TWI781347B - 針對源自c9orf72二肽重複蛋白的胜肽免疫原結構 - Google Patents

針對源自c9orf72二肽重複蛋白的胜肽免疫原結構 Download PDF

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TWI781347B
TWI781347B TW108135458A TW108135458A TWI781347B TW I781347 B TWI781347 B TW I781347B TW 108135458 A TW108135458 A TW 108135458A TW 108135458 A TW108135458 A TW 108135458A TW I781347 B TWI781347 B TW I781347B
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poly
seq
dpr
lys
peptide immunogen
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TW108135458A
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TW202028223A (zh
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長怡 王
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美商Ｕｎｓ Ｉｐ控股公司
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
    • C08G69/08—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids derived from amino-carboxylic acids
    • C08G69/10—Alpha-amino-carboxylic acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues

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TW108135458A 2018-10-01 2019-10-01 針對源自c9orf72二肽重複蛋白的胜肽免疫原結構 TWI781347B (zh)

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US201862739794P 2018-10-01 2018-10-01
US62/739,794 2018-10-01

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TW202028223A TW202028223A (zh) 2020-08-01
TWI781347B true TWI781347B (zh) 2022-10-21

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US (1) US20210347866A1 (enExample)
EP (1) EP3861007A4 (enExample)
JP (1) JP7505788B2 (enExample)
CN (1) CN113227116A (enExample)
AU (1) AU2019354291A1 (enExample)
CA (1) CA3114657A1 (enExample)
TW (1) TWI781347B (enExample)
WO (1) WO2020072428A1 (enExample)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4034550A4 (en) * 2019-09-23 2023-09-27 University of Florida Research Foundation, Incorporated VACCINE THERAPY FOR RAN PROTEIN DISEASES

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1315869A (zh) * 1998-06-20 2001-10-03 美国联合生物医学公司 人工t辅助细胞表位作为包括免疫原性lhrh肽的合成肽免疫原的免疫刺激物
CN108064248A (zh) * 2014-09-30 2018-05-22 生物控股有限公司 人源抗二肽重复（dpr）抗体

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6906169B2 (en) * 2001-05-25 2005-06-14 United Biomedical, Inc. Immunogenic peptide composition comprising measles virus Fprotein Thelper cell epitope (MUFThl-16) and N-terminus of β-amyloid peptide
GB0510763D0 (en) * 2005-05-27 2005-06-29 London School Hygiene & Tropical Medicine Malaria vaccines
PT2948777T (pt) * 2013-01-22 2019-09-26 Deutsches Zentrum Fuer Neurodegenerative Erkrankungen E V Proteínas de repetição por dipeptídeos como alvo terapêutico em doenças neurodegenerativas com expansão de hexanucleotídico repetido
WO2014116865A1 (en) * 2013-01-24 2014-07-31 Mayo Foundation For Medical Education And Research Methods and materials for detecting c9orf72 hexanucleotide repeat expansion positive frontotemporal lobar degeneration or c9orf72 hexanucleotide repeat expansion positive amyotrophic lateral sclerosis
US9102752B2 (en) 2013-03-15 2015-08-11 United Biomedical, Inc. Peptide vaccine for prevention and immunotherapy of dementia of the Alzheimer's type
BR112016007751A2 (pt) * 2013-10-11 2017-09-12 Ionis Pharmaceuticals Inc composições para modulação de expressão de c9orf72

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1315869A (zh) * 1998-06-20 2001-10-03 美国联合生物医学公司 人工t辅助细胞表位作为包括免疫原性lhrh肽的合成肽免疫原的免疫刺激物
CN108064248A (zh) * 2014-09-30 2018-05-22 生物控股有限公司 人源抗二肽重复（dpr）抗体

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JP7505788B2 (ja) 2024-06-25
US20210347866A1 (en) 2021-11-11
JP2022511995A (ja) 2022-02-01
CA3114657A1 (en) 2020-04-09
AU2019354291A1 (en) 2021-05-06
WO2020072428A1 (en) 2020-04-09
CN113227116A (zh) 2021-08-06
EP3861007A4 (en) 2022-07-13
EP3861007A1 (en) 2021-08-11
TW202028223A (zh) 2020-08-01

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