JPWO2020096059A1 - 育毛用又は脱毛防止用外用剤 - Google Patents
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- A—HUMAN NECESSITIES
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Abstract
Description
項2.前記エンテロコッカス属に属する乳酸菌がエンテロコッカス・フェカリスである、項1に記載の外用剤。
項3.前記エンテロコッカス属に属する乳酸菌がエンテロコッカス・フェカリスNF-1011株(FERM BP-10902)である、項1又は2に記載の外用剤。
項4.前記菌体が死菌体である、項1〜3のいずれか一項に記載の外用剤。
項5.前記乳酸菌の菌体成分が、乳酸菌の溶菌酵素及び加熱処理物である、項1〜4のいずれか一項に記載の外用剤。
項6.エンテロコッカス属に属する乳酸菌の菌体及びその菌体成分からなる群から選択される少なくとも1種を育毛又は脱毛予防を必要とする哺乳動物の皮膚に適用する工程を含む、育毛又は脱毛予防方法。
項7.前記エンテロコッカス属に属する乳酸菌がエンテロコッカス・フェカリスである、項6に記載の方法。
項8.前記エンテロコッカス属に属する乳酸菌がエンテロコッカス・フェカリスNF-1011株(FERM BP-10902)である、項6又は7に記載の方法。
項9.前記菌体が死菌体である、項6〜8のいずれか一項に記載の方法。
項10.前記乳酸菌の菌体成分が、乳酸菌の溶菌酵素及び加熱処理物である、項6〜9のいずれか一項に記載の方法。
項11.育毛用又は脱毛防止用外用剤の製造における、エンテロコッカス属に属する乳酸菌の菌体及びその菌体成分からなる群から選択される少なくとも1種の使用。
項12.前記エンテロコッカス属に属する乳酸菌がエンテロコッカス・フェカリスである、項11に記載の使用。
項13.前記エンテロコッカス属に属する乳酸菌がエンテロコッカス・フェカリスNF-1011株(FERM BP-10902)である、項11又は12に記載の使用。
項14.前記菌体が死菌体である、項11〜13のいずれか一項に記載の使用。
項15.前記乳酸菌の菌体成分が、乳酸菌の溶菌酵素及び加熱処理物である、項11〜14のいずれか一項に記載の使用。
エンテロコッカス・フェカリスNF-1011株を液体培地(グルコース2%、酵母エキス2%、ペプトン2%、リン酸水素二カリウム4%)中で37℃、18時間培養した。マイクロフィルトレーション膜で集菌及び洗浄し、生菌体を回収した。これを110℃で10分間熱処理し、処理後、スプレードライで乾燥させた。得られた死菌体乾燥物を、菌体試料(FK-23)として、以下の実験で用いた。
エンテロッコカス・フェカリスNF-1011株をロゴサ液体培地10 mlに播種し、37℃にて15時間好気的に静置培養(前培養)し、菌体濃度が約109個/mlの菌体液(シード)を得た。これをロゴサ液体培地10Lに播種(菌体濃度:106個/ml)し、37℃で16時間好気的に静置培養し、生菌数約109個/mlの菌体液を得た。得られた菌体液を遠心分離(12,000×g、20分間)して集菌し、これを生理食塩水(0.85%塩化ナトリウム水溶液)で2回洗浄して、蒸留水100 mlに懸濁し、菌体懸濁液を得た。当該菌体懸濁液にリゾチームを終濃度0.1 mg/ml量となるよう添加し、37℃で4時間処理後、110℃で10分間加熱処理して、菌体処理物を得た。得られた菌体処理物を、菌体試料(LFK)として、以下の実験で用いた。
39歳の男性被験者に対して、エタノールと水とを主成分とする溶液にFK-23:LFKを1:1で混合した粉末を1%懸濁した整髪料を、頭皮の主に地肌が見えて気になっている部分に1日1回使用した。使用時間帯は特に指定しなかったが、主に就寝前、洗髪時には髪を乾燥させた後に使用した。
40〜70代の男女被験者5名に対して、試験例1と同様の整髪料を、頭皮の主に地肌が見えて気になっている部分に1日1回使用した。使用時間帯は特に指定しなかったが、主に就寝前、洗髪時には髪を乾燥させた後に使用した。
Claims (5)
- エンテロコッカス属に属する乳酸菌の菌体及びその菌体成分からなる群から選択される少なくとも1種を含有する育毛用又は脱毛防止用外用剤。
- 前記エンテロコッカス属に属する乳酸菌がエンテロコッカス・フェカリスである、請求項1に記載の外用剤。
- 前記エンテロコッカス属に属する乳酸菌がエンテロコッカス・フェカリスNF-1011株(FERM BP-10902)である、請求項1又は2に記載の外用剤。
- 前記菌体が死菌体である、請求項1〜3のいずれか一項に記載の外用剤。
- 前記乳酸菌の菌体成分が、乳酸菌の溶菌酵素及び加熱処理物である、請求項1〜4のいずれか一項に記載の外用剤。
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