JPWO2020097372A5 - - Google Patents

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Publication number
JPWO2020097372A5
JPWO2020097372A5 JP2021524060A JP2021524060A JPWO2020097372A5 JP WO2020097372 A5 JPWO2020097372 A5 JP WO2020097372A5 JP 2021524060 A JP2021524060 A JP 2021524060A JP 2021524060 A JP2021524060 A JP 2021524060A JP WO2020097372 A5 JPWO2020097372 A5 JP WO2020097372A5
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JP
Japan
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composition
promoter
item
primate
raav
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JP2021524060A
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English (en)
Japanese (ja)
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JP2022506613A5 (https=
JP2022506613A (ja
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Priority claimed from PCT/US2019/060328 external-priority patent/WO2020097372A1/en
Publication of JP2022506613A publication Critical patent/JP2022506613A/ja
Publication of JPWO2020097372A5 publication Critical patent/JPWO2020097372A5/ja
Publication of JP2022506613A5 publication Critical patent/JP2022506613A5/ja
Priority to JP2024048210A priority Critical patent/JP2024086735A/ja
Pending legal-status Critical Current

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JP2021524060A 2018-11-07 2019-11-07 内耳の有毛細胞及び支持細胞における遺伝子欠陥／発現タンパク質を修正するためのアデノ随伴ウイルスベクターの使用 Pending JP2022506613A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2024048210A JP2024086735A (ja) 2018-11-07 2024-03-25 内耳の有毛細胞及び支持細胞における遺伝子欠陥／発現タンパク質を修正するためのアデノ随伴ウイルスベクターの使用

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862756953P 2018-11-07 2018-11-07
US62/756,953 2018-11-07
US201962888093P 2019-08-16 2019-08-16
US62/888,093 2019-08-16
PCT/US2019/060328 WO2020097372A1 (en) 2018-11-07 2019-11-07 Use of adeno-associated viral vectors to correct gene defects/ express proteins in hair cells and supporting cells in the inner ear

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2024048210A Division JP2024086735A (ja) 2018-11-07 2024-03-25 内耳の有毛細胞及び支持細胞における遺伝子欠陥／発現タンパク質を修正するためのアデノ随伴ウイルスベクターの使用

Publications (3)

Publication Number Publication Date
JP2022506613A JP2022506613A (ja) 2022-01-17
JPWO2020097372A5 true JPWO2020097372A5 (https=) 2023-07-07
JP2022506613A5 JP2022506613A5 (https=) 2023-07-07

Family

ID=70611216

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2021524060A Pending JP2022506613A (ja) 2018-11-07 2019-11-07 内耳の有毛細胞及び支持細胞における遺伝子欠陥／発現タンパク質を修正するためのアデノ随伴ウイルスベクターの使用
JP2024048210A Pending JP2024086735A (ja) 2018-11-07 2024-03-25 内耳の有毛細胞及び支持細胞における遺伝子欠陥／発現タンパク質を修正するためのアデノ随伴ウイルスベクターの使用

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2024048210A Pending JP2024086735A (ja) 2018-11-07 2024-03-25 内耳の有毛細胞及び支持細胞における遺伝子欠陥／発現タンパク質を修正するためのアデノ随伴ウイルスベクターの使用

Country Status (7)

Country Link
US (2) US20230056182A1 (https=)
EP (2) EP4063510A1 (https=)
JP (2) JP2022506613A (https=)
CN (2) CN118497276A (https=)
AU (1) AU2019377115A1 (https=)
CA (1) CA3119065A1 (https=)
WO (1) WO2020097372A1 (https=)

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Publication number Priority date Publication date Assignee Title
JP2019530737A (ja) 2016-08-23 2019-10-24 アコーオス インコーポレイテッド ヒト対象において非加齢性聴力障害を治療するための組成物および方法
MX2020006435A (es) 2017-12-19 2021-02-09 Akouos Inc Administracion de anticuerpos terapeuticos mediada por vector de virus adenoasociado (aav) en el oido interno.
US12054724B2 (en) 2018-04-10 2024-08-06 President And Fellows Of Harvard College AAV vectors encoding clarin-1 or GJB2 and uses thereof
US11660353B2 (en) 2018-04-27 2023-05-30 Decibel Therapeutics, Inc. Compositions and methods for treating sensorineural hearing loss using otoferlin dual vector systems
CN119410636A (zh) 2018-04-27 2025-02-11 分贝治疗公司 肌球蛋白15启动子及其用途
AU2020218547A1 (en) 2019-02-08 2021-08-26 Decibel Therapeutics, Inc. Myosin 15 promoters and uses thereof
EP3921032A4 (en) 2019-02-08 2022-11-30 Decibel Therapeutics, Inc. COMPOSITIONS AND METHODS FOR TREATMENT OF SENSORINEURAL HEARING LOSS USING OTOFERLIN DOUBLE VECTOR SYSTEMS
CA3159549A1 (en) 2019-10-30 2021-05-06 Decibel Therapeutics, Inc. Compositions and methods for treating sensorineural hearing loss using otoferlin dual vector systems
JP7807380B2 (ja) 2020-02-21 2026-01-27 アコーオス インコーポレイテッド ヒト対象において非加齢関連聴力障害を処置するための組成物および方法
EP4164695A4 (en) * 2020-05-13 2024-06-05 Akouos, Inc. COMPOSITIONS AND METHODS FOR TREATING GJB2-ASSOCIATED HEARING LOSS
US20240016955A1 (en) * 2020-09-14 2024-01-18 President And Fellows Of Harvard College Dual-aav vector delivery of pcdh15 and uses thereof
JP2023541443A (ja) * 2020-09-14 2023-10-02 プレジデント アンド フェローズ オブ ハーバード カレッジ ＧＪＢ２をコードする組換えアデノ随伴ウイルス（ｒＡＡＶ）およびその使用。
US12129287B2 (en) 2020-09-14 2024-10-29 President And Fellows Of Harvard College Recombinant adeno associated virus encoding clarin-1 and uses thereof
AU2021376225A1 (en) * 2020-11-06 2023-06-22 Eli Lilly And Company Variant adeno-associated virus (aav)capsid polypeptides and gene therapeutics thereof for treatment of hearing loss
IL303317A (en) * 2020-12-01 2023-07-01 Akouos Inc ANTI-NATURAL ANTIBODY STRUCTURES AND RELATED METHODS FOR THE TREATMENT OF SYMPTOMS ASSOCIATED WITH VESTIBULAR SWANNOMA
MX2023007800A (es) 2020-12-29 2023-07-11 Akouos Inc Composiciones y metodos para tratar la perdida de audicion y/o la perdida de vision asociada a clrn1.
US20220267795A1 (en) * 2021-02-24 2022-08-25 Kinase Pharma Inc. Compositions and methods for regulating production of an angiogensis inhibitor
EP4473011A1 (en) * 2022-02-02 2024-12-11 Akouos, Inc. Anti-vegf antibody constructs and related methods for treating vestibular schwannoma associated symptoms
KR20250080886A (ko) * 2022-09-30 2025-06-05 데시벨 테라퓨틱스, 인크. Slc26a4 조절 요소 및 이의 용도
WO2025179016A1 (en) * 2024-02-20 2025-08-28 Skylark Bio, Inc. Recombinant adeno associated virus and uses thereof

Family Cites Families (12)

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Publication number Priority date Publication date Assignee Title
EP0928202A4 (en) * 1996-09-25 2001-09-05 Cell Genesys Inc NON-INVASIVE ADMINISTRATION OF ADENO-ASSOCIATED VIRAL VECTORS
EP1082445A2 (en) * 1998-05-27 2001-03-14 Cell Genesys, Inc. Adeno-associated viral vector-mediated expression of factor viii activity
WO2011075838A1 (en) * 2009-12-21 2011-06-30 Audigen Inc. Method of treating or preventing hearing loss
CA2890061A1 (en) * 2012-12-04 2014-06-12 Merck Sharp & Dohme Corp. Conditional replicating viral vectors
CA2909733C (en) * 2013-04-18 2023-10-17 Fondazione Telethon Effective delivery of large genes by dual aav vectors
US9790490B2 (en) * 2015-06-18 2017-10-17 The Broad Institute Inc. CRISPR enzymes and systems
TWI813532B (zh) * 2015-06-18 2023-09-01 美商博得學院股份有限公司 降低脱靶效應的ｃｒｉｓｐｒ酶突變
SG11201804814YA (en) * 2015-12-11 2018-07-30 Massachusetts Eye & Ear Infirmary Materials and methods for delivering nucleic acids to cochlear and vestibular cells
WO2017136764A1 (en) * 2016-02-05 2017-08-10 The General Hospital Corporation Hybrid system for efficient gene delivery to cells of the inner ear
WO2017181021A1 (en) * 2016-04-15 2017-10-19 Regenxbio Inc. Treatment of ocular diseases with fully-human post-translationally modified anti-vegf fab
JP2019530737A (ja) * 2016-08-23 2019-10-24 アコーオス インコーポレイテッド ヒト対象において非加齢性聴力障害を治療するための組成物および方法
KR102746901B1 (ko) * 2017-03-03 2024-12-26 옵시디안 테라퓨틱스, 인크. Cd19 조성물 및 면역요법을 위한 방법

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