JPWO2021050571A5 - - Google Patents
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- Publication number
- JPWO2021050571A5 JPWO2021050571A5 JP2022514994A JP2022514994A JPWO2021050571A5 JP WO2021050571 A5 JPWO2021050571 A5 JP WO2021050571A5 JP 2022514994 A JP2022514994 A JP 2022514994A JP 2022514994 A JP2022514994 A JP 2022514994A JP WO2021050571 A5 JPWO2021050571 A5 JP WO2021050571A5
- Authority
- JP
- Japan
- Prior art keywords
- adenosine deaminase
- fusion protein
- base editor
- protein according
- modification
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025122950A JP2025170240A (ja) | 2019-09-09 | 2025-07-23 | 新規核酸塩基エディター及びその使用方法 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962897777P | 2019-09-09 | 2019-09-09 | |
| US62/897,777 | 2019-09-09 | ||
| USPCT/US2020/018195 | 2020-02-13 | ||
| PCT/US2020/018195 WO2020168135A1 (en) | 2019-02-13 | 2020-02-13 | Compositions and methods for treating alpha-1 antitrypsin deficiency |
| PCT/US2020/049975 WO2021050571A1 (en) | 2019-09-09 | 2020-09-09 | Novel nucleobase editors and methods of using same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025122950A Division JP2025170240A (ja) | 2019-09-09 | 2025-07-23 | 新規核酸塩基エディター及びその使用方法 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2022546608A JP2022546608A (ja) | 2022-11-04 |
| JP2022546608A5 JP2022546608A5 (https=) | 2023-09-19 |
| JPWO2021050571A5 true JPWO2021050571A5 (https=) | 2023-09-19 |
| JP7717684B2 JP7717684B2 (ja) | 2025-08-04 |
Family
ID=74867196
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022514994A Active JP7717684B2 (ja) | 2019-09-09 | 2020-09-09 | 新規核酸塩基エディター及びその使用方法 |
| JP2025122950A Pending JP2025170240A (ja) | 2019-09-09 | 2025-07-23 | 新規核酸塩基エディター及びその使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025122950A Pending JP2025170240A (ja) | 2019-09-09 | 2025-07-23 | 新規核酸塩基エディター及びその使用方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20230075877A1 (https=) |
| EP (1) | EP4028026A4 (https=) |
| JP (2) | JP7717684B2 (https=) |
| KR (1) | KR20220076467A (https=) |
| CN (1) | CN114667149A (https=) |
| AU (1) | AU2020344547A1 (https=) |
| CA (1) | CA3153624A1 (https=) |
| WO (1) | WO2021050571A1 (https=) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN121555430A (zh) | 2018-05-11 | 2026-02-24 | 比姆医疗股份有限公司 | 使用可编程碱基编辑器系统取代病原性氨基酸的方法 |
| EP3850088A4 (en) | 2018-09-07 | 2023-07-19 | Beam Therapeutics, Inc. | Compositions and methods for improving base editing |
| KR20210055733A (ko) | 2018-09-07 | 2021-05-17 | 빔 테라퓨틱스, 인크. | 핵염기 편집 시스템을 전달하기 위한 조성물 및 방법 |
| US20220235347A1 (en) | 2019-02-13 | 2022-07-28 | Beam Therapeutics Inc. | Compositions and methods for treating hemoglobinopathies |
| KR20210126680A (ko) * | 2019-02-13 | 2021-10-20 | 빔 테라퓨틱스, 인크. | 알파-1 항트립신 결핍증을 치료하기 위한 조성물 및 방법 |
| WO2020168122A1 (en) | 2019-02-13 | 2020-08-20 | Beam Therapeutics Inc. | Modified immune cells having adenosine deaminase base editors for modifying a nucleobase in a target sequence |
| EP4034138A4 (en) | 2019-09-27 | 2024-07-31 | Beam Therapeutics, Inc. | COMPOSITIONS AND METHODS FOR THE TREATMENT OF LIQUID CANCERS |
| AU2021347359A1 (en) | 2020-09-25 | 2023-05-18 | Beam Therapeutics Inc. | Fratricide resistant modified immune cells and methods of using the same |
| CA3214494A1 (en) * | 2021-03-26 | 2022-09-29 | Beam Therapeutics Inc. | Adenosine deaminase variants and uses thereof |
| EP4337701A4 (en) | 2021-05-10 | 2025-04-09 | Mammoth Biosciences, Inc. | EFFECTOR PROTEINS AND METHODS OF USE |
| WO2023275892A1 (en) * | 2021-06-29 | 2023-01-05 | Council Of Scientific & Industrial Research | Engineered fncas9 and uses thereof |
| US20240352439A1 (en) * | 2021-09-03 | 2024-10-24 | The University Of Chicago | Polypeptides and methods for modifying nucleic acids |
| AU2022342169A1 (en) * | 2021-09-08 | 2024-03-28 | Flagship Pioneering Innovations Vi, Llc | Hbb-modulating compositions and methods |
| WO2023052366A1 (en) | 2021-09-28 | 2023-04-06 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Base editing approaches for the treatment of beta-hemoglobinopathies |
| WO2023099591A1 (en) | 2021-12-01 | 2023-06-08 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for increasing fetal hemoglobin content by editing the +55-kb region of the erythroid-specific bcl11a enhancer |
| AU2023209457A1 (en) | 2022-01-21 | 2024-08-08 | Mammoth Biosciences, Inc. | Effector proteins and methods of use |
| US20250161492A1 (en) | 2022-01-25 | 2025-05-22 | Institut National de la Santé et de la Recherche Médicale | Base editing approaches for the treatment of beta-thalassemia |
| AU2023248451A1 (en) | 2022-04-04 | 2024-10-17 | President And Fellows Of Harvard College | Cas9 variants having non-canonical pam specificities and uses thereof |
| CN120456933A (zh) | 2022-04-28 | 2025-08-08 | 布罗德研究所股份有限公司 | 编码碱基编辑器的aav载体及其用途 |
| EP4522647A1 (en) | 2022-05-10 | 2025-03-19 | Institut National de la Santé et de la Recherche Médicale | Base editing approaches for correcting the cd39 (cag>tag) mutation in patients suffering from beta-thalassemia |
| WO2023217904A1 (en) | 2022-05-10 | 2023-11-16 | Institut National de la Santé et de la Recherche Médicale | Syncitin-1 fusion proteins and uses thereof for cargo delivery into target cells |
| EP4558633A1 (en) | 2022-07-22 | 2025-05-28 | Institut National de la Santé et de la Recherche Médicale | Base editing approaches for correcting the ivs2-1 (g>a) mutation in patients suffering from beta-thalassemia |
| CN115820691B (zh) * | 2022-07-25 | 2023-08-22 | 安徽农业大学 | 一种基于LbCpf1变体的水稻碱基编辑系统和应用 |
| CA3263821A1 (en) | 2022-08-16 | 2024-02-22 | The Broad Institute, Inc. | ADVANCED CYTOSIN DESAMINASE AND DNA EDITING METHODS USING IT |
| CN116790558A (zh) * | 2022-08-22 | 2023-09-22 | 山东舜丰生物科技有限公司 | 突变的Cas12j蛋白及其应用 |
| CN119998447A (zh) * | 2022-09-23 | 2025-05-13 | 基础科学研究院 | 新型腺嘌呤脱氨酶变体及使用其进行碱基编辑的方法 |
| JP2026506554A (ja) | 2023-02-06 | 2026-02-25 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | 多重塩基編集による遺伝子改変造血幹細胞の濃縮 |
| WO2024230760A1 (zh) * | 2023-05-09 | 2024-11-14 | 北京齐禾生科生物科技有限公司 | 一种可作用于dna的腺苷脱氨酶及其应用 |
| CN117965505A (zh) * | 2023-06-28 | 2024-05-03 | 微光基因(苏州)有限公司 | 工程化的腺苷脱氨酶及碱基编辑器 |
| AU2024299627A1 (en) | 2023-07-25 | 2026-01-22 | Flagship Pioneering Innovations Vii, Llc | Cas endonucleases and related methods |
| WO2025059520A1 (en) * | 2023-09-15 | 2025-03-20 | Beam Therapeutics Inc. | Compositions and methods for base editing a phenylalanine hydroxylase polynucleotide |
| WO2025072331A1 (en) | 2023-09-26 | 2025-04-03 | Flagship Pioneering Innovations Vii, Llc | Cas nucleases and related methods |
| WO2025117877A2 (en) | 2023-12-01 | 2025-06-05 | Flagship Pioneering Innovations Vii, Llc | Cas nucleases and related methods |
| CN120536418A (zh) * | 2024-02-26 | 2025-08-26 | 尧唐(上海)生物科技有限公司 | 一种脱氨酶变体、包含其的碱基编辑器及其应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2753391T3 (es) * | 2014-10-14 | 2020-04-08 | Halozyme Inc | Composiciones de adenosina desaminasa 2 (ADA2), variantes de la misma y métodos de uso de las mismas |
| KR102547316B1 (ko) * | 2016-08-03 | 2023-06-23 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 아데노신 핵염기 편집제 및 그의 용도 |
| US11242542B2 (en) * | 2016-10-07 | 2022-02-08 | Integrated Dna Technologies, Inc. | S. pyogenes Cas9 mutant genes and polypeptides encoded by same |
| EP3526320A1 (en) * | 2016-10-14 | 2019-08-21 | President and Fellows of Harvard College | Aav delivery of nucleobase editors |
| WO2018089664A1 (en) * | 2016-11-11 | 2018-05-17 | The Regents Of The University Of California | Variant rna-guided polypeptides and methods of use |
| KR20250107288A (ko) * | 2017-10-16 | 2025-07-11 | 더 브로드 인스티튜트, 인코퍼레이티드 | 아데노신 염기 편집제의 용도 |
| CN109957569B (zh) * | 2017-12-22 | 2022-10-25 | 苏州齐禾生科生物科技有限公司 | 基于cpf1蛋白的碱基编辑系统和方法 |
| CN109295186B (zh) * | 2018-09-30 | 2023-10-03 | 中山大学 | 一种基于全基因组测序检测腺嘌呤单碱基编辑系统脱靶效应的方法及其在基因编辑中的应用 |
-
2020
- 2020-09-09 CN CN202080077983.2A patent/CN114667149A/zh active Pending
- 2020-09-09 CA CA3153624A patent/CA3153624A1/en active Pending
- 2020-09-09 AU AU2020344547A patent/AU2020344547A1/en active Pending
- 2020-09-09 EP EP20863422.0A patent/EP4028026A4/en active Pending
- 2020-09-09 WO PCT/US2020/049975 patent/WO2021050571A1/en not_active Ceased
- 2020-09-09 JP JP2022514994A patent/JP7717684B2/ja active Active
- 2020-09-09 US US17/641,343 patent/US20230075877A1/en active Pending
- 2020-09-09 KR KR1020227011386A patent/KR20220076467A/ko active Pending
-
2025
- 2025-07-23 JP JP2025122950A patent/JP2025170240A/ja active Pending
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