JPWO2021021986A5 - - Google Patents
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- Publication number
- JPWO2021021986A5 JPWO2021021986A5 JP2022506169A JP2022506169A JPWO2021021986A5 JP WO2021021986 A5 JPWO2021021986 A5 JP WO2021021986A5 JP 2022506169 A JP2022506169 A JP 2022506169A JP 2022506169 A JP2022506169 A JP 2022506169A JP WO2021021986 A5 JPWO2021021986 A5 JP WO2021021986A5
- Authority
- JP
- Japan
- Prior art keywords
- carboxamide
- imidazol
- alkyl
- pyrimidine
- cyclohexyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962880923P | 2019-07-31 | 2019-07-31 | |
| US62/880,923 | 2019-07-31 | ||
| US201962951604P | 2019-12-20 | 2019-12-20 | |
| US62/951,604 | 2019-12-20 | ||
| US202063034750P | 2020-06-04 | 2020-06-04 | |
| US63/034,750 | 2020-06-04 | ||
| PCT/US2020/044156 WO2021021986A1 (en) | 2019-07-31 | 2020-07-30 | Heterobicyclic amides as inhibitors of cd38 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022542396A JP2022542396A (ja) | 2022-10-03 |
| JPWO2021021986A5 true JPWO2021021986A5 (es) | 2023-08-07 |
Family
ID=72139677
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022506169A Pending JP2022542396A (ja) | 2019-07-31 | 2020-07-30 | Ｃｄ３８の阻害剤としてのヘテロ二環式アミド |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US11535621B2 (es) |
| EP (1) | EP4003980A1 (es) |
| JP (1) | JP2022542396A (es) |
| KR (1) | KR20220061958A (es) |
| CN (1) | CN114423753A (es) |
| AU (1) | AU2020321956A1 (es) |
| BR (1) | BR112022001291A2 (es) |
| CA (1) | CA3147902A1 (es) |
| IL (1) | IL289878A (es) |
| MX (1) | MX2022001019A (es) |
| TW (1) | TW202120496A (es) |
| WO (1) | WO2021021986A1 (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2022542396A (ja) | 2019-07-31 | 2022-10-03 | ライボン・セラピューティクス・インコーポレイテッド | Ｃｄ３８の阻害剤としてのヘテロ二環式アミド |
| WO2022165114A1 (en) | 2021-01-29 | 2022-08-04 | Ribon Therapeutics, Inc. | Quinolines and azaquinolines as inhibitors of cd38 |
| CN117813296A (zh) * | 2021-07-12 | 2024-04-02 | 赛特凯恩蒂克公司 | Cd38调节剂和其使用方法 |
| WO2023084206A1 (en) | 2021-11-09 | 2023-05-19 | Cerevance Ltd | N-(4-aminocyclohexyl)pyrimidine-4-carboxamide derivatives as cd38 inhibitors |
| CN114306366B (zh) * | 2021-11-30 | 2023-01-06 | 合肥康诺生物制药有限公司 | 含nad和cd38抑制剂的药物组合物及其用途 |
| WO2023098699A1 (en) * | 2021-12-01 | 2023-06-08 | Nanjing Immunophage Biotech Co., Ltd | Compounds and their uses as cd38 inhibitors |
| GB202207721D0 (en) * | 2022-05-25 | 2022-07-06 | Cerevance Ltd | Novel Compounds |
| KR20240020201A (ko) * | 2022-08-05 | 2024-02-14 | 주식회사 넥스트젠바이오사이언스 | 저산소증 유도 인자 1(hif-1) 억제제 또는 혈관내피성장인자(vegf)억제제 로서의 신규 화합물 및 이를 포함하는 약학적 조성물 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2666624C (en) * | 2006-10-19 | 2015-12-29 | Signal Pharmaceuticals, Llc | Heteroaryl compounds, compositions thereof, and use thereof as protein kinase inhibitors |
| US8765792B2 (en) * | 2010-12-01 | 2014-07-01 | Glaxosmithkline Llc | Indoles |
| MY183661A (en) * | 2011-10-19 | 2021-03-05 | Signal Pharm Llc | Treatment of cancer with tor kinase inhibitors |
| RU2621148C2 (ru) * | 2011-11-04 | 2017-05-31 | Глэксосмитклайн Интеллекчуал Проперти (Но.2) Лимитед | Способ лечения |
| NZ628410A (en) * | 2012-02-24 | 2016-03-31 | Signal Pharm Llc | Methods for treating non-small cell lung cancer using tor kinase inhibitor combination therapy |
| EA201591746A1 (ru) | 2013-03-14 | 2016-08-31 | КОНВЕРДЖЕН ЭлЭлСи | Способы и композиции для ингибирования бромодомен-содержащих белков |
| KR20170090478A (ko) | 2014-12-03 | 2017-08-07 | 글락소스미스클라인 인털렉츄얼 프로퍼티 (넘버 2) 리미티드 | Cd38 억제제 및 치료 방법 |
| WO2017053604A1 (en) | 2015-09-23 | 2017-03-30 | The Regents Of The University Of California | Potent antiviral pyrazolopyridine compounds |
| WO2018151830A1 (en) | 2017-02-17 | 2018-08-23 | Fronthera U.S. Pharmaceuticals Llc | Pyridinyl based apoptosis signal-regulation kinase inhibitors |
| EP3434692A1 (en) | 2017-07-24 | 2019-01-30 | Encefa | Compounds which specifically binds to cd38 for use in the treatment of neurodegenerative diseases |
| EP3687529B1 (en) * | 2017-09-27 | 2023-07-12 | The Regents of the University of California | Potent antiviral pyridine-containing compounds |
| JP2022542396A (ja) | 2019-07-31 | 2022-10-03 | ライボン・セラピューティクス・インコーポレイテッド | Ｃｄ３８の阻害剤としてのヘテロ二環式アミド |
| US20230025807A1 (en) | 2019-10-30 | 2023-01-26 | Mitobridge Inc. | Cd38 inhibitors |
| IL297128A (en) | 2020-04-07 | 2022-12-01 | Mitobridge Inc | cd38 inhibitors |
| WO2022165114A1 (en) | 2021-01-29 | 2022-08-04 | Ribon Therapeutics, Inc. | Quinolines and azaquinolines as inhibitors of cd38 |
-
2020
- 2020-07-30 JP JP2022506169A patent/JP2022542396A/ja active Pending
- 2020-07-30 TW TW109125742A patent/TW202120496A/zh unknown
- 2020-07-30 CN CN202080066542.2A patent/CN114423753A/zh active Pending
- 2020-07-30 WO PCT/US2020/044156 patent/WO2021021986A1/en unknown
- 2020-07-30 US US16/942,857 patent/US11535621B2/en active Active
- 2020-07-30 MX MX2022001019A patent/MX2022001019A/es unknown
- 2020-07-30 AU AU2020321956A patent/AU2020321956A1/en active Pending
- 2020-07-30 KR KR1020227006571A patent/KR20220061958A/ko unknown
- 2020-07-30 CA CA3147902A patent/CA3147902A1/en active Pending
- 2020-07-30 BR BR112022001291A patent/BR112022001291A2/pt unknown
- 2020-07-30 EP EP20757729.7A patent/EP4003980A1/en active Pending
-
2022
- 2022-01-16 IL IL289878A patent/IL289878A/en unknown
- 2022-12-05 US US18/074,746 patent/US11987584B2/en active Active
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