JP2022500428A5 - - Google Patents

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Publication number
JP2022500428A5
JP2022500428A5 JP2021514039A JP2021514039A JP2022500428A5 JP 2022500428 A5 JP2022500428 A5 JP 2022500428A5 JP 2021514039 A JP2021514039 A JP 2021514039A JP 2021514039 A JP2021514039 A JP 2021514039A JP 2022500428 A5 JP2022500428 A5 JP 2022500428A5
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JP
Japan
Prior art keywords
methyl
fluoro
isopropyl
imidazo
dihydro
Prior art date
Application number
JP2021514039A
Other languages
English (en)
Japanese (ja)
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JPWO2020052688A5 (https=
JP2022500428A (ja
JP7436465B2 (ja
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Priority claimed from PCT/CN2019/105951 external-priority patent/WO2020052688A1/en
Publication of JP2022500428A publication Critical patent/JP2022500428A/ja
Publication of JP2022500428A5 publication Critical patent/JP2022500428A5/ja
Publication of JPWO2020052688A5 publication Critical patent/JPWO2020052688A5/ja
Priority to JP2024017316A priority Critical patent/JP7706585B2/ja
Application granted granted Critical
Publication of JP7436465B2 publication Critical patent/JP7436465B2/ja
Active legal-status Critical Current
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JP2021514039A 2018-09-14 2019-09-16 毛細血管拡張性運動失調症変異（ＡＴＭ）キナーゼの選択的調節物質としての１－イソプロピル－３－メチル－８－（ピリジン－３－イル）－１，３－ジヒドロ－２Ｈ－イミダゾ［４，５－ｃ］シンノリン－２－オンおよびその使用 Active JP7436465B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2024017316A JP7706585B2 (ja) 2018-09-14 2024-02-07 毛細血管拡張性運動失調症変異（ＡＴＭ）キナーゼの選択的調節物質としての１－イソプロピル－３－メチル－８－（ピリジン－３－イル）－１，３－ジヒドロ－２Ｈ－イミダゾ［４，５－ｃ］シンノリン－２－オンおよびその使用

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CNPCT/CN2018/105675 2018-09-14
CN2018105675 2018-09-14
PCT/CN2019/105951 WO2020052688A1 (en) 2018-09-14 2019-09-16 1-ISOPROPYL-3-METHYL-8- (PYRIDIN-3-YL) -1, 3-DIHYDRO-2H-IMIDAZO [4, 5-c] CINNOLIN-2-ONE AS SELECTIVE MODULATORS OF ATAXIA TELANGIECTASIA MUTATED (ATM) KINASE AND USES THEREOF

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2024017316A Division JP7706585B2 (ja) 2018-09-14 2024-02-07 毛細血管拡張性運動失調症変異（ＡＴＭ）キナーゼの選択的調節物質としての１－イソプロピル－３－メチル－８－（ピリジン－３－イル）－１，３－ジヒドロ－２Ｈ－イミダゾ［４，５－ｃ］シンノリン－２－オンおよびその使用

Publications (4)

Publication Number Publication Date
JP2022500428A JP2022500428A (ja) 2022-01-04
JP2022500428A5 true JP2022500428A5 (https=) 2022-09-30
JPWO2020052688A5 JPWO2020052688A5 (https=) 2022-09-30
JP7436465B2 JP7436465B2 (ja) 2024-02-21

Family

ID=69777300

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2021514039A Active JP7436465B2 (ja) 2018-09-14 2019-09-16 毛細血管拡張性運動失調症変異（ＡＴＭ）キナーゼの選択的調節物質としての１－イソプロピル－３－メチル－８－（ピリジン－３－イル）－１，３－ジヒドロ－２Ｈ－イミダゾ［４，５－ｃ］シンノリン－２－オンおよびその使用
JP2024017316A Active JP7706585B2 (ja) 2018-09-14 2024-02-07 毛細血管拡張性運動失調症変異（ＡＴＭ）キナーゼの選択的調節物質としての１－イソプロピル－３－メチル－８－（ピリジン－３－イル）－１，３－ジヒドロ－２Ｈ－イミダゾ［４，５－ｃ］シンノリン－２－オンおよびその使用

Family Applications After (1)

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JP2024017316A Active JP7706585B2 (ja) 2018-09-14 2024-02-07 毛細血管拡張性運動失調症変異（ＡＴＭ）キナーゼの選択的調節物質としての１－イソプロピル－３－メチル－８－（ピリジン－３－イル）－１，３－ジヒドロ－２Ｈ－イミダゾ［４，５－ｃ］シンノリン－２－オンおよびその使用

Country Status (9)

Country Link
US (1) US12226414B2 (https=)
EP (2) EP4516318A3 (https=)
JP (2) JP7436465B2 (https=)
KR (1) KR102813324B1 (https=)
CN (2) CN112752758B (https=)
AU (1) AU2019339006B2 (https=)
CA (1) CA3111994A1 (https=)
ES (1) ES3001444T3 (https=)
WO (1) WO2020052688A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7436465B2 (ja) * 2018-09-14 2024-02-21 スゾウ、ザンロン、ファーマ、リミテッド 毛細血管拡張性運動失調症変異（ＡＴＭ）キナーゼの選択的調節物質としての１－イソプロピル－３－メチル－８－（ピリジン－３－イル）－１，３－ジヒドロ－２Ｈ－イミダゾ［４，５－ｃ］シンノリン－２－オンおよびその使用
AU2021433713A1 (en) * 2021-03-17 2023-09-28 Suzhou Zanrong Pharma Limited Selective modulators of ataxia telangiectasia mutated (atm) kinase and uses thereof
CN115304598B (zh) * 2021-08-25 2024-05-31 石药集团中奇制药技术（石家庄）有限公司 一种杂环类化合物及其制备方法和用途
GB202114704D0 (en) * 2021-10-14 2021-12-01 Univ Birmingham ATM inhibition
MX2024009184A (es) * 2022-01-26 2024-07-30 Chia Tai Tianqing Pharmaceutical Group Co Ltd Compuesto que contiene grupo hidrazino.
WO2025183591A1 (ru) * 2024-02-29 2025-09-04 Федеральное государственное унитарное предприятие "Всероссийский научно-исследовательский институт автоматики им. Н.Л. Духова" (ФГУП "ВНИИА") Производные 2н-[1,4]оксазино- и 2h-[1, 4]тиазино[3,2-c]хинолин-3(4h)-онов в качестве ингибиторов атм и dna-pk киназ

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9624482D0 (en) 1995-12-18 1997-01-15 Zeneca Phaema S A Chemical compounds
BR9707495A (pt) 1996-02-13 1999-07-27 Zeneca Ltd Derivado de quinazolina processo para a preparação do mesmo composição farmacêutica e processo para a produç o de um efeito antiangiogênico e/ou de redução de permeabilidade vascular em um animal de sangue quente
US6291455B1 (en) 1996-03-05 2001-09-18 Zeneca Limited 4-anilinoquinazoline derivatives
GB9718972D0 (en) 1996-09-25 1997-11-12 Zeneca Ltd Chemical compounds
NO2714752T3 (https=) * 2014-05-08 2018-04-21
GB201516504D0 (en) * 2015-09-17 2015-11-04 Astrazeneca Ab Imadazo(4,5-c)quinolin-2-one Compounds and their use in treating cancer
GB201519406D0 (en) 2015-11-03 2015-12-16 Astrazeneca Ab Imidazo[4,5-c]quinolin-2-one compounds and their use in treating cancer
GB201519568D0 (en) * 2015-11-05 2015-12-23 Astrazeneca Ab Imidazo[4,5-c]quinolin-2-one compounds and their use in treating cancer
US20190099421A1 (en) * 2016-03-21 2019-04-04 Astrazeneca Ab Cinnolin-4-amine compounds and their use in treating cancer
GB201608227D0 (en) * 2016-05-11 2016-06-22 Astrazeneca Ab Imidazo[4,5-c]quinolin-2-one compounds and their use in treating cancer
WO2019057757A1 (en) * 2017-09-20 2019-03-28 Astrazeneca Ab 1,3-DIHYDROIMIDAZO [4,5-C] CINNOLIN-2-ONE COMPOUNDS AND THEIR USE IN THE TREATMENT OF CANCER
JP7436465B2 (ja) * 2018-09-14 2024-02-21 スゾウ、ザンロン、ファーマ、リミテッド 毛細血管拡張性運動失調症変異（ＡＴＭ）キナーゼの選択的調節物質としての１－イソプロピル－３－メチル－８－（ピリジン－３－イル）－１，３－ジヒドロ－２Ｈ－イミダゾ［４，５－ｃ］シンノリン－２－オンおよびその使用

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