CN113784980B - 人源化抗Claudin18.2嵌合抗原受体及其用途 - Google Patents

人源化抗Claudin18.2嵌合抗原受体及其用途 Download PDF

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CN113784980B
CN113784980B CN202080026574.XA CN202080026574A CN113784980B CN 113784980 B CN113784980 B CN 113784980B CN 202080026574 A CN202080026574 A CN 202080026574A CN 113784980 B CN113784980 B CN 113784980B
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CN113784980A (zh
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王明晗
邹晖
贾海群
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Van Enshi Pharmaceutical Beijing Co ltd
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CN202080026574.XA 2019-03-29 2020-03-24 人源化抗Claudin18.2嵌合抗原受体及其用途 Active CN113784980B (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201962825955P 2019-03-29 2019-03-29
US62/825,955 2019-03-29
US201962859843P 2019-06-11 2019-06-11
US62/859,843 2019-06-11
US201962896758P 2019-09-06 2019-09-06
US62/896,758 2019-09-06
PCT/US2020/024432 WO2020205331A1 (en) 2019-03-29 2020-03-24 Humanized anti-claudin 18.2 chimeric antigen receptors and uses thereof

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CN113784980A CN113784980A (zh) 2021-12-10
CN113784980B true CN113784980B (zh) 2024-04-30

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US (1) US20220184126A1 (enExample)
EP (1) EP3947468A1 (enExample)
JP (1) JP2022527173A (enExample)
KR (1) KR20210144792A (enExample)
CN (1) CN113784980B (enExample)
AU (1) AU2020253792A1 (enExample)
BR (1) BR112021016673A2 (enExample)
CA (1) CA3132201A1 (enExample)
IL (1) IL286696A (enExample)
MX (1) MX2021011887A (enExample)
SG (1) SG11202109052YA (enExample)
WO (1) WO2020205331A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11407828B2 (en) 2019-02-01 2022-08-09 Novarock Biotherapeutics, Ltd. Anti-CLauDiN 18 antibodies and methods of use thereof
WO2022122709A1 (en) * 2020-12-07 2022-06-16 Sotio Biotech A.S. Antibody-drug conjugates based on humanized cldn18.2 antibodies
CN115073606B (zh) * 2021-03-10 2025-05-02 上海莱馥医疗科技有限公司 一种靶向表达cldn 18.2的细胞的人源化嵌合抗原受体
CN113354739B (zh) * 2021-01-11 2022-08-23 上海莱馥医疗科技有限公司 一种靶向表达Claudin18.2细胞的嵌合抗原受体及其应用
CA3228137A1 (en) 2021-08-09 2023-02-16 Harbour Biomed (Shanghai) Co., Ltd Cldn18.2-targeting antibody, bispecific antibody and use thereof
AU2023276514A1 (en) * 2022-05-27 2024-12-05 Suzhou Immunofoco Biotechnology Co., Ltd Chimeric antigen receptor containing cldn18.2 single domain antibody and application thereof
US20240228610A9 (en) * 2022-10-10 2024-07-11 Medimmune, Llc Compositions and methods of treating cancer with chimeric antigen receptors targeting claudin 18.2

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014075697A1 (en) * 2012-11-13 2014-05-22 Biontech Ag Agents for treatment of claudin expressing cancer diseases
WO2014075788A1 (en) * 2012-11-13 2014-05-22 Biontech Ag Agents for treatment of claudin expressing cancer diseases
WO2016165762A1 (en) * 2015-04-15 2016-10-20 Ganymed Pharmaceuticals Ag Drug conjugates comprising antibodies against claudin 18.2
WO2018054973A1 (en) * 2016-09-23 2018-03-29 Biontech Ag Bispecific trivalent antibodies binding to claudin6 or claudin18.2 and cd3 for treatment of claudin expressing cancer diseases
CN107960056A (zh) * 2015-05-11 2018-04-24 拜恩科技细胞&基因治疗有限公司 闭合蛋白-18.2特异性免疫受体和t细胞表位

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013174404A1 (en) * 2012-05-23 2013-11-28 Ganymed Pharmaceuticals Ag Combination therapy involving antibodies against claudin 18.2 for treatment of cancer
WO2018006882A1 (zh) * 2016-07-08 2018-01-11 科济生物医药（上海）有限公司 抗密蛋白18a2的抗体及其应用
BR112020015479A2 (pt) * 2018-03-08 2020-12-08 Phanes Therapeutics, Inc. Anticorpos anticlaudina 18.2 e usos dos mesmos

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014075697A1 (en) * 2012-11-13 2014-05-22 Biontech Ag Agents for treatment of claudin expressing cancer diseases
WO2014075788A1 (en) * 2012-11-13 2014-05-22 Biontech Ag Agents for treatment of claudin expressing cancer diseases
WO2016165762A1 (en) * 2015-04-15 2016-10-20 Ganymed Pharmaceuticals Ag Drug conjugates comprising antibodies against claudin 18.2
CN107960056A (zh) * 2015-05-11 2018-04-24 拜恩科技细胞&基因治疗有限公司 闭合蛋白-18.2特异性免疫受体和t细胞表位
WO2018054973A1 (en) * 2016-09-23 2018-03-29 Biontech Ag Bispecific trivalent antibodies binding to claudin6 or claudin18.2 and cd3 for treatment of claudin expressing cancer diseases

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SG11202109052YA (en) 2021-10-28
IL286696A (en) 2021-10-31
CN113784980A (zh) 2021-12-10
JP2022527173A (ja) 2022-05-31
US20220184126A1 (en) 2022-06-16
BR112021016673A2 (pt) 2021-10-13
AU2020253792A1 (en) 2021-09-09
KR20210144792A (ko) 2021-11-30
MX2021011887A (es) 2021-10-26
WO2020205331A1 (en) 2020-10-08
CA3132201A1 (en) 2020-10-08
EP3947468A1 (en) 2022-02-09

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