AU2020253792A1 - Humanized anti-claudin 18.2 chimeric antigen receptors and uses thereof - Google Patents
Humanized anti-claudin 18.2 chimeric antigen receptors and uses thereof Download PDFInfo
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
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- C—CHEMISTRY; METALLURGY
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- C12N2510/00—Genetically modified cells
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Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
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| US201962825955P | 2019-03-29 | 2019-03-29 | |
| US62/825,955 | 2019-03-29 | ||
| US201962859843P | 2019-06-11 | 2019-06-11 | |
| US62/859,843 | 2019-06-11 | ||
| US201962896758P | 2019-09-06 | 2019-09-06 | |
| US62/896,758 | 2019-09-06 | ||
| PCT/US2020/024432 WO2020205331A1 (en) | 2019-03-29 | 2020-03-24 | Humanized anti-claudin 18.2 chimeric antigen receptors and uses thereof |
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| AU2020253792A1 true AU2020253792A1 (en) | 2021-09-09 |
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| AU2020253792A Abandoned AU2020253792A1 (en) | 2019-03-29 | 2020-03-24 | Humanized anti-claudin 18.2 chimeric antigen receptors and uses thereof |
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| EP (1) | EP3947468A1 (enExample) |
| JP (1) | JP2022527173A (enExample) |
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| MX (1) | MX2021011887A (enExample) |
| SG (1) | SG11202109052YA (enExample) |
| WO (1) | WO2020205331A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
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| EP3917564A4 (en) | 2019-02-01 | 2022-12-21 | NovaRock Biotherapeutics, Ltd. | ANTI-CLAUDINE 18 ANTIBODIES AND THEIR METHODS OF USE |
| WO2022122709A1 (en) * | 2020-12-07 | 2022-06-16 | Sotio Biotech A.S. | Antibody-drug conjugates based on humanized cldn18.2 antibodies |
| CN115073606B (zh) * | 2021-03-10 | 2025-05-02 | 上海莱馥医疗科技有限公司 | 一种靶向表达cldn 18.2的细胞的人源化嵌合抗原受体 |
| CN113354739B (zh) * | 2021-01-11 | 2022-08-23 | 上海莱馥医疗科技有限公司 | 一种靶向表达Claudin18.2细胞的嵌合抗原受体及其应用 |
| JP2024531944A (ja) | 2021-08-09 | 2024-09-03 | ハーバー バイオメッド（シャンハイ）カンパニー リミテッド | Ｃｌｄｎ１８．２標的化抗体、二重特異性抗体、及びそれらの使用 |
| EP4534556A1 (en) * | 2022-05-27 | 2025-04-09 | Suzhou Immunofoco Biotechnology Co., Ltd. | Chimeric antigen receptor containing cldn18.2 single domain antibody and application thereof |
| IL320102A (en) * | 2022-10-10 | 2025-06-01 | Medimmune Llc | Compositions and methods for treating cancer with chimeric antigen receptors targeting claudin 18.2 |
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| WO2013174404A1 (en) * | 2012-05-23 | 2013-11-28 | Ganymed Pharmaceuticals Ag | Combination therapy involving antibodies against claudin 18.2 for treatment of cancer |
| WO2014075697A1 (en) * | 2012-11-13 | 2014-05-22 | Biontech Ag | Agents for treatment of claudin expressing cancer diseases |
| KR102643443B1 (ko) * | 2012-11-13 | 2024-03-06 | 비온테크 에스이 | 클라우딘 발현 암 질환의 치료제 |
| WO2016165762A1 (en) * | 2015-04-15 | 2016-10-20 | Ganymed Pharmaceuticals Ag | Drug conjugates comprising antibodies against claudin 18.2 |
| WO2016180468A1 (en) * | 2015-05-11 | 2016-11-17 | Biontech Cell & Gene Therapies Gmbh | Claudin-18.2-specific immunoreceptors and t cell epitopes |
| SG11201900171QA (en) * | 2016-07-08 | 2019-02-27 | Carsgen Therapeutics Co Ltd | Antibody for anti-claudin 18a2 and use thereof |
| WO2018054484A1 (en) * | 2016-09-23 | 2018-03-29 | Biontech Ag | Bispecific trivalent antibodies binding to claudin 6 or claudin18.2 and cd3 for treatment of claudin expressing cancer diseases |
| AU2019232762B2 (en) * | 2018-03-08 | 2023-11-16 | Phanes Therapeutics, Inc. | Anti-claudin 18.2 antibodies and uses thereof |
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2020
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- 2020-03-24 WO PCT/US2020/024432 patent/WO2020205331A1/en not_active Ceased
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| IL286696A (en) | 2021-10-31 |
| KR20210144792A (ko) | 2021-11-30 |
| US20220184126A1 (en) | 2022-06-16 |
| CN113784980A (zh) | 2021-12-10 |
| EP3947468A1 (en) | 2022-02-09 |
| WO2020205331A1 (en) | 2020-10-08 |
| BR112021016673A2 (pt) | 2021-10-13 |
| CN113784980B (zh) | 2024-04-30 |
| CA3132201A1 (en) | 2020-10-08 |
| SG11202109052YA (en) | 2021-10-28 |
| JP2022527173A (ja) | 2022-05-31 |
| MX2021011887A (es) | 2021-10-26 |
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| MK1 | Application lapsed section 142(2)(a) - no request for examination in relevant period |