JP2022506613A5 - - Google Patents
Info
- Publication number
- JP2022506613A5 JP2022506613A5 JP2021524060A JP2021524060A JP2022506613A5 JP 2022506613 A5 JP2022506613 A5 JP 2022506613A5 JP 2021524060 A JP2021524060 A JP 2021524060A JP 2021524060 A JP2021524060 A JP 2021524060A JP 2022506613 A5 JP2022506613 A5 JP 2022506613A5
- Authority
- JP
- Japan
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024048210A JP2024086735A (ja) | 2018-11-07 | 2024-03-25 | 内耳の有毛細胞及び支持細胞における遺伝子欠陥／発現タンパク質を修正するためのアデノ随伴ウイルスベクターの使用 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862756953P | 2018-11-07 | 2018-11-07 | |
| US62/756,953 | 2018-11-07 | ||
| US201962888093P | 2019-08-16 | 2019-08-16 | |
| US62/888,093 | 2019-08-16 | ||
| PCT/US2019/060328 WO2020097372A1 (en) | 2018-11-07 | 2019-11-07 | Use of adeno-associated viral vectors to correct gene defects/ express proteins in hair cells and supporting cells in the inner ear |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024048210A Division JP2024086735A (ja) | 2018-11-07 | 2024-03-25 | 内耳の有毛細胞及び支持細胞における遺伝子欠陥／発現タンパク質を修正するためのアデノ随伴ウイルスベクターの使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022506613A JP2022506613A (ja) | 2022-01-17 |
| JPWO2020097372A5 JPWO2020097372A5 (https=) | 2023-07-07 |
| JP2022506613A5 true JP2022506613A5 (https=) | 2023-07-07 |
Family
ID=70611216
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021524060A Pending JP2022506613A (ja) | 2018-11-07 | 2019-11-07 | 内耳の有毛細胞及び支持細胞における遺伝子欠陥／発現タンパク質を修正するためのアデノ随伴ウイルスベクターの使用 |
| JP2024048210A Pending JP2024086735A (ja) | 2018-11-07 | 2024-03-25 | 内耳の有毛細胞及び支持細胞における遺伝子欠陥／発現タンパク質を修正するためのアデノ随伴ウイルスベクターの使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024048210A Pending JP2024086735A (ja) | 2018-11-07 | 2024-03-25 | 内耳の有毛細胞及び支持細胞における遺伝子欠陥／発現タンパク質を修正するためのアデノ随伴ウイルスベクターの使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20230056182A1 (https=) |
| EP (2) | EP4063510A1 (https=) |
| JP (2) | JP2022506613A (https=) |
| CN (2) | CN118497276A (https=) |
| AU (1) | AU2019377115A1 (https=) |
| CA (1) | CA3119065A1 (https=) |
| WO (1) | WO2020097372A1 (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2019530737A (ja) | 2016-08-23 | 2019-10-24 | アコーオス インコーポレイテッド | ヒト対象において非加齢性聴力障害を治療するための組成物および方法 |
| MX2020006435A (es) | 2017-12-19 | 2021-02-09 | Akouos Inc | Administracion de anticuerpos terapeuticos mediada por vector de virus adenoasociado (aav) en el oido interno. |
| US12054724B2 (en) | 2018-04-10 | 2024-08-06 | President And Fellows Of Harvard College | AAV vectors encoding clarin-1 or GJB2 and uses thereof |
| US11660353B2 (en) | 2018-04-27 | 2023-05-30 | Decibel Therapeutics, Inc. | Compositions and methods for treating sensorineural hearing loss using otoferlin dual vector systems |
| CN119410636A (zh) | 2018-04-27 | 2025-02-11 | 分贝治疗公司 | 肌球蛋白15启动子及其用途 |
| AU2020218547A1 (en) | 2019-02-08 | 2021-08-26 | Decibel Therapeutics, Inc. | Myosin 15 promoters and uses thereof |
| EP3921032A4 (en) | 2019-02-08 | 2022-11-30 | Decibel Therapeutics, Inc. | COMPOSITIONS AND METHODS FOR TREATMENT OF SENSORINEURAL HEARING LOSS USING OTOFERLIN DOUBLE VECTOR SYSTEMS |
| CA3159549A1 (en) | 2019-10-30 | 2021-05-06 | Decibel Therapeutics, Inc. | Compositions and methods for treating sensorineural hearing loss using otoferlin dual vector systems |
| JP7807380B2 (ja) | 2020-02-21 | 2026-01-27 | アコーオス インコーポレイテッド | ヒト対象において非加齢関連聴力障害を処置するための組成物および方法 |
| EP4164695A4 (en) * | 2020-05-13 | 2024-06-05 | Akouos, Inc. | COMPOSITIONS AND METHODS FOR TREATING GJB2-ASSOCIATED HEARING LOSS |
| US20240016955A1 (en) * | 2020-09-14 | 2024-01-18 | President And Fellows Of Harvard College | Dual-aav vector delivery of pcdh15 and uses thereof |
| JP2023541443A (ja) * | 2020-09-14 | 2023-10-02 | プレジデント アンド フェローズ オブ ハーバード カレッジ | ＧＪＢ２をコードする組換えアデノ随伴ウイルス（ｒＡＡＶ）およびその使用。 |
| US12129287B2 (en) | 2020-09-14 | 2024-10-29 | President And Fellows Of Harvard College | Recombinant adeno associated virus encoding clarin-1 and uses thereof |
| AU2021376225A1 (en) * | 2020-11-06 | 2023-06-22 | Eli Lilly And Company | Variant adeno-associated virus (aav)capsid polypeptides and gene therapeutics thereof for treatment of hearing loss |
| IL303317A (en) * | 2020-12-01 | 2023-07-01 | Akouos Inc | ANTI-NATURAL ANTIBODY STRUCTURES AND RELATED METHODS FOR THE TREATMENT OF SYMPTOMS ASSOCIATED WITH VESTIBULAR SWANNOMA |
| MX2023007800A (es) | 2020-12-29 | 2023-07-11 | Akouos Inc | Composiciones y metodos para tratar la perdida de audicion y/o la perdida de vision asociada a clrn1. |
| US20220267795A1 (en) * | 2021-02-24 | 2022-08-25 | Kinase Pharma Inc. | Compositions and methods for regulating production of an angiogensis inhibitor |
| EP4473011A1 (en) * | 2022-02-02 | 2024-12-11 | Akouos, Inc. | Anti-vegf antibody constructs and related methods for treating vestibular schwannoma associated symptoms |
| KR20250080886A (ko) * | 2022-09-30 | 2025-06-05 | 데시벨 테라퓨틱스, 인크. | Slc26a4 조절 요소 및 이의 용도 |
| WO2025179016A1 (en) * | 2024-02-20 | 2025-08-28 | Skylark Bio, Inc. | Recombinant adeno associated virus and uses thereof |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0928202A4 (en) * | 1996-09-25 | 2001-09-05 | Cell Genesys Inc | NON-INVASIVE ADMINISTRATION OF ADENO-ASSOCIATED VIRAL VECTORS |
| EP1082445A2 (en) * | 1998-05-27 | 2001-03-14 | Cell Genesys, Inc. | Adeno-associated viral vector-mediated expression of factor viii activity |
| WO2011075838A1 (en) * | 2009-12-21 | 2011-06-30 | Audigen Inc. | Method of treating or preventing hearing loss |
| CA2890061A1 (en) * | 2012-12-04 | 2014-06-12 | Merck Sharp & Dohme Corp. | Conditional replicating viral vectors |
| CA2909733C (en) * | 2013-04-18 | 2023-10-17 | Fondazione Telethon | Effective delivery of large genes by dual aav vectors |
| US9790490B2 (en) * | 2015-06-18 | 2017-10-17 | The Broad Institute Inc. | CRISPR enzymes and systems |
| TWI813532B (zh) * | 2015-06-18 | 2023-09-01 | 美商博得學院股份有限公司 | 降低脱靶效應的ｃｒｉｓｐｒ酶突變 |
| SG11201804814YA (en) * | 2015-12-11 | 2018-07-30 | Massachusetts Eye & Ear Infirmary | Materials and methods for delivering nucleic acids to cochlear and vestibular cells |
| WO2017136764A1 (en) * | 2016-02-05 | 2017-08-10 | The General Hospital Corporation | Hybrid system for efficient gene delivery to cells of the inner ear |
| WO2017181021A1 (en) * | 2016-04-15 | 2017-10-19 | Regenxbio Inc. | Treatment of ocular diseases with fully-human post-translationally modified anti-vegf fab |
| JP2019530737A (ja) * | 2016-08-23 | 2019-10-24 | アコーオス インコーポレイテッド | ヒト対象において非加齢性聴力障害を治療するための組成物および方法 |
| KR102746901B1 (ko) * | 2017-03-03 | 2024-12-26 | 옵시디안 테라퓨틱스, 인크. | Cd19 조성물 및 면역요법을 위한 방법 |
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2019
- 2019-11-07 CN CN202410531995.8A patent/CN118497276A/zh active Pending
- 2019-11-07 CN CN201980082439.4A patent/CN113853437A/zh active Pending
- 2019-11-07 JP JP2021524060A patent/JP2022506613A/ja active Pending
- 2019-11-07 WO PCT/US2019/060328 patent/WO2020097372A1/en not_active Ceased
- 2019-11-07 EP EP22155160.9A patent/EP4063510A1/en not_active Withdrawn
- 2019-11-07 EP EP19881503.7A patent/EP3880826A4/en not_active Withdrawn
- 2019-11-07 US US17/291,931 patent/US20230056182A1/en not_active Abandoned
- 2019-11-07 CA CA3119065A patent/CA3119065A1/en active Pending
- 2019-11-07 AU AU2019377115A patent/AU2019377115A1/en active Pending
-
2024
- 2024-03-25 JP JP2024048210A patent/JP2024086735A/ja active Pending
- 2024-08-15 US US18/806,641 patent/US20250041457A1/en active Pending