JPWO2020234432A5 - - Google Patents
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- JPWO2020234432A5 JPWO2020234432A5 JP2021569042A JP2021569042A JPWO2020234432A5 JP WO2020234432 A5 JPWO2020234432 A5 JP WO2020234432A5 JP 2021569042 A JP2021569042 A JP 2021569042A JP 2021569042 A JP2021569042 A JP 2021569042A JP WO2020234432 A5 JPWO2020234432 A5 JP WO2020234432A5
- Authority
- JP
- Japan
- Prior art keywords
- neuropathy
- pharmaceutical composition
- seq
- amino acid
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 208000033808 peripheral neuropathy Diseases 0.000 claims description 26
- 239000000427 antigen Substances 0.000 claims description 23
- 102000036639 antigens Human genes 0.000 claims description 23
- 108091007433 antigens Proteins 0.000 claims description 23
- 201000001119 neuropathy Diseases 0.000 claims description 23
- 239000012634 fragment Substances 0.000 claims description 21
- 230000007823 neuropathy Effects 0.000 claims description 21
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 18
- 206010065579 multifocal motor neuropathy Diseases 0.000 claims description 11
- 208000030939 Chronic inflammatory demyelinating polyneuropathy Diseases 0.000 claims description 7
- 208000035895 Guillain-Barré syndrome Diseases 0.000 claims description 7
- 206010049567 Miller Fisher syndrome Diseases 0.000 claims description 7
- 201000005795 chronic inflammatory demyelinating polyneuritis Diseases 0.000 claims description 7
- 230000024203 complement activation Effects 0.000 claims description 7
- 150000002270 gangliosides Chemical class 0.000 claims description 6
- 102000017099 Myelin-Associated Glycoprotein Human genes 0.000 claims description 4
- 108010013731 Myelin-Associated Glycoprotein Proteins 0.000 claims description 4
- 208000027137 acute motor axonal neuropathy Diseases 0.000 claims description 4
- 230000003210 demyelinating effect Effects 0.000 claims description 4
- 230000001537 neural effect Effects 0.000 claims description 4
- 208000011580 syndromic disease Diseases 0.000 claims description 4
- 206010003591 Ataxia Diseases 0.000 claims description 2
- 108060003951 Immunoglobulin Proteins 0.000 claims description 2
- 102000004856 Lectins Human genes 0.000 claims description 2
- 108090001090 Lectins Proteins 0.000 claims description 2
- 206010060880 Monoclonal gammopathy Diseases 0.000 claims description 2
- 206010053869 POEMS syndrome Diseases 0.000 claims description 2
- 208000002774 Paraproteinemias Diseases 0.000 claims description 2
- 230000001154 acute effect Effects 0.000 claims description 2
- 208000027094 acute motor and sensory axonal neuropathy Diseases 0.000 claims description 2
- 230000001977 ataxic effect Effects 0.000 claims description 2
- 206010003882 axonal neuropathy Diseases 0.000 claims description 2
- 230000001684 chronic effect Effects 0.000 claims description 2
- 102000018358 immunoglobulin Human genes 0.000 claims description 2
- 229940072221 immunoglobulins Drugs 0.000 claims description 2
- 230000003155 kinesthetic effect Effects 0.000 claims description 2
- 239000002523 lectin Substances 0.000 claims description 2
- 206010030875 ophthalmoplegia Diseases 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 16
- 238000000034 method Methods 0.000 description 32
- 239000005557 antagonist Substances 0.000 description 13
- 230000000295 complement effect Effects 0.000 description 12
- 230000004154 complement system Effects 0.000 description 5
- 230000002401 inhibitory effect Effects 0.000 description 4
- 238000011144 upstream manufacturing Methods 0.000 description 3
- 102100035360 Cerebellar degeneration-related antigen 1 Human genes 0.000 description 2
- 210000002161 motor neuron Anatomy 0.000 description 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 1
- MUSGYEMSJUFFHT-UWABRSFTSA-N 2-[(4R,7S,10S,13S,19S,22S,25S,28S,31S,34R)-34-[[(2S,3S)-2-[[(2R)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-4-[[(2S,3S)-1-amino-3-methyl-1-oxopentan-2-yl]-methylcarbamoyl]-25-(3-amino-3-oxopropyl)-7-(3-carbamimidamidopropyl)-10-(1H-imidazol-5-ylmethyl)-19-(1H-indol-3-ylmethyl)-13,17-dimethyl-28-[(1-methylindol-3-yl)methyl]-6,9,12,15,18,21,24,27,30,33-decaoxo-31-propan-2-yl-1,2-dithia-5,8,11,14,17,20,23,26,29,32-decazacyclopentatriacont-22-yl]acetic acid Chemical compound CC[C@H](C)[C@H](NC(=O)[C@H](N)Cc1ccc(O)cc1)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](C)NC(=O)CN(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc2cn(C)c3ccccc23)NC(=O)[C@@H](NC1=O)C(C)C)C(=O)N(C)[C@@H]([C@@H](C)CC)C(N)=O MUSGYEMSJUFFHT-UWABRSFTSA-N 0.000 description 1
- 229940125990 ANX005 Drugs 0.000 description 1
- 102100022002 CD59 glycoprotein Human genes 0.000 description 1
- 101100268548 Caenorhabditis elegans apl-1 gene Proteins 0.000 description 1
- 108700022150 Designed Ankyrin Repeat Proteins Proteins 0.000 description 1
- 101000897400 Homo sapiens CD59 glycoprotein Proteins 0.000 description 1
- 101001081555 Homo sapiens Plasma protease C1 inhibitor Proteins 0.000 description 1
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 description 1
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 description 1
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 description 1
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 description 1
- 108010003723 Single-Domain Antibodies Proteins 0.000 description 1
- 108091027967 Small hairpin RNA Proteins 0.000 description 1
- 108020004459 Small interfering RNA Proteins 0.000 description 1
- 101900335902 Vaccinia virus Complement control protein C3 Proteins 0.000 description 1
- 229940088949 cinryze Drugs 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 102000034356 gene-regulatory proteins Human genes 0.000 description 1
- 108091006104 gene-regulatory proteins Proteins 0.000 description 1
- 102000044507 human SERPING1 Human genes 0.000 description 1
- 238000010874 in vitro model Methods 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- MQQNFDZXWVTQEH-UHFFFAOYSA-N nafamostat Chemical compound C1=CC(N=C(N)N)=CC=C1C(=O)OC1=CC=C(C=C(C=C2)C(N)=N)C2=C1 MQQNFDZXWVTQEH-UHFFFAOYSA-N 0.000 description 1
- 229950009865 nafamostat Drugs 0.000 description 1
- 230000007310 pathophysiology Effects 0.000 description 1
- 239000013610 patient sample Substances 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 229960004641 rituximab Drugs 0.000 description 1
- 239000004055 small Interfering RNA Substances 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024220534A JP2025038109A (ja) | 2019-05-21 | 2024-12-17 | 異常タンパク質性ニューロパチーを治療する方法において使用するための補体系のアンタゴニスト |
| JP2024221343A JP2025041724A (ja) | 2019-05-21 | 2024-12-18 | 異常タンパク質性ニューロパチーを治療する方法において使用するための補体系のアンタゴニスト |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1907153.9A GB2584105B (en) | 2019-05-21 | 2019-05-21 | Methods of treating neuropathy |
| GB1907153.9 | 2019-05-21 | ||
| PCT/EP2020/064234 WO2020234432A1 (en) | 2019-05-21 | 2020-05-21 | Antagonists of the complement system for use in methods of treating paraproteinemic neuropathies |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024220534A Division JP2025038109A (ja) | 2019-05-21 | 2024-12-17 | 異常タンパク質性ニューロパチーを治療する方法において使用するための補体系のアンタゴニスト |
| JP2024221343A Division JP2025041724A (ja) | 2019-05-21 | 2024-12-18 | 異常タンパク質性ニューロパチーを治療する方法において使用するための補体系のアンタゴニスト |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2022533705A JP2022533705A (ja) | 2022-07-25 |
| JP2022533705A5 JP2022533705A5 (https=) | 2023-05-31 |
| JPWO2020234432A5 true JPWO2020234432A5 (https=) | 2023-05-31 |
| JP7607590B2 JP7607590B2 (ja) | 2024-12-27 |
Family
ID=67385155
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021569042A Active JP7607590B2 (ja) | 2019-05-21 | 2020-05-21 | 異常タンパク質性ニューロパチーを治療する方法において使用するための補体系のアンタゴニスト |
| JP2024220534A Pending JP2025038109A (ja) | 2019-05-21 | 2024-12-17 | 異常タンパク質性ニューロパチーを治療する方法において使用するための補体系のアンタゴニスト |
| JP2024221343A Pending JP2025041724A (ja) | 2019-05-21 | 2024-12-18 | 異常タンパク質性ニューロパチーを治療する方法において使用するための補体系のアンタゴニスト |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024220534A Pending JP2025038109A (ja) | 2019-05-21 | 2024-12-17 | 異常タンパク質性ニューロパチーを治療する方法において使用するための補体系のアンタゴニスト |
| JP2024221343A Pending JP2025041724A (ja) | 2019-05-21 | 2024-12-18 | 異常タンパク質性ニューロパチーを治療する方法において使用するための補体系のアンタゴニスト |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US20250066460A1 (https=) |
| EP (2) | EP4570316A3 (https=) |
| JP (3) | JP7607590B2 (https=) |
| KR (1) | KR20220010505A (https=) |
| CN (2) | CN114269382B (https=) |
| AU (1) | AU2020279543A1 (https=) |
| BR (1) | BR112021023198A2 (https=) |
| CA (1) | CA3138401A1 (https=) |
| DK (1) | DK3972643T3 (https=) |
| EA (1) | EA202193189A1 (https=) |
| ES (1) | ES3035736T3 (https=) |
| FI (1) | FI3972643T3 (https=) |
| GB (1) | GB2584105B (https=) |
| HU (1) | HUE072743T2 (https=) |
| IL (1) | IL288010A (https=) |
| LT (1) | LT3972643T (https=) |
| MA (1) | MA71752A (https=) |
| MX (2) | MX2021014170A (https=) |
| PL (1) | PL3972643T3 (https=) |
| PT (1) | PT3972643T (https=) |
| SG (1) | SG11202112232YA (https=) |
| WO (1) | WO2020234432A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020121282A1 (en) * | 2018-12-13 | 2020-06-18 | Argenx Bvba | Antibodies to human complement factor c2b and methods of use |
| EP4059949A1 (en) * | 2021-03-18 | 2022-09-21 | Affilogic | Anti-factor c3 sac7d variants and their medical use for treating complement-mediated disorders |
| EP4308590A1 (en) | 2021-03-18 | 2024-01-24 | Affilogic | Anti-factor c3 sac7d variants and their medical use for treating complement-mediated disorders |
| EP4308591A4 (en) * | 2021-03-18 | 2025-04-02 | Affilogic | POLYPEPTIDES FOR COMPLEMENT INHIBITION |
| CN117597353A (zh) * | 2021-03-18 | 2024-02-23 | 艾菲洛之克公司 | 抗因子c3的sac7d变体及其治疗补体介导疾患的医疗用途 |
| JP2025503545A (ja) * | 2021-12-30 | 2025-02-04 | アネクソン,インコーポレーテッド | ハンチントン病を治療するための組成物及び方法 |
| CA3259060A1 (en) * | 2022-07-14 | 2024-01-18 | argenx BV | DOSAGE REGIMEN FOR THE TREATMENT OF MULTIFOCAL MOTOR NEUROPATHY (MMN) |
| CN121443634A (zh) * | 2023-03-07 | 2026-01-30 | 克利夫兰诊所基金会 | 人补体成分2结合分子 |
| WO2025146509A1 (en) * | 2024-01-05 | 2025-07-10 | argenx BV | Methods of treating multifocal motor neuropathy (mmn) |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5892019A (en) | 1987-07-15 | 1999-04-06 | The United States Of America, As Represented By The Department Of Health And Human Services | Production of a single-gene-encoded immunoglobulin |
| US8501705B2 (en) * | 2003-09-11 | 2013-08-06 | The Board Of Regents Of The University Of Texas System | Methods and materials for treating autoimmune and/or complement mediated diseases and conditions |
| CA2662480C (en) * | 2006-09-05 | 2016-11-08 | Alexion Pharmaceuticals, Inc. | Methods and compositions for the treatment of antibody mediated neuropathies |
| GB0617734D0 (en) * | 2006-09-08 | 2006-10-18 | Evolutec Ltd | Method of treating peripheral nerve disorders |
| LT3028716T (lt) * | 2006-10-10 | 2020-12-10 | Regenesance B.V. | Komplemento slopinimas nervų regeneracijos pagerinimui |
| LT2894165T (lt) * | 2008-11-10 | 2023-03-10 | Alexion Pharmaceuticals, Inc. | Būdai ir kompozicijos, skirti su komplementu susijusių sutrikimų gydymui |
| WO2010056399A1 (en) * | 2008-11-17 | 2010-05-20 | Incode Biopharmaceutics, Inc. | Method and composition for modulating the immune system and various inflammatory conditions comprising complement depletors |
| CN110229216B (zh) * | 2011-09-07 | 2023-06-16 | 宾夕法尼亚州大学理事会 | 具有改善的药代动力学性质的坎普他汀类肽 |
| CN102949719A (zh) * | 2012-04-28 | 2013-03-06 | 上海市徐汇区中心医院 | 静脉注射免疫球蛋白抑制霍乱毒素和半乳糖凝集素-1结合到神经节苷脂gm1 |
| WO2014096958A1 (en) * | 2012-11-02 | 2014-06-26 | Academisch Medisch Centrum | Inosine monophosphate and salts thereof for use in the treatment of complement-related disorders |
| EP2996722A4 (en) * | 2013-05-15 | 2017-01-11 | Annexon, Inc. | Methods of treatment for guillain-barre syndrome |
| CN105492461B (zh) * | 2013-05-23 | 2019-11-26 | 布罗泰欧制药有限公司 | 结合人类补体因子c2的结合分子及其应用 |
| SG10201804960RA (en) * | 2013-12-12 | 2018-07-30 | Alnylam Pharmaceuticals Inc | Complement component irna compositions and methods of use thereof |
| HUE070383T2 (hu) * | 2014-11-05 | 2025-06-28 | Annexon Inc | Humanizált C1Q anti-komplement faktor antitestek és alkalmazásaik |
| US11091591B2 (en) * | 2015-09-16 | 2021-08-17 | Universität Basel | Carbohydrate ligands that bind to antibodies against glycoepitopes of glycosphingolipids |
| WO2017091719A1 (en) * | 2015-11-24 | 2017-06-01 | Annexon, Inc. | Anti-complement factor c1q fab fragments and uses thereof |
| EP3454902A4 (en) * | 2016-05-10 | 2019-10-09 | Annexon, Inc. | ANTI-COMPLEMENT FACTOR C4 / C4B ANTIBODIES AND USES THEREOF |
| CA3055781A1 (en) * | 2017-03-14 | 2018-09-20 | Bioverativ Usa Inc. | Methods for treating complement-mediated diseases and disorders |
| AU2018360697A1 (en) * | 2017-11-01 | 2020-05-14 | Alnylam Pharmaceuticals, Inc. | Complement component C3 iRNA compositions and methods of use thereof |
| WO2020121282A1 (en) * | 2018-12-13 | 2020-06-18 | Argenx Bvba | Antibodies to human complement factor c2b and methods of use |
-
2019
- 2019-05-21 GB GB1907153.9A patent/GB2584105B/en active Active
-
2020
- 2020-05-21 ES ES20729653T patent/ES3035736T3/es active Active
- 2020-05-21 LT LTEPPCT/EP2020/064234T patent/LT3972643T/lt unknown
- 2020-05-21 WO PCT/EP2020/064234 patent/WO2020234432A1/en not_active Ceased
- 2020-05-21 EA EA202193189A patent/EA202193189A1/ru unknown
- 2020-05-21 PL PL20729653.4T patent/PL3972643T3/pl unknown
- 2020-05-21 US US17/608,637 patent/US20250066460A1/en active Pending
- 2020-05-21 CN CN202080037596.6A patent/CN114269382B/zh active Active
- 2020-05-21 MX MX2021014170A patent/MX2021014170A/es unknown
- 2020-05-21 SG SG11202112232YA patent/SG11202112232YA/en unknown
- 2020-05-21 AU AU2020279543A patent/AU2020279543A1/en active Pending
- 2020-05-21 PT PT207296534T patent/PT3972643T/pt unknown
- 2020-05-21 DK DK20729653.4T patent/DK3972643T3/da active
- 2020-05-21 CN CN202410047987.6A patent/CN118021970A/zh active Pending
- 2020-05-21 BR BR112021023198A patent/BR112021023198A2/pt unknown
- 2020-05-21 HU HUE20729653A patent/HUE072743T2/hu unknown
- 2020-05-21 JP JP2021569042A patent/JP7607590B2/ja active Active
- 2020-05-21 EP EP25159620.1A patent/EP4570316A3/en active Pending
- 2020-05-21 MA MA71752A patent/MA71752A/fr unknown
- 2020-05-21 KR KR1020217039139A patent/KR20220010505A/ko active Pending
- 2020-05-21 EP EP20729653.4A patent/EP3972643B1/en active Active
- 2020-05-21 CA CA3138401A patent/CA3138401A1/en active Pending
- 2020-05-21 FI FIEP20729653.4T patent/FI3972643T3/fi active
-
2021
- 2021-11-11 IL IL288010A patent/IL288010A/en unknown
- 2021-11-18 MX MX2025014486A patent/MX2025014486A/es unknown
-
2024
- 2024-12-17 JP JP2024220534A patent/JP2025038109A/ja active Pending
- 2024-12-18 JP JP2024221343A patent/JP2025041724A/ja active Pending
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