KR20210133953A - 로다트리스타트 에틸로 폐동맥 고혈압을 치료하기 위한 투여 요법 및 방법 - Google Patents

로다트리스타트 에틸로 폐동맥 고혈압을 치료하기 위한 투여 요법 및 방법 Download PDF

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Publication number
KR20210133953A
KR20210133953A KR1020217024232A KR20217024232A KR20210133953A KR 20210133953 A KR20210133953 A KR 20210133953A KR 1020217024232 A KR1020217024232 A KR 1020217024232A KR 20217024232 A KR20217024232 A KR 20217024232A KR 20210133953 A KR20210133953 A KR 20210133953A
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South Korea
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kar5585
diazaspiro
decane
biphenyl
pyrimidin
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Abandoned
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KR1020217024232A
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English (en)
Korean (ko)
Inventor
미셸 팔라시오스
에릭 제이. 가우켈
스티븐 에이. 링
마그달레나 알론소-갈리시아
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알타반트 사이언시스 게엠베하
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Publication of KR20210133953A publication Critical patent/KR20210133953A/ko
Abandoned legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
KR1020217024232A 2019-01-30 2020-01-30 로다트리스타트 에틸로 폐동맥 고혈압을 치료하기 위한 투여 요법 및 방법 Abandoned KR20210133953A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962798827P 2019-01-30 2019-01-30
US62/798,827 2019-01-30
PCT/IB2020/000074 WO2020157577A1 (en) 2019-01-30 2020-01-30 A dosage regime and method for treating pulmonary arterial hypertension with rodatristat ethyl

Publications (1)

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KR20210133953A true KR20210133953A (ko) 2021-11-08

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KR1020217024232A Abandoned KR20210133953A (ko) 2019-01-30 2020-01-30 로다트리스타트 에틸로 폐동맥 고혈압을 치료하기 위한 투여 요법 및 방법

Country Status (9)

Country Link
US (2) US11607413B2 (https=)
EP (1) EP3917531A1 (https=)
JP (1) JP2022518944A (https=)
KR (1) KR20210133953A (https=)
CN (1) CN113557022A (https=)
AU (1) AU2020213746A1 (https=)
CA (1) CA3128327A1 (https=)
MX (1) MX2021009055A (https=)
WO (1) WO2020157577A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20210102887A (ko) * 2018-11-14 2021-08-20 알타반트 사이언시스 게엠베하 말초 세로토닌과 관련된 질병 또는 장애를 치료하기 위한 트립토판 하이드록실라제 1 (tph1)의 결정질 스피로사이클릭 화합물 억제제
JP2022507533A (ja) * 2018-11-16 2022-01-18 アルタバント・サイエンシズ・ゲーエムベーハー 肺動脈性高血圧症および他疾患に関連する肺動脈性肺高血圧症の治療法
US20200188399A1 (en) * 2018-12-17 2020-06-18 Altavant Sciences Gmbh Method for treating interstitial lung disease
US11607413B2 (en) 2019-01-30 2023-03-21 Altavant Sciences Gmbh Dosage regime and method for treating pulmonary arterial hypertension
US11576915B2 (en) 2019-03-15 2023-02-14 Altavant Sciences Gmbh Method for treating pulmonary arterial hypertension and associated pulmonary arterial hypertension and daily dosing
WO2023062595A1 (en) 2021-10-14 2023-04-20 Altavant Sciences Gmbh Treatment of subjects having pulmonary arterial hypertension with rodatristat ethyl

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101815534A (zh) 2007-07-11 2010-08-25 莱西肯医药有限公司 用于治疗肺动脉高压以及相关疾病和病症的方法和组合物
UA119247C2 (uk) 2013-09-06 2019-05-27 РОЙВЕНТ САЙЕНСИЗ ҐмбГ Спіроциклічні сполуки як інгібітори триптофангідроксилази
KR20210102887A (ko) 2018-11-14 2021-08-20 알타반트 사이언시스 게엠베하 말초 세로토닌과 관련된 질병 또는 장애를 치료하기 위한 트립토판 하이드록실라제 1 (tph1)의 결정질 스피로사이클릭 화합물 억제제
JP2022507533A (ja) 2018-11-16 2022-01-18 アルタバント・サイエンシズ・ゲーエムベーハー 肺動脈性高血圧症および他疾患に関連する肺動脈性肺高血圧症の治療法
US20200188399A1 (en) 2018-12-17 2020-06-18 Altavant Sciences Gmbh Method for treating interstitial lung disease
WO2020128608A1 (en) 2018-12-17 2020-06-25 Altavant Sciences Gmbh Compound for use in a method for treating sarcoidosis-associated pulmonary hypertension
US11607413B2 (en) 2019-01-30 2023-03-21 Altavant Sciences Gmbh Dosage regime and method for treating pulmonary arterial hypertension
US11576915B2 (en) * 2019-03-15 2023-02-14 Altavant Sciences Gmbh Method for treating pulmonary arterial hypertension and associated pulmonary arterial hypertension and daily dosing

Also Published As

Publication number Publication date
US11607413B2 (en) 2023-03-21
JP2022518944A (ja) 2022-03-17
CN113557022A (zh) 2021-10-26
CA3128327A1 (en) 2020-08-06
US20200237759A1 (en) 2020-07-30
AU2020213746A1 (en) 2021-08-19
WO2020157577A8 (en) 2020-10-15
MX2021009055A (es) 2021-10-22
WO2020157577A1 (en) 2020-08-06
EP3917531A1 (en) 2021-12-08
US20240041877A1 (en) 2024-02-08

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Date Code Title Description
PA0105 International application

Patent event date: 20210729

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
PC1902 Submission of document of abandonment before decision of registration