JPWO2021003310A5 - - Google Patents
Download PDFInfo
- Publication number
- JPWO2021003310A5 JPWO2021003310A5 JP2022500105A JP2022500105A JPWO2021003310A5 JP WO2021003310 A5 JPWO2021003310 A5 JP WO2021003310A5 JP 2022500105 A JP2022500105 A JP 2022500105A JP 2022500105 A JP2022500105 A JP 2022500105A JP WO2021003310 A5 JPWO2021003310 A5 JP WO2021003310A5
- Authority
- JP
- Japan
- Prior art keywords
- halogen
- alkyl
- oxo
- independently
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229910052736 halogen Inorganic materials 0.000 claims 45
- 150000002367 halogens Chemical class 0.000 claims 45
- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 claims 40
- 125000004093 cyano group Chemical group *C#N 0.000 claims 38
- 125000004043 oxo group Chemical group O=* 0.000 claims 36
- 150000001875 compounds Chemical class 0.000 claims 35
- 125000000623 heterocyclic group Chemical group 0.000 claims 32
- 150000003839 salts Chemical class 0.000 claims 29
- 229910052739 hydrogen Inorganic materials 0.000 claims 24
- 239000001257 hydrogen Substances 0.000 claims 24
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 23
- 150000002431 hydrogen Chemical class 0.000 claims 22
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 14
- 125000004429 atom Chemical group 0.000 claims 10
- 125000004767 (C1-C4) haloalkoxy group Chemical group 0.000 claims 8
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims 8
- -1 C 1 -C 4 alkoxy Chemical group 0.000 claims 6
- 125000001313 C5-C10 heteroaryl group Chemical group 0.000 claims 6
- 125000003118 aryl group Chemical group 0.000 claims 5
- 229910052717 sulfur Inorganic materials 0.000 claims 4
- 125000006656 (C2-C4) alkenyl group Chemical group 0.000 claims 2
- 125000006645 (C3-C4) cycloalkyl group Chemical group 0.000 claims 2
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- GBXQPDCOMJJCMJ-UHFFFAOYSA-M trimethyl-[6-(trimethylazaniumyl)hexyl]azanium;bromide Chemical compound [Br-].C[N+](C)(C)CCCCCC[N+](C)(C)C GBXQPDCOMJJCMJ-UHFFFAOYSA-M 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962870020P | 2019-07-02 | 2019-07-02 | |
| US62/870,020 | 2019-07-02 | ||
| US202063017547P | 2020-04-29 | 2020-04-29 | |
| US63/017,547 | 2020-04-29 | ||
| PCT/US2020/040566 WO2021003310A1 (en) | 2019-07-02 | 2020-07-01 | Heterocyclic compounds as bet inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022538917A JP2022538917A (ja) | 2022-09-06 |
| JPWO2021003310A5 true JPWO2021003310A5 (he) | 2023-07-11 |
| JP7465945B2 JP7465945B2 (ja) | 2024-04-11 |
Family
ID=74065335
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022500105A Active JP7465945B2 (ja) | 2019-07-02 | 2020-07-01 | Ｂｅｔ阻害剤としてのヘテロ環式化合物 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US11584756B2 (he) |
| EP (1) | EP3997070A4 (he) |
| JP (1) | JP7465945B2 (he) |
| CN (1) | CN114286818A (he) |
| AU (1) | AU2020299592A1 (he) |
| BR (1) | BR112021026668A2 (he) |
| CA (1) | CA3145827A1 (he) |
| CL (1) | CL2021003513A1 (he) |
| IL (1) | IL289439A (he) |
| MX (1) | MX2022000050A (he) |
| WO (1) | WO2021003310A1 (he) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113226322A (zh) | 2018-10-30 | 2021-08-06 | 诺维逊生物股份有限公司 | 作为bet抑制剂的杂环化合物 |
| AU2020299592A1 (en) * | 2019-07-02 | 2022-02-17 | Nuvation Bio Inc. | Heterocyclic compounds as BET inhibitors |
| WO2021222466A1 (en) * | 2020-04-29 | 2021-11-04 | Nuvation Bio Inc. | Heterocyclic compounds as bet inhibitors |
| CA3224302A1 (en) | 2021-06-29 | 2023-01-05 | Tay Therapeutics Limited | Pyrrolopyridone derivatives useful in the treatment of cancer |
| CN116135858A (zh) * | 2021-11-16 | 2023-05-19 | 中国科学院广州生物医药与健康研究院 | 一种呋喃并吡啶酮类化合物及其应用 |
| TW202334148A (zh) * | 2022-01-06 | 2023-09-01 | 美商規劃醫療公司 | 用於治療弗里德希氏共濟失調（ｆｒｉｅｄｒｅｉｃｈ＇ｓ ａｔａｘｉａ）之化合物及方法 |
| CN114907335A (zh) * | 2022-02-25 | 2022-08-16 | 陕西维世诺新材料有限公司 | 2-（苯并噻吩-2-基）苯并[d]惡唑衍生物、制备方法及应用 |
| CN115028646B (zh) * | 2022-05-31 | 2023-06-30 | 山东第一医科大学(山东省医学科学院) | 一种含氮杂环类化合物、制备方法及在抗肿瘤制剂中的应用 |
Family Cites Families (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL118631A (he) | 1995-06-27 | 2002-05-23 | Tanabe Seiyaku Co | תולדות פירידאזינון ותהליכים להכנתן |
| US20040067955A1 (en) | 2002-09-06 | 2004-04-08 | Fujisawa Pharmaceutical Co. Ltd. | Pyridazinone compound and pharmaceutical use thereof |
| US7378423B2 (en) | 2004-06-11 | 2008-05-27 | Japan Tobacco Inc. | Pyrimidine compound and medical use thereof |
| US8263772B2 (en) | 2006-06-08 | 2012-09-11 | Eli Lilly And Company | MCH receptor antagonists |
| WO2009054952A2 (en) | 2007-10-22 | 2009-04-30 | Angion Biomedica Corp. | Small molecule inhibitors of parp activity |
| WO2013097052A1 (en) | 2011-12-30 | 2013-07-04 | Abbott Laboratories | Bromodomain inhibitors |
| EP2920183B1 (en) | 2012-11-14 | 2017-03-08 | Glaxosmithkline LLC | Thieno[3,2-c]pyridin-4(5h)-ones as bet inhibitors |
| US9266891B2 (en) | 2012-11-16 | 2016-02-23 | Boehringer Ingelheim International Gmbh | Substituted [1,2,4]triazolo[4,3-A]pyrazines that are BRD4 inhibitors |
| CN105189488B (zh) | 2013-02-27 | 2018-07-24 | 百时美施贵宝公司 | 用作溴区结构域抑制剂的咔唑化合物 |
| US9675697B2 (en) | 2013-03-11 | 2017-06-13 | The Regents Of The University Of Michigan | BET bromodomain inhibitors and therapeutic methods using the same |
| EP2970262A1 (en) | 2013-03-11 | 2016-01-20 | AbbVie Inc. | Bromodomain inhibitors |
| CN105026403B (zh) | 2013-03-12 | 2018-05-18 | 艾伯维公司 | 四环布罗莫结构域抑制剂 |
| PT2970127T (pt) | 2013-03-14 | 2019-01-16 | Glaxosmithkline Ip No 2 Ltd | Derivados de 1-acil-4-amino-1,2,3,4-tetra-hidroquinolina 2,3-dissubstituída e sua utilização como inibidores de bromodomínio |
| JP6280573B2 (ja) | 2013-03-14 | 2018-02-14 | グラクソスミスクライン、インテレクチュアル、プロパティー、（ナンバー２）、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ （Ｎｏ．２） Ｌｉｍｉｔｅｄ | ブロモドメイン阻害薬としてのフロピリジン |
| WO2015002754A2 (en) | 2013-06-21 | 2015-01-08 | Zenith Epigenetics Corp. | Novel bicyclic bromodomain inhibitors |
| BR112015032710A2 (pt) | 2013-06-28 | 2017-07-25 | Abbvie Inc | inibidores de bromodomínio |
| SI3640241T1 (sl) | 2013-10-18 | 2023-01-31 | Celgene Quanticel Research, Inc. | Inhibitorji bromodomene |
| PL3071203T3 (pl) | 2013-11-18 | 2021-08-23 | Forma Therapeutics, Inc. | Kompozycje tetrahydrochinolinowe jako inhibitory bromodomeny bet |
| EP3071205B1 (en) | 2013-11-18 | 2020-02-05 | Forma Therapeutics, Inc. | Benzopiperazine compositions as bet bromodomain inhibitors |
| US9988373B2 (en) | 2013-12-26 | 2018-06-05 | Shionogi & Co., Ltd. | Nitrogen-containing six-membered cyclic derivatives and pharmaceutical composition comprising the same |
| ES2687497T3 (es) | 2014-01-09 | 2018-10-25 | Orion Corporation | Derivados bicíclicos heterocíclicos como inhibidores de bromodominio |
| WO2015131005A1 (en) | 2014-02-28 | 2015-09-03 | The Regents Of The University Of Michigan | 9h-pyrimido[4,5-b]indoles and related analogs as bet bromodomain inhibitors |
| NZ763737A (en) | 2014-04-23 | 2023-04-28 | Incyte Holdings Corp | 1h-pyrrolo[2,3-c]pyridin-7(6h)-ones and pyrazolo[3,4-c]pyridin-7(6h)-ones as inhibitors of bet proteins |
| BR112017004580A2 (pt) | 2014-09-12 | 2018-01-23 | GlaxoSmithKline Intellectual Property | composto, composição farmacêutica, produto de combinação, uso de um composto ou sal farmaceuticamente aceitável, e, método de tratamento. |
| WO2016092375A1 (en) | 2014-12-11 | 2016-06-16 | Zenith Epigenetics Corp. | Substituted heterocycles as bromodomain inhibitors |
| WO2016138332A1 (en) | 2015-02-27 | 2016-09-01 | The Regents Of The University Of Michigan | 9h-pyrimido [4,5-b] indoles as bet bromodomain inhibitors |
| AR104259A1 (es) * | 2015-04-15 | 2017-07-05 | Celgene Quanticel Res Inc | Inhibidores de bromodominio |
| CA2988209A1 (en) | 2015-06-16 | 2016-12-22 | Orion Corporation | Spiro[cyclobutane-1,3'-indolin]-2'-one derivatives as bromodomain inhibitors |
| CA3129180A1 (en) | 2015-09-21 | 2017-03-30 | Plexxikon Inc. | Heterocyclic compounds and uses thereof |
| WO2017050714A1 (en) | 2015-09-22 | 2017-03-30 | Glaxosmithkline Intellectual Property (No.2) Limited | Pyridinone dicarboxamide for use as bromodomain inhibitors |
| WO2017083431A2 (en) | 2015-11-09 | 2017-05-18 | Forge Therapeutics, Inc. | Hydroxypyridinone and hydroxypyrimidinone based compounds for treating bacterial infections |
| US20190263799A1 (en) | 2015-12-14 | 2019-08-29 | Zenith Epigenetics Ltd. | 1h-imidazo[4,5-b]pyridinyl and 2-oxo-2,3-dihydro-1h-imidazo[4,5-b]pyridinyl heterocyclic bet bromodomain inhibitors |
| MX2018012541A (es) | 2016-04-15 | 2019-01-17 | Abbvie Inc | Inhibidores de bromodominios. |
| EP3445750A4 (en) | 2016-04-18 | 2019-11-27 | Celgene Quanticel Research, Inc. | THERAPEUTIC COMPOUNDS |
| WO2017197056A1 (en) | 2016-05-10 | 2017-11-16 | C4 Therapeutics, Inc. | Bromodomain targeting degronimers for target protein degradation |
| CA3025806C (en) | 2016-06-23 | 2023-04-04 | Dana-Farber Cancer Institute, Inc. | Degradation of bromodomain-containing protein 9 (brd9) by conjugation of brd9 inhibitors with e3 ligase ligand and methods of use |
| CN108069958A (zh) | 2016-11-10 | 2018-05-25 | 凯惠科技发展(上海)有限公司 | 一种含氮杂环类化合物、其制备方法、药物组合物及应用 |
| WO2018130174A1 (zh) | 2017-01-11 | 2018-07-19 | 江苏豪森药业集团有限公司 | 吡咯并[2,3-c]吡啶类衍生物、其制备方法及其在医药上的应用 |
| US11466034B2 (en) | 2017-12-20 | 2022-10-11 | Betta Pharmaceuticals Co., Ltd. | Compound functioning as bromodomain protein inhibitor, and composition |
| WO2019141131A1 (zh) | 2018-01-16 | 2019-07-25 | 中国科学院上海药物研究所 | 溴结构域抑制剂化合物及其用途 |
| CN110041253B (zh) | 2018-01-17 | 2022-03-29 | 上海翰森生物医药科技有限公司 | 吡啶类n-氧化衍生物及其制备方法和应用 |
| AU2019312393B2 (en) * | 2018-07-25 | 2022-12-22 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Iminosulfanone compound as bromodomain protein inhibitor and pharmaceutical composition and medical use thereof |
| CN110964012B (zh) | 2018-09-29 | 2021-08-13 | 上海凌达生物医药有限公司 | 一类稠杂环联芳基苄醇类化合物、制备方法和用途 |
| CN113226322A (zh) | 2018-10-30 | 2021-08-06 | 诺维逊生物股份有限公司 | 作为bet抑制剂的杂环化合物 |
| EP3917934A4 (en) | 2019-01-29 | 2023-02-15 | Foghorn Therapeutics Inc. | CONNECTIONS AND USES THEREOF |
| US20220185808A1 (en) | 2019-03-17 | 2022-06-16 | Shanghai Ringene Biopharma Co., Ltd. | Acylaminopyrrolo-pyridone compound, preparation method therefor and use thereof |
| CN112094266B (zh) | 2019-06-17 | 2023-03-21 | 中国科学院上海药物研究所 | 一种吡咯并吡啶酮类化合物、其制备方法、其组合物和用途 |
| AU2020299592A1 (en) * | 2019-07-02 | 2022-02-17 | Nuvation Bio Inc. | Heterocyclic compounds as BET inhibitors |
| WO2021222466A1 (en) | 2020-04-29 | 2021-11-04 | Nuvation Bio Inc. | Heterocyclic compounds as bet inhibitors |
-
2020
- 2020-07-01 AU AU2020299592A patent/AU2020299592A1/en active Pending
- 2020-07-01 CN CN202080060057.4A patent/CN114286818A/zh active Pending
- 2020-07-01 EP EP20834516.5A patent/EP3997070A4/en active Pending
- 2020-07-01 JP JP2022500105A patent/JP7465945B2/ja active Active
- 2020-07-01 US US16/918,997 patent/US11584756B2/en active Active
- 2020-07-01 MX MX2022000050A patent/MX2022000050A/es unknown
- 2020-07-01 BR BR112021026668A patent/BR112021026668A2/pt active Search and Examination
- 2020-07-01 WO PCT/US2020/040566 patent/WO2021003310A1/en active Application Filing
- 2020-07-01 CA CA3145827A patent/CA3145827A1/en active Pending
-
2021
- 2021-12-27 IL IL289439A patent/IL289439A/he unknown
- 2021-12-27 CL CL2021003513A patent/CL2021003513A1/es unknown
-
2023
- 2023-01-09 US US18/152,049 patent/US20230339964A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2018504437A5 (he) | ||
| JP2021169499A5 (he) | ||
| JP2011509309A5 (he) | ||
| JP2022081661A5 (he) | ||
| JP2010506854A5 (he) | ||
| JP2018535963A5 (he) | ||
| JP2018526399A5 (he) | ||
| JPWO2019155399A5 (he) | ||
| JP2014521688A5 (he) | ||
| JP2018515581A5 (he) | ||
| JP2009536660A5 (he) | ||
| JP2017506666A5 (he) | ||
| JP2020507589A5 (he) | ||
| JP2015522036A5 (he) | ||
| JP2011515341A5 (he) | ||
| JP2010524932A5 (he) | ||
| JP2007502295A5 (he) | ||
| JP2020520957A5 (he) | ||
| JP2011523952A5 (he) | ||
| JP7159440B2 (ja) | ジカチオン化合物及びその製造方法と使用 | |
| JP2006507355A5 (he) | ||
| RU2007101238A (ru) | Пептидные агонисты вазопрессинового рецептора | |
| JPWO2021003310A5 (he) | ||
| JP2011509302A5 (he) | ||
| JP2020128426A5 (he) |