JPWO2020205331A5 - - Google Patents

Info

Publication number

JPWO2020205331A5

JPWO2020205331A5 JP2021557602A JP2021557602A JPWO2020205331A5 JP WO2020205331 A5 JPWO2020205331 A5 JP WO2020205331A5 JP 2021557602 A JP2021557602 A JP 2021557602A JP 2021557602 A JP2021557602 A JP 2021557602A JP WO2020205331 A5 JPWO2020205331 A5 JP WO2020205331A5

Authority

JP

Japan

Prior art keywords

seq

chain variable

polypeptide sequence

variable region

heavy chain

Prior art date

2022-06-29

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
• Discuss

• 229920001184 polypeptide Polymers 0.000 claims description 135
• 108090000765 processed proteins & peptides Proteins 0.000 claims description 135
• 102000004196 processed proteins & peptides Human genes 0.000 claims description 135
• 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims description 50
• 210000004027 cell Anatomy 0.000 claims description 37
• 108091033319 polynucleotide Proteins 0.000 claims description 30
• 102000040430 polynucleotide Human genes 0.000 claims description 30
• 239000002157 polynucleotide Substances 0.000 claims description 30
• 206010028980 Neoplasm Diseases 0.000 claims description 17
• 239000000427 antigen Substances 0.000 claims description 15
• 102000036639 antigens Human genes 0.000 claims description 15
• 108091007433 antigens Proteins 0.000 claims description 15
• 238000000034 method Methods 0.000 claims description 13
• 238000004519 manufacturing process Methods 0.000 claims description 9
• 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims description 8
• 208000010833 Chronic myeloid leukaemia Diseases 0.000 claims description 8
• 208000032612 Glial tumor Diseases 0.000 claims description 8
• 206010018338 Glioma Diseases 0.000 claims description 8
• 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 claims description 8
• 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims description 8
• 206010035226 Plasma cell myeloma Diseases 0.000 claims description 8
• 210000001744 T-lymphocyte Anatomy 0.000 claims description 8
• 208000006990 cholangiocarcinoma Diseases 0.000 claims description 8
• 210000000822 natural killer cell Anatomy 0.000 claims description 8
• 201000011510 cancer Diseases 0.000 claims description 7
• 239000003814 drug Substances 0.000 claims description 7
• 229940079593 drug Drugs 0.000 claims description 7
• 150000007523 nucleic acids Chemical group 0.000 claims description 7
• 102000002029 Claudin Human genes 0.000 claims description 6
• 108050009302 Claudin Proteins 0.000 claims description 6
• 108010047041 Complementarity Determining Regions Proteins 0.000 claims description 6
• 239000012634 fragment Substances 0.000 claims description 6
• 239000003795 chemical substances by application Substances 0.000 claims description 5
• 102000039446 nucleic acids Human genes 0.000 claims description 5
• 108020004707 nucleic acids Proteins 0.000 claims description 5
• 208000031261 Acute myeloid leukaemia Diseases 0.000 claims description 4
• 206010004593 Bile duct cancer Diseases 0.000 claims description 4
• 206010006187 Breast cancer Diseases 0.000 claims description 4
• 208000026310 Breast neoplasm Diseases 0.000 claims description 4
• 201000009030 Carcinoma Diseases 0.000 claims description 4
• 206010008342 Cervix carcinoma Diseases 0.000 claims description 4
• 206010009944 Colon cancer Diseases 0.000 claims description 4
• 208000000461 Esophageal Neoplasms Diseases 0.000 claims description 4
• 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 4
• 208000034578 Multiple myelomas Diseases 0.000 claims description 4
• 206010030155 Oesophageal carcinoma Diseases 0.000 claims description 4
• 206010033128 Ovarian cancer Diseases 0.000 claims description 4
• 206010061535 Ovarian neoplasm Diseases 0.000 claims description 4
• 206010061902 Pancreatic neoplasm Diseases 0.000 claims description 4
• 208000006265 Renal cell carcinoma Diseases 0.000 claims description 4
• 208000005718 Stomach Neoplasms Diseases 0.000 claims description 4
• 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims description 4
• 208000026900 bile duct neoplasm Diseases 0.000 claims description 4
• 201000010881 cervical cancer Diseases 0.000 claims description 4
• 208000029742 colonic neoplasm Diseases 0.000 claims description 4
• 201000010099 disease Diseases 0.000 claims description 4
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 4
• 230000000694 effects Effects 0.000 claims description 4
• 201000004101 esophageal cancer Diseases 0.000 claims description 4
• 206010017758 gastric cancer Diseases 0.000 claims description 4
• 201000010536 head and neck cancer Diseases 0.000 claims description 4
• 208000014829 head and neck neoplasm Diseases 0.000 claims description 4
• 206010073071 hepatocellular carcinoma Diseases 0.000 claims description 4
• 231100000844 hepatocellular carcinoma Toxicity 0.000 claims description 4
• 208000027866 inflammatory disease Diseases 0.000 claims description 4
• 208000032839 leukemia Diseases 0.000 claims description 4
• 201000005202 lung cancer Diseases 0.000 claims description 4
• 208000020816 lung neoplasm Diseases 0.000 claims description 4
• 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims description 4
• 201000000050 myeloid neoplasm Diseases 0.000 claims description 4
• 201000002528 pancreatic cancer Diseases 0.000 claims description 4
• 208000008443 pancreatic carcinoma Diseases 0.000 claims description 4
• 201000011549 stomach cancer Diseases 0.000 claims description 4
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 3
• 238000012258 culturing Methods 0.000 claims description 3
• 230000002463 transducing effect Effects 0.000 claims description 3
• 108091028043 Nucleic acid sequence Proteins 0.000 claims description 2
• 230000004913 activation Effects 0.000 claims description 2
• 230000000139 costimulatory effect Effects 0.000 claims description 2
• 238000000338 in vitro Methods 0.000 claims description 2
• 239000008194 pharmaceutical composition Substances 0.000 claims 8
• 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims 6
• 208000014697 Acute lymphocytic leukaemia Diseases 0.000 claims 6
• 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 6
• 206010027480 Metastatic malignant melanoma Diseases 0.000 claims 3
• 230000001684 chronic effect Effects 0.000 claims 3
• 210000004698 lymphocyte Anatomy 0.000 claims 3
• 208000021039 metastatic melanoma Diseases 0.000 claims 3
• 230000001568 sexual effect Effects 0.000 claims 3
• 230000004068 intracellular signaling Effects 0.000 claims 2
• 239000002773 nucleotide Substances 0.000 claims 1
• 125000003729 nucleotide group Chemical group 0.000 claims 1
• 230000031146 intracellular signal transduction Effects 0.000 description 2
• 238000012986 modification Methods 0.000 description 2
• 230000004048 modification Effects 0.000 description 2
• 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 description 1
• 230000001154 acute effect Effects 0.000 description 1
• 238000002955 isolation Methods 0.000 description 1
• 230000000527 lymphocytic effect Effects 0.000 description 1
• 230000001394 metastastic effect Effects 0.000 description 1
• 206010061289 metastatic neoplasm Diseases 0.000 description 1