JP7607590B2 - 異常タンパク質性ニューロパチーを治療する方法において使用するための補体系のアンタゴニスト - Google Patents

異常タンパク質性ニューロパチーを治療する方法において使用するための補体系のアンタゴニスト Download PDF

Info

Publication number
JP7607590B2
JP7607590B2 JP2021569042A JP2021569042A JP7607590B2 JP 7607590 B2 JP7607590 B2 JP 7607590B2 JP 2021569042 A JP2021569042 A JP 2021569042A JP 2021569042 A JP2021569042 A JP 2021569042A JP 7607590 B2 JP7607590 B2 JP 7607590B2
Authority
JP
Japan
Prior art keywords
complement
antibody
domain
cells
mmn
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2021569042A
Other languages
English (en)
Japanese (ja)
Other versions
JP2022533705A5 (https=
JPWO2020234432A5 (https=
JP2022533705A (ja
Inventor
ブランシェット クリストフ
ブディング ケビン
ハック エリック
サイレンス カレン
バン デ ウォール インジ
バン デール ポル ルド
ボロス ピーター
Original Assignee
アルジェニクス ビーブイ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by アルジェニクス ビーブイ filed Critical アルジェニクス ビーブイ
Publication of JP2022533705A publication Critical patent/JP2022533705A/ja
Publication of JP2022533705A5 publication Critical patent/JP2022533705A5/ja
Publication of JPWO2020234432A5 publication Critical patent/JPWO2020234432A5/ja
Priority to JP2024220534A priority Critical patent/JP2025038109A/ja
Priority to JP2024221343A priority patent/JP2025041724A/ja
Application granted granted Critical
Publication of JP7607590B2 publication Critical patent/JP7607590B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3076—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
    • C07K16/3084—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties against tumour-associated gangliosides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6402—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals
    • C12N9/6405—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals not being snakes
    • C12N9/6408—Serine endopeptidases (3.4.21)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21043—Classical-complement-pathway C3/C5 convertase (3.4.21.43)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Cell Biology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2021569042A 2019-05-21 2020-05-21 異常タンパク質性ニューロパチーを治療する方法において使用するための補体系のアンタゴニスト Active JP7607590B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2024220534A JP2025038109A (ja) 2019-05-21 2024-12-17 異常タンパク質性ニューロパチーを治療する方法において使用するための補体系のアンタゴニスト
JP2024221343A JP2025041724A (ja) 2019-05-21 2024-12-18 異常タンパク質性ニューロパチーを治療する方法において使用するための補体系のアンタゴニスト

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1907153.9A GB2584105B (en) 2019-05-21 2019-05-21 Methods of treating neuropathy
GB1907153.9 2019-05-21
PCT/EP2020/064234 WO2020234432A1 (en) 2019-05-21 2020-05-21 Antagonists of the complement system for use in methods of treating paraproteinemic neuropathies

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP2024220534A Division JP2025038109A (ja) 2019-05-21 2024-12-17 異常タンパク質性ニューロパチーを治療する方法において使用するための補体系のアンタゴニスト
JP2024221343A Division JP2025041724A (ja) 2019-05-21 2024-12-18 異常タンパク質性ニューロパチーを治療する方法において使用するための補体系のアンタゴニスト

Publications (4)

Publication Number Publication Date
JP2022533705A JP2022533705A (ja) 2022-07-25
JP2022533705A5 JP2022533705A5 (https=) 2023-05-31
JPWO2020234432A5 JPWO2020234432A5 (https=) 2023-05-31
JP7607590B2 true JP7607590B2 (ja) 2024-12-27

Family

ID=67385155

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2021569042A Active JP7607590B2 (ja) 2019-05-21 2020-05-21 異常タンパク質性ニューロパチーを治療する方法において使用するための補体系のアンタゴニスト
JP2024220534A Pending JP2025038109A (ja) 2019-05-21 2024-12-17 異常タンパク質性ニューロパチーを治療する方法において使用するための補体系のアンタゴニスト
JP2024221343A Pending JP2025041724A (ja) 2019-05-21 2024-12-18 異常タンパク質性ニューロパチーを治療する方法において使用するための補体系のアンタゴニスト

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2024220534A Pending JP2025038109A (ja) 2019-05-21 2024-12-17 異常タンパク質性ニューロパチーを治療する方法において使用するための補体系のアンタゴニスト
JP2024221343A Pending JP2025041724A (ja) 2019-05-21 2024-12-18 異常タンパク質性ニューロパチーを治療する方法において使用するための補体系のアンタゴニスト

Country Status (22)

Country Link
US (1) US20250066460A1 (https=)
EP (2) EP4570316A3 (https=)
JP (3) JP7607590B2 (https=)
KR (1) KR20220010505A (https=)
CN (2) CN114269382B (https=)
AU (1) AU2020279543A1 (https=)
BR (1) BR112021023198A2 (https=)
CA (1) CA3138401A1 (https=)
DK (1) DK3972643T3 (https=)
EA (1) EA202193189A1 (https=)
ES (1) ES3035736T3 (https=)
FI (1) FI3972643T3 (https=)
GB (1) GB2584105B (https=)
HU (1) HUE072743T2 (https=)
IL (1) IL288010A (https=)
LT (1) LT3972643T (https=)
MA (1) MA71752A (https=)
MX (2) MX2021014170A (https=)
PL (1) PL3972643T3 (https=)
PT (1) PT3972643T (https=)
SG (1) SG11202112232YA (https=)
WO (1) WO2020234432A1 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020121282A1 (en) * 2018-12-13 2020-06-18 Argenx Bvba Antibodies to human complement factor c2b and methods of use
EP4059949A1 (en) * 2021-03-18 2022-09-21 Affilogic Anti-factor c3 sac7d variants and their medical use for treating complement-mediated disorders
EP4308590A1 (en) 2021-03-18 2024-01-24 Affilogic Anti-factor c3 sac7d variants and their medical use for treating complement-mediated disorders
EP4308591A4 (en) * 2021-03-18 2025-04-02 Affilogic POLYPEPTIDES FOR COMPLEMENT INHIBITION
CN117597353A (zh) * 2021-03-18 2024-02-23 艾菲洛之克公司 抗因子c3的sac7d变体及其治疗补体介导疾患的医疗用途
JP2025503545A (ja) * 2021-12-30 2025-02-04 アネクソン，インコーポレーテッド ハンチントン病を治療するための組成物及び方法
CA3259060A1 (en) * 2022-07-14 2024-01-18 argenx BV DOSAGE REGIMEN FOR THE TREATMENT OF MULTIFOCAL MOTOR NEUROPATHY (MMN)
CN121443634A (zh) * 2023-03-07 2026-01-30 克利夫兰诊所基金会 人补体成分2结合分子
WO2025146509A1 (en) * 2024-01-05 2025-07-10 argenx BV Methods of treating multifocal motor neuropathy (mmn)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110104156A1 (en) 2003-09-11 2011-05-05 Premkumar Christadoss Methods and materials for treating autoimmune and/or complement mediated diseases and conditions
JP2016520313A (ja) 2013-05-23 2016-07-14 ブロテイオ ファーマ ビーヴィＢｒｏｔｅｉｏ Ｐｈａｒｍａ Ｂ．Ｖ． ヒト補体因子ｃ２に結合する結合分子、及び、その使用。
WO2019089922A1 (en) 2017-11-01 2019-05-09 Alnylam Pharmaceuticals, Inc. Complement component c3 irna compositions and methods of use thereof

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5892019A (en) 1987-07-15 1999-04-06 The United States Of America, As Represented By The Department Of Health And Human Services Production of a single-gene-encoded immunoglobulin
CA2662480C (en) * 2006-09-05 2016-11-08 Alexion Pharmaceuticals, Inc. Methods and compositions for the treatment of antibody mediated neuropathies
GB0617734D0 (en) * 2006-09-08 2006-10-18 Evolutec Ltd Method of treating peripheral nerve disorders
LT3028716T (lt) * 2006-10-10 2020-12-10 Regenesance B.V. Komplemento slopinimas nervų regeneracijos pagerinimui
LT2894165T (lt) * 2008-11-10 2023-03-10 Alexion Pharmaceuticals, Inc. Būdai ir kompozicijos, skirti su komplementu susijusių sutrikimų gydymui
WO2010056399A1 (en) * 2008-11-17 2010-05-20 Incode Biopharmaceutics, Inc. Method and composition for modulating the immune system and various inflammatory conditions comprising complement depletors
CN110229216B (zh) * 2011-09-07 2023-06-16 宾夕法尼亚州大学理事会 具有改善的药代动力学性质的坎普他汀类肽
CN102949719A (zh) * 2012-04-28 2013-03-06 上海市徐汇区中心医院 静脉注射免疫球蛋白抑制霍乱毒素和半乳糖凝集素-1结合到神经节苷脂gm1
WO2014096958A1 (en) * 2012-11-02 2014-06-26 Academisch Medisch Centrum Inosine monophosphate and salts thereof for use in the treatment of complement-related disorders
EP2996722A4 (en) * 2013-05-15 2017-01-11 Annexon, Inc. Methods of treatment for guillain-barre syndrome
SG10201804960RA (en) * 2013-12-12 2018-07-30 Alnylam Pharmaceuticals Inc Complement component irna compositions and methods of use thereof
HUE070383T2 (hu) * 2014-11-05 2025-06-28 Annexon Inc Humanizált C1Q anti-komplement faktor antitestek és alkalmazásaik
US11091591B2 (en) * 2015-09-16 2021-08-17 Universität Basel Carbohydrate ligands that bind to antibodies against glycoepitopes of glycosphingolipids
WO2017091719A1 (en) * 2015-11-24 2017-06-01 Annexon, Inc. Anti-complement factor c1q fab fragments and uses thereof
EP3454902A4 (en) * 2016-05-10 2019-10-09 Annexon, Inc. ANTI-COMPLEMENT FACTOR C4 / C4B ANTIBODIES AND USES THEREOF
CA3055781A1 (en) * 2017-03-14 2018-09-20 Bioverativ Usa Inc. Methods for treating complement-mediated diseases and disorders
WO2020121282A1 (en) * 2018-12-13 2020-06-18 Argenx Bvba Antibodies to human complement factor c2b and methods of use

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110104156A1 (en) 2003-09-11 2011-05-05 Premkumar Christadoss Methods and materials for treating autoimmune and/or complement mediated diseases and conditions
JP2016520313A (ja) 2013-05-23 2016-07-14 ブロテイオ ファーマ ビーヴィＢｒｏｔｅｉｏ Ｐｈａｒｍａ Ｂ．Ｖ． ヒト補体因子ｃ２に結合する結合分子、及び、その使用。
WO2019089922A1 (en) 2017-11-01 2019-05-09 Alnylam Pharmaceuticals, Inc. Complement component c3 irna compositions and methods of use thereof

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
ACTA NEUROPATHOLOGICA COMMUNICATIONS，2016年03月02日，VOL:4, NR:23，PAGE(S):1-16
ANONYMOUS，ARGENX ANNOUNCES EXPANSION OF ITS PIPELINE WITH ADDITION OF COMPLEMENT-TARGETED 以下備考，［ONLINE］，2018年03月22日，PAGE(S):1-3，https://www.globenewswire.com/news-release/2018/03/22/1444011/0/en/argenx-announces-expansion-of-its-pipeline-with-addition-of-complement-targeted-ARGX-117-for-treatment-of-severe-autoimmune-diseases.html?print=1，ARGX-117 FOR TREATMENT OF SEVERE AUTOIMMUNE DISEASES
CLINICAL IMMUNOLOGY，2015年09月，VOL:161, NR:2，PAGE(S):225-240
JOURNAL OF NEUROIMMUNOLOGY，2008年12月15日，VOL:205, NR:1-2，PAGE(S):101-104
JOURNAL OF NEUROIMMUNOLOGY，2010年12月15日，VOL:229, NR:1-2，PAGE(S):256-262

Also Published As

Publication number Publication date
US20250066460A1 (en) 2025-02-27
SG11202112232YA (en) 2021-12-30
DK3972643T3 (da) 2025-07-21
IL288010A (en) 2022-01-01
HUE072743T2 (hu) 2025-12-28
JP2025038109A (ja) 2025-03-18
NZ781789A (en) 2025-03-28
JP2025041724A (ja) 2025-03-26
EP4570316A3 (en) 2025-08-13
ES3035736T3 (en) 2025-09-08
GB2584105A (en) 2020-11-25
BR112021023198A2 (pt) 2022-01-04
PT3972643T (pt) 2025-07-15
MA71752A (fr) 2025-05-30
CN118021970A (zh) 2024-05-14
EP3972643A1 (en) 2022-03-30
FI3972643T3 (fi) 2025-07-16
LT3972643T (lt) 2025-07-10
AU2020279543A1 (en) 2021-11-25
CN114269382A (zh) 2022-04-01
PL3972643T3 (pl) 2025-09-08
CN114269382B (zh) 2024-02-23
CA3138401A1 (en) 2020-11-26
EA202193189A1 (ru) 2022-03-11
GB2584105B (en) 2023-08-02
JP2022533705A (ja) 2022-07-25
EP4570316A2 (en) 2025-06-18
KR20220010505A (ko) 2022-01-25
EP3972643B1 (en) 2025-05-14
MX2025014486A (es) 2026-01-07
MX2021014170A (es) 2022-01-04
WO2020234432A1 (en) 2020-11-26
GB201907153D0 (en) 2019-07-03

Similar Documents

Publication Publication Date Title
JP7607590B2 (ja) 異常タンパク質性ニューロパチーを治療する方法において使用するための補体系のアンタゴニスト
US20240343830A1 (en) Methods for Treating Conditions Associated with MASP-2 Dependent Complement Activation
US20240293465A1 (en) Methods for Treating and/or Preventing Graft-Versus-Host Disease and/or Diffuse Alveolar Hemorrhage and/or Veno-Occlusive Disease Associated with Hematopoietic Stem Cell Transplant
US10723788B2 (en) Anti-complement factor C1q Fab fragments and uses thereof
JP6672533B1 (ja) Ｃ５関連疾患の治療または予防用の医薬組成物およびｃ５関連疾患を治療または予防するための方法
CN110167961A (zh) 用于治疗或预防c5相关疾病的药物组合物和治疗或预防c5相关疾病的方法
RS61351B1 (sr) Postupci za lečenje stanja udruženih sa aktivacijom komplementa zavisnom od masp-2
JP7499760B2 (ja) 脳損傷を治療するための組成物及び方法
AU2017299579A1 (en) Compositions and methods for treating frontotemporal dementia
CN107074939B (zh) H因子增强抗体及其用途
KR20250114942A (ko) 보체-매개 질환의 치료에 사용하기 위한 인자 h에 융합된 항-c5 항체
HK40105187A (zh) 用於治疗副蛋白血症性神经病的方法的补体系统的拮抗剂
EA048122B1 (ru) Способы лечения нейропатий
HK40063067A (en) Antagonists of the complement system for use in methods of treating paraproteinemic neuropathies
HK40063067B (zh) 用於治疗副蛋白血症性神经病的方法的补体系统的拮抗剂
HK40062141B (en) Antagonists of the complement system for use in methods of treating paraproteinemic neuropathies
HK40062141A (en) Antagonists of the complement system for use in methods of treating paraproteinemic neuropathies
EA046178B1 (ru) Способы лечения и/или предотвращения реакции трансплантат против хозяина и/или диффузного альвеолярного кровотечения, и/или веноокклюзионной болезни, связанных с трансплантатом гемопоэтических стволовых клеток
BR112018009311B1 (pt) Uso de uma composição compreendendo uma quantidade de um anticorpo inibidor de masp-2

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20220311

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20230519

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20230519

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20240423

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20240719

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20240830

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20241126

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20241217

R150 Certificate of patent or registration of utility model

Ref document number: 7607590

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150