JPWO2020048976A5 - - Google Patents

Info

Publication number

JPWO2020048976A5

JPWO2020048976A5 JP2021510835A JP2021510835A JPWO2020048976A5 JP WO2020048976 A5 JPWO2020048976 A5 JP WO2020048976A5 JP 2021510835 A JP2021510835 A JP 2021510835A JP 2021510835 A JP2021510835 A JP 2021510835A JP WO2020048976 A5 JPWO2020048976 A5 JP WO2020048976A5

Authority

JP

Japan

Prior art keywords

virucidal

nanoparticle

nanoparticles

sln

cyclodextrin

Prior art date

2022-09-05

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 230000003253 viricidal Effects 0.000 claims description 56
• 239000002105 nanoparticle Substances 0.000 claims description 46
• 230000027455 binding Effects 0.000 claims description 38
• 239000003446 ligand Substances 0.000 claims description 38
• 229920000858 Cyclodextrin Polymers 0.000 claims description 14
• 239000000203 mixture Substances 0.000 claims description 12
• 125000000217 alkyl group Chemical group 0.000 claims description 11
• 238000004659 sterilization and disinfection Methods 0.000 claims description 8
• 150000004043 trisaccharides Chemical group 0.000 claims description 8
• 229920001450 Alpha-Cyclodextrin Polymers 0.000 claims description 4
• 239000001116 FEMA 4028 Substances 0.000 claims description 4
• 208000001756 Virus Disease Diseases 0.000 claims description 4
• 229940043377 alpha-cyclodextrin Drugs 0.000 claims description 4
• 235000011175 beta-cyclodextrine Nutrition 0.000 claims description 4
• 229960004853 betadex Drugs 0.000 claims description 4
• 230000000249 desinfective Effects 0.000 claims description 4
• 229940080345 gamma-cyclodextrin Drugs 0.000 claims description 4
• 230000001954 sterilising Effects 0.000 claims description 4
• 125000000547 substituted alkyl group Chemical group 0.000 claims description 4
• 241000712461 unidentified influenza virus Species 0.000 claims description 4
• HFHDHCJBZVLPGP-RWMJIURBSA-N α-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO HFHDHCJBZVLPGP-RWMJIURBSA-N 0.000 claims description 4
• WHGYBXFWUBPSRW-FOUAGVGXSA-N β-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 claims description 4
• GDSRMADSINPKSL-HSEONFRVSA-N γ-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO GDSRMADSINPKSL-HSEONFRVSA-N 0.000 claims description 4
• HUNVSYPDCXFGLB-KROWHOKKSA-N 3-Sialyl-N-acetyllactosamine Chemical compound O[C@@H]1[C@@H](O)C(NC(=O)C)O[C@H](CO)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@]2(O[C@H]([C@H](NC(C)=O)[C@@H](O)C2)[C@H](O)[C@H](O)CO)C(O)=O)[C@@H](O)[C@@H](CO)O1 HUNVSYPDCXFGLB-KROWHOKKSA-N 0.000 claims description 2
• 239000000443 aerosol Substances 0.000 claims description 2
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 2
• 239000000969 carrier Substances 0.000 claims description 2
• 150000001875 compounds Chemical class 0.000 claims description 2
• 239000003085 diluting agent Substances 0.000 claims description 2
• 239000003937 drug carrier Substances 0.000 claims description 2
• 239000000546 pharmaceutic aid Substances 0.000 claims description 2
• 229920000642 polymer Polymers 0.000 claims description 2
• 150000003839 salts Chemical class 0.000 claims description 2
• 239000011780 sodium chloride Substances 0.000 claims description 2
• 230000003381 solubilizing Effects 0.000 claims description 2
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 2
• 239000008194 pharmaceutical composition Substances 0.000 claims 4
• 125000006733 (C6-C15) alkyl group Chemical group 0.000 claims 1
• 239000003814 drug Substances 0.000 description 1