JPWO2021016724A5 - - Google Patents
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- Publication number
- JPWO2021016724A5 JPWO2021016724A5 JP2022506525A JP2022506525A JPWO2021016724A5 JP WO2021016724 A5 JPWO2021016724 A5 JP WO2021016724A5 JP 2022506525 A JP2022506525 A JP 2022506525A JP 2022506525 A JP2022506525 A JP 2022506525A JP WO2021016724 A5 JPWO2021016724 A5 JP WO2021016724A5
- Authority
- JP
- Japan
- Prior art keywords
- nanocage
- fusion protein
- fragment
- ferritin
- antigen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102000037865 fusion proteins Human genes 0.000 claims 71
- 108020001507 fusion proteins Proteins 0.000 claims 71
- 239000002091 nanocage Substances 0.000 claims 70
- 239000000427 antigen Substances 0.000 claims 26
- 102000036639 antigens Human genes 0.000 claims 26
- 108091007433 antigens Proteins 0.000 claims 26
- 239000000178 monomer Substances 0.000 claims 24
- 238000008416 Ferritin Methods 0.000 claims 20
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 20
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 20
- 102000000546 Apoferritins Human genes 0.000 claims 13
- 108010002084 Apoferritins Proteins 0.000 claims 13
- 239000012634 fragment Substances 0.000 claims 13
- 102000018071 Immunoglobulin Fc Fragments Human genes 0.000 claims 11
- 108010091135 Immunoglobulin Fc Fragments Proteins 0.000 claims 11
- 102000008857 Ferritin Human genes 0.000 claims 6
- 108050000784 Ferritin Proteins 0.000 claims 6
- 201000010099 disease Diseases 0.000 claims 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 5
- 229960005486 vaccine Drugs 0.000 claims 5
- 241000725303 Human immunodeficiency virus Species 0.000 claims 4
- 241000700605 Viruses Species 0.000 claims 4
- 239000012678 infectious agent Substances 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 3
- 238000002059 diagnostic imaging Methods 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 108010068996 6,7-dimethyl-8-ribityllumazine synthase Proteins 0.000 claims 2
- 208000023275 Autoimmune disease Diseases 0.000 claims 2
- 101710132601 Capsid protein Proteins 0.000 claims 2
- 108010058432 Chaperonin 60 Proteins 0.000 claims 2
- 102000006303 Chaperonin 60 Human genes 0.000 claims 2
- 101710094648 Coat protein Proteins 0.000 claims 2
- 208000035473 Communicable disease Diseases 0.000 claims 2
- 101710088194 Dehydrogenase Proteins 0.000 claims 2
- -1 E2P Proteins 0.000 claims 2
- 102100021181 Golgi phosphoprotein 3 Human genes 0.000 claims 2
- 102000002812 Heat-Shock Proteins Human genes 0.000 claims 2
- 108010004889 Heat-Shock Proteins Proteins 0.000 claims 2
- 241000713772 Human immunodeficiency virus 1 Species 0.000 claims 2
- 101710125418 Major capsid protein Proteins 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 101710141454 Nucleoprotein Proteins 0.000 claims 2
- 101710083689 Probable capsid protein Proteins 0.000 claims 2
- LCTONWCANYUPML-UHFFFAOYSA-M Pyruvate Chemical compound CC(=O)C([O-])=O LCTONWCANYUPML-UHFFFAOYSA-M 0.000 claims 2
- 241000702670 Rotavirus Species 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 102000034287 fluorescent proteins Human genes 0.000 claims 2
- 108091006047 fluorescent proteins Proteins 0.000 claims 2
- 238000003384 imaging method Methods 0.000 claims 2
- 230000003053 immunization Effects 0.000 claims 2
- 208000015181 infectious disease Diseases 0.000 claims 2
- 206010022000 influenza Diseases 0.000 claims 2
- 201000004792 malaria Diseases 0.000 claims 2
- 239000003550 marker Substances 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 102000040430 polynucleotide Human genes 0.000 claims 2
- 108091033319 polynucleotide Proteins 0.000 claims 2
- 239000002157 polynucleotide Substances 0.000 claims 2
- 229920001184 polypeptide Polymers 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 230000000069 prophylactic effect Effects 0.000 claims 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- 238000002965 ELISA Methods 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 108090000854 Oxidoreductases Proteins 0.000 claims 1
- XOCUXOWLYLLJLV-UHFFFAOYSA-N [O].[S] Chemical compound [O].[S] XOCUXOWLYLLJLV-UHFFFAOYSA-N 0.000 claims 1
- 238000003314 affinity selection Methods 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 210000004899 c-terminal region Anatomy 0.000 claims 1
- 238000012761 co-transfection Methods 0.000 claims 1
- 239000000032 diagnostic agent Substances 0.000 claims 1
- 229940039227 diagnostic agent Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000013613 expression plasmid Substances 0.000 claims 1
- 238000001943 fluorescence-activated cell sorting Methods 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 239000008177 pharmaceutical agent Substances 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025154827A JP2026004351A (ja) | 2019-08-01 | 2025-09-18 | 多価及び多重特異性ナノ粒子プラットフォーム及び方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962881899P | 2019-08-01 | 2019-08-01 | |
| US62/881,899 | 2019-08-01 | ||
| PCT/CA2020/051061 WO2021016724A1 (en) | 2019-08-01 | 2020-07-31 | Multi-valent and multi-specific nanoparticle platforms and methods |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025154827A Division JP2026004351A (ja) | 2019-08-01 | 2025-09-18 | 多価及び多重特異性ナノ粒子プラットフォーム及び方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022543070A JP2022543070A (ja) | 2022-10-07 |
| JP2022543070A5 JP2022543070A5 (https=) | 2023-08-08 |
| JPWO2021016724A5 true JPWO2021016724A5 (https=) | 2023-08-08 |
Family
ID=74228187
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022506525A Pending JP2022543070A (ja) | 2019-08-01 | 2020-07-31 | 多価及び多重特異性ナノ粒子プラットフォーム及び方法 |
| JP2025154827A Pending JP2026004351A (ja) | 2019-08-01 | 2025-09-18 | 多価及び多重特異性ナノ粒子プラットフォーム及び方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025154827A Pending JP2026004351A (ja) | 2019-08-01 | 2025-09-18 | 多価及び多重特異性ナノ粒子プラットフォーム及び方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20230145060A1 (https=) |
| EP (1) | EP4007779A4 (https=) |
| JP (2) | JP2022543070A (https=) |
| KR (1) | KR20220107151A (https=) |
| CN (3) | CN121203033A (https=) |
| AU (1) | AU2020320459A1 (https=) |
| BR (1) | BR112022001800A2 (https=) |
| CA (1) | CA3149320A1 (https=) |
| MX (1) | MX2022001387A (https=) |
| WO (1) | WO2021016724A1 (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20220411508A1 (en) * | 2019-09-09 | 2022-12-29 | The Regents Of The University Of California | Compositions and methods for making and using multispecific antibodies |
| AU2022212978A1 (en) * | 2021-01-28 | 2023-08-31 | The Hospital For Sick Children | Multabody constructs, compositions, and methods |
| KR20240032875A (ko) * | 2021-07-12 | 2024-03-12 | 더 호스피탈 포 식 칠드런 | 최적화된 멀타바디 작제물, 조성물 및 방법 |
| US20240409652A1 (en) * | 2021-09-13 | 2024-12-12 | The Hospital For Sick Children | Dr5-targeting multabodies for the treatment of cancer |
| MX2024003140A (es) * | 2021-09-13 | 2024-06-24 | Hospital For Sick Children | Construcciones, composiciones y metodos de multabody optimizados. |
| WO2023060359A1 (en) * | 2021-10-16 | 2023-04-20 | The Hospital For Sick Children | Modified multabody constructs, compositions, and methods targeting sars-cov-2 |
| KR20240101591A9 (ko) * | 2021-10-16 | 2025-12-10 | 더 호스피탈 포 식 칠드런 | 변형된 멀타바디 작제물, 조성물 및 방법 |
| KR20240043842A (ko) * | 2022-09-27 | 2024-04-04 | 크리포 주식회사 | 주요 아미노산이 전하성 아미노산으로 구성된 펩타이드 태그를 포함하여 자가 조립체를 형성하는 융합 단백질 및 이를 이용하여 재조합 단백질을 정제하는 방법 |
| KR20240043840A (ko) * | 2022-09-27 | 2024-04-04 | 크리포 주식회사 | 주요 아미노산이 전하성 및 극성 아미노산으로 구성된 펩타이드 태그를 포함하여 자가 조립체를 형성하는 융합 단백질 및 이를 이용하여 재조합 단백질을 정제하는 방법 |
| KR102946895B1 (ko) * | 2022-10-21 | 2026-04-02 | 충남대학교산학협력단 | SARS-CoV-2 S1 유래 단백질 및 항체 Fc 영역 단백질을 표면에 동시에 디스플레이하는 페리틴 단백질 구조체 및 이의 코로나바이러스 SARS-CoV-2에 대한 백신 용도 |
| KR20250103763A (ko) * | 2022-11-07 | 2025-07-07 | 시아먼 유니버시티 | 융합 단백질 및 이를 포함하는 입자형 항원 |
| CN120752261A (zh) * | 2022-12-18 | 2025-10-03 | 锐迪恩特生物治疗股份有限公司 | 多价和多特异性细胞因子拮抗剂 |
| CN120603858A (zh) * | 2022-12-18 | 2025-09-05 | 锐迪恩特生物治疗股份有限公司 | 多价造血细胞接合剂或激活剂 |
| WO2024141955A1 (en) * | 2022-12-28 | 2024-07-04 | BioNTech SE | Rna compositions targeting hiv |
| WO2024254514A1 (en) * | 2023-06-08 | 2024-12-12 | The University Of North Carolina At Chapel Hill | Engineered antibody fusion proteins with modulable binding constants and their applications |
| WO2025054730A1 (en) * | 2023-09-13 | 2025-03-20 | The Hospital For Sick Children | Hiv-1-targeted multabody constructs, compositions, and methods |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1504037B1 (en) * | 2002-05-10 | 2009-12-30 | New Century Pharmaceuticals, Inc. | Ferritin fusion proteins for use in vaccines and other applications |
| KR20160094550A (ko) * | 2015-01-30 | 2016-08-10 | 동국대학교 산학협력단 | 단일사슬항체조각과 페리틴을 포함하는 융합단백질 및 그의 용도 |
| WO2019023811A1 (en) * | 2017-08-04 | 2019-02-07 | The Hospital For Sick Children | NANOPARTICLE PLATFORM FOR ANTIBODY AND VACCINE DELIVERY |
-
2020
- 2020-07-31 JP JP2022506525A patent/JP2022543070A/ja active Pending
- 2020-07-31 US US17/631,588 patent/US20230145060A1/en active Pending
- 2020-07-31 CN CN202511333627.3A patent/CN121203033A/zh active Pending
- 2020-07-31 WO PCT/CA2020/051061 patent/WO2021016724A1/en not_active Ceased
- 2020-07-31 BR BR112022001800A patent/BR112022001800A2/pt unknown
- 2020-07-31 MX MX2022001387A patent/MX2022001387A/es unknown
- 2020-07-31 CA CA3149320A patent/CA3149320A1/en active Pending
- 2020-07-31 EP EP20847401.5A patent/EP4007779A4/en active Pending
- 2020-07-31 AU AU2020320459A patent/AU2020320459A1/en active Pending
- 2020-07-31 CN CN202080069559.3A patent/CN114867754A/zh active Pending
- 2020-07-31 CN CN202511333631.XA patent/CN121449754A/zh active Pending
- 2020-07-31 KR KR1020227005980A patent/KR20220107151A/ko active Pending
-
2025
- 2025-09-18 JP JP2025154827A patent/JP2026004351A/ja active Pending
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