JPWO2020112880A5 - - Google Patents
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- JPWO2020112880A5 JPWO2020112880A5 JP2021530816A JP2021530816A JPWO2020112880A5 JP WO2020112880 A5 JPWO2020112880 A5 JP WO2020112880A5 JP 2021530816 A JP2021530816 A JP 2021530816A JP 2021530816 A JP2021530816 A JP 2021530816A JP WO2020112880 A5 JPWO2020112880 A5 JP WO2020112880A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- individual
- period
- compound
- administering
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims description 63
- 229940125904 compound 1 Drugs 0.000 claims description 39
- 150000003839 salts Chemical class 0.000 claims description 28
- 239000012453 solvate Substances 0.000 claims description 28
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 11
- 208000035475 disorder Diseases 0.000 claims description 11
- 230000004044 response Effects 0.000 claims description 11
- 108010074051 C-Reactive Protein Proteins 0.000 claims description 10
- 102100032752 C-reactive protein Human genes 0.000 claims description 10
- 230000002550 fecal effect Effects 0.000 claims description 10
- 102000001109 Leukocyte L1 Antigen Complex Human genes 0.000 claims description 9
- 108010069316 Leukocyte L1 Antigen Complex Proteins 0.000 claims description 9
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims description 7
- 230000001939 inductive effect Effects 0.000 claims description 6
- 206010009900 Colitis ulcerative Diseases 0.000 claims description 4
- 201000006704 Ulcerative Colitis Diseases 0.000 claims description 4
- 239000005557 antagonist Substances 0.000 claims description 4
- 210000004400 mucous membrane Anatomy 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 3
- 229960003444 immunosuppressant agent Drugs 0.000 claims description 2
- 239000003018 immunosuppressive agent Substances 0.000 claims description 2
- 102000006495 integrins Human genes 0.000 claims description 2
- 108010044426 integrins Proteins 0.000 claims description 2
- 229960004914 vedolizumab Drugs 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 20
- MVGWUTBTXDYMND-QGZVFWFLSA-N 2-[(3r)-7-[[4-cyclopentyl-3-(trifluoromethyl)phenyl]methoxy]-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]acetic acid Chemical compound C([C@@H]1CC(=O)O)CC(C2=C3)=C1NC2=CC=C3OCC(C=C1C(F)(F)F)=CC=C1C1CCCC1 MVGWUTBTXDYMND-QGZVFWFLSA-N 0.000 claims 2
- 102100025750 Sphingosine 1-phosphate receptor 1 Human genes 0.000 claims 1
- 101710155454 Sphingosine 1-phosphate receptor 1 Proteins 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000008177 pharmaceutical agent Substances 0.000 claims 1
- DUYSYHSSBDVJSM-KRWOKUGFSA-N sphingosine 1-phosphate Chemical compound CCCCCCCCCCCCC\C=C\[C@@H](O)[C@@H](N)COP(O)(O)=O DUYSYHSSBDVJSM-KRWOKUGFSA-N 0.000 description 18
- 102000005962 receptors Human genes 0.000 description 10
- 108020003175 receptors Proteins 0.000 description 10
- AICOOMRHRUFYCM-ZRRPKQBOSA-N oxazine, 1 Chemical compound C([C@@H]1[C@H](C(C[C@]2(C)[C@@H]([C@H](C)N(C)C)[C@H](O)C[C@]21C)=O)CC1=CC2)C[C@H]1[C@@]1(C)[C@H]2N=C(C(C)C)OC1 AICOOMRHRUFYCM-ZRRPKQBOSA-N 0.000 description 8
- 230000004043 responsiveness Effects 0.000 description 8
- 230000000694 effects Effects 0.000 description 4
- 238000012423 maintenance Methods 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 125000002059 L-arginyl group Chemical class O=C([*])[C@](N([H])[H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H] 0.000 description 3
- 230000006698 induction Effects 0.000 description 3
- 238000005259 measurement Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 208000011231 Crohn disease Diseases 0.000 description 1
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 description 1
- 159000000007 calcium salts Chemical class 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 208000002551 irritable bowel syndrome Diseases 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- 230000037221 weight management Effects 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024195531A JP2025024035A (ja) | 2018-11-30 | 2024-11-08 | Ｓ１ｐ１受容体に関連する状態を治療する方法 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862773936P | 2018-11-30 | 2018-11-30 | |
| US62/773,936 | 2018-11-30 | ||
| US201962850464P | 2019-05-20 | 2019-05-20 | |
| US62/850,464 | 2019-05-20 | ||
| PCT/US2019/063413 WO2020112880A1 (en) | 2018-11-30 | 2019-11-26 | Methods of treating conditions related to the s1p1 receptor |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024195531A Division JP2025024035A (ja) | 2018-11-30 | 2024-11-08 | Ｓ１ｐ１受容体に関連する状態を治療する方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022511788A JP2022511788A (ja) | 2022-02-01 |
| JP2022511788A5 JP2022511788A5 (https=) | 2022-12-05 |
| JPWO2020112880A5 true JPWO2020112880A5 (https=) | 2022-12-05 |
Family
ID=68966033
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021530816A Withdrawn JP2022511788A (ja) | 2018-11-30 | 2019-11-26 | Ｓ１ｐ１受容体に関連する状態を治療する方法 |
| JP2024195531A Pending JP2025024035A (ja) | 2018-11-30 | 2024-11-08 | Ｓ１ｐ１受容体に関連する状態を治療する方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024195531A Pending JP2025024035A (ja) | 2018-11-30 | 2024-11-08 | Ｓ１ｐ１受容体に関連する状態を治療する方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20220023258A1 (https=) |
| EP (1) | EP3886841A1 (https=) |
| JP (2) | JP2022511788A (https=) |
| KR (1) | KR102824401B1 (https=) |
| CN (2) | CN118649163A (https=) |
| AU (1) | AU2019387212A1 (https=) |
| CA (1) | CA3120706A1 (https=) |
| IL (1) | IL283414A (https=) |
| WO (1) | WO2020112880A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG10201906876PA (en) | 2010-01-27 | 2019-09-27 | Arena Pharm Inc | Processes for the preparation of (r)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid and salts thereof |
| MX386419B (es) | 2015-01-06 | 2025-03-18 | Arena Pharm Inc | Metodos de condiciones de tratamiento relacionadas con el receptor s1p1. |
| EP3939965A1 (en) | 2015-06-22 | 2022-01-19 | Arena Pharmaceuticals, Inc. | Crystalline l-arginine salt of (r)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclo-penta[b]indol-3-yl)acetic acid for use in sipi receptor-associated disorders |
| MA47504A (fr) | 2017-02-16 | 2019-12-25 | Arena Pharm Inc | Composés et méthodes de traitement de l'angiocholite biliaire primitive |
| WO2018151834A1 (en) | 2017-02-16 | 2018-08-23 | Arena Pharmaceuticals, Inc. | Compounds and methods for treatment of inflammatory bowel disease with extra-intestinal manifestations |
| ES2987794T3 (es) | 2018-06-06 | 2024-11-18 | Arena Pharm Inc | Procedimientos de tratamiento de afecciones relacionadas con el receptor S1P1 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA019252B1 (ru) * | 2008-07-23 | 2014-02-28 | Арена Фармасьютикалз, Инк. | ЗАМЕЩЕННЫЕ ПРОИЗВОДНЫЕ (1,2,3,4-ТЕТРАГИДРОЦИКЛОПЕНТА[b]ИНДОЛ-3-ИЛ)УКСУСНОЙ КИСЛОТЫ, ПРИМЕНИМЫЕ В ЛЕЧЕНИИ АУТОИММУННЫХ И ВОСПАЛИТЕЛЬНЫХ РАССТРОЙСТВ |
| SG10201906876PA (en) * | 2010-01-27 | 2019-09-27 | Arena Pharm Inc | Processes for the preparation of (r)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid and salts thereof |
| CN106063787A (zh) * | 2012-02-03 | 2016-11-02 | 泰华制药工业有限公司 | 拉喹莫德用于治疗一线抗TNFα疗法失败的克罗恩氏病患者的用途 |
| AU2015257589A1 (en) * | 2014-05-09 | 2016-11-24 | Nogra Pharma Limited | Methods for treating inflammatory bowel disease |
| MX386419B (es) * | 2015-01-06 | 2025-03-18 | Arena Pharm Inc | Metodos de condiciones de tratamiento relacionadas con el receptor s1p1. |
| EP3355896A2 (en) * | 2015-09-30 | 2018-08-08 | Nogra Pharma Limited | Methods of using smad7 antisense oligonucleotides based on biomarker expression |
| MA47504A (fr) * | 2017-02-16 | 2019-12-25 | Arena Pharm Inc | Composés et méthodes de traitement de l'angiocholite biliaire primitive |
-
2019
- 2019-11-26 CA CA3120706A patent/CA3120706A1/en active Pending
- 2019-11-26 AU AU2019387212A patent/AU2019387212A1/en not_active Abandoned
- 2019-11-26 US US17/299,741 patent/US20220023258A1/en not_active Abandoned
- 2019-11-26 CN CN202410692934.XA patent/CN118649163A/zh active Pending
- 2019-11-26 WO PCT/US2019/063413 patent/WO2020112880A1/en not_active Ceased
- 2019-11-26 EP EP19824097.0A patent/EP3886841A1/en active Pending
- 2019-11-26 KR KR1020217019803A patent/KR102824401B1/ko active Active
- 2019-11-26 JP JP2021530816A patent/JP2022511788A/ja not_active Withdrawn
- 2019-11-26 CN CN201980087042.4A patent/CN113226307A/zh active Pending
-
2021
- 2021-05-25 IL IL283414A patent/IL283414A/en unknown
-
2024
- 2024-11-08 JP JP2024195531A patent/JP2025024035A/ja active Pending
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