PE20230824A1 - Inhibidores alostericos de cromenona del fosfoinositido 3-quinasa (pi3k) para el tratamiento de enfermedades - Google Patents
Inhibidores alostericos de cromenona del fosfoinositido 3-quinasa (pi3k) para el tratamiento de enfermedadesInfo
- Publication number
- PE20230824A1 PE20230824A1 PE2022002162A PE2022002162A PE20230824A1 PE 20230824 A1 PE20230824 A1 PE 20230824A1 PE 2022002162 A PE2022002162 A PE 2022002162A PE 2022002162 A PE2022002162 A PE 2022002162A PE 20230824 A1 PE20230824 A1 PE 20230824A1
- Authority
- PE
- Peru
- Prior art keywords
- cancer
- phosphoinositide
- pi3k
- kinase
- allosteric inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/4035—Isoindoles, e.g. phthalimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/056—Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Referido a un compuesto de formula (I), o un profarmaco, solvato, enantiomero, estereoisomero, tautomero o sal farmaceuticamente aceptable de este, en donde: X es -NR12- o -O-; Y es -C(R11)2-, -O-, -NR11- o -S-; cada R3, R4, R5 y R6 es independientemente H, halogeno, -CN, alquilo C1-C6, entre otros; cada R7 y R8 es independientemente H, halogeno, -CN, alquilo C1-C6, entre otros; al menos un R9 es -C(O)OR12; el Anillo A es cicloalquilo C3-C10, arilo, heterociclo que comprende 1-4 heteroatomos seleccionados de N, O y S, entre otros; y s es 1, 2, 3, 4, 5 o 6. Un compuesto seleccionado es acido (2-((1-(2-(4,4-dimetilpiperidin-1-il)-6-metil-4-oxo-4H-cromen-8-il)etil)amino)fenil)boronico. Dichos compuestos son inhibidores alostericos de cromenona del fosfoinositido 3-quinasa (PI3K). Tambien refiere a una composicion farmaceutica siendo utiles para tratar una enfermedad o un trastorno asociado con la modulacion de la fosfoinositido 3-quinasa (PI3K), tal como el cancer, en particular cancer de endometrio, cancer gastrico, leucemia, linfoma, sarcoma, cancer colorrectal, cancer de pulmon, cancer de ovario, entre otros.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063005096P | 2020-04-03 | 2020-04-03 | |
| PCT/US2021/025521 WO2021202964A1 (en) | 2020-04-03 | 2021-04-02 | Allosteric chromenone inhibitors of phosphoinositide 3-kinase (pi3k) for the treatment of diseases associated with p13k modulation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20230824A1 true PE20230824A1 (es) | 2023-05-19 |
Family
ID=75674963
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2022002162A PE20230824A1 (es) | 2020-04-03 | 2021-04-02 | Inhibidores alostericos de cromenona del fosfoinositido 3-quinasa (pi3k) para el tratamiento de enfermedades |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US11649227B2 (es) |
| EP (1) | EP4126851A1 (es) |
| JP (1) | JP7505023B2 (es) |
| KR (1) | KR20220163462A (es) |
| CN (1) | CN115956075A (es) |
| AR (1) | AR121719A1 (es) |
| AU (1) | AU2021248415B2 (es) |
| BR (1) | BR112022019918A2 (es) |
| CA (1) | CA3173569A1 (es) |
| CO (1) | CO2022014160A2 (es) |
| CR (1) | CR20220493A (es) |
| EC (1) | ECSP22077299A (es) |
| IL (1) | IL296918A (es) |
| JO (1) | JOP20220247A1 (es) |
| MX (1) | MX2022012306A (es) |
| PE (1) | PE20230824A1 (es) |
| TW (1) | TWI794780B (es) |
| WO (1) | WO2021202964A1 (es) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR121719A1 (es) * | 2020-04-03 | 2022-06-29 | Petra Pharma Corp | Inhibidores alostéricos de cromenona del fosfoinosítido 3-quinasa (pi3k) para el tratamiento de enfermedades |
| CR20230517A (es) | 2021-05-03 | 2023-11-28 | Petra Pharma Corp | Inhibidores alostéricos de cromenona del fosfoinosítido 3-quinasa (pi3k) para el tratamiento de enfermedades |
| TWI829179B (zh) | 2021-05-27 | 2024-01-11 | 美商佩特拉製藥公司 | 用於治療疾病之磷酸肌醇3-激酶(pi3k)異位色烯酮抑制劑 |
| TW202334137A (zh) * | 2021-11-03 | 2023-09-01 | 美商薩諾管理公司 | Ｐｉ３ｋ抑制劑及治療癌症之方法 |
| WO2023104111A1 (en) * | 2021-12-08 | 2023-06-15 | Nanjing Zenshine Pharmaceuticals Co., Ltd. | Fused heterocyclic compounds as pi3kalpha inhibitors |
| AU2022421224A1 (en) * | 2021-12-22 | 2024-06-20 | The Regents Of The University Of California | Covalently binding inhibitors of g12s, g12d and/or g12e mutants of k-ras gtpase |
| US20240124422A1 (en) * | 2022-03-29 | 2024-04-18 | Prelude Therapeutics Incorporated | Mutant pi3k-alpha inhibitors and their use as pharmaceuticals |
| TW202404968A (zh) * | 2022-04-20 | 2024-02-01 | 美商思諾維新醫藥公司 | ＰＩ３Ｋα抑制劑 |
| WO2023207881A1 (en) * | 2022-04-24 | 2023-11-02 | InventisBio Co., Ltd. | Compounds, preparation methods and uses thereof |
| TW202408481A (zh) * | 2022-04-29 | 2024-03-01 | 美商佩特拉製藥公司 | 用於治療疾病之磷酸肌醇3-激酶(pi3k)異位色烯酮抑制劑 |
| WO2023239710A1 (en) | 2022-06-08 | 2023-12-14 | Onkure, Inc. | Benzopyrimidin-4(3h)-ones as pi3k inhibitors |
| CN117362281A (zh) * | 2022-07-07 | 2024-01-09 | 海创药业股份有限公司 | 一种pi3k抑制剂及其制备方法和用途 |
| WO2024054469A1 (en) | 2022-09-08 | 2024-03-14 | Onkure, Inc. | Isoquinolones as pi3k inhibitors |
| WO2024051778A1 (en) * | 2022-09-09 | 2024-03-14 | InventisBio Co., Ltd. | Compounds, preparation methods and uses thereof |
| WO2024064024A1 (en) | 2022-09-19 | 2024-03-28 | Onkure, Inc. | ((4-oxo-3,4-dihydroquinazolin-8-yl)methyl)amine derivatives as p13k inhibitors for the treatment of cancer |
| WO2024081345A1 (en) | 2022-10-14 | 2024-04-18 | Onkure, Inc. | Benzopyrimidin-4(3h)-ones as pi3k inhibitors |
| WO2024081904A1 (en) * | 2022-10-14 | 2024-04-18 | Genesis Therapeutics, Inc. | Methods for treating cancer |
| US20240182460A1 (en) * | 2022-11-01 | 2024-06-06 | Petra Pharma Corporation | Allosteric chromenone inhibitors of phosphoinositide 3-kinase (pi3k) for the treatment of disease |
| WO2024097205A1 (en) * | 2022-11-02 | 2024-05-10 | Petra Pharma Corporation | Allosteric chromenone inhibitors of phosphoinositide 3-kinase (pi3k) for the treatment of disease |
| WO2024097721A1 (en) | 2022-11-02 | 2024-05-10 | Petra Pharma Corporation | Targeting allosteric and orthosteric pockets of phosphoinositide 3-kinase (pi3k) for the treatment of disease |
| WO2024099437A1 (en) * | 2022-11-11 | 2024-05-16 | Fochon Biosciences, Ltd. | Compounds as protein kinase inhibitors |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1190405B (it) | 1985-10-22 | 1988-02-16 | Recordati Chem Pharm | Derivati del flavone |
| MA21528A1 (fr) | 1988-04-06 | 1989-12-31 | Lipha | Composants substituants du flavonoide, leurs sels, leurs manufactures et produits contenant ces matieres . |
| HUT58310A (en) | 1988-12-21 | 1992-02-28 | Upjohn Co | Anti-atherosclerotic and anti-thrombotic 1-benzopyran-4-one- and 2-amino-1,3-benzoxazin-4-one derivatives, process for producing them and pharmaceutical compositions containing them |
| US5763263A (en) | 1995-11-27 | 1998-06-09 | Dehlinger; Peter J. | Method and apparatus for producing position addressable combinatorial libraries |
| NZ520300A (en) | 2000-01-24 | 2004-05-28 | Kinacia Pty Ltd | Morpholino-substituted pyridopyrimidine, quinolone and benzopyranone derivatives that inhibit the enzyme phosphoinositide (PI) 3-kinase |
| TWI331034B (en) | 2002-07-08 | 2010-10-01 | Piramal Life Sciences Ltd | Inhibitors of cyclin-dependent kinases and their use |
| US7884127B2 (en) | 2002-07-08 | 2011-02-08 | Pirimal Life Sciences Ltd. | Inhibitors of cyclin dependent kinases and their use |
| JP4646626B2 (ja) | 2002-08-16 | 2011-03-09 | アストラゼネカ アクチボラグ | ホスホイノシチド３−キナーゼβの阻害 |
| EP2342188B1 (en) | 2008-09-29 | 2014-07-30 | GlaxoSmithKline LLC | Chromenone analogs as sirtuin modulators |
| US8399460B2 (en) * | 2009-10-27 | 2013-03-19 | Astrazeneca Ab | Chromenone derivatives |
| KR102012398B1 (ko) * | 2009-11-05 | 2019-08-20 | 리젠 파마슈티컬스 소시에떼 아노님 | 신규한 벤조피란 키나제 조절제 |
| CN106008479B (zh) * | 2015-03-06 | 2020-01-10 | 南京圣和药业股份有限公司 | 作为磷脂酰肌醇3-激酶δ抑制剂的取代嘧啶类化合物及其应用 |
| EP3426242A4 (en) | 2016-03-11 | 2020-03-18 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | ICARITINE AND ICARITINE DERIVATIVES |
| CN108299365B (zh) | 2018-01-31 | 2021-08-06 | 中南大学 | 一种黄酮衍生物及其应用 |
| AR121719A1 (es) | 2020-04-03 | 2022-06-29 | Petra Pharma Corp | Inhibidores alostéricos de cromenona del fosfoinosítido 3-quinasa (pi3k) para el tratamiento de enfermedades |
-
2021
- 2021-03-31 AR ARP210100822A patent/AR121719A1/es unknown
- 2021-04-01 TW TW110112268A patent/TWI794780B/zh active
- 2021-04-02 CA CA3173569A patent/CA3173569A1/en active Pending
- 2021-04-02 US US17/221,209 patent/US11649227B2/en active Active
- 2021-04-02 EP EP21721700.9A patent/EP4126851A1/en active Pending
- 2021-04-02 PE PE2022002162A patent/PE20230824A1/es unknown
- 2021-04-02 IL IL296918A patent/IL296918A/en unknown
- 2021-04-02 CN CN202180039596.4A patent/CN115956075A/zh active Pending
- 2021-04-02 AU AU2021248415A patent/AU2021248415B2/en active Active
- 2021-04-02 BR BR112022019918A patent/BR112022019918A2/pt unknown
- 2021-04-02 MX MX2022012306A patent/MX2022012306A/es unknown
- 2021-04-02 KR KR1020227038553A patent/KR20220163462A/ko active Search and Examination
- 2021-04-02 CR CR20220493A patent/CR20220493A/es unknown
- 2021-04-02 JP JP2022560305A patent/JP7505023B2/ja active Active
- 2021-04-02 WO PCT/US2021/025521 patent/WO2021202964A1/en active Application Filing
-
2022
- 2022-10-03 CO CONC2022/0014160A patent/CO2022014160A2/es unknown
- 2022-10-03 EC ECSENADI202277299A patent/ECSP22077299A/es unknown
- 2022-10-04 JO JOP/2022/0247A patent/JOP20220247A1/ar unknown
-
2023
- 2023-04-18 US US18/302,573 patent/US20230286960A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| TW202200567A (zh) | 2022-01-01 |
| US11649227B2 (en) | 2023-05-16 |
| AR121719A1 (es) | 2022-06-29 |
| AU2021248415B2 (en) | 2024-03-21 |
| AU2021248415A1 (en) | 2022-10-20 |
| CR20220493A (es) | 2022-12-15 |
| MX2022012306A (es) | 2023-01-04 |
| IL296918A (en) | 2022-12-01 |
| US20220372023A1 (en) | 2022-11-24 |
| JOP20220247A1 (ar) | 2023-01-30 |
| TWI794780B (zh) | 2023-03-01 |
| US20230286960A1 (en) | 2023-09-14 |
| JP2023521321A (ja) | 2023-05-24 |
| CN115956075A (zh) | 2023-04-11 |
| BR112022019918A2 (pt) | 2023-02-14 |
| WO2021202964A1 (en) | 2021-10-07 |
| CO2022014160A2 (es) | 2023-02-16 |
| KR20220163462A (ko) | 2022-12-09 |
| JP7505023B2 (ja) | 2024-06-24 |
| ECSP22077299A (es) | 2023-01-31 |
| EP4126851A1 (en) | 2023-02-08 |
| CA3173569A1 (en) | 2021-10-07 |
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