JPWO2021033729A1 - - Google Patents

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Publication number
JPWO2021033729A1
JPWO2021033729A1 JP2021540972A JP2021540972A JPWO2021033729A1 JP WO2021033729 A1 JPWO2021033729 A1 JP WO2021033729A1 JP 2021540972 A JP2021540972 A JP 2021540972A JP 2021540972 A JP2021540972 A JP 2021540972A JP WO2021033729 A1 JPWO2021033729 A1 JP WO2021033729A1
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JP
Japan
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JP2021540972A
Other versions
JP7409383B2 (ja
JPWO2021033729A5 (ja
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Publication of JPWO2021033729A1 publication Critical patent/JPWO2021033729A1/ja
Publication of JPWO2021033729A5 publication Critical patent/JPWO2021033729A5/ja
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
    • C07C55/02—Dicarboxylic acids
    • C07C55/10—Succinic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
    • C07C65/03—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups monocyclic and having all hydroxy or O-metal groups bound to the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP2021540972A 2019-08-20 2020-08-19 Ｓ１ｐ５受容体作動活性を有する化合物の塩および結晶形 Active JP7409383B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962889091P 2019-08-20 2019-08-20
US62/889,091 2019-08-20
PCT/JP2020/031326 WO2021033729A1 (ja) 2019-08-20 2020-08-19 Ｓ１ｐ５受容体作動活性を有する化合物の塩および結晶形

Publications (3)

Publication Number Publication Date
JPWO2021033729A1 true JPWO2021033729A1 (ja) 2021-02-25
JPWO2021033729A5 JPWO2021033729A5 (ja) 2022-09-14
JP7409383B2 JP7409383B2 (ja) 2024-01-09

Family

ID=74660224

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2021540972A Active JP7409383B2 (ja) 2019-08-20 2020-08-19 Ｓ１ｐ５受容体作動活性を有する化合物の塩および結晶形

Country Status (13)

Country Link
US (1) US20220289675A1 (ja)
EP (1) EP4019496B1 (ja)
JP (1) JP7409383B2 (ja)
KR (1) KR20220050886A (ja)
CN (1) CN114302873A (ja)
AU (1) AU2020334489A1 (ja)
BR (1) BR112022002632A2 (ja)
CA (1) CA3150303A1 (ja)
IL (1) IL290432A (ja)
MX (1) MX2022001820A (ja)
TW (1) TW202114984A (ja)
WO (1) WO2021033729A1 (ja)
ZA (1) ZA202201784B (ja)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2024522718A (ja) * 2021-06-16 2024-06-21 セルジーン コーポレーション 神経変性疾患の治療のための、カルボン酸基を含むアゼチジニル化合物
WO2024129948A1 (en) * 2022-12-16 2024-06-20 Celgene Corporation Heterocyclic compounds as modulators of s1p5

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01149790A (ja) * 1987-10-27 1989-06-12 Ciba Geigy Ag 新規なリファマイシン誘導体
JPH02500744A (ja) * 1986-11-21 1990-03-15 アクチエボラゲツト・ヘツスレ 新規な薬学的化合物
WO2006064757A1 (ja) * 2004-12-13 2006-06-22 Ono Pharmaceutical Co., Ltd. アミノカルボン酸誘導体およびその医薬用途
JP2009540006A (ja) * 2006-06-12 2009-11-19 ノバルティス アクチエンゲゼルシャフト Ｎ−ヒドロキシ−３−［４−［［［２−（２−メチル−１ｈ−インドール−３−イル）エチル］アミノ］メチル］フェニル］−２ｅ−２−プロペンアミドの多形
WO2016088834A1 (ja) * 2014-12-04 2016-06-09 小野薬品工業株式会社 ジヒドロナフタレン誘導体
JP7211410B2 (ja) * 2018-02-22 2023-01-24 小野薬品工業株式会社 Ｓ１ｐ５受容体作動活性を有する化合物

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005020882A (ja) 2003-06-25 2005-01-20 Matsushita Electric Works Ltd モータアクチュエータ装置
JP2006064757A (ja) 2004-08-24 2006-03-09 Systec Kyowa:Kk ディスプレイ固定用スタンド

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02500744A (ja) * 1986-11-21 1990-03-15 アクチエボラゲツト・ヘツスレ 新規な薬学的化合物
JPH01149790A (ja) * 1987-10-27 1989-06-12 Ciba Geigy Ag 新規なリファマイシン誘導体
WO2006064757A1 (ja) * 2004-12-13 2006-06-22 Ono Pharmaceutical Co., Ltd. アミノカルボン酸誘導体およびその医薬用途
JP2009540006A (ja) * 2006-06-12 2009-11-19 ノバルティス アクチエンゲゼルシャフト Ｎ−ヒドロキシ−３−［４−［［［２−（２−メチル−１ｈ−インドール−３−イル）エチル］アミノ］メチル］フェニル］−２ｅ−２−プロペンアミドの多形
WO2016088834A1 (ja) * 2014-12-04 2016-06-09 小野薬品工業株式会社 ジヒドロナフタレン誘導体
JP7211410B2 (ja) * 2018-02-22 2023-01-24 小野薬品工業株式会社 Ｓ１ｐ５受容体作動活性を有する化合物
JP2023029542A (ja) * 2018-02-22 2023-03-03 小野薬品工業株式会社 Ｓ１ｐ５受容体作動活性を有する化合物

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
"Pharmaceutical Salts", JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 66, no. 1, JPN6014023656, 1977, pages 1 - 19, ISSN: 0005114159 *
小嶌隆史: "医薬品開発における結晶性選択の効率化を目指して", 薬剤学, vol. 68, no. 5, JPN6009053757, 1 September 2008 (2008-09-01), pages 344 - 349, ISSN: 0005114156 *
芦澤 一英: "塩・結晶形の最適化と結晶化技術", PHARM TECH JAPAN, vol. 18, no. 10, JPN6013060608, 2002, pages 81 - 96, ISSN: 0005114157 *
高田則幸: "創薬段階における原薬Formスクリーニングと選択", PHARM STAGE, vol. 6, no. 10, JPN6009053755, 15 January 2007 (2007-01-15), pages 20 - 25, ISSN: 0005114158 *

Also Published As

Publication number Publication date
BR112022002632A2 (pt) 2022-05-03
EP4019496A1 (en) 2022-06-29
AU2020334489A1 (en) 2022-03-03
JP7409383B2 (ja) 2024-01-09
EP4019496B1 (en) 2024-06-05
ZA202201784B (en) 2024-02-28
MX2022001820A (es) 2022-03-17
IL290432A (en) 2022-04-01
US20220289675A1 (en) 2022-09-15
WO2021033729A1 (ja) 2021-02-25
CN114302873A (zh) 2022-04-08
KR20220050886A (ko) 2022-04-25
CA3150303A1 (en) 2021-02-25
TW202114984A (zh) 2021-04-16
EP4019496A4 (en) 2023-01-11

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