JPWO2020072428A5 - - Google Patents
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- Publication number
- JPWO2020072428A5 JPWO2020072428A5 JP2021542077A JP2021542077A JPWO2020072428A5 JP WO2020072428 A5 JPWO2020072428 A5 JP WO2020072428A5 JP 2021542077 A JP2021542077 A JP 2021542077A JP 2021542077 A JP2021542077 A JP 2021542077A JP WO2020072428 A5 JPWO2020072428 A5 JP WO2020072428A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- lys
- dpr
- poly
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 230000002163 immunogen Effects 0.000 claims 12
- 108090000765 processed proteins & peptides Proteins 0.000 claims 12
- 125000003275 alpha amino acid group Chemical group 0.000 claims 8
- 238000000034 method Methods 0.000 claims 7
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 108090000623 proteins and genes Proteins 0.000 claims 5
- 102000004169 proteins and genes Human genes 0.000 claims 5
- 210000003719 b-lymphocyte Anatomy 0.000 claims 4
- 239000012634 fragment Substances 0.000 claims 4
- 210000002443 helper t lymphocyte Anatomy 0.000 claims 4
- 125000006850 spacer group Chemical group 0.000 claims 4
- 239000012472 biological sample Substances 0.000 claims 3
- 239000002671 adjuvant Substances 0.000 claims 2
- 229910052782 aluminium Inorganic materials 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 229940046168 CpG oligodeoxynucleotide Drugs 0.000 claims 1
- 108010016626 Dipeptides Proteins 0.000 claims 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 230000003308 immunostimulating effect Effects 0.000 claims 1
- 229910017053 inorganic salt Inorganic materials 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 229940046166 oligodeoxynucleotide Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862739794P | 2018-10-01 | 2018-10-01 | |
| US62/739,794 | 2018-10-01 | ||
| PCT/US2019/053967 WO2020072428A1 (en) | 2018-10-01 | 2019-10-01 | Peptide immunogen constructs directed against dipeptide repeat proteins from c9orf72 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022511995A JP2022511995A (ja) | 2022-02-01 |
| JPWO2020072428A5 true JPWO2020072428A5 (enExample) | 2022-10-05 |
| JP7505788B2 JP7505788B2 (ja) | 2024-06-25 |
Family
ID=70055826
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021542077A Active JP7505788B2 (ja) | 2018-10-01 | 2019-10-01 | Ｃ９ｏｒｆ７２に由来するジペプチドリピートタンパク質に対して指向化されたペプチド免疫原コンストラクト |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20210347866A1 (enExample) |
| EP (1) | EP3861007A4 (enExample) |
| JP (1) | JP7505788B2 (enExample) |
| CN (1) | CN113227116A (enExample) |
| AU (1) | AU2019354291A1 (enExample) |
| CA (1) | CA3114657A1 (enExample) |
| TW (1) | TWI781347B (enExample) |
| WO (1) | WO2020072428A1 (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4034550A4 (en) * | 2019-09-23 | 2023-09-27 | University of Florida Research Foundation, Incorporated | VACCINE THERAPY FOR RAN PROTEIN DISEASES |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6025468A (en) | 1998-06-20 | 2000-02-15 | United Biomedical, Inc. | Artificial T helper cell epitopes as immune stimulators for synthetic peptide immunogens including immunogenic LHRH peptides |
| US6906169B2 (en) * | 2001-05-25 | 2005-06-14 | United Biomedical, Inc. | Immunogenic peptide composition comprising measles virus Fprotein Thelper cell epitope (MUFThl-16) and N-terminus of β-amyloid peptide |
| GB0510763D0 (en) * | 2005-05-27 | 2005-06-29 | London School Hygiene & Tropical Medicine | Malaria vaccines |
| PT2948777T (pt) * | 2013-01-22 | 2019-09-26 | Deutsches Zentrum Fuer Neurodegenerative Erkrankungen E V | Proteínas de repetição por dipeptídeos como alvo terapêutico em doenças neurodegenerativas com expansão de hexanucleotídico repetido |
| WO2014116865A1 (en) * | 2013-01-24 | 2014-07-31 | Mayo Foundation For Medical Education And Research | Methods and materials for detecting c9orf72 hexanucleotide repeat expansion positive frontotemporal lobar degeneration or c9orf72 hexanucleotide repeat expansion positive amyotrophic lateral sclerosis |
| US9102752B2 (en) | 2013-03-15 | 2015-08-11 | United Biomedical, Inc. | Peptide vaccine for prevention and immunotherapy of dementia of the Alzheimer's type |
| BR112016007751A2 (pt) * | 2013-10-11 | 2017-09-12 | Ionis Pharmaceuticals Inc | composições para modulação de expressão de c9orf72 |
| CN108064248B (zh) * | 2014-09-30 | 2022-03-15 | 生物控股有限公司 | 人源抗二肽重复(dpr)抗体 |
-
2019
- 2019-10-01 WO PCT/US2019/053967 patent/WO2020072428A1/en not_active Ceased
- 2019-10-01 TW TW108135458A patent/TWI781347B/zh active
- 2019-10-01 JP JP2021542077A patent/JP7505788B2/ja active Active
- 2019-10-01 CN CN201980079206.9A patent/CN113227116A/zh active Pending
- 2019-10-01 US US17/282,336 patent/US20210347866A1/en active Pending
- 2019-10-01 AU AU2019354291A patent/AU2019354291A1/en not_active Abandoned
- 2019-10-01 CA CA3114657A patent/CA3114657A1/en active Pending
- 2019-10-01 EP EP19869951.4A patent/EP3861007A4/en not_active Withdrawn
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