JPWO2020159904A5 - - Google Patents
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- Publication number
- JPWO2020159904A5 JPWO2020159904A5 JP2021544435A JP2021544435A JPWO2020159904A5 JP WO2020159904 A5 JPWO2020159904 A5 JP WO2020159904A5 JP 2021544435 A JP2021544435 A JP 2021544435A JP 2021544435 A JP2021544435 A JP 2021544435A JP WO2020159904 A5 JPWO2020159904 A5 JP WO2020159904A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- substituted
- membered heterocycle
- cycloalkyl
- alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 82
- 125000000623 heterocyclic group Chemical group 0.000 claims 44
- 125000003545 alkoxy group Chemical group 0.000 claims 25
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 21
- 229910052736 halogen Inorganic materials 0.000 claims 18
- 150000002367 halogens Chemical class 0.000 claims 18
- 150000003839 salts Chemical class 0.000 claims 11
- 125000003118 aryl group Chemical group 0.000 claims 9
- 125000002837 carbocyclic group Chemical group 0.000 claims 9
- 208000023275 Autoimmune disease Diseases 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 208000027866 inflammatory disease Diseases 0.000 claims 2
- 230000002757 inflammatory effect Effects 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 206010002556 Ankylosing Spondylitis Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 201000001263 Psoriatic Arthritis Diseases 0.000 claims 1
- 208000036824 Psoriatic arthropathy Diseases 0.000 claims 1
- 206010039710 Scleroderma Diseases 0.000 claims 1
- 208000021386 Sjogren Syndrome Diseases 0.000 claims 1
- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- WCPAKWJPBJAGKN-UHFFFAOYSA-N oxadiazole Chemical group C1=CON=N1 WCPAKWJPBJAGKN-UHFFFAOYSA-N 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 1
- 150000003536 tetrazoles Chemical class 0.000 claims 1
- 150000003852 triazoles Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962798566P | 2019-01-30 | 2019-01-30 | |
| US62/798,566 | 2019-01-30 | ||
| PCT/US2020/015291 WO2020159904A1 (en) | 2019-01-30 | 2020-01-28 | Amide-disubstituted pyridine or pyridazine compounds |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2022519239A JP2022519239A (ja) | 2022-03-22 |
| JP2022519239A5 JP2022519239A5 (https=) | 2023-02-06 |
| JPWO2020159904A5 true JPWO2020159904A5 (https=) | 2023-02-06 |
| JP7637626B2 JP7637626B2 (ja) | 2025-02-28 |
Family
ID=69780292
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021544435A Active JP7637626B2 (ja) | 2019-01-30 | 2020-01-28 | アミド二置換のピリジンまたはピリダジン化合物 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20230150979A1 (https=) |
| EP (1) | EP3917912B1 (https=) |
| JP (1) | JP7637626B2 (https=) |
| KR (1) | KR20210121140A (https=) |
| CN (2) | CN119176796A (https=) |
| AU (1) | AU2020216914A1 (https=) |
| BR (1) | BR112021014709A2 (https=) |
| CA (1) | CA3128014A1 (https=) |
| EA (1) | EA202192134A1 (https=) |
| ES (1) | ES3035735T3 (https=) |
| IL (1) | IL285157B2 (https=) |
| MX (1) | MX2021008752A (https=) |
| SG (1) | SG11202108162SA (https=) |
| WO (1) | WO2020159904A1 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021202652A1 (en) * | 2020-04-01 | 2021-10-07 | Eternity Bioscience Inc. | Tyrosine kinase 2 inhibitors, preparation methods and medicinal uses thereof |
| WO2022135430A1 (en) | 2020-12-22 | 2022-06-30 | InventisBio Co., Ltd. | Heteroaryl compounds, preparation methods and uses thereof |
| EP4308556A4 (en) * | 2021-03-16 | 2025-02-19 | Anrui Biomedical Technology (Guangzhou) Co., Ltd. | Amino heteroaryl compounds and compositions |
| CN115141149A (zh) * | 2021-03-30 | 2022-10-04 | 浙江文达医药科技有限公司 | 作为tyk2假激酶结构域抑制剂的杂环化合物及合成方法和用途 |
| AU2022268464B2 (en) * | 2021-05-04 | 2025-04-17 | Shanghai Zheye Biotechnology Co. Ltd. | Nitrogen-containing heterocyclic pyridine compound |
| TWI825800B (zh) * | 2021-06-22 | 2023-12-11 | 大陸商南京明德新藥研發有限公司 | 亞磺醯亞胺類化合物及其應用 |
| JP2024539280A (ja) | 2021-10-25 | 2024-10-28 | カイメラ セラピューティクス， インコーポレイテッド | Ｔｙｋ２分解剤およびそれらの使用 |
| WO2023213308A1 (zh) * | 2022-05-05 | 2023-11-09 | 苏州隆博泰药业有限公司 | 酰胺取代的杂环化合物及其医药用途 |
| WO2024102683A1 (en) * | 2022-11-08 | 2024-05-16 | Bristol-Myers Squibb Company | Substituted heterocyclic compounds |
| WO2024131882A1 (zh) * | 2022-12-22 | 2024-06-27 | 南京明德新药研发有限公司 | 一种吡啶多取代化合物的盐型、晶型及其制备方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY194668A (en) | 2012-11-08 | 2022-12-12 | Bristol Myers Squibb Co | Amide-substituted heterocyclic compounds useful as modulators of il-12, il-23 and/or ifn() responses |
| AR094537A1 (es) | 2013-11-07 | 2015-08-12 | Bristol Myers Squibb Co | COMPUESTOS DE PIRIDILO SUSTITUIDOS CON ALQUILAMIDA ÚTILES COMO MODULADORES DE LAS RESPUESTAS DE IL-12, IL-23 Y/O IFNa |
| EP3848370B1 (en) | 2016-10-14 | 2025-05-07 | Takeda Pharmaceutical Company Limited | Tyk2 inhibitors and uses thereof |
| AU2019364336B2 (en) * | 2018-10-22 | 2023-11-16 | Alumis Inc. | TYK2 inhibitors and uses thereof |
| CN111757878B (zh) | 2019-01-28 | 2023-07-28 | 江苏豪森药业集团有限公司 | 一种哒嗪类衍生物抑制剂、其制备方法和应用 |
-
2020
- 2020-01-28 WO PCT/US2020/015291 patent/WO2020159904A1/en not_active Ceased
- 2020-01-28 JP JP2021544435A patent/JP7637626B2/ja active Active
- 2020-01-28 AU AU2020216914A patent/AU2020216914A1/en not_active Abandoned
- 2020-01-28 CN CN202411002531.4A patent/CN119176796A/zh active Pending
- 2020-01-28 ES ES20710338T patent/ES3035735T3/es active Active
- 2020-01-28 SG SG11202108162SA patent/SG11202108162SA/en unknown
- 2020-01-28 CN CN202080011693.8A patent/CN113365982A/zh active Pending
- 2020-01-28 US US17/425,336 patent/US20230150979A1/en not_active Abandoned
- 2020-01-28 KR KR1020217027099A patent/KR20210121140A/ko active Pending
- 2020-01-28 BR BR112021014709-8A patent/BR112021014709A2/pt not_active Application Discontinuation
- 2020-01-28 EA EA202192134A patent/EA202192134A1/ru unknown
- 2020-01-28 MX MX2021008752A patent/MX2021008752A/es unknown
- 2020-01-28 CA CA3128014A patent/CA3128014A1/en active Pending
- 2020-01-28 EP EP20710338.3A patent/EP3917912B1/en active Active
- 2020-01-28 IL IL285157A patent/IL285157B2/en unknown