JPWO2020052688A5 - - Google Patents

Download PDF

Info

Publication number
JPWO2020052688A5
JPWO2020052688A5 JP2021514039A JP2021514039A JPWO2020052688A5 JP WO2020052688 A5 JPWO2020052688 A5 JP WO2020052688A5 JP 2021514039 A JP2021514039 A JP 2021514039A JP 2021514039 A JP2021514039 A JP 2021514039A JP WO2020052688 A5 JPWO2020052688 A5 JP WO2020052688A5
Authority
JP
Japan
Prior art keywords
methyl
fluoro
isopropyl
imidazo
dihydro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2021514039A
Other languages
English (en)
Japanese (ja)
Other versions
JP2022500428A5 (https=
JP2022500428A (ja
JP7436465B2 (ja
Publication date
Application filed filed Critical
Priority claimed from PCT/CN2019/105951 external-priority patent/WO2020052688A1/en
Publication of JP2022500428A publication Critical patent/JP2022500428A/ja
Publication of JP2022500428A5 publication Critical patent/JP2022500428A5/ja
Publication of JPWO2020052688A5 publication Critical patent/JPWO2020052688A5/ja
Priority to JP2024017316A priority Critical patent/JP7706585B2/ja
Application granted granted Critical
Publication of JP7436465B2 publication Critical patent/JP7436465B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2021514039A 2018-09-14 2019-09-16 毛細血管拡張性運動失調症変異（ＡＴＭ）キナーゼの選択的調節物質としての１－イソプロピル－３－メチル－８－（ピリジン－３－イル）－１，３－ジヒドロ－２Ｈ－イミダゾ［４，５－ｃ］シンノリン－２－オンおよびその使用 Active JP7436465B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2024017316A JP7706585B2 (ja) 2018-09-14 2024-02-07 毛細血管拡張性運動失調症変異（ＡＴＭ）キナーゼの選択的調節物質としての１－イソプロピル－３－メチル－８－（ピリジン－３－イル）－１，３－ジヒドロ－２Ｈ－イミダゾ［４，５－ｃ］シンノリン－２－オンおよびその使用

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CNPCT/CN2018/105675 2018-09-14
CN2018105675 2018-09-14
PCT/CN2019/105951 WO2020052688A1 (en) 2018-09-14 2019-09-16 1-ISOPROPYL-3-METHYL-8- (PYRIDIN-3-YL) -1, 3-DIHYDRO-2H-IMIDAZO [4, 5-c] CINNOLIN-2-ONE AS SELECTIVE MODULATORS OF ATAXIA TELANGIECTASIA MUTATED (ATM) KINASE AND USES THEREOF

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2024017316A Division JP7706585B2 (ja) 2018-09-14 2024-02-07 毛細血管拡張性運動失調症変異（ＡＴＭ）キナーゼの選択的調節物質としての１－イソプロピル－３－メチル－８－（ピリジン－３－イル）－１，３－ジヒドロ－２Ｈ－イミダゾ［４，５－ｃ］シンノリン－２－オンおよびその使用

Publications (4)

Publication Number Publication Date
JP2022500428A JP2022500428A (ja) 2022-01-04
JP2022500428A5 JP2022500428A5 (https=) 2022-09-30
JPWO2020052688A5 true JPWO2020052688A5 (https=) 2022-09-30
JP7436465B2 JP7436465B2 (ja) 2024-02-21

Family

ID=69777300

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2021514039A Active JP7436465B2 (ja) 2018-09-14 2019-09-16 毛細血管拡張性運動失調症変異（ＡＴＭ）キナーゼの選択的調節物質としての１－イソプロピル－３－メチル－８－（ピリジン－３－イル）－１，３－ジヒドロ－２Ｈ－イミダゾ［４，５－ｃ］シンノリン－２－オンおよびその使用
JP2024017316A Active JP7706585B2 (ja) 2018-09-14 2024-02-07 毛細血管拡張性運動失調症変異（ＡＴＭ）キナーゼの選択的調節物質としての１－イソプロピル－３－メチル－８－（ピリジン－３－イル）－１，３－ジヒドロ－２Ｈ－イミダゾ［４，５－ｃ］シンノリン－２－オンおよびその使用

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2024017316A Active JP7706585B2 (ja) 2018-09-14 2024-02-07 毛細血管拡張性運動失調症変異（ＡＴＭ）キナーゼの選択的調節物質としての１－イソプロピル－３－メチル－８－（ピリジン－３－イル）－１，３－ジヒドロ－２Ｈ－イミダゾ［４，５－ｃ］シンノリン－２－オンおよびその使用

Country Status (9)

Country Link
US (1) US12226414B2 (https=)
EP (2) EP4516318A3 (https=)
JP (2) JP7436465B2 (https=)
KR (1) KR102813324B1 (https=)
CN (2) CN112752758B (https=)
AU (1) AU2019339006B2 (https=)
CA (1) CA3111994A1 (https=)
ES (1) ES3001444T3 (https=)
WO (1) WO2020052688A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7436465B2 (ja) * 2018-09-14 2024-02-21 スゾウ、ザンロン、ファーマ、リミテッド 毛細血管拡張性運動失調症変異（ＡＴＭ）キナーゼの選択的調節物質としての１－イソプロピル－３－メチル－８－（ピリジン－３－イル）－１，３－ジヒドロ－２Ｈ－イミダゾ［４，５－ｃ］シンノリン－２－オンおよびその使用
AU2021433713A1 (en) * 2021-03-17 2023-09-28 Suzhou Zanrong Pharma Limited Selective modulators of ataxia telangiectasia mutated (atm) kinase and uses thereof
CN115304598B (zh) * 2021-08-25 2024-05-31 石药集团中奇制药技术（石家庄）有限公司 一种杂环类化合物及其制备方法和用途
GB202114704D0 (en) * 2021-10-14 2021-12-01 Univ Birmingham ATM inhibition
MX2024009184A (es) * 2022-01-26 2024-07-30 Chia Tai Tianqing Pharmaceutical Group Co Ltd Compuesto que contiene grupo hidrazino.
WO2025183591A1 (ru) * 2024-02-29 2025-09-04 Федеральное государственное унитарное предприятие "Всероссийский научно-исследовательский институт автоматики им. Н.Л. Духова" (ФГУП "ВНИИА") Производные 2н-[1,4]оксазино- и 2h-[1, 4]тиазино[3,2-c]хинолин-3(4h)-онов в качестве ингибиторов атм и dna-pk киназ

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9624482D0 (en) 1995-12-18 1997-01-15 Zeneca Phaema S A Chemical compounds
BR9707495A (pt) 1996-02-13 1999-07-27 Zeneca Ltd Derivado de quinazolina processo para a preparação do mesmo composição farmacêutica e processo para a produç o de um efeito antiangiogênico e/ou de redução de permeabilidade vascular em um animal de sangue quente
US6291455B1 (en) 1996-03-05 2001-09-18 Zeneca Limited 4-anilinoquinazoline derivatives
GB9718972D0 (en) 1996-09-25 1997-11-12 Zeneca Ltd Chemical compounds
NO2714752T3 (https=) * 2014-05-08 2018-04-21
GB201516504D0 (en) * 2015-09-17 2015-11-04 Astrazeneca Ab Imadazo(4,5-c)quinolin-2-one Compounds and their use in treating cancer
GB201519406D0 (en) 2015-11-03 2015-12-16 Astrazeneca Ab Imidazo[4,5-c]quinolin-2-one compounds and their use in treating cancer
GB201519568D0 (en) * 2015-11-05 2015-12-23 Astrazeneca Ab Imidazo[4,5-c]quinolin-2-one compounds and their use in treating cancer
US20190099421A1 (en) * 2016-03-21 2019-04-04 Astrazeneca Ab Cinnolin-4-amine compounds and their use in treating cancer
GB201608227D0 (en) * 2016-05-11 2016-06-22 Astrazeneca Ab Imidazo[4,5-c]quinolin-2-one compounds and their use in treating cancer
WO2019057757A1 (en) * 2017-09-20 2019-03-28 Astrazeneca Ab 1,3-DIHYDROIMIDAZO [4,5-C] CINNOLIN-2-ONE COMPOUNDS AND THEIR USE IN THE TREATMENT OF CANCER
JP7436465B2 (ja) * 2018-09-14 2024-02-21 スゾウ、ザンロン、ファーマ、リミテッド 毛細血管拡張性運動失調症変異（ＡＴＭ）キナーゼの選択的調節物質としての１－イソプロピル－３－メチル－８－（ピリジン－３－イル）－１，３－ジヒドロ－２Ｈ－イミダゾ［４，５－ｃ］シンノリン－２－オンおよびその使用

Similar Documents

Publication Publication Date Title
US20240374571A1 (en) Pharmaceutical combinations comprising a tead inhibitor and uses thereof for the treatment of cancers
JP7146016B2 (ja) Ｓｈｐ２の活性を阻害するための化合物および組成物
JP2022500428A5 (https=)
CN109415360B (zh) 用于抑制shp2活性的化合物和组合物
ES2805232T3 (es) Compuestos y composiciones para inhibir la actividad de SHP2
CN107864625B (zh) 含有取代的2,3-二氢咪唑并[1,2-c]喹唑啉的组合产品
JP7208659B2 (ja) インドリノン化合物の使用
CN111201223A (zh) SHP2的八氢环戊二烯并[c]吡咯别构抑制剂
US11702427B2 (en) Substituted 2-pyridone tricyclic compounds, analogues thereof, and methods using same
CA2506308A1 (en) Combination administration of an indolinone with a chemotherapeutic agent for cell proliferation disorders
JP2011503063A5 (https=)
WO2010031265A1 (zh) 用于治疗增生性疾病的药物组合物
JP2023526283A (ja) 単独療法及び併用療法
JP2019048822A (ja) Ｅｇｆｒ依存性疾患またはｅｇｆｒファミリーメンバーを標的とする薬剤に対して獲得耐性を有する疾患の治療における２−カルボキサミドシクロアミノウレア誘導体の使用
TW202003487A (zh) 經取代的２，２＇—聯嘧啶基化合物、其類似物及其使用方法
CN1511036B (zh) 包含信号转导抑制剂和埃坡霉素衍生物的联合形式
JPWO2020052688A5 (https=)
CA3116137A1 (en) Tlr7 agonist for treating colorectal cancer and pharmaceutical combination thereof
TWI671083B (zh) 醫藥調製劑
EP3585437A1 (en) Combinations of copanlisib with anti-pd-1 antibody
CN117835978A (zh) 包含tead抑制剂的药物组合及其用于癌症治疗的用途
CN118891255A (zh) 新化合物及其抑制检查点激酶2的用途
TWI528960B (zh) 用於治療增生性疾病的醫藥組合物
WO2019105835A1 (en) Combinations of copanlisib and anetumab ravtansine
HK1141447B (en) Pharmaceutical composition for the treatment of proliferative diseases