JPWO2020157577A5 - - Google Patents
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- Publication number
- JPWO2020157577A5 JPWO2020157577A5 JP2021544351A JP2021544351A JPWO2020157577A5 JP WO2020157577 A5 JPWO2020157577 A5 JP WO2020157577A5 JP 2021544351 A JP2021544351 A JP 2021544351A JP 2021544351 A JP2021544351 A JP 2021544351A JP WO2020157577 A5 JPWO2020157577 A5 JP WO2020157577A5
- Authority
- JP
- Japan
- Prior art keywords
- medicament
- biphenyl
- chloro
- amino
- diazaspiro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000002552 dosage form Substances 0.000 claims description 10
- 206010064911 Pulmonary arterial hypertension Diseases 0.000 claims description 8
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical group C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 claims description 8
- DUUGKQCEGZLZNO-UHFFFAOYSA-N 5-hydroxyindoleacetic acid Chemical compound C1=C(O)C=C2C(CC(=O)O)=CNC2=C1 DUUGKQCEGZLZNO-UHFFFAOYSA-N 0.000 claims description 6
- TZSZZENYCISATO-WIOPSUGQSA-N rodatristat Chemical compound CCOC(=O)[C@@H]1CC2(CN1)CCN(CC2)c1cc(O[C@H](c2ccc(Cl)cc2-c2ccccc2)C(F)(F)F)nc(N)n1 TZSZZENYCISATO-WIOPSUGQSA-N 0.000 claims description 5
- 235000010290 biphenyl Nutrition 0.000 claims description 4
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 4
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 claims description 4
- 230000000977 initiatory effect Effects 0.000 claims description 3
- 230000002485 urinary effect Effects 0.000 claims description 3
- 206010020772 Hypertension Diseases 0.000 claims description 2
- 230000015572 biosynthetic process Effects 0.000 claims description 2
- 210000004072 lung Anatomy 0.000 claims description 2
- 239000006186 oral dosage form Substances 0.000 claims description 2
- 230000002685 pulmonary effect Effects 0.000 claims description 2
- 229940076279 serotonin Drugs 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims 30
- 229940079593 drug Drugs 0.000 claims 3
- BGMBESSESNFHQD-UHFFFAOYSA-N 2,8-diazaspiro[4.5]decane-3-carboxylic acid Chemical compound C1NC(C(=O)O)CC21CCNCC2 BGMBESSESNFHQD-UHFFFAOYSA-N 0.000 claims 1
- 239000004305 biphenyl Substances 0.000 claims 1
- 125000006005 fluoroethoxy group Chemical group 0.000 claims 1
- 125000003652 trifluoroethoxy group Chemical group FC(CO*)(F)F 0.000 claims 1
- 238000000034 method Methods 0.000 description 14
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- YRCGAHTZOXPQPR-UHFFFAOYSA-N 2-ethylnonanoic acid Chemical compound CCCCCCCC(CC)C(O)=O YRCGAHTZOXPQPR-UHFFFAOYSA-N 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962798827P | 2019-01-30 | 2019-01-30 | |
| US62/798,827 | 2019-01-30 | ||
| PCT/IB2020/000074 WO2020157577A1 (en) | 2019-01-30 | 2020-01-30 | A dosage regime and method for treating pulmonary arterial hypertension with rodatristat ethyl |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022518944A JP2022518944A (ja) | 2022-03-17 |
| JPWO2020157577A5 true JPWO2020157577A5 (https=) | 2022-12-19 |
| JP2022518944A5 JP2022518944A5 (https=) | 2022-12-19 |
Family
ID=70285725
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021544351A Pending JP2022518944A (ja) | 2019-01-30 | 2020-01-30 | 肺動脈性肺高血圧症を治療するための投与レジメンおよび方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US11607413B2 (https=) |
| EP (1) | EP3917531A1 (https=) |
| JP (1) | JP2022518944A (https=) |
| KR (1) | KR20210133953A (https=) |
| CN (1) | CN113557022A (https=) |
| AU (1) | AU2020213746A1 (https=) |
| CA (1) | CA3128327A1 (https=) |
| MX (1) | MX2021009055A (https=) |
| WO (1) | WO2020157577A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20210102887A (ko) * | 2018-11-14 | 2021-08-20 | 알타반트 사이언시스 게엠베하 | 말초 세로토닌과 관련된 질병 또는 장애를 치료하기 위한 트립토판 하이드록실라제 1 (tph1)의 결정질 스피로사이클릭 화합물 억제제 |
| JP2022507533A (ja) * | 2018-11-16 | 2022-01-18 | アルタバント・サイエンシズ・ゲーエムベーハー | 肺動脈性高血圧症および他疾患に関連する肺動脈性肺高血圧症の治療法 |
| US20200188399A1 (en) * | 2018-12-17 | 2020-06-18 | Altavant Sciences Gmbh | Method for treating interstitial lung disease |
| US11607413B2 (en) | 2019-01-30 | 2023-03-21 | Altavant Sciences Gmbh | Dosage regime and method for treating pulmonary arterial hypertension |
| US11576915B2 (en) | 2019-03-15 | 2023-02-14 | Altavant Sciences Gmbh | Method for treating pulmonary arterial hypertension and associated pulmonary arterial hypertension and daily dosing |
| WO2023062595A1 (en) | 2021-10-14 | 2023-04-20 | Altavant Sciences Gmbh | Treatment of subjects having pulmonary arterial hypertension with rodatristat ethyl |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101815534A (zh) | 2007-07-11 | 2010-08-25 | 莱西肯医药有限公司 | 用于治疗肺动脉高压以及相关疾病和病症的方法和组合物 |
| UA119247C2 (uk) | 2013-09-06 | 2019-05-27 | РОЙВЕНТ САЙЕНСИЗ ҐмбГ | Спіроциклічні сполуки як інгібітори триптофангідроксилази |
| KR20210102887A (ko) | 2018-11-14 | 2021-08-20 | 알타반트 사이언시스 게엠베하 | 말초 세로토닌과 관련된 질병 또는 장애를 치료하기 위한 트립토판 하이드록실라제 1 (tph1)의 결정질 스피로사이클릭 화합물 억제제 |
| JP2022507533A (ja) | 2018-11-16 | 2022-01-18 | アルタバント・サイエンシズ・ゲーエムベーハー | 肺動脈性高血圧症および他疾患に関連する肺動脈性肺高血圧症の治療法 |
| US20200188399A1 (en) | 2018-12-17 | 2020-06-18 | Altavant Sciences Gmbh | Method for treating interstitial lung disease |
| WO2020128608A1 (en) | 2018-12-17 | 2020-06-25 | Altavant Sciences Gmbh | Compound for use in a method for treating sarcoidosis-associated pulmonary hypertension |
| US11607413B2 (en) | 2019-01-30 | 2023-03-21 | Altavant Sciences Gmbh | Dosage regime and method for treating pulmonary arterial hypertension |
| US11576915B2 (en) * | 2019-03-15 | 2023-02-14 | Altavant Sciences Gmbh | Method for treating pulmonary arterial hypertension and associated pulmonary arterial hypertension and daily dosing |
-
2020
- 2020-01-30 US US16/777,458 patent/US11607413B2/en active Active
- 2020-01-30 JP JP2021544351A patent/JP2022518944A/ja active Pending
- 2020-01-30 AU AU2020213746A patent/AU2020213746A1/en not_active Abandoned
- 2020-01-30 CN CN202080016400.5A patent/CN113557022A/zh active Pending
- 2020-01-30 CA CA3128327A patent/CA3128327A1/en active Pending
- 2020-01-30 EP EP20718760.0A patent/EP3917531A1/en not_active Withdrawn
- 2020-01-30 MX MX2021009055A patent/MX2021009055A/es unknown
- 2020-01-30 KR KR1020217024232A patent/KR20210133953A/ko not_active Abandoned
- 2020-01-30 WO PCT/IB2020/000074 patent/WO2020157577A1/en not_active Ceased
-
2023
- 2023-01-25 US US18/159,494 patent/US20240041877A1/en not_active Abandoned
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