JPWO2020139988A5 - - Google Patents
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- Publication number
- JPWO2020139988A5 JPWO2020139988A5 JP2021537781A JP2021537781A JPWO2020139988A5 JP WO2020139988 A5 JPWO2020139988 A5 JP WO2020139988A5 JP 2021537781 A JP2021537781 A JP 2021537781A JP 2021537781 A JP2021537781 A JP 2021537781A JP WO2020139988 A5 JPWO2020139988 A5 JP WO2020139988A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- nitrogen
- sulfur
- oxygen
- cycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 96
- 150000001875 compounds Chemical class 0.000 claims description 50
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 48
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 48
- 125000005842 heteroatom Chemical group 0.000 claims description 48
- 229910052757 nitrogen Inorganic materials 0.000 claims description 48
- 229910052760 oxygen Inorganic materials 0.000 claims description 48
- 239000001301 oxygen Substances 0.000 claims description 48
- 229910052717 sulfur Inorganic materials 0.000 claims description 48
- 239000011593 sulfur Substances 0.000 claims description 48
- 125000001072 heteroaryl group Chemical group 0.000 claims description 38
- 125000000623 heterocyclic group Chemical group 0.000 claims description 38
- 125000000217 alkyl group Chemical group 0.000 claims description 36
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 36
- 125000003118 aryl group Chemical group 0.000 claims description 32
- 150000003839 salts Chemical class 0.000 claims description 25
- 229910052736 halogen Inorganic materials 0.000 claims description 24
- 150000002367 halogens Chemical class 0.000 claims description 18
- 125000000392 cycloalkenyl group Chemical group 0.000 claims description 16
- 125000006708 (C5-C14) heteroaryl group Chemical group 0.000 claims description 10
- 125000004429 atom Chemical group 0.000 claims description 8
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 8
- 125000000304 alkynyl group Chemical group 0.000 claims description 7
- 125000003342 alkenyl group Chemical group 0.000 claims description 6
- 125000005843 halogen group Chemical group 0.000 claims description 6
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 4
- 125000001424 substituent group Chemical group 0.000 claims description 4
- 125000006163 5-membered heteroaryl group Chemical group 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 5
- 101000607909 Homo sapiens Ubiquitin carboxyl-terminal hydrolase 1 Proteins 0.000 claims 2
- 102100039865 Ubiquitin carboxyl-terminal hydrolase 1 Human genes 0.000 claims 2
- 239000012472 biological sample Substances 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 125000002947 alkylene group Chemical group 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862785733P | 2018-12-28 | 2018-12-28 | |
| US62/785,733 | 2018-12-28 | ||
| PCT/US2019/068648 WO2020139988A1 (en) | 2018-12-28 | 2019-12-27 | Compositions for inhibiting ubiquitin specific protease 1 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2022516469A JP2022516469A (ja) | 2022-02-28 |
| JP2022516469A5 JP2022516469A5 (https=) | 2022-12-22 |
| JPWO2020139988A5 true JPWO2020139988A5 (https=) | 2022-12-22 |
| JP7553450B2 JP7553450B2 (ja) | 2024-09-18 |
Family
ID=71126375
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021537781A Active JP7553450B2 (ja) | 2018-12-28 | 2019-12-27 | ユビキチン特異的プロテアーゼ１を阻害するための組成物 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20220073525A1 (https=) |
| EP (1) | EP3902802A4 (https=) |
| JP (1) | JP7553450B2 (https=) |
| CN (1) | CN113474346B (https=) |
| WO (1) | WO2020139988A1 (https=) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10189841B2 (en) | 2015-11-20 | 2019-01-29 | Forma Therapeutics, Inc. | Purinones as ubiquitin-specific protease 1 inhibitors |
| US20240182481A1 (en) * | 2021-02-15 | 2024-06-06 | Tango Therapeutics, Inc. | Pyrrolo[3,2-d]pyrimidine compounds and methods of use in the treatment of cancer |
| MX2023011709A (es) * | 2021-04-07 | 2023-10-12 | Forma Therapeutics Inc | Inhibidor de la proteasa 1 especifica de ubiquitina (usp1). |
| EP4321515A4 (en) * | 2021-04-09 | 2025-06-25 | Hainan Simcere Zaiming Pharmaceutical Co., Ltd. | UBIQUITIN-SPECIFIC PROTEASE-1 INHIBITOR |
| KR102910851B1 (ko) * | 2021-04-21 | 2026-01-09 | 장춘 진사이언스 파마슈티컬 씨오., 엘티디. | 이미다졸 함유 축합고리계 유도체, 이의 제조방법 및 이의 의약적 용도 |
| WO2022253188A1 (en) * | 2021-05-31 | 2022-12-08 | Impact Therapeutics (Shanghai) , Inc | Nitrogen-containing fused heteroaromatic bicyclic compounds as usp1 inhibitors and the use thereof |
| JP2024540921A (ja) * | 2021-10-19 | 2024-11-06 | 上海瑛派▲薬▼▲業▼有限公司 | Ｕｓｐ１阻害剤としての置換トリアゾロヘテロアリール化合物及びその応用 |
| CR20240191A (es) | 2021-11-12 | 2024-09-13 | Insilico Medicine Ip Ltd | Inhibidores de molécula pequeña de proteasa 1 específica de ubiquitina (usp1) y usos de los mismos |
| US20250163049A1 (en) * | 2022-02-03 | 2025-05-22 | Exelixis, Inc. | Fused bicyclic heterocyclyl compounds as usp1 inhibitors |
| AU2023261809A1 (en) * | 2022-04-29 | 2024-12-05 | Asieris Pharmaceuticals (Shanghai) Co., Ltd. | Pyrimidine compound, method for preparing same, and pharmaceutical use thereof |
| WO2024006879A1 (en) * | 2022-06-29 | 2024-01-04 | Zentaur Therapeutics Usa Inc. | Usp1 inhibitors and uses thereof |
| WO2024022519A1 (zh) * | 2022-07-28 | 2024-02-01 | 先声再明医药有限公司 | 杂环并嘧啶类化合物及其应用 |
| CN119790043A (zh) * | 2022-08-26 | 2025-04-08 | 海南先声再明医药股份有限公司 | 三环类化合物及其应用 |
| WO2024078436A1 (zh) * | 2022-10-09 | 2024-04-18 | 海南先声再明医药股份有限公司 | 杂环并嘧啶类化合物、药物组合物及其应用 |
| WO2024086790A1 (en) | 2022-10-21 | 2024-04-25 | Exelixis, Inc. | 4,5,6,7-TETRAHYDRO-1H-PYRAZOLO[4,3-c]PYRIDINE COMPOUNDS AND DERIVATIVES AS USP1 INHIBITORS |
| CN120603835A (zh) * | 2023-01-20 | 2025-09-05 | 杭州英创医药科技有限公司 | 作为usp1抑制剂的化合物 |
| WO2024233665A1 (en) | 2023-05-08 | 2024-11-14 | Tango Therapeutics, Inc. | Compounds and their use against cancer |
| WO2024233605A1 (en) | 2023-05-08 | 2024-11-14 | Tango Therapeutics, Inc. | Compounds and their use against cancer |
| WO2024236528A1 (en) * | 2023-05-18 | 2024-11-21 | Insilico Medicine Ip Limited | Small molecule inhibitors of ubiquitin specific protease 1 (usp1) and uses thereof |
| WO2025010245A1 (en) | 2023-07-06 | 2025-01-09 | Exelixis, Inc. | Fused pyrazole derivatives as usp1 inhibitors |
| CN119930633B (zh) * | 2023-11-06 | 2025-11-18 | 中国医学科学院药物研究所 | 一种吡咯并蝶啶酮类泛素特异性蛋白酶1抑制剂及其制备方法、用途和药物组合物 |
| CN119930632B (zh) * | 2023-11-06 | 2025-11-18 | 中国医学科学院药物研究所 | 一种三并环类泛素特异性蛋白酶1抑制剂及其制备方法、用途和药物组合物 |
| WO2025102016A1 (en) | 2023-11-10 | 2025-05-15 | Vrise Therapeutics, Inc. | Novel molecules as inhibitors of dna damage repair pathway |
| WO2025151705A1 (en) | 2024-01-10 | 2025-07-17 | Vrise Therapeutics, Inc. | Novel inhibitors of dna damage repair pathway |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU4035893A (en) * | 1991-12-17 | 1993-07-19 | Upjohn Company, The | 3-substituted imidazo (1,5-a) and imidazo (1,5-a)-triazolo (1,5-c) quinoxalines and quinazolines with cns activity |
| EP2170350B1 (en) * | 2007-06-21 | 2013-09-11 | Cara Therapeutics, Inc. | Substituted imidazoheterocycles |
| EP2334672B1 (en) * | 2008-09-16 | 2013-11-20 | Proximagen Limited | 4,5,6,7-Tetrahydroimidazo[4,5-c]pyridine compounds as inhibitors of SSAO |
| CN101824036A (zh) * | 2009-03-05 | 2010-09-08 | 上海恒瑞医药有限公司 | 四氢咪唑并[1，5-a]吡嗪衍生物的盐,其制备方法及其在医药上的应用 |
| US10189841B2 (en) * | 2015-11-20 | 2019-01-29 | Forma Therapeutics, Inc. | Purinones as ubiquitin-specific protease 1 inhibitors |
-
2019
- 2019-12-27 JP JP2021537781A patent/JP7553450B2/ja active Active
- 2019-12-27 WO PCT/US2019/068648 patent/WO2020139988A1/en not_active Ceased
- 2019-12-27 EP EP19904923.0A patent/EP3902802A4/en not_active Withdrawn
- 2019-12-27 US US17/417,805 patent/US20220073525A1/en not_active Abandoned
- 2019-12-27 CN CN201980093028.5A patent/CN113474346B/zh active Active
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