JPWO2020165734A5 - - Google Patents
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- Publication number
- JPWO2020165734A5 JPWO2020165734A5 JP2021546211A JP2021546211A JPWO2020165734A5 JP WO2020165734 A5 JPWO2020165734 A5 JP WO2020165734A5 JP 2021546211 A JP2021546211 A JP 2021546211A JP 2021546211 A JP2021546211 A JP 2021546211A JP WO2020165734 A5 JPWO2020165734 A5 JP WO2020165734A5
- Authority
- JP
- Japan
- Prior art keywords
- day
- amino
- composition
- cancer
- azaspiro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims description 19
- 239000003814 drug Substances 0.000 claims description 14
- 150000003839 salts Chemical class 0.000 claims description 14
- 229940124597 therapeutic agent Drugs 0.000 claims description 14
- 206010028980 Neoplasm Diseases 0.000 claims description 11
- 201000011510 cancer Diseases 0.000 claims description 11
- RHXHGRAEPCAFML-UHFFFAOYSA-N 7-cyclopentyl-n,n-dimethyl-2-[(5-piperazin-1-ylpyridin-2-yl)amino]pyrrolo[2,3-d]pyrimidine-6-carboxamide Chemical compound N1=C2N(C3CCCC3)C(C(=O)N(C)C)=CC2=CN=C1NC(N=C1)=CC=C1N1CCNCC1 RHXHGRAEPCAFML-UHFFFAOYSA-N 0.000 claims description 10
- 229940124297 CDK 4/6 inhibitor Drugs 0.000 claims description 8
- JYRWFZZKEKTMSK-UHFFFAOYSA-N decan-4-amine Chemical compound CCCCCCC(N)CCC JYRWFZZKEKTMSK-UHFFFAOYSA-N 0.000 claims description 5
- UCJZOKGUEJUNIO-IINYFYTJSA-N (3S,4S)-8-[6-amino-5-(2-amino-3-chloropyridin-4-yl)sulfanylpyrazin-2-yl]-3-methyl-2-oxa-8-azaspiro[4.5]decan-4-amine Chemical compound C[C@@H]1OCC2(CCN(CC2)C2=CN=C(SC3=C(Cl)C(N)=NC=C3)C(N)=N2)[C@@H]1N UCJZOKGUEJUNIO-IINYFYTJSA-N 0.000 claims description 4
- 206010009944 Colon cancer Diseases 0.000 claims description 4
- 206010061534 Oesophageal squamous cell carcinoma Diseases 0.000 claims description 4
- 206010033128 Ovarian cancer Diseases 0.000 claims description 4
- 206010061535 Ovarian neoplasm Diseases 0.000 claims description 4
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims description 4
- 208000006265 Renal cell carcinoma Diseases 0.000 claims description 4
- 208000000102 Squamous Cell Carcinoma of Head and Neck Diseases 0.000 claims description 4
- 208000036765 Squamous cell carcinoma of the esophagus Diseases 0.000 claims description 4
- 208000029742 colonic neoplasm Diseases 0.000 claims description 4
- 208000007276 esophageal squamous cell carcinoma Diseases 0.000 claims description 4
- 201000000459 head and neck squamous cell carcinoma Diseases 0.000 claims description 4
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims description 4
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims description 4
- 201000002528 pancreatic cancer Diseases 0.000 claims description 4
- 208000008443 pancreatic carcinoma Diseases 0.000 claims description 4
- HKSQZEGSMBFHGC-UHFFFAOYSA-N pyrimidine-4-carboxamide Chemical compound NC(=O)C1=CC=NC=N1 HKSQZEGSMBFHGC-UHFFFAOYSA-N 0.000 claims description 4
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims 21
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- -1 2-amino-3-chloropyridin-4-yl Chemical group 0.000 description 1
- QORIMRSQLRAMSF-UHFFFAOYSA-N CC1OCC2(C1N)CCNCC2 Chemical compound CC1OCC2(C1N)CCNCC2 QORIMRSQLRAMSF-UHFFFAOYSA-N 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 125000000446 sulfanediyl group Chemical group *S* 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962804708P | 2019-02-12 | 2019-02-12 | |
| US62/804,708 | 2019-02-12 | ||
| PCT/IB2020/051031 WO2020165734A1 (en) | 2019-02-12 | 2020-02-10 | Pharmaceutical combination comprising tno155 and ribociclib |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022519375A JP2022519375A (ja) | 2022-03-23 |
| JPWO2020165734A5 true JPWO2020165734A5 (enExample) | 2023-02-17 |
| JP7493521B2 JP7493521B2 (ja) | 2024-05-31 |
Family
ID=69724013
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021546211A Active JP7493521B2 (ja) | 2019-02-12 | 2020-02-10 | Ｔｎｏ１５５及びリボシクリブを含む医薬組合せ |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US12343344B2 (enExample) |
| EP (1) | EP3923941B1 (enExample) |
| JP (1) | JP7493521B2 (enExample) |
| KR (1) | KR20210126653A (enExample) |
| CN (1) | CN113382731A (enExample) |
| AU (3) | AU2020222296B2 (enExample) |
| BR (1) | BR112021015632A2 (enExample) |
| CA (1) | CA3127286A1 (enExample) |
| CL (1) | CL2021002099A1 (enExample) |
| IL (1) | IL284835B2 (enExample) |
| MX (1) | MX2021009563A (enExample) |
| TW (1) | TWI831916B (enExample) |
| WO (1) | WO2020165734A1 (enExample) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN120208856A (zh) | 2018-09-29 | 2025-06-27 | 诺华股份有限公司 | 用于抑制shp2活性的化合物和组合物的制造 |
| US12138262B2 (en) | 2018-09-29 | 2024-11-12 | Novartis Ag | Process of manufacture of a compound for inhibiting the activity of SHP2, as well as products resulting from acid addition |
| WO2020072656A1 (en) | 2018-10-03 | 2020-04-09 | Gilead Sciences, Inc. | Imidozopyrimidine derivatives |
| US20220160706A1 (en) * | 2019-02-12 | 2022-05-26 | Novartis Ag | Pharmaceutical combination comprising tno155 and a pd-1 inhibitor |
| AU2021293228A1 (en) | 2020-06-18 | 2023-02-09 | Revolution Medicines, Inc. | Methods for delaying, preventing, and treating acquired resistance to RAS inhibitors |
| KR20230038197A (ko) | 2020-07-08 | 2023-03-17 | 노파르티스 아게 | Shp2의 활성 억제를 위한 화합물 및 조성물의 제조 |
| US20250195521A1 (en) | 2020-09-03 | 2025-06-19 | Revolution Medicines, Inc. | Use of sos1 inhibitors to treat malignancies with shp2 mutations |
| IL301298A (en) | 2020-09-15 | 2023-05-01 | Revolution Medicines Inc | Indole derivatives as RAS inhibitors in cancer therapy |
| EP4334324A1 (en) | 2021-05-05 | 2024-03-13 | Revolution Medicines, Inc. | Covalent ras inhibitors and uses thereof |
| US20240238284A1 (en) * | 2021-05-05 | 2024-07-18 | Novartis Ag | Compounds and compositions for the treatment of mpnst |
| WO2022235870A1 (en) | 2021-05-05 | 2022-11-10 | Revolution Medicines, Inc. | Ras inhibitors for the treatment of cancer |
| US12390469B2 (en) * | 2021-05-05 | 2025-08-19 | Huyabio International, Llc | SHP2 inhibitor monotherapy and uses thereof |
| TW202309052A (zh) | 2021-05-05 | 2023-03-01 | 美商銳新醫藥公司 | Ｒａｓ抑制劑 |
| US20240293422A1 (en) * | 2021-06-24 | 2024-09-05 | Erasca, Inc. | Shp2 and cdk4/6 inhibitors combination therapies for the treatment of cancer |
| AR127308A1 (es) | 2021-10-08 | 2024-01-10 | Revolution Medicines Inc | Inhibidores ras |
| TW202342040A (zh) | 2022-02-21 | 2023-11-01 | 瑞士商諾華公司 | 藥物配製物 |
| WO2023172940A1 (en) | 2022-03-08 | 2023-09-14 | Revolution Medicines, Inc. | Methods for treating immune refractory lung cancer |
| KR20250022133A (ko) | 2022-06-10 | 2025-02-14 | 레볼루션 메디슨즈, 인크. | 거대고리 ras 억제제 |
| WO2024115680A1 (en) | 2022-12-01 | 2024-06-06 | Krka, D.D., Novo Mesto | Ribociclib salts and formulations thereof |
| KR20240097396A (ko) | 2022-12-20 | 2024-06-27 | 재단법인대구경북과학기술원 | 리보시클립을 유효성분으로 포함하는 신경염증 또는 퇴행성 뇌질환의 예방 또는 치료용 약학적 조성물 |
| KR20250164828A (ko) | 2023-03-30 | 2025-11-25 | 레볼루션 메디슨즈, 인크. | Ras gtp 가수분해 유도를 위한 조성물 및 이의 용도 |
| WO2024211663A1 (en) | 2023-04-07 | 2024-10-10 | Revolution Medicines, Inc. | Condensed macrocyclic compounds as ras inhibitors |
| AU2024243852A1 (en) | 2023-04-07 | 2025-11-06 | Revolution Medicines, Inc. | Macrocyclic ras inhibitors |
| KR20250172857A (ko) | 2023-04-14 | 2025-12-09 | 레볼루션 메디슨즈, 인크. | Ras 억제제의 결정형 |
| KR20250169290A (ko) | 2023-04-14 | 2025-12-02 | 레볼루션 메디슨즈, 인크. | Ras 억제제의 결정형, 이를 함유하는 조성물 및 이의 사용 방법 |
| AU2024265078A1 (en) | 2023-05-04 | 2025-12-11 | Revolution Medicines, Inc. | Combination therapy for a ras related disease or disorder |
| WO2025034702A1 (en) | 2023-08-07 | 2025-02-13 | Revolution Medicines, Inc. | Rmc-6291 for use in the treatment of ras protein-related disease or disorder |
| WO2025080946A2 (en) | 2023-10-12 | 2025-04-17 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2025171296A1 (en) | 2024-02-09 | 2025-08-14 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2025240847A1 (en) | 2024-05-17 | 2025-11-20 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2025255438A1 (en) | 2024-06-07 | 2025-12-11 | Revolution Medicines, Inc. | Methods of treating a ras protein-related disease or disorder |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8685980B2 (en) | 2008-08-22 | 2014-04-01 | Novartis Ag | Pyrrolopyrimidine compounds and their uses |
| JO3517B1 (ar) * | 2014-01-17 | 2020-07-05 | Novartis Ag | ان-ازاسبيرو الكان حلقي كبديل مركبات اريل-ان مغايرة وتركيبات لتثبيط نشاط shp2 |
| JP7503380B2 (ja) * | 2017-01-10 | 2024-06-20 | ノバルティス アーゲー | Ａｌｋ阻害剤およびｓｈｐ２阻害剤を含む組合せ医薬 |
| BR112020004246A2 (pt) * | 2017-09-07 | 2020-09-01 | Revolution Medicines, Inc. | composições inibidoras de shp2 e métodos para o tratamento de câncer |
| EP3897659A4 (en) | 2018-12-17 | 2022-09-07 | Lunella Biotech, Inc. | Triple combination therapies for anti-aging |
| AU2019403048B2 (en) | 2018-12-17 | 2025-01-23 | Lunella Biotech, Inc. | Triple combination therapies for targeting mitochondria and killing cancer stem cells |
| EP4249000A3 (en) | 2019-02-12 | 2023-12-27 | Novartis AG | Pharmaceutical combination comprising tno155 and a krasg12c inhibitor |
| US20220160706A1 (en) | 2019-02-12 | 2022-05-26 | Novartis Ag | Pharmaceutical combination comprising tno155 and a pd-1 inhibitor |
-
2020
- 2020-02-10 CN CN202080012520.8A patent/CN113382731A/zh active Pending
- 2020-02-10 WO PCT/IB2020/051031 patent/WO2020165734A1/en not_active Ceased
- 2020-02-10 TW TW109104042A patent/TWI831916B/zh active
- 2020-02-10 BR BR112021015632-1A patent/BR112021015632A2/pt unknown
- 2020-02-10 IL IL284835A patent/IL284835B2/en unknown
- 2020-02-10 JP JP2021546211A patent/JP7493521B2/ja active Active
- 2020-02-10 KR KR1020217028654A patent/KR20210126653A/ko not_active Ceased
- 2020-02-10 MX MX2021009563A patent/MX2021009563A/es unknown
- 2020-02-10 EP EP20707827.0A patent/EP3923941B1/en active Active
- 2020-02-10 CA CA3127286A patent/CA3127286A1/en active Pending
- 2020-02-10 AU AU2020222296A patent/AU2020222296B2/en active Active
- 2020-02-10 US US17/430,219 patent/US12343344B2/en active Active
-
2021
- 2021-08-10 CL CL2021002099A patent/CL2021002099A1/es unknown
-
2023
- 2023-06-15 AU AU2023203751A patent/AU2023203751A1/en not_active Abandoned
-
2025
- 2025-05-23 AU AU2025203816A patent/AU2025203816A1/en active Pending
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