JPWO2020002851A5 - - Google Patents
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- Publication number
- JPWO2020002851A5 JPWO2020002851A5 JP2020573107A JP2020573107A JPWO2020002851A5 JP WO2020002851 A5 JPWO2020002851 A5 JP WO2020002851A5 JP 2020573107 A JP2020573107 A JP 2020573107A JP 2020573107 A JP2020573107 A JP 2020573107A JP WO2020002851 A5 JPWO2020002851 A5 JP WO2020002851A5
- Authority
- JP
- Japan
- Prior art keywords
- substance
- cyclodextrin
- hydroxypropyl
- less
- dry weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000126 substance Substances 0.000 claims description 40
- 229920000858 Cyclodextrin Polymers 0.000 claims description 4
- 239000012736 aqueous medium Substances 0.000 claims description 3
- 230000003993 interaction Effects 0.000 claims description 3
- 239000012528 membrane Substances 0.000 claims description 3
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 3
- 230000003381 solubilizing effect Effects 0.000 claims description 3
- 238000013268 sustained release Methods 0.000 claims description 3
- 239000012730 sustained-release form Substances 0.000 claims description 3
- 235000019640 taste Nutrition 0.000 claims description 3
- 230000000699 topical effect Effects 0.000 claims description 3
- 238000010521 absorption reaction Methods 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims 9
- ODLHGICHYURWBS-LKONHMLTSA-N trappsol cyclo Chemical compound CC(O)COC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)COCC(O)C)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1COCC(C)O ODLHGICHYURWBS-LKONHMLTSA-N 0.000 claims 9
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 claims 7
- GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical compound CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 claims 4
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 3
- 239000007864 aqueous solution Substances 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 239000003960 organic solvent Substances 0.000 claims 3
- XMGQYMWWDOXHJM-JTQLQIEISA-N (+)-α-limonene Chemical compound CC(=C)[C@@H]1CCC(C)=CC1 XMGQYMWWDOXHJM-JTQLQIEISA-N 0.000 claims 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
- 239000001116 FEMA 4028 Substances 0.000 claims 2
- 239000013543 active substance Substances 0.000 claims 2
- 235000011175 beta-cyclodextrine Nutrition 0.000 claims 2
- 229960004853 betadex Drugs 0.000 claims 2
- 239000008186 active pharmaceutical agent Substances 0.000 claims 1
- 230000000622 irritating effect Effects 0.000 claims 1
- TWNIBLMWSKIRAT-VFUOTHLCSA-N levoglucosan Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@H]2CO[C@@H]1O2 TWNIBLMWSKIRAT-VFUOTHLCSA-N 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 238000000746 purification Methods 0.000 claims 1
- 208000011117 substance-related disease Diseases 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 235000019658 bitter taste Nutrition 0.000 description 2
- 230000007794 irritation Effects 0.000 description 2
- 229940079593 drug Drugs 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024130931A JP2024150779A (ja) | 2018-06-29 | 2024-08-07 | 新規なヒドロキシプロピル－β－シクロデキストリン及びそれを生成するための方法 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1855952A FR3083234B1 (fr) | 2018-06-29 | 2018-06-29 | Nouvelles hydroxypropyl-beta-cyclodextrines et leurs procedes de preparation |
| FR1855952 | 2018-06-29 | ||
| FR1902375 | 2019-03-08 | ||
| FR1902375 | 2019-03-08 | ||
| PCT/FR2019/051602 WO2020002851A1 (fr) | 2018-06-29 | 2019-06-28 | NOUVELLE HYDROXYPROPYL-β-CYCLODEXTRINE ET SON PROCÉDÉ DE PRÉPARATION |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024130931A Division JP2024150779A (ja) | 2018-06-29 | 2024-08-07 | 新規なヒドロキシプロピル－β－シクロデキストリン及びそれを生成するための方法 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2021529243A JP2021529243A (ja) | 2021-10-28 |
| JPWO2020002851A5 true JPWO2020002851A5 (https=) | 2023-08-10 |
| JP2021529243A5 JP2021529243A5 (https=) | 2023-08-10 |
| JP7581055B2 JP7581055B2 (ja) | 2024-11-12 |
Family
ID=67551566
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020573107A Active JP7581055B2 (ja) | 2018-06-29 | 2019-06-28 | 新規なヒドロキシプロピル－β－シクロデキストリン及びそれを生成するための方法 |
| JP2024130931A Pending JP2024150779A (ja) | 2018-06-29 | 2024-08-07 | 新規なヒドロキシプロピル－β－シクロデキストリン及びそれを生成するための方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024130931A Pending JP2024150779A (ja) | 2018-06-29 | 2024-08-07 | 新規なヒドロキシプロピル－β－シクロデキストリン及びそれを生成するための方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US12522670B2 (https=) |
| EP (1) | EP3814386A1 (https=) |
| JP (2) | JP7581055B2 (https=) |
| KR (1) | KR102912248B1 (https=) |
| CN (1) | CN112334494A (https=) |
| CA (1) | CA3104568A1 (https=) |
| IL (1) | IL279845A (https=) |
| MX (1) | MX2020013689A (https=) |
| SG (1) | SG11202013126QA (https=) |
| WO (1) | WO2020002851A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7607935B2 (ja) | 2019-01-03 | 2025-01-06 | サイクラリティ・セラピューティクス・インコーポレイテッド | シクロデキストリン二量体、それらの組成物、及びそれらの使用 |
| WO2023156966A1 (en) | 2022-02-18 | 2023-08-24 | Beren Therapeutics P.B.C. | Compositions of hydroxypropyl-beta-cyclodextrin and methods of purifying the same |
| JP2024064599A (ja) * | 2022-10-28 | 2024-05-14 | 国立大学法人 熊本大学 | 細胞内コレステロール輸送障害に起因する疾患又は障害の治療、予防又は改善用組成物 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3346123A1 (de) * | 1983-12-21 | 1985-06-27 | Janssen Pharmaceutica, N.V., Beerse | Pharmazeutische praeparate von in wasser schwerloeslichen oder instabilen arzneistoffen und verfahren zu ihrer herstellung |
| HK1009335A1 (en) * | 1989-04-03 | 1999-05-28 | Janssen Pharmaceutica N.V. | Regioselective substitutions in cyclodextrins |
| US5096893A (en) | 1989-04-03 | 1992-03-17 | The United States Of America As Represented By The Department Of Health And Human Services | Regioselective substitutions in cyclodextrins |
| KR920008700A (ko) * | 1990-10-29 | 1992-05-28 | 이헌조 | 데크의 테이프 삽입유무 표시방법 |
| DE19505263A1 (de) * | 1995-02-16 | 1996-08-22 | Consortium Elektrochem Ind | Verfahren zur Reinigung von wasserlöslichen Cyclodextrinderivaten |
| CN1155888A (zh) * | 1995-06-08 | 1997-07-30 | 火箭兄弟公司 | 粉状羟丙基-β-环糊精组合物和其制备方法 |
| FR2735136B1 (fr) * | 1995-06-08 | 1997-08-14 | Roquette Freres | Composition pulverulente d'hydroxypropyl-betacyclodextrine et son procede de preparation. |
| FR2738149B1 (fr) * | 1995-09-06 | 1997-11-14 | Chauvin Lab Sa | Collyre a base d'indometacine pret a l'emploi |
| US5744154A (en) | 1995-09-06 | 1998-04-28 | Laboratoire Chauvin S.A. | Ready-to-use indomethacin-based eye lotion |
| EP1655034A1 (en) | 2004-10-10 | 2006-05-10 | Université de Liège | Use of cyclodextrin for treatment and prevention of bronchial inflammatory diseases. |
| WO2012037117A1 (en) | 2010-09-13 | 2012-03-22 | Bev-Rx, Inc. | Aqueous drug delivery system comprising off - flavor masking agent |
| CN102558394B (zh) * | 2010-12-07 | 2014-11-12 | 石药集团中奇制药技术（石家庄）有限公司 | 羟丙基-β-环糊精的制备方法 |
| CN102040675B (zh) * | 2010-12-22 | 2012-10-03 | 石药集团中诺药业（石家庄）有限公司 | 一种羟丙基-β-环糊精的制备方法 |
| US8791269B2 (en) | 2011-07-01 | 2014-07-29 | Fondazione Istituto Insubrico Di Ricerca Per La Vita | Complex of amorphous tomoxiprole and cyclodextrin with fast dissolution rate and process for the preparation thereof |
| FR3014694B1 (fr) * | 2013-12-13 | 2016-11-11 | Roquette Freres | Compositions a base de methyl-cyclodextrines pour le traitement et/ou la prevention de maladies par augmentation du taux de cholesterol-hdl |
| CA2988529A1 (en) | 2015-06-10 | 2016-12-15 | Vtesse, Inc. | Hydroxypropyl beta-cyclodextrin compositions and methods |
| CN108034010A (zh) * | 2017-12-29 | 2018-05-15 | 山东滨州智源生物科技有限公司 | 一种羟丙基环糊精的绿色制备方法 |
-
2019
- 2019-06-28 MX MX2020013689A patent/MX2020013689A/es unknown
- 2019-06-28 US US17/255,153 patent/US12522670B2/en active Active
- 2019-06-28 WO PCT/FR2019/051602 patent/WO2020002851A1/fr not_active Ceased
- 2019-06-28 SG SG11202013126QA patent/SG11202013126QA/en unknown
- 2019-06-28 CN CN201980044053.4A patent/CN112334494A/zh active Pending
- 2019-06-28 EP EP19752213.9A patent/EP3814386A1/fr active Pending
- 2019-06-28 JP JP2020573107A patent/JP7581055B2/ja active Active
- 2019-06-28 KR KR1020207037131A patent/KR102912248B1/ko active Active
- 2019-06-28 CA CA3104568A patent/CA3104568A1/fr active Pending
-
2020
- 2020-12-29 IL IL279845A patent/IL279845A/en unknown
-
2024
- 2024-08-07 JP JP2024130931A patent/JP2024150779A/ja active Pending
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