JPWO2020123816A5 - - Google Patents
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- JPWO2020123816A5 JPWO2020123816A5 JP2021533528A JP2021533528A JPWO2020123816A5 JP WO2020123816 A5 JPWO2020123816 A5 JP WO2020123816A5 JP 2021533528 A JP2021533528 A JP 2021533528A JP 2021533528 A JP2021533528 A JP 2021533528A JP WO2020123816 A5 JPWO2020123816 A5 JP WO2020123816A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- acid sequence
- orf1
- amino acid
- orf2
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 150000007523 nucleic acids Chemical group 0.000 claims description 166
- 150000001413 amino acids Chemical group 0.000 claims description 142
- 230000002068 genetic effect Effects 0.000 claims description 108
- 101000651236 Homo sapiens NCK-interacting protein with SH3 domain Proteins 0.000 claims description 101
- 101710159752 Poly(3-hydroxyalkanoate) polymerase subunit PhaE Proteins 0.000 claims description 89
- 101710130262 Probable Vpr-like protein Proteins 0.000 claims description 89
- 101000833492 Homo sapiens Jouberin Proteins 0.000 claims description 88
- 102100024407 Jouberin Human genes 0.000 claims description 88
- 108020004707 nucleic acids Proteins 0.000 claims description 82
- 102000039446 nucleic acids Human genes 0.000 claims description 82
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 80
- 239000002245 particle Substances 0.000 claims description 56
- 239000002773 nucleotide Substances 0.000 claims description 54
- 125000003729 nucleotide group Chemical group 0.000 claims description 54
- 241001339993 Anelloviridae Species 0.000 claims description 50
- 210000004027 cell Anatomy 0.000 claims description 39
- 101150097234 ORF2/3 gene Proteins 0.000 claims description 38
- 101100028137 Torque teno virus (isolate Human/Finland/Hel32/2002) ORF1/1 gene Proteins 0.000 claims description 38
- 101100028140 Torque teno virus (isolate Human/Finland/Hel32/2002) ORF1/2 gene Proteins 0.000 claims description 38
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 34
- 239000012636 effector Substances 0.000 claims description 33
- -1 TAIP Proteins 0.000 claims description 30
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 29
- 238000000034 method Methods 0.000 claims description 23
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 22
- 239000008194 pharmaceutical composition Substances 0.000 claims description 17
- 108020003589 5' Untranslated Regions Proteins 0.000 claims description 16
- 235000001014 amino acid Nutrition 0.000 claims description 15
- 229940024606 amino acid Drugs 0.000 claims description 15
- 229920001184 polypeptide Polymers 0.000 claims description 15
- 206010028980 Neoplasm Diseases 0.000 claims description 12
- 239000003112 inhibitor Substances 0.000 claims description 12
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- 208000035475 disorder Diseases 0.000 claims description 11
- 230000001225 therapeutic effect Effects 0.000 claims description 11
- 108020004414 DNA Proteins 0.000 claims description 10
- 239000011541 reaction mixture Substances 0.000 claims description 10
- 101000768957 Acholeplasma phage L2 Uncharacterized 37.2 kDa protein Proteins 0.000 claims description 9
- 101000823746 Acidianus ambivalens Uncharacterized 17.7 kDa protein in bps2 3'region Proteins 0.000 claims description 9
- 101000916369 Acidianus ambivalens Uncharacterized protein in sor 5'region Proteins 0.000 claims description 9
- 101000769342 Acinetobacter guillouiae Uncharacterized protein in rpoN-murA intergenic region Proteins 0.000 claims description 9
- 101000823696 Actinobacillus pleuropneumoniae Uncharacterized glycosyltransferase in aroQ 3'region Proteins 0.000 claims description 9
- 101000786513 Agrobacterium tumefaciens (strain 15955) Uncharacterized protein outside the virF region Proteins 0.000 claims description 9
- 101000618005 Alkalihalobacillus pseudofirmus (strain ATCC BAA-2126 / JCM 17055 / OF4) Uncharacterized protein BpOF4_00885 Proteins 0.000 claims description 9
- 102100020724 Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 Human genes 0.000 claims description 9
- 101000967489 Azorhizobium caulinodans (strain ATCC 43989 / DSM 5975 / JCM 20966 / LMG 6465 / NBRC 14845 / NCIMB 13405 / ORS 571) Uncharacterized protein AZC_3924 Proteins 0.000 claims description 9
- 101000823761 Bacillus licheniformis Uncharacterized 9.4 kDa protein in flaL 3'region Proteins 0.000 claims description 9
- 101000819719 Bacillus methanolicus Uncharacterized N-acetyltransferase in lysA 3'region Proteins 0.000 claims description 9
- 101000789586 Bacillus subtilis (strain 168) UPF0702 transmembrane protein YkjA Proteins 0.000 claims description 9
- 101000792624 Bacillus subtilis (strain 168) Uncharacterized protein YbxH Proteins 0.000 claims description 9
- 101000790792 Bacillus subtilis (strain 168) Uncharacterized protein YckC Proteins 0.000 claims description 9
- 101000819705 Bacillus subtilis (strain 168) Uncharacterized protein YlxR Proteins 0.000 claims description 9
- 101000948218 Bacillus subtilis (strain 168) Uncharacterized protein YtxJ Proteins 0.000 claims description 9
- 101000718627 Bacillus thuringiensis subsp. kurstaki Putative RNA polymerase sigma-G factor Proteins 0.000 claims description 9
- 101000641200 Bombyx mori densovirus Putative non-structural protein Proteins 0.000 claims description 9
- 101000947633 Claviceps purpurea Uncharacterized 13.8 kDa protein Proteins 0.000 claims description 9
- 101000948901 Enterobacteria phage T4 Uncharacterized 16.0 kDa protein in segB-ipI intergenic region Proteins 0.000 claims description 9
- 101000805958 Equine herpesvirus 4 (strain 1942) Virion protein US10 homolog Proteins 0.000 claims description 9
- 101000790442 Escherichia coli Insertion element IS2 uncharacterized 11.1 kDa protein Proteins 0.000 claims description 9
- 101000788354 Escherichia phage P2 Uncharacterized 8.2 kDa protein in gpA 5'region Proteins 0.000 claims description 9
- 101000770304 Frankia alni UPF0460 protein in nifX-nifW intergenic region Proteins 0.000 claims description 9
- 101000797344 Geobacillus stearothermophilus Putative tRNA (cytidine(34)-2'-O)-methyltransferase Proteins 0.000 claims description 9
- 101000748410 Geobacillus stearothermophilus Uncharacterized protein in fumA 3'region Proteins 0.000 claims description 9
- 101000772675 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) UPF0438 protein HI_0847 Proteins 0.000 claims description 9
- 101000631019 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) Uncharacterized protein HI_0350 Proteins 0.000 claims description 9
- 101000768938 Haemophilus phage HP1 (strain HP1c1) Uncharacterized 8.9 kDa protein in int-C1 intergenic region Proteins 0.000 claims description 9
- 101000785414 Homo sapiens Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 Proteins 0.000 claims description 9
- 101000782488 Junonia coenia densovirus (isolate pBRJ/1990) Putative non-structural protein NS2 Proteins 0.000 claims description 9
- 101000811523 Klebsiella pneumoniae Uncharacterized 55.8 kDa protein in cps region Proteins 0.000 claims description 9
- 101000818409 Lactococcus lactis subsp. lactis Uncharacterized HTH-type transcriptional regulator in lacX 3'region Proteins 0.000 claims description 9
- 101000878851 Leptolyngbya boryana Putative Fe(2+) transport protein A Proteins 0.000 claims description 9
- 101000758828 Methanosarcina barkeri (strain Fusaro / DSM 804) Uncharacterized protein Mbar_A1602 Proteins 0.000 claims description 9
- 101001122401 Middle East respiratory syndrome-related coronavirus (isolate United Kingdom/H123990006/2012) Non-structural protein ORF3 Proteins 0.000 claims description 9
- 101001055788 Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) Pentapeptide repeat protein MfpA Proteins 0.000 claims description 9
- 101000740670 Orgyia pseudotsugata multicapsid polyhedrosis virus Protein C42 Proteins 0.000 claims description 9
- 101000769182 Photorhabdus luminescens Uncharacterized protein in pnp 3'region Proteins 0.000 claims description 9
- 101000961392 Pseudescherichia vulneris Uncharacterized 29.9 kDa protein in crtE 3'region Proteins 0.000 claims description 9
- 101000731030 Pseudomonas oleovorans Poly(3-hydroxyalkanoate) polymerase 2 Proteins 0.000 claims description 9
- 101001065485 Pseudomonas putida Probable fatty acid methyltransferase Proteins 0.000 claims description 9
- 101000711023 Rhizobium leguminosarum bv. trifolii Uncharacterized protein in tfuA 3'region Proteins 0.000 claims description 9
- 101000948156 Rhodococcus erythropolis Uncharacterized 47.3 kDa protein in thcA 5'region Proteins 0.000 claims description 9
- 101000917565 Rhodococcus fascians Uncharacterized 33.6 kDa protein in fasciation locus Proteins 0.000 claims description 9
- 101000790284 Saimiriine herpesvirus 2 (strain 488) Uncharacterized 9.5 kDa protein in DHFR 3'region Proteins 0.000 claims description 9
- 101000936719 Streptococcus gordonii Accessory Sec system protein Asp3 Proteins 0.000 claims description 9
- 101000788499 Streptomyces coelicolor Uncharacterized oxidoreductase in mprA 5'region Proteins 0.000 claims description 9
- 101001102841 Streptomyces griseus Purine nucleoside phosphorylase ORF3 Proteins 0.000 claims description 9
- 101000708557 Streptomyces lincolnensis Uncharacterized 17.2 kDa protein in melC2-rnhH intergenic region Proteins 0.000 claims description 9
- 101000649826 Thermotoga neapolitana Putative anti-sigma factor antagonist TM1081 homolog Proteins 0.000 claims description 9
- 101000827562 Vibrio alginolyticus Uncharacterized protein in proC 3'region Proteins 0.000 claims description 9
- 101000778915 Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633) Uncharacterized membrane protein VP2115 Proteins 0.000 claims description 9
- 210000005260 human cell Anatomy 0.000 claims description 9
- 108020004638 Circular DNA Proteins 0.000 claims description 8
- 210000004962 mammalian cell Anatomy 0.000 claims description 8
- 108090000790 Enzymes Proteins 0.000 claims description 6
- 102000004190 Enzymes Human genes 0.000 claims description 6
- 210000004899 c-terminal region Anatomy 0.000 claims description 6
- 210000003527 eukaryotic cell Anatomy 0.000 claims description 6
- 230000028993 immune response Effects 0.000 claims description 6
- 235000015110 jellies Nutrition 0.000 claims description 6
- 239000008274 jelly Substances 0.000 claims description 6
- 238000004519 manufacturing process Methods 0.000 claims description 6
- 239000013612 plasmid Substances 0.000 claims description 6
- 108090000623 proteins and genes Proteins 0.000 claims description 6
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 claims description 5
- 208000023275 Autoimmune disease Diseases 0.000 claims description 5
- 208000035473 Communicable disease Diseases 0.000 claims description 5
- 208000018522 Gastrointestinal disease Diseases 0.000 claims description 5
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims description 5
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 5
- 229960001230 asparagine Drugs 0.000 claims description 5
- 235000009582 asparagine Nutrition 0.000 claims description 5
- 208000026278 immune system disease Diseases 0.000 claims description 5
- 208000015181 infectious disease Diseases 0.000 claims description 5
- 208000027866 inflammatory disease Diseases 0.000 claims description 5
- 201000005202 lung cancer Diseases 0.000 claims description 5
- 208000020816 lung neoplasm Diseases 0.000 claims description 5
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims description 5
- 230000003612 virological effect Effects 0.000 claims description 5
- 239000003814 drug Substances 0.000 claims description 4
- 230000001973 epigenetic effect Effects 0.000 claims description 4
- 230000002163 immunogen Effects 0.000 claims description 4
- 230000002458 infectious effect Effects 0.000 claims description 4
- 108091070501 miRNA Proteins 0.000 claims description 4
- 239000002679 microRNA Substances 0.000 claims description 4
- 235000018102 proteins Nutrition 0.000 claims description 4
- 102000004169 proteins and genes Human genes 0.000 claims description 4
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 claims description 3
- 241000700605 Viruses Species 0.000 claims description 3
- 230000010076 replication Effects 0.000 claims description 3
- 238000005096 rolling process Methods 0.000 claims description 3
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims description 2
- 108700042778 Antimicrobial Peptides Proteins 0.000 claims description 2
- 102000044503 Antimicrobial Peptides Human genes 0.000 claims description 2
- 108020005544 Antisense RNA Proteins 0.000 claims description 2
- 108091033409 CRISPR Proteins 0.000 claims description 2
- 238000010354 CRISPR gene editing Methods 0.000 claims description 2
- 102100027199 Cell death-inducing p53-target protein 1 Human genes 0.000 claims description 2
- 239000012625 DNA intercalator Substances 0.000 claims description 2
- 108020005004 Guide RNA Proteins 0.000 claims description 2
- 101000914537 Homo sapiens Cell death-inducing p53-target protein 1 Proteins 0.000 claims description 2
- 108020005198 Long Noncoding RNA Proteins 0.000 claims description 2
- 102000007399 Nuclear hormone receptor Human genes 0.000 claims description 2
- 108020005497 Nuclear hormone receptor Proteins 0.000 claims description 2
- 101710163270 Nuclease Proteins 0.000 claims description 2
- 229940079156 Proteasome inhibitor Drugs 0.000 claims description 2
- 108020004459 Small interfering RNA Proteins 0.000 claims description 2
- 108091023040 Transcription factor Proteins 0.000 claims description 2
- 102000040945 Transcription factor Human genes 0.000 claims description 2
- 239000012190 activator Substances 0.000 claims description 2
- 239000000556 agonist Substances 0.000 claims description 2
- 239000005557 antagonist Substances 0.000 claims description 2
- 230000006907 apoptotic process Effects 0.000 claims description 2
- 125000002619 bicyclic group Chemical group 0.000 claims description 2
- 201000011510 cancer Diseases 0.000 claims description 2
- 230000002860 competitive effect Effects 0.000 claims description 2
- 239000003184 complementary RNA Substances 0.000 claims description 2
- 239000000356 contaminant Substances 0.000 claims description 2
- 231100000433 cytotoxic Toxicity 0.000 claims description 2
- 230000001472 cytotoxic effect Effects 0.000 claims description 2
- 230000003413 degradative effect Effects 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 210000002919 epithelial cell Anatomy 0.000 claims description 2
- 239000012634 fragment Substances 0.000 claims description 2
- 210000002443 helper t lymphocyte Anatomy 0.000 claims description 2
- 238000004128 high performance liquid chromatography Methods 0.000 claims description 2
- 210000002865 immune cell Anatomy 0.000 claims description 2
- 239000012642 immune effector Substances 0.000 claims description 2
- 230000008086 immune related sensitivity Effects 0.000 claims description 2
- 229940121354 immunomodulator Drugs 0.000 claims description 2
- 238000000338 in vitro Methods 0.000 claims description 2
- 239000000411 inducer Substances 0.000 claims description 2
- 239000003446 ligand Substances 0.000 claims description 2
- 210000004072 lung Anatomy 0.000 claims description 2
- 230000002101 lytic effect Effects 0.000 claims description 2
- 108020004999 messenger RNA Proteins 0.000 claims description 2
- 239000003607 modifier Substances 0.000 claims description 2
- 230000017074 necrotic cell death Effects 0.000 claims description 2
- 108020004017 nuclear receptors Proteins 0.000 claims description 2
- 102000027450 oncoproteins Human genes 0.000 claims description 2
- 108091008819 oncoproteins Proteins 0.000 claims description 2
- 238000000424 optical density measurement Methods 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 238000002360 preparation method Methods 0.000 claims description 2
- 239000003207 proteasome inhibitor Substances 0.000 claims description 2
- 238000001243 protein synthesis Methods 0.000 claims description 2
- 108091006082 receptor inhibitors Proteins 0.000 claims description 2
- 102000005962 receptors Human genes 0.000 claims description 2
- 108020003175 receptors Proteins 0.000 claims description 2
- 230000001105 regulatory effect Effects 0.000 claims description 2
- 150000003384 small molecules Chemical class 0.000 claims description 2
- 230000008685 targeting Effects 0.000 claims description 2
- 229940124597 therapeutic agent Drugs 0.000 claims description 2
- 230000014616 translation Effects 0.000 claims description 2
- 230000000295 complement effect Effects 0.000 claims 55
- 210000000349 chromosome Anatomy 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 241001339888 Alphatorquevirus Species 0.000 claims 2
- 101710189078 Helicase Proteins 0.000 claims 2
- 108091007491 NSP3 Papain-like protease domains Proteins 0.000 claims 2
- 101710118046 RNA-directed RNA polymerase Proteins 0.000 claims 2
- 101710172711 Structural protein Proteins 0.000 claims 2
- 230000001413 cellular effect Effects 0.000 claims 2
- 239000004475 Arginine Substances 0.000 claims 1
- 241001339887 Betatorquevirus Species 0.000 claims 1
- 241001339886 Gammatorquevirus Species 0.000 claims 1
- 108091030087 Initiator element Proteins 0.000 claims 1
- 108700026226 TATA Box Proteins 0.000 claims 1
- 108700009124 Transcription Initiation Site Proteins 0.000 claims 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 125000004122 cyclic group Chemical group 0.000 claims 1
- 238000012217 deletion Methods 0.000 claims 1
- 230000037430 deletion Effects 0.000 claims 1
- 210000005229 liver cell Anatomy 0.000 claims 1
- 238000004806 packaging method and process Methods 0.000 claims 1
- 208000029265 Type 1 interferonopathy Diseases 0.000 description 4
- 125000000613 asparagine group Chemical group N[C@@H](CC(N)=O)C(=O)* 0.000 description 2
- GOJUJUVQIVIZAV-UHFFFAOYSA-N 2-amino-4,6-dichloropyrimidine-5-carbaldehyde Chemical group NC1=NC(Cl)=C(C=O)C(Cl)=N1 GOJUJUVQIVIZAV-UHFFFAOYSA-N 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 210000003494 hepatocyte Anatomy 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024075373A JP2024099834A (ja) | 2018-12-12 | 2024-05-07 | アネロソーム及び使用の方法 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862778866P | 2018-12-12 | 2018-12-12 | |
| US201862778841P | 2018-12-12 | 2018-12-12 | |
| US62/778,841 | 2018-12-12 | ||
| US62/778,866 | 2018-12-12 | ||
| PCT/US2019/065995 WO2020123816A2 (en) | 2018-12-12 | 2019-12-12 | Anellosomes and methods of use |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024075373A Division JP2024099834A (ja) | 2018-12-12 | 2024-05-07 | アネロソーム及び使用の方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022513797A JP2022513797A (ja) | 2022-02-09 |
| JP2022513797A5 JP2022513797A5 (https=) | 2022-12-20 |
| JPWO2020123816A5 true JPWO2020123816A5 (https=) | 2022-12-20 |
Family
ID=69165586
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021533528A Withdrawn JP2022513797A (ja) | 2018-12-12 | 2019-12-12 | アネロソーム及び使用の方法 |
| JP2024075373A Pending JP2024099834A (ja) | 2018-12-12 | 2024-05-07 | アネロソーム及び使用の方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024075373A Pending JP2024099834A (ja) | 2018-12-12 | 2024-05-07 | アネロソーム及び使用の方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20220042042A1 (https=) |
| EP (1) | EP3894570A2 (https=) |
| JP (2) | JP2022513797A (https=) |
| KR (1) | KR20210131310A (https=) |
| CN (1) | CN113631716A (https=) |
| AU (1) | AU2019397058A1 (https=) |
| BR (1) | BR112021011124A2 (https=) |
| CA (1) | CA3121528A1 (https=) |
| IL (1) | IL283782A (https=) |
| MX (1) | MX2021006977A (https=) |
| WO (1) | WO2020123816A2 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2018256925B2 (en) | 2017-04-28 | 2024-11-21 | Agrospheres, Inc. | Compositions and methods for the encapsulation and scalable delivery of agrochemicals |
| US11624061B2 (en) | 2017-04-28 | 2023-04-11 | Agrospheres, Inc. | Compositions and methods for enzyme immobilization |
| BR112020005803A2 (pt) | 2017-09-25 | 2020-12-01 | Agrospheres, Inc. | composições e métodos para produção e administração moduláveis de produtos biológicos |
| JP2022513459A (ja) * | 2018-12-12 | 2022-02-08 | フラッグシップ パイオニアリング イノベーションズ ブイ， インコーポレイテッド | タンパク質代替治療モダリティを送達するためのアネロソーム |
| AU2021288320A1 (en) * | 2020-06-12 | 2023-01-19 | Flagship Pioneering Innovations V, Inc. | Tandem anellovirus constructs |
| EP4267157A4 (en) * | 2020-12-23 | 2025-05-07 | Flagship Pioneering Innovations V, Inc. | IN VITRO ASSEMBLY OF ANELLOVIRUS CAPSIDS WITH RNA |
| WO2022241013A1 (en) * | 2021-05-12 | 2022-11-17 | Flagship Pioneering Innovations V, Inc. | Anellovectors and methods of use |
| TW202430215A (zh) | 2022-12-14 | 2024-08-01 | 美商旗艦先鋒創新有限責任（Ｖｉｉ）公司 | 用於將治療劑遞送至骨之組成物和方法 |
| TW202529819A (zh) | 2023-10-13 | 2025-08-01 | 美商旗艦先鋒創新公司 | 組織特異性指環載體(anellovector)遞送 |
| WO2025160409A1 (en) | 2024-01-26 | 2025-07-31 | Flagship Pioneering Innovations V, Inc. | Viral vectors for modulating vegf function |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6395472B1 (en) * | 1999-02-05 | 2002-05-28 | Abbott Laboratories | Methods of utilizing the TT virus |
| BR112016013207A2 (pt) * | 2013-12-12 | 2017-09-26 | Massachusetts Inst Technology | administração, uso e aplicações terapêuticas dos sistemas crispr-cas e composições para o hbv e distúrbios e doenças virais |
| IL271275B1 (en) * | 2017-06-13 | 2026-04-01 | Flagship Pioneering Innovations V Inc | Preparations containing croons and their uses |
| KR20210131309A (ko) * | 2018-12-12 | 2021-11-02 | 플래그쉽 파이어니어링 이노베이션스 브이, 인크. | 분비형 치료 양식을 운반하기 위한 아넬로좀 |
| WO2020123753A2 (en) * | 2018-12-12 | 2020-06-18 | Flagship Pioneering Innovations V, Inc. | Anellosomes for delivering intracellular therapeutic modalities |
| JP2022513459A (ja) * | 2018-12-12 | 2022-02-08 | フラッグシップ パイオニアリング イノベーションズ ブイ， インコーポレイテッド | タンパク質代替治療モダリティを送達するためのアネロソーム |
-
2019
- 2019-12-12 BR BR112021011124A patent/BR112021011124A2/pt unknown
- 2019-12-12 CA CA3121528A patent/CA3121528A1/en active Pending
- 2019-12-12 US US17/413,392 patent/US20220042042A1/en active Pending
- 2019-12-12 JP JP2021533528A patent/JP2022513797A/ja not_active Withdrawn
- 2019-12-12 KR KR1020217021777A patent/KR20210131310A/ko not_active Ceased
- 2019-12-12 AU AU2019397058A patent/AU2019397058A1/en active Pending
- 2019-12-12 MX MX2021006977A patent/MX2021006977A/es unknown
- 2019-12-12 WO PCT/US2019/065995 patent/WO2020123816A2/en not_active Ceased
- 2019-12-12 CN CN201980091082.6A patent/CN113631716A/zh active Pending
- 2019-12-12 EP EP19836738.5A patent/EP3894570A2/en active Pending
-
2021
- 2021-06-07 IL IL283782A patent/IL283782A/en unknown
-
2024
- 2024-05-07 JP JP2024075373A patent/JP2024099834A/ja active Pending
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