JPWO2020249693A5 - - Google Patents
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- JPWO2020249693A5 JPWO2020249693A5 JP2021573569A JP2021573569A JPWO2020249693A5 JP WO2020249693 A5 JPWO2020249693 A5 JP WO2020249693A5 JP 2021573569 A JP2021573569 A JP 2021573569A JP 2021573569 A JP2021573569 A JP 2021573569A JP WO2020249693 A5 JPWO2020249693 A5 JP WO2020249693A5
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- 239000008194 pharmaceutical composition Substances 0.000 claims 19
- 238000007920 subcutaneous administration Methods 0.000 claims 11
- 108020001507 fusion proteins Proteins 0.000 claims 10
- 102000037865 fusion proteins Human genes 0.000 claims 10
- 206010028980 Neoplasm Diseases 0.000 claims 8
- 238000000034 method Methods 0.000 claims 6
- 229960002621 pembrolizumab Drugs 0.000 claims 6
- 201000011510 cancer Diseases 0.000 claims 5
- 210000005259 peripheral blood Anatomy 0.000 claims 5
- 239000011886 peripheral blood Substances 0.000 claims 5
- 210000002381 plasma Anatomy 0.000 claims 5
- 210000002966 serum Anatomy 0.000 claims 5
- 210000001266 CD8-positive T-lymphocyte Anatomy 0.000 claims 4
- 238000001990 intravenous administration Methods 0.000 claims 4
- 229940076838 Immune checkpoint inhibitor Drugs 0.000 claims 3
- 108090001005 Interleukin-6 Proteins 0.000 claims 3
- 239000012274 immune-checkpoint protein inhibitor Substances 0.000 claims 3
- 230000000737 periodic effect Effects 0.000 claims 3
- 201000005488 Capillary Leak Syndrome Diseases 0.000 claims 2
- 102000037984 Inhibitory immune checkpoint proteins Human genes 0.000 claims 2
- 108091008026 Inhibitory immune checkpoint proteins Proteins 0.000 claims 2
- 206010025323 Lymphomas Diseases 0.000 claims 2
- 208000006265 Renal cell carcinoma Diseases 0.000 claims 2
- 206010041067 Small cell lung cancer Diseases 0.000 claims 2
- 208000000102 Squamous Cell Carcinoma of Head and Neck Diseases 0.000 claims 2
- 208000031932 Systemic capillary leak syndrome Diseases 0.000 claims 2
- 210000001744 T-lymphocyte Anatomy 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 206010052015 cytokine release syndrome Diseases 0.000 claims 2
- 229940127089 cytotoxic agent Drugs 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 201000000459 head and neck squamous cell carcinoma Diseases 0.000 claims 2
- 201000005787 hematologic cancer Diseases 0.000 claims 2
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims 2
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims 2
- 238000002347 injection Methods 0.000 claims 2
- 239000007924 injection Substances 0.000 claims 2
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 2
- 210000003289 regulatory T cell Anatomy 0.000 claims 2
- 208000000587 small cell lung carcinoma Diseases 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 2
- 102000008096 B7-H1 Antigen Human genes 0.000 claims 1
- 108010074708 B7-H1 Antigen Proteins 0.000 claims 1
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 201000009030 Carcinoma Diseases 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
- 208000017604 Hodgkin disease Diseases 0.000 claims 1
- 208000021519 Hodgkin lymphoma Diseases 0.000 claims 1
- 208000010747 Hodgkins lymphoma Diseases 0.000 claims 1
- 206010061523 Lip and/or oral cavity cancer Diseases 0.000 claims 1
- 206010027406 Mesothelioma Diseases 0.000 claims 1
- 208000003445 Mouth Neoplasms Diseases 0.000 claims 1
- 208000034578 Multiple myelomas Diseases 0.000 claims 1
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
- 239000012661 PARP inhibitor Substances 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 229940121906 Poly ADP ribose polymerase inhibitor Drugs 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 208000015634 Rectal Neoplasms Diseases 0.000 claims 1
- 206010039491 Sarcoma Diseases 0.000 claims 1
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 230000010261 cell growth Effects 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 210000001072 colon Anatomy 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 239000002254 cytotoxic agent Substances 0.000 claims 1
- 231100000599 cytotoxic agent Toxicity 0.000 claims 1
- 201000004101 esophageal cancer Diseases 0.000 claims 1
- 238000001802 infusion Methods 0.000 claims 1
- 230000003993 interaction Effects 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 206010038038 rectal cancer Diseases 0.000 claims 1
- 201000001275 rectum cancer Diseases 0.000 claims 1
- 201000008261 skin carcinoma Diseases 0.000 claims 1
- 201000002510 thyroid cancer Diseases 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
- 208000016261 weight loss Diseases 0.000 claims 1
- 230000004580 weight loss Effects 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962860182P | 2019-06-11 | 2019-06-11 | |
| US62/860,182 | 2019-06-11 | ||
| US201962924356P | 2019-10-22 | 2019-10-22 | |
| US62/924,356 | 2019-10-22 | ||
| US201962932160P | 2019-11-07 | 2019-11-07 | |
| US62/932,160 | 2019-11-07 | ||
| PCT/EP2020/066234 WO2020249693A1 (en) | 2019-06-11 | 2020-06-11 | Compositions and methods for subcutaneous administration of cancer immunotherapy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022535972A JP2022535972A (ja) | 2022-08-10 |
| JPWO2020249693A5 true JPWO2020249693A5 (enExample) | 2023-06-20 |
Family
ID=71092539
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021573569A Pending JP2022535972A (ja) | 2019-06-11 | 2020-06-11 | がん免疫療法の皮下投与のための組成物及び方法 |
| JP2021573568A Pending JP2022535610A (ja) | 2019-06-11 | 2020-06-11 | がん免疫療法のための組成物及び方法 |
| JP2025061430A Pending JP2025107180A (ja) | 2019-06-11 | 2025-04-02 | がん免疫療法のための組成物及び方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021573568A Pending JP2022535610A (ja) | 2019-06-11 | 2020-06-11 | がん免疫療法のための組成物及び方法 |
| JP2025061430A Pending JP2025107180A (ja) | 2019-06-11 | 2025-04-02 | がん免疫療法のための組成物及び方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (4) | US20210038684A1 (enExample) |
| EP (2) | EP3983530A1 (enExample) |
| JP (3) | JP2022535972A (enExample) |
| KR (2) | KR20220044481A (enExample) |
| CN (2) | CN114555126A (enExample) |
| AU (2) | AU2020292590A1 (enExample) |
| BR (2) | BR112021025035A2 (enExample) |
| CA (2) | CA3143097A1 (enExample) |
| IL (2) | IL288754A (enExample) |
| MA (1) | MA56176A (enExample) |
| MX (2) | MX2021015353A (enExample) |
| WO (2) | WO2020249693A1 (enExample) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20210038684A1 (en) | 2019-06-11 | 2021-02-11 | Alkermes Pharma Ireland Limited | Compositions and Methods for Cancer Immunotherapy |
| CN114555110A (zh) * | 2019-10-18 | 2022-05-27 | 奥克梅斯制药爱尔兰有限公司 | 与免疫检查点抑制剂组合的免疫调节性il-2剂 |
| WO2021211860A1 (en) * | 2020-04-15 | 2021-10-21 | Alkermes Pharma Ireland Limited | Immunostimulatory agents in combination with angiogenesis inhibitors |
| IL297279A (en) | 2020-04-15 | 2022-12-01 | Alkermes Pharma Ireland Ltd | Immunostimulants in combination with blood vessel formation inhibitors |
| IL297442A (en) | 2020-04-22 | 2022-12-01 | Iovance Biotherapeutics Inc | Systems and methods for coordinating production of cells for patient-specific immunotherapy |
| JP2023523855A (ja) | 2020-05-04 | 2023-06-07 | アイオバンス バイオセラピューティクス，インコーポレイテッド | 腫瘍浸潤リンパ球の製造方法及び免疫療法におけるその使用 |
| JP2023524108A (ja) | 2020-05-04 | 2023-06-08 | アイオバンス バイオセラピューティクス，インコーポレイテッド | 改良された腫瘍反応性ｔ細胞の選択 |
| EP4149515A4 (en) * | 2020-05-11 | 2023-12-06 | Alkermes Pharma Ireland Limited | IL-2 FUSION POLYPEPTIDE COMPOSITIONS AND METHODS OF MAKING AND USING THEM |
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| TW201134488A (en) | 2010-03-11 | 2011-10-16 | Ucb Pharma Sa | PD-1 antibodies |
| PL2699264T3 (pl) | 2011-04-20 | 2018-08-31 | Medimmune, Llc | Przeciwciała i inne cząsteczki wiążące B7-H1 i PD-1 |
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