238000001840 matrix-assisted laser desorption--ionisation time-of-flight mass spectrometry Methods 0.000 description 1
- 201000009023 maxillary cancer Diseases 0.000 description 1
- 208000023356 medullary thyroid gland carcinoma Diseases 0.000 description 1
- 206010027191 meningioma Diseases 0.000 description 1
- 238000001000 micrograph Methods 0.000 description 1
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- 208000025189 neoplasm of testis Diseases 0.000 description 1
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- 208000004019 papillary adenocarcinoma Diseases 0.000 description 1
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- 238000010647 peptide synthesis reaction Methods 0.000 description 1
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- 201000009410 rhabdomyosarcoma Diseases 0.000 description 1
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- 206010042863 synovial sarcoma Diseases 0.000 description 1
- 201000003120 testicular cancer Diseases 0.000 description 1
- HNKJADCVZUBCPG-UHFFFAOYSA-N thioanisole Chemical compound CSC1=CC=CC=C1 HNKJADCVZUBCPG-UHFFFAOYSA-N 0.000 description 1
- 201000002510 thyroid cancer Diseases 0.000 description 1
- 208000030901 thyroid gland follicular carcinoma Diseases 0.000 description 1
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- 206010046766 uterine cancer Diseases 0.000 description 1
- 201000005290 uterine carcinosarcoma Diseases 0.000 description 1
- 208000037965 uterine sarcoma Diseases 0.000 description 1
- 210000004291 uterus Anatomy 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023127504A JP2023133582A (ja) | 2019-09-20 | 2023-08-04 | ペプチド並びにそれを含む細胞融合剤及びがん治療用医薬組成物 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019171919 | 2019-09-20 | ||
| JP2019171919 | 2019-09-20 | ||
| PCT/JP2020/035491 WO2021054448A1 (ja) | 2019-09-20 | 2020-09-18 | ペプチド並びにそれを含む細胞融合剤及びがん治療用医薬組成物 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023127504A Division JP2023133582A (ja) | 2019-09-20 | 2023-08-04 | ペプチド並びにそれを含む細胞融合剤及びがん治療用医薬組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JPWO2021054448A1 JPWO2021054448A1 (https=) | 2021-03-25 |
| JPWO2021054448A5 true JPWO2021054448A5 (https=) | 2022-11-18 |
| JP7329056B2 JP7329056B2 (ja) | 2023-08-17 |
Family
ID=74883555
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021546983A Active JP7329056B2 (ja) | 2019-09-20 | 2020-09-18 | ペプチド並びにそれを含む細胞融合剤及びがん治療用医薬組成物 |
| JP2023127504A Pending JP2023133582A (ja) | 2019-09-20 | 2023-08-04 | ペプチド並びにそれを含む細胞融合剤及びがん治療用医薬組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023127504A Pending JP2023133582A (ja) | 2019-09-20 | 2023-08-04 | ペプチド並びにそれを含む細胞融合剤及びがん治療用医薬組成物 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20230034205A1 (https=) |
| EP (1) | EP4032589A4 (https=) |
| JP (2) | JP7329056B2 (https=) |
| KR (1) | KR20220066309A (https=) |
| CN (1) | CN114423778B (https=) |
| AU (1) | AU2020349967A1 (https=) |
| CA (1) | CA3158336A1 (https=) |
| WO (1) | WO2021054448A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022202785A1 (ja) * | 2021-03-22 | 2022-09-29 | 美智子 甲賀 | ポリペプチド並びにそれを含む細胞融合剤及びがん治療用医薬組成物 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5768790A (en) * | 1980-10-15 | 1982-04-27 | Hidetoshi Tsuchida | Cell fusion agent |
| DE3321226C2 (de) * | 1983-06-11 | 1985-05-09 | Kernforschungsanlage Jülich GmbH, 5170 Jülich | Verfahren zur Fusion von Zellen |
| JP3099049B2 (ja) * | 1992-07-29 | 2000-10-16 | 農林水産省果樹試験場長 | 電気的細胞融合及び電気的核酸導入のための大量処理用電極 |
| EP1454988A1 (en) * | 2003-03-03 | 2004-09-08 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Infectious flavivirus pseudo-particles containing functional prM-E envelope proteins |
| US20080176923A1 (en) * | 2003-12-18 | 2008-07-24 | Salama Zoser B | Proline Derivatives Used as Pharmaceutical Active Ingredients for the Treatment of Tumors |
| EP1831373A2 (en) * | 2004-12-22 | 2007-09-12 | Novozymes A/S | Recombinant production of serum albumin |
| EP2508606B1 (en) * | 2006-10-24 | 2017-09-13 | Momotaro-Gene Inc. | Partial fragment of REIC/Dkk-3 gene and therapeutic agent for cancer containing the same |
| EP2323679A4 (en) * | 2008-07-25 | 2012-08-22 | Univ Colorado | CLIP INHIBITORS AND METHODS FOR MODULATING IMMUNE FUNCTION |
| CN107201344A (zh) * | 2017-06-13 | 2017-09-26 | 成都源泉生物科技有限公司 | 一种动物细胞融合基础培养基 |
| CN108315319A (zh) * | 2018-02-05 | 2018-07-24 | 翁炳焕 | 一种cd138单抗靶向捕获的细胞融合方法 |
| CN108707600A (zh) * | 2018-05-31 | 2018-10-26 | 东北农业大学 | 一种猪鼠细胞单细胞融合方法 |
-
2020
- 2020-09-18 WO PCT/JP2020/035491 patent/WO2021054448A1/ja not_active Ceased
- 2020-09-18 AU AU2020349967A patent/AU2020349967A1/en active Pending
- 2020-09-18 US US17/753,919 patent/US20230034205A1/en active Pending
- 2020-09-18 EP EP20865680.1A patent/EP4032589A4/en active Pending
- 2020-09-18 JP JP2021546983A patent/JP7329056B2/ja active Active
- 2020-09-18 KR KR1020227012189A patent/KR20220066309A/ko not_active Ceased
- 2020-09-18 CN CN202080065700.2A patent/CN114423778B/zh active Active
- 2020-09-18 CA CA3158336A patent/CA3158336A1/en active Pending
-
2023
- 2023-08-04 JP JP2023127504A patent/JP2023133582A/ja active Pending
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