JPWO2020262259A5 - - Google Patents
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- Publication number
- JPWO2020262259A5 JPWO2020262259A5 JP2021526942A JP2021526942A JPWO2020262259A5 JP WO2020262259 A5 JPWO2020262259 A5 JP WO2020262259A5 JP 2021526942 A JP2021526942 A JP 2021526942A JP 2021526942 A JP2021526942 A JP 2021526942A JP WO2020262259 A5 JPWO2020262259 A5 JP WO2020262259A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- terminal
- aliphatic hydrocarbon
- independently
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims 24
- 108090000765 processed proteins & peptides Proteins 0.000 claims 24
- 125000001931 aliphatic group Chemical group 0.000 claims 20
- -1 9-fluorenylmethoxycarbonyl group Chemical group 0.000 claims 15
- 210000004899 c-terminal region Anatomy 0.000 claims 14
- 125000004432 carbon atom Chemical group C* 0.000 claims 13
- 125000000217 alkyl group Chemical group 0.000 claims 12
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 12
- 238000004519 manufacturing process Methods 0.000 claims 10
- 125000006239 protecting group Chemical group 0.000 claims 8
- 239000003153 chemical reaction reagent Substances 0.000 claims 7
- 150000002148 esters Chemical class 0.000 claims 6
- 125000005843 halogen group Chemical group 0.000 claims 6
- 238000010511 deprotection reaction Methods 0.000 claims 4
- 125000003545 alkoxy group Chemical group 0.000 claims 3
- 125000003710 aryl alkyl group Chemical group 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 3
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 3
- 230000008878 coupling Effects 0.000 claims 3
- 238000010168 coupling process Methods 0.000 claims 3
- 238000005859 coupling reaction Methods 0.000 claims 3
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims 3
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 3
- 125000000962 organic group Chemical group 0.000 claims 3
- 125000004469 siloxy group Chemical group [SiH3]O* 0.000 claims 3
- 125000003808 silyl group Chemical group [H][Si]([H])([H])[*] 0.000 claims 3
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 3
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical group OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 claims 2
- 239000003377 acid catalyst Substances 0.000 claims 2
- 125000003368 amide group Chemical group 0.000 claims 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
- 230000001376 precipitating effect Effects 0.000 claims 2
- 238000001556 precipitation Methods 0.000 claims 2
- 229910017711 NHRa Inorganic materials 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019122492 | 2019-06-28 | ||
| JP2019122492 | 2019-06-28 | ||
| JP2019221545 | 2019-12-06 | ||
| JP2019221545 | 2019-12-06 | ||
| PCT/JP2020/024232 WO2020262259A1 (ja) | 2019-06-28 | 2020-06-19 | ペプチド化合物の製造方法、保護基形成用試薬、及び、縮合多環化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JPWO2020262259A1 JPWO2020262259A1 (https=) | 2020-12-30 |
| JPWO2020262259A5 true JPWO2020262259A5 (https=) | 2022-04-19 |
| JP7301965B2 JP7301965B2 (ja) | 2023-07-03 |
Family
ID=74060996
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021526942A Active JP7301965B2 (ja) | 2019-06-28 | 2020-06-19 | ペプチド化合物の製造方法、保護基形成用試薬、及び、縮合多環化合物 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US12227542B2 (https=) |
| EP (1) | EP3992187A4 (https=) |
| JP (1) | JP7301965B2 (https=) |
| CN (1) | CN114026110A (https=) |
| TW (1) | TWI860373B (https=) |
| WO (1) | WO2020262259A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW202233574A (zh) * | 2020-12-22 | 2022-09-01 | 日商富士軟片股份有限公司 | 肽之製造方法、保護基形成用試藥及縮合多環化合物 |
| WO2022196797A1 (ja) | 2021-03-19 | 2022-09-22 | 富士フイルム株式会社 | アミノ酸又はペプチドの製造方法、保護基形成用試薬、及び、化合物 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5117009A (en) * | 1990-08-31 | 1992-05-26 | University Of Minnesota | Xanthenylamide handle for use in peptide synthesis |
| JP2000044493A (ja) | 1998-07-27 | 2000-02-15 | Asahi Chem Ind Co Ltd | 化合物ライブラリー合成用保護基 |
| ES2615083T3 (es) | 2005-09-20 | 2017-06-05 | Jitsubo Co., Ltd. | Vehículo de separación, método de separación de un compuesto, y método de síntesis del péptido utilizando el vehículo |
| ES2546808T3 (es) | 2006-03-24 | 2015-09-28 | Jitsubo Co., Ltd. | Reactivo para síntesis orgánica y método de reacción de síntesis orgánica con dicho reactivo |
| EP2415744A4 (en) | 2009-03-12 | 2014-03-19 | Ajinomoto Kk | FLUORENE COMPOUND |
| WO2010113939A1 (ja) | 2009-03-30 | 2010-10-07 | 味の素株式会社 | ジフェニルメタン化合物 |
| JP5803674B2 (ja) | 2009-12-25 | 2015-11-04 | 味の素株式会社 | ベンジル化合物 |
| CN107011132B (zh) * | 2010-08-30 | 2020-11-10 | 味之素株式会社 | 含有支链的芳香族化合物 |
| KR102630720B1 (ko) | 2015-08-28 | 2024-01-29 | 세키스이 메디칼 가부시키가이샤 | 벤질 화합물 |
| JP6283775B1 (ja) | 2016-07-25 | 2018-02-21 | 積水メディカル株式会社 | 新規キサンテン保護剤 |
| CN109478521B (zh) | 2016-07-26 | 2022-10-11 | 三菱电机株式会社 | 半导体装置 |
| US10870667B2 (en) | 2017-12-19 | 2020-12-22 | Sekisui Medical Co., Ltd. | Alkyldiphenylmethane protective agent |
| JP7023120B2 (ja) | 2018-01-12 | 2022-02-21 | オリンパス株式会社 | 内視鏡装置、内視鏡装置の作動方法およびプログラム |
| CN110317188B (zh) * | 2018-03-29 | 2023-01-17 | 深圳翰宇药业股份有限公司 | 化合物及其制备方法和应用 |
| JP7628073B2 (ja) | 2019-02-28 | 2025-02-07 | 富士フイルム株式会社 | ペプチド化合物の製造方法、保護基形成用試薬、及び、芳香族複素環化合物 |
| CN113508103A (zh) | 2019-02-28 | 2021-10-15 | 富士胶片株式会社 | 肽化合物的制造方法、保护基形成用试药及稠合多环芳香族烃化合物 |
-
2020
- 2020-06-19 JP JP2021526942A patent/JP7301965B2/ja active Active
- 2020-06-19 EP EP20831684.4A patent/EP3992187A4/en active Pending
- 2020-06-19 WO PCT/JP2020/024232 patent/WO2020262259A1/ja not_active Ceased
- 2020-06-19 CN CN202080046996.3A patent/CN114026110A/zh active Pending
- 2020-06-24 TW TW109121463A patent/TWI860373B/zh active
-
2021
- 2021-12-21 US US17/558,542 patent/US12227542B2/en active Active
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