JPWO2020061478A5 - - Google Patents
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- Publication number
- JPWO2020061478A5 JPWO2020061478A5 JP2021515172A JP2021515172A JPWO2020061478A5 JP WO2020061478 A5 JPWO2020061478 A5 JP WO2020061478A5 JP 2021515172 A JP2021515172 A JP 2021515172A JP 2021515172 A JP2021515172 A JP 2021515172A JP WO2020061478 A5 JPWO2020061478 A5 JP WO2020061478A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- elution buffer
- multispecific
- binding
- heavy chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024065251A JP2024099610A (ja) | 2018-09-21 | 2024-04-15 | ヘテロ二量体多重特異性抗体を精製するための方法 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862734566P | 2018-09-21 | 2018-09-21 | |
| US62/734,566 | 2018-09-21 | ||
| US201862742821P | 2018-10-08 | 2018-10-08 | |
| US62/742,821 | 2018-10-08 | ||
| PCT/US2019/052199 WO2020061478A2 (en) | 2018-09-21 | 2019-09-20 | Methods for purifying heterodimeric, multispecific antibodies |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024065251A Division JP2024099610A (ja) | 2018-09-21 | 2024-04-15 | ヘテロ二量体多重特異性抗体を精製するための方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022501357A JP2022501357A (ja) | 2022-01-06 |
| JP2022501357A5 JP2022501357A5 (https=) | 2022-09-29 |
| JPWO2020061478A5 true JPWO2020061478A5 (https=) | 2022-09-29 |
Family
ID=68240802
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021515172A Pending JP2022501357A (ja) | 2018-09-21 | 2019-09-20 | ヘテロ二量体多重特異性抗体を精製するための方法 |
| JP2024065251A Pending JP2024099610A (ja) | 2018-09-21 | 2024-04-15 | ヘテロ二量体多重特異性抗体を精製するための方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024065251A Pending JP2024099610A (ja) | 2018-09-21 | 2024-04-15 | ヘテロ二量体多重特異性抗体を精製するための方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US20210355215A1 (https=) |
| EP (1) | EP3853253A2 (https=) |
| JP (2) | JP2022501357A (https=) |
| KR (1) | KR20210063354A (https=) |
| CN (1) | CN112839959A (https=) |
| BR (1) | BR112021004680A2 (https=) |
| CA (1) | CA3113057A1 (https=) |
| IL (1) | IL281570A (https=) |
| MX (1) | MX2021003169A (https=) |
| SG (1) | SG11202102713TA (https=) |
| WO (1) | WO2020061478A2 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3029209A1 (en) | 2016-06-21 | 2017-12-28 | Teneobio, Inc. | Cd3 binding antibodies |
| IL264941B2 (en) | 2016-08-24 | 2025-12-01 | Teneobio Inc | Transgenic non-human animals producing modified heavy chain-only antibodies |
| FI4050034T3 (fi) * | 2016-09-14 | 2024-06-10 | Teneoone Inc | Cd3:een sitoutuvia vasta-aineita |
| NZ754713A (en) | 2016-12-21 | 2025-11-28 | Teneobio Inc | Anti-bcma heavy chain-only antibodies |
| US11427642B2 (en) | 2017-06-20 | 2022-08-30 | Teneoone, Inc. | Anti-BCMA heavy chain-only antibodies |
| WO2019126756A1 (en) | 2017-12-22 | 2019-06-27 | Teneobio, Inc. | Heavy chain antibodies binding to cd22 |
| JP7776987B2 (ja) | 2019-04-05 | 2025-11-27 | テネオバイオ， インコーポレイテッド | Ｐｓｍａに結合する重鎖抗体 |
| CN114206927B (zh) | 2019-06-14 | 2025-03-21 | 特尼奥生物股份有限公司 | 与cd22和cd3结合的多特异性重链抗体 |
| KR102153258B1 (ko) * | 2020-02-21 | 2020-09-07 | 프레스티지바이오로직스 주식회사 | 베바시주맙 정제의 최적화된 방법 |
| TWI838621B (zh) * | 2020-04-29 | 2024-04-11 | 美商泰尼歐萬公司 | 具有經修飾重鏈恆定區之多特異性重鏈抗體 |
| AU2021263448B2 (en) * | 2020-04-29 | 2026-02-05 | Teneobio, Inc. | Multispecific heavy chain antibodies with modified heavy chain constant regions |
| KR102744698B1 (ko) * | 2020-04-29 | 2024-12-24 | 테네오원, 인코포레이티드 | 변형된 중쇄 불변 영역을 갖는 다중특이적 중쇄 항체 |
| CN114539417A (zh) * | 2020-11-26 | 2022-05-27 | 盛禾(中国)生物制药有限公司 | 一种有效去除双特异性抗体同源二聚体的层析纯化工艺 |
| WO2022222949A1 (zh) * | 2021-04-23 | 2022-10-27 | 和铂医药(上海)有限责任公司 | 一种双特异性抗体的纯化方法 |
| WO2025251034A1 (en) * | 2024-05-31 | 2025-12-04 | Amgen Inc. | Purification method |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USRE30985E (en) | 1978-01-01 | 1982-06-29 | Serum-free cell culture media | |
| US4560655A (en) | 1982-12-16 | 1985-12-24 | Immunex Corporation | Serum-free cell culture medium and process for making same |
| US4657866A (en) | 1982-12-21 | 1987-04-14 | Sudhir Kumar | Serum-free, synthetic, completely chemically defined tissue culture media |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4767704A (en) | 1983-10-07 | 1988-08-30 | Columbia University In The City Of New York | Protein-free culture medium |
| GB8516415D0 (en) | 1985-06-28 | 1985-07-31 | Celltech Ltd | Culture of animal cells |
| US4927762A (en) | 1986-04-01 | 1990-05-22 | Cell Enterprises, Inc. | Cell culture medium with antioxidant |
| IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
| AU632065B2 (en) | 1988-09-23 | 1992-12-17 | Novartis Vaccines And Diagnostics, Inc. | Cell culture medium for enhanced cell growth, culture longevity and product expression |
| US5122469A (en) | 1990-10-03 | 1992-06-16 | Genentech, Inc. | Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins |
| EP1400536A1 (en) | 1991-06-14 | 2004-03-24 | Genentech Inc. | Method for making humanized antibodies |
| US5534615A (en) | 1994-04-25 | 1996-07-09 | Genentech, Inc. | Cardiac hypertrophy factor and uses therefor |
| US6096871A (en) | 1995-04-14 | 2000-08-01 | Genentech, Inc. | Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life |
| JP4046354B2 (ja) | 1996-03-18 | 2008-02-13 | ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム | 増大した半減期を有する免疫グロブリン様ドメイン |
| DE19836213A1 (de) * | 1998-08-11 | 2000-02-24 | Gerhard Harry Scholz | Verfahren zur Elution von Biomolekülen von Chromatographie-Materialien |
| CA2410551A1 (en) * | 2000-06-30 | 2002-01-10 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw (Vib) | Heterodimeric fusion proteins |
| WO2004042017A2 (en) | 2002-10-31 | 2004-05-21 | Genentech, Inc. | Methods and compositions for increasing antibody production |
| CA2513113A1 (en) | 2003-01-23 | 2004-08-05 | Genentech, Inc. | Methods for producing humanized antibodies and improving yield of antibodies or antigen binding fragments in cell culture |
| US20080286819A1 (en) | 2005-11-07 | 2008-11-20 | Ravetch Jeffrey V | Reagents, Methods and Systems for Selecting a Cytotoxic Antibody or Variant Thereof |
| MX2008012843A (es) | 2006-04-05 | 2009-01-19 | Univ Rockefeller | Polipeptidos con propiedades antiinflamatorias aumentadas y citotoxicas reducidas y metodos relacionados. |
| LT3660032T (lt) * | 2009-06-25 | 2026-02-25 | Amgen Inc. | Ne žinduolių sistemoje ekspresuotų baltymų surišamojo gryninimo būdai |
| JP2014515598A (ja) * | 2011-03-10 | 2014-07-03 | エイチシーオー アンティボディ， インク． | 二重特異性三鎖抗体様分子 |
| PT2825559T (pt) * | 2012-03-13 | 2019-06-07 | Novimmune Sa | Anticorpos biespecíficos prontamente isolados com formato de imunoglobulina nativo |
| US11261262B2 (en) * | 2013-09-03 | 2022-03-01 | Novimmune Sa | Readily isolated bispecific binding molecules with native format having mutated constant regions |
| ES2936810T3 (es) * | 2014-05-16 | 2023-03-22 | Pfizer | Anticuerpos biespecíficos con interfaces CH1-CL de ingeniería |
| AR101262A1 (es) * | 2014-07-26 | 2016-12-07 | Regeneron Pharma | Plataforma de purificación para anticuerpos biespecíficos |
| AU2016245887B2 (en) * | 2015-04-10 | 2021-09-23 | Adimab, Llc. | Methods for purifying heterodimeric multispecific antibodies from parental homodimeric antibody species |
| CN107446044B (zh) * | 2016-05-30 | 2021-04-30 | 越海百奥药业(绍兴)有限公司 | 一种纯化抗体的方法及所用缓冲液 |
| CA3218290A1 (en) * | 2016-07-22 | 2018-01-25 | Amgen Inc. | Methods of purifying fc-containing proteins |
| NZ754713A (en) | 2016-12-21 | 2025-11-28 | Teneobio Inc | Anti-bcma heavy chain-only antibodies |
| WO2019183406A1 (en) * | 2018-03-21 | 2019-09-26 | Invenra Inc. | Multispecific antibody purification with ch1 resin |
-
2019
- 2019-09-20 CN CN201980066235.1A patent/CN112839959A/zh active Pending
- 2019-09-20 CA CA3113057A patent/CA3113057A1/en active Pending
- 2019-09-20 SG SG11202102713TA patent/SG11202102713TA/en unknown
- 2019-09-20 EP EP19787122.1A patent/EP3853253A2/en active Pending
- 2019-09-20 WO PCT/US2019/052199 patent/WO2020061478A2/en not_active Ceased
- 2019-09-20 MX MX2021003169A patent/MX2021003169A/es unknown
- 2019-09-20 BR BR112021004680-1A patent/BR112021004680A2/pt unknown
- 2019-09-20 US US17/278,268 patent/US20210355215A1/en not_active Abandoned
- 2019-09-20 JP JP2021515172A patent/JP2022501357A/ja active Pending
- 2019-09-20 KR KR1020217010141A patent/KR20210063354A/ko not_active Ceased
-
2021
- 2021-03-16 IL IL281570A patent/IL281570A/en unknown
-
2024
- 2024-04-15 JP JP2024065251A patent/JP2024099610A/ja active Pending
-
2025
- 2025-01-17 US US19/030,905 patent/US20250197497A1/en active Pending
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