JPWO2020153414A5 - - Google Patents
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- JPWO2020153414A5 JPWO2020153414A5 JP2020568192A JP2020568192A JPWO2020153414A5 JP WO2020153414 A5 JPWO2020153414 A5 JP WO2020153414A5 JP 2020568192 A JP2020568192 A JP 2020568192A JP 2020568192 A JP2020568192 A JP 2020568192A JP WO2020153414 A5 JPWO2020153414 A5 JP WO2020153414A5
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- JP
- Japan
- Prior art keywords
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- salt
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- formula
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000005843 halogen group Chemical group 0.000 claims 9
- 150000003839 salts Chemical class 0.000 claims 9
- 150000001875 compounds Chemical class 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 6
- 125000006583 (C1-C3) haloalkyl group Chemical group 0.000 claims 5
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 5
- 208000020925 Bipolar disease Diseases 0.000 claims 4
- 206010012289 Dementia Diseases 0.000 claims 4
- 208000019695 Migraine disease Diseases 0.000 claims 4
- 208000002193 Pain Diseases 0.000 claims 4
- 206010027599 migraine Diseases 0.000 claims 4
- 208000024891 symptom Diseases 0.000 claims 4
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 3
- 229940124597 therapeutic agent Drugs 0.000 claims 3
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 2
- 102100022630 Glutamate receptor ionotropic, NMDA 2B Human genes 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 108010038912 Retinoid X Receptors Proteins 0.000 claims 2
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical group C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- 230000002093 peripheral effect Effects 0.000 claims 2
- 230000000069 prophylactic effect Effects 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 claims 1
- 208000020401 Depressive disease Diseases 0.000 claims 1
- 102000004868 N-Methyl-D-Aspartate Receptors Human genes 0.000 claims 1
- 108090001041 N-Methyl-D-Aspartate Receptors Proteins 0.000 claims 1
- LUQSMDJQBWVZMW-UHFFFAOYSA-N N-[(3-cyano-2-fluoro-6-methoxyphenyl)methyl]-6-(difluoromethoxy)-5-fluoropyridine-3-carboxamide Chemical compound COC1=C(C(=C(C=C1)C#N)F)CNC(=O)C2=CC(=C(N=C2)OC(F)F)F LUQSMDJQBWVZMW-UHFFFAOYSA-N 0.000 claims 1
- XHSFEOLOVOCJRV-UHFFFAOYSA-N N-[(5-cyano-2-methoxypyridin-3-yl)methyl]-6-(difluoromethoxy)-5-fluoropyridine-3-carboxamide Chemical compound COC1=C(C=C(C=N1)C#N)CNC(=O)C2=CC(=C(N=C2)OC(F)F)F XHSFEOLOVOCJRV-UHFFFAOYSA-N 0.000 claims 1
- 229940099433 NMDA receptor antagonist Drugs 0.000 claims 1
- 239000005557 antagonist Substances 0.000 claims 1
- 229910052731 fluorine Inorganic materials 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000003703 n methyl dextro aspartic acid receptor blocking agent Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 230000003449 preventive effect Effects 0.000 claims 1
- 125000005750 substituted cyclic group Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019010536 | 2019-01-24 | ||
| JP2019010536 | 2019-01-24 | ||
| PCT/JP2020/002216 WO2020153414A1 (ja) | 2019-01-24 | 2020-01-23 | 複素環化合物及びその用途 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JPWO2020153414A1 JPWO2020153414A1 (ja) | 2021-12-02 |
| JPWO2020153414A5 true JPWO2020153414A5 (cg-RX-API-DMAC7.html) | 2023-01-31 |
| JP7541487B2 JP7541487B2 (ja) | 2024-08-28 |
Family
ID=71736449
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020568192A Active JP7541487B2 (ja) | 2019-01-24 | 2020-01-23 | 複素環化合物及びその用途 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20220089525A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3915638A4 (cg-RX-API-DMAC7.html) |
| JP (1) | JP7541487B2 (cg-RX-API-DMAC7.html) |
| MA (1) | MA54823A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2020153414A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7279067B2 (ja) | 2018-03-28 | 2023-05-22 | 武田薬品工業株式会社 | 複素環化合物及びその用途 |
| JP2021050161A (ja) | 2019-09-25 | 2021-04-01 | 武田薬品工業株式会社 | 複素環化合物及びその用途 |
| CN115354349B (zh) * | 2022-08-29 | 2025-07-18 | 河北农业大学 | 一种电催化制备过氧化氢的碳催化剂的制备方法及催化剂 |
| CN116120226A (zh) * | 2022-12-28 | 2023-05-16 | 湖南阿斯迪康药业有限公司 | 一种5-羟甲基烟腈的合成工艺 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW212792B (cg-RX-API-DMAC7.html) * | 1991-09-13 | 1993-09-11 | Shell Internat Res Schappej B V | |
| US5854204A (en) | 1995-03-14 | 1998-12-29 | Praecis Pharmaceuticals, Inc. | Aβ peptides that modulate β-amyloid aggregation |
| JP2001500852A (ja) | 1996-08-27 | 2001-01-23 | プレーシス ファーマスーティカルズ インコーポレイテッド | Ｄ―アミノ酸を含むβ―アミロイドペプチド凝集のモジュレーター |
| CA2374610A1 (en) | 1999-06-28 | 2001-01-04 | Jordan J. N. Tang | Catalytically active recombinant memapsin and methods of use thereof |
| TWI262185B (en) | 1999-10-01 | 2006-09-21 | Eisai Co Ltd | Carboxylic acid derivatives having anti-hyperglycemia and anti-hyperlipemia action, and pharmaceutical composition containing the derivatives |
| US20020151534A1 (en) | 2001-02-02 | 2002-10-17 | Ries Uwe Joerg | Antithrombotic compounds |
| DE10111842A1 (de) | 2001-03-13 | 2002-09-19 | Boehringer Ingelheim Pharma | Antithrombotische Carbonsäureamide, deren Herstellung und deren Verwendung als Arzneimittel |
| US7244861B2 (en) | 2001-03-30 | 2007-07-17 | Eisai Co., Ltd. | Benzene compound and salt thereof |
| WO2002080899A1 (fr) | 2001-03-30 | 2002-10-17 | Eisai Co., Ltd. | Agent de traitement de maladie digestive |
| CA2443108A1 (en) * | 2001-04-03 | 2002-10-17 | Merck & Co. Inc. | N-substituted nonaryl-heterocyclo amidyl nmda/nr2b antagonists |
| EP1569907B1 (en) * | 2002-12-13 | 2016-03-09 | YM BioSciences Australia Pty Ltd | Nicotinamide-based kinase inhibitors |
| CA2637620A1 (en) * | 2006-02-16 | 2007-08-30 | Boehringer Ingelheim International Gmbh | Substituted pyridineamide compounds useful as soluble epoxide hydrolase inhibitors |
| JP2010120852A (ja) | 2007-03-09 | 2010-06-03 | Daiichi Sankyo Co Ltd | 新規なジアミド誘導体 |
| EP2712290A4 (en) | 2011-05-19 | 2014-11-19 | Univ Leland Stanford Junior | ANTIPROLIFERATIVE COMPOUNDS AND METHOD FOR THEIR USE |
| EP3178520B1 (en) | 2013-03-08 | 2018-12-12 | Becton, Dickinson and Company | Syringe-iv access locking device |
| CA2903572A1 (en) | 2013-03-15 | 2014-10-23 | Epizyme, Inc. | Substituted benzene compounds |
| EP3239150B1 (en) | 2014-12-24 | 2020-02-05 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| TWI636041B (zh) | 2015-08-12 | 2018-09-21 | 美國禮來大藥廠 | Ｃｇｒｐ受體拮抗劑 |
| TW201718574A (zh) | 2015-08-12 | 2017-06-01 | 美國禮來大藥廠 | Ｃｇｒｐ受體拮抗劑 |
| JP2019514860A (ja) | 2016-04-08 | 2019-06-06 | シンジェンタ パーティシペーションズ アーゲー | 殺微生物性オキサジアゾール誘導体 |
-
2020
- 2020-01-23 EP EP20744243.5A patent/EP3915638A4/en active Pending
- 2020-01-23 MA MA054823A patent/MA54823A/fr unknown
- 2020-01-23 WO PCT/JP2020/002216 patent/WO2020153414A1/ja not_active Ceased
- 2020-01-23 US US17/310,164 patent/US20220089525A1/en active Pending
- 2020-01-23 JP JP2020568192A patent/JP7541487B2/ja active Active