JPWO2020128527A5 - - Google Patents
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- Publication number
- JPWO2020128527A5 JPWO2020128527A5 JP2021536064A JP2021536064A JPWO2020128527A5 JP WO2020128527 A5 JPWO2020128527 A5 JP WO2020128527A5 JP 2021536064 A JP2021536064 A JP 2021536064A JP 2021536064 A JP2021536064 A JP 2021536064A JP WO2020128527 A5 JPWO2020128527 A5 JP WO2020128527A5
- Authority
- JP
- Japan
- Prior art keywords
- referred
- seq
- peptide ligand
- ligand according
- sar
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000027455 binding Effects 0.000 description 21
- 239000003446 ligand Substances 0.000 description 21
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 description 9
- 125000003275 alpha amino acid group Chemical group 0.000 description 6
- 150000003839 salts Chemical class 0.000 description 6
- 239000011780 sodium chloride Substances 0.000 description 6
- 235000001014 amino acid Nutrition 0.000 description 5
- 150000001413 amino acids Chemical class 0.000 description 5
- 102100007290 CD274 Human genes 0.000 description 4
- 101710012053 CD274 Proteins 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 229940079593 drugs Drugs 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 229920001184 polypeptide Polymers 0.000 description 3
- 125000000539 amino acid group Chemical group 0.000 description 2
- 125000002619 bicyclic group Chemical group 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 239000002062 molecular scaffold Substances 0.000 description 2
- 238000000159 protein binding assay Methods 0.000 description 2
- GHITVUOBZBZMND-UHFFFAOYSA-N 1,3,5-tris(bromomethyl)benzene Chemical compound BrCC1=CC(CBr)=CC(CBr)=C1 GHITVUOBZBZMND-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000003863 ammonium salts Chemical class 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000002254 cytotoxic agent Substances 0.000 description 1
- 231100000599 cytotoxic agent Toxicity 0.000 description 1
- 125000000524 functional group Chemical group 0.000 description 1
- 230000001404 mediated Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000000546 pharmaceutic aid Substances 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- KEAYESYHFKHZAL-UHFFFAOYSA-N sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1820969.2A GB201820969D0 (en) | 2018-12-21 | 2018-12-21 | Bicyclic peptide ligands specific for pd-l |
| GB1820969.2 | 2018-12-21 | ||
| GB1904622.6 | 2019-04-02 | ||
| GBGB1904622.6A GB201904622D0 (en) | 2019-04-02 | 2019-04-02 | Bicyclic peptide ligands specific for pd-l1 |
| PCT/GB2019/053680 WO2020128527A1 (en) | 2018-12-21 | 2019-12-23 | Bicyclic peptide ligands specific for pd-l1 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022514687A JP2022514687A (ja) | 2022-02-14 |
| JPWO2020128527A5 true JPWO2020128527A5 (hr) | 2022-12-28 |
Family
ID=69104802
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021536064A Pending JP2022514687A (ja) | 2018-12-21 | 2019-12-23 | Ｐｄ－ｌ１に特異的な二環式ペプチドリガンド |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20220088207A1 (hr) |
| EP (1) | EP3897850A1 (hr) |
| JP (1) | JP2022514687A (hr) |
| CN (1) | CN113260420A (hr) |
| WO (1) | WO2020128527A1 (hr) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019025811A1 (en) | 2017-08-04 | 2019-02-07 | Bicycletx Limited | SPECIFIC BICYCLIC PEPTIDE LIGANDS OF CD137 |
| TW202118770A (zh) | 2019-07-30 | 2021-05-16 | 英商拜西可泰克斯有限公司 | 異質雙環肽複合物 |
| US20240197897A1 (en) | 2021-01-08 | 2024-06-20 | Bicycle TX Limited | Heterotandem bicyclic peptide complexes |
| US20240325554A1 (en) | 2021-01-11 | 2024-10-03 | Bicycle TX Limited | Methods for treating cancer |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1452868A2 (en) | 2003-02-27 | 2004-09-01 | Pepscan Systems B.V. | Method for selecting a candidate drug compound |
| CA2595902C (en) | 2005-01-24 | 2017-08-22 | Pepscan Systems B.V. | Binding compounds, immunogenic compounds and peptidomimetics of the beta-3 hairpin loop of cystine-knot growth factors |
| ES2383191T3 (es) | 2008-02-05 | 2012-06-19 | Medical Research Council | Métodos y composiciones |
| SI3215518T1 (sl) * | 2014-10-29 | 2021-08-31 | Bicyclerd Limited | Biciklični peptidni ligandi, značilni za MT1-MMP |
| GB201607827D0 (en) * | 2016-05-04 | 2016-06-15 | Bicycle Therapeutics Ltd | Bicyclic peptide-toxin conjugates specific for MT1-MMP |
| EP3572429A4 (en) * | 2017-01-23 | 2021-04-07 | Suzhou Alphamab Co., Ltd | POLYPEPTIDE OR COMPOSITE BINDER PD-L1 |
| GB2562721A (en) * | 2017-05-16 | 2018-11-28 | Fastbase Solutions Ltd | Kits, methods and their uses for detecting cell-cell interactions in a sample |
| KR20200139236A (ko) * | 2018-04-04 | 2020-12-11 | 바이사이클티엑스 리미티드 | 헤테로탠덤 비사이클릭 펩티드 복합체 |
-
2019
- 2019-12-23 US US17/416,562 patent/US20220088207A1/en active Pending
- 2019-12-23 JP JP2021536064A patent/JP2022514687A/ja active Pending
- 2019-12-23 EP EP19831859.4A patent/EP3897850A1/en active Pending
- 2019-12-23 CN CN201980083299.2A patent/CN113260420A/zh active Pending
- 2019-12-23 WO PCT/GB2019/053680 patent/WO2020128527A1/en unknown
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