CA3132201A1 - Humanized anti-claudin 18.2 chimeric antigen receptors and uses thereof - Google Patents
Humanized anti-claudin 18.2 chimeric antigen receptors and uses thereof Download PDFInfo
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- CA3132201A1 CA3132201A1 CA3132201A CA3132201A CA3132201A1 CA 3132201 A1 CA3132201 A1 CA 3132201A1 CA 3132201 A CA3132201 A CA 3132201A CA 3132201 A CA3132201 A CA 3132201A CA 3132201 A1 CA3132201 A1 CA 3132201A1
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
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- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0646—Natural killers cells [NK], NKT cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C07K2317/622—Single chain antibody (scFv)
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- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
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Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
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| US201962825955P | 2019-03-29 | 2019-03-29 | |
| US62/825,955 | 2019-03-29 | ||
| US201962859843P | 2019-06-11 | 2019-06-11 | |
| US62/859,843 | 2019-06-11 | ||
| US201962896758P | 2019-09-06 | 2019-09-06 | |
| US62/896,758 | 2019-09-06 | ||
| PCT/US2020/024432 WO2020205331A1 (en) | 2019-03-29 | 2020-03-24 | Humanized anti-claudin 18.2 chimeric antigen receptors and uses thereof |
Publications (1)
| Publication Number | Publication Date |
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| CA3132201A1 true CA3132201A1 (en) | 2020-10-08 |
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| Application Number | Title | Priority Date | Filing Date |
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| CA3132201A Pending CA3132201A1 (en) | 2019-03-29 | 2020-03-24 | Humanized anti-claudin 18.2 chimeric antigen receptors and uses thereof |
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| EP (1) | EP3947468A1 (enExample) |
| JP (1) | JP2022527173A (enExample) |
| KR (1) | KR20210144792A (enExample) |
| CN (1) | CN113784980B (enExample) |
| AU (1) | AU2020253792A1 (enExample) |
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| CA (1) | CA3132201A1 (enExample) |
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| MX (1) | MX2021011887A (enExample) |
| SG (1) | SG11202109052YA (enExample) |
| WO (1) | WO2020205331A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US11407828B2 (en) | 2019-02-01 | 2022-08-09 | Novarock Biotherapeutics, Ltd. | Anti-CLauDiN 18 antibodies and methods of use thereof |
| WO2022122709A1 (en) * | 2020-12-07 | 2022-06-16 | Sotio Biotech A.S. | Antibody-drug conjugates based on humanized cldn18.2 antibodies |
| CN115073606B (zh) * | 2021-03-10 | 2025-05-02 | 上海莱馥医疗科技有限公司 | 一种靶向表达cldn 18.2的细胞的人源化嵌合抗原受体 |
| CN113354739B (zh) * | 2021-01-11 | 2022-08-23 | 上海莱馥医疗科技有限公司 | 一种靶向表达Claudin18.2细胞的嵌合抗原受体及其应用 |
| CA3228137A1 (en) | 2021-08-09 | 2023-02-16 | Harbour Biomed (Shanghai) Co., Ltd | Cldn18.2-targeting antibody, bispecific antibody and use thereof |
| AU2023276514A1 (en) * | 2022-05-27 | 2024-12-05 | Suzhou Immunofoco Biotechnology Co., Ltd | Chimeric antigen receptor containing cldn18.2 single domain antibody and application thereof |
| US20240228610A9 (en) * | 2022-10-10 | 2024-07-11 | Medimmune, Llc | Compositions and methods of treating cancer with chimeric antigen receptors targeting claudin 18.2 |
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| WO2013174404A1 (en) * | 2012-05-23 | 2013-11-28 | Ganymed Pharmaceuticals Ag | Combination therapy involving antibodies against claudin 18.2 for treatment of cancer |
| UA128182C2 (uk) * | 2012-11-13 | 2024-05-01 | Біонтех Аґ | Агенти для лікування експресуючих клаудин ракових захворювань |
| WO2014075697A1 (en) * | 2012-11-13 | 2014-05-22 | Biontech Ag | Agents for treatment of claudin expressing cancer diseases |
| WO2016165762A1 (en) * | 2015-04-15 | 2016-10-20 | Ganymed Pharmaceuticals Ag | Drug conjugates comprising antibodies against claudin 18.2 |
| WO2016180468A1 (en) * | 2015-05-11 | 2016-11-17 | Biontech Cell & Gene Therapies Gmbh | Claudin-18.2-specific immunoreceptors and t cell epitopes |
| WO2018006882A1 (zh) * | 2016-07-08 | 2018-01-11 | 科济生物医药（上海）有限公司 | 抗密蛋白18a2的抗体及其应用 |
| WO2018054484A1 (en) * | 2016-09-23 | 2018-03-29 | Biontech Ag | Bispecific trivalent antibodies binding to claudin 6 or claudin18.2 and cd3 for treatment of claudin expressing cancer diseases |
| BR112020015479A2 (pt) * | 2018-03-08 | 2020-12-08 | Phanes Therapeutics, Inc. | Anticorpos anticlaudina 18.2 e usos dos mesmos |
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| SG11202109052YA (en) | 2021-10-28 |
| IL286696A (en) | 2021-10-31 |
| CN113784980A (zh) | 2021-12-10 |
| CN113784980B (zh) | 2024-04-30 |
| JP2022527173A (ja) | 2022-05-31 |
| US20220184126A1 (en) | 2022-06-16 |
| BR112021016673A2 (pt) | 2021-10-13 |
| AU2020253792A1 (en) | 2021-09-09 |
| KR20210144792A (ko) | 2021-11-30 |
| MX2021011887A (es) | 2021-10-26 |
| WO2020205331A1 (en) | 2020-10-08 |
| EP3947468A1 (en) | 2022-02-09 |
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