JPWO2019222764A5 - - Google Patents
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- JPWO2019222764A5 JPWO2019222764A5 JP2020563751A JP2020563751A JPWO2019222764A5 JP WO2019222764 A5 JPWO2019222764 A5 JP WO2019222764A5 JP 2020563751 A JP2020563751 A JP 2020563751A JP 2020563751 A JP2020563751 A JP 2020563751A JP WO2019222764 A5 JPWO2019222764 A5 JP WO2019222764A5
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- JP
- Japan
- Prior art keywords
- compound
- composition
- composition according
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- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 230000036470 plasma concentration Effects 0.000 claims 15
- 229940125904 compound 1 Drugs 0.000 claims 14
- 239000012736 aqueous medium Substances 0.000 claims 4
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 4
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 4
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 4
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 4
- 239000000546 pharmaceutical excipient Substances 0.000 claims 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 3
- AICOOMRHRUFYCM-ZRRPKQBOSA-N oxazine, 1 Chemical compound C([C@@H]1[C@H](C(C[C@]2(C)[C@@H]([C@H](C)N(C)C)[C@H](O)C[C@]21C)=O)CC1=CC2)C[C@H]1[C@@]1(C)[C@H]2N=C(C(C)C)OC1 AICOOMRHRUFYCM-ZRRPKQBOSA-N 0.000 claims 3
- 239000011248 coating agent Substances 0.000 claims 2
- 238000000576 coating method Methods 0.000 claims 2
- 208000002815 pulmonary hypertension Diseases 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000012453 solvate Substances 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- -1 (4-chlorophenyl) (phenyl) carbamoyloxy Chemical group 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 239000001488 sodium phosphate Substances 0.000 claims 1
- 229910000162 sodium phosphate Inorganic materials 0.000 claims 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024109855A JP2025011059A (ja) | 2018-05-16 | 2024-07-08 | Ｐｇｉ２－受容体アゴニストを含む組成物、およびその調製のためのプロセス |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862672384P | 2018-05-16 | 2018-05-16 | |
| PCT/US2019/033727 WO2019222764A1 (en) | 2018-05-16 | 2019-05-23 | Compositions comprising pgi2-receptor agonists and processes for the preparation thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024109855A Division JP2025011059A (ja) | 2018-05-16 | 2024-07-08 | Ｐｇｉ２－受容体アゴニストを含む組成物、およびその調製のためのプロセス |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2021525704A JP2021525704A (ja) | 2021-09-27 |
| JPWO2019222764A5 true JPWO2019222764A5 (https=) | 2022-05-27 |
| JP2021525704A5 JP2021525704A5 (https=) | 2022-05-27 |
| JP7519909B2 JP7519909B2 (ja) | 2024-07-22 |
Family
ID=67660444
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020563751A Active JP7519909B2 (ja) | 2018-05-16 | 2019-05-23 | Ｐｇｉ２－受容体アゴニストを含む組成物、およびその調製のためのプロセス |
| JP2024109855A Pending JP2025011059A (ja) | 2018-05-16 | 2024-07-08 | Ｐｇｉ２－受容体アゴニストを含む組成物、およびその調製のためのプロセス |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024109855A Pending JP2025011059A (ja) | 2018-05-16 | 2024-07-08 | Ｐｇｉ２－受容体アゴニストを含む組成物、およびその調製のためのプロセス |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US12433865B2 (https=) |
| EP (1) | EP3796902A1 (https=) |
| JP (2) | JP7519909B2 (https=) |
| KR (1) | KR20210040837A (https=) |
| WO (1) | WO2019222764A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3977985B1 (en) | 2017-03-01 | 2023-09-06 | Arena Pharmaceuticals, Inc. | Compositions comprising pgi2-receptor agonists and processes for the preparation thereof |
| US12098116B2 (en) | 2022-02-15 | 2024-09-24 | United Therapeutics Corporation | Crystalline prostacyclin (IP) receptor agonist and uses thereof |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2945530A1 (de) | 1979-11-10 | 1981-06-04 | Chemische Werke Hüls AG, 4370 Marl | Harnstoffe mit cyclischen substituenten, ihre herstellung und verwendung als herbizide |
| JPH03160438A (ja) | 1989-11-20 | 1991-07-10 | Konica Corp | ハロゲン化銀カラー写真感光材料 |
| EP0442448A3 (en) | 1990-02-13 | 1992-08-12 | Bristol-Myers Squibb Company | Heterocyclic carboxylic acids and esters |
| CA2085844A1 (en) | 1991-12-27 | 1993-06-28 | Nobuyuki Hamanaka | Fused benzeneoxyacetic acid derivatives |
| JPH06329598A (ja) | 1993-05-19 | 1994-11-29 | Daicel Chem Ind Ltd | エステルの製造方法 |
| GT199800126A (es) | 1997-08-29 | 2000-01-29 | Terapia de combinacion. | |
| JPH11269138A (ja) | 1998-03-20 | 1999-10-05 | Mitsubishi Paper Mills Ltd | 有機塩基発生剤 |
| EP1046631A1 (en) | 1999-04-19 | 2000-10-25 | Rolic AG | Liquid crystalline compounds |
| GB9908934D0 (en) | 1999-04-19 | 1999-06-16 | Rolic Ag | Liquid crystalline compounds |
| US20040048844A1 (en) | 1999-10-20 | 2004-03-11 | Bristol-Myers Squibb Pharma Company | Acylsemicarbazides as cyclin dependent kinase inhibitors useful as anti-cancer and anti-proliferative agents |
| WO2002055484A1 (en) | 2001-01-12 | 2002-07-18 | Takeda Chemical Industries, Ltd. | Biaryl compound, process for producing the same, and agent |
| WO2003007888A2 (en) | 2001-07-20 | 2003-01-30 | Adipogenix, Inc. | Fat accumulation-modulating compounds |
| MXPA04001253A (es) | 2001-08-09 | 2004-06-03 | Ono Pharmaceutical Co | Derivados de acidos carboxilicos y agente farmaceutico que comprende los mismos como ingrediente activo. |
| TW200307539A (en) | 2002-02-01 | 2003-12-16 | Bristol Myers Squibb Co | Cycloalkyl inhibitors of potassium channel function |
| US7086532B2 (en) | 2003-07-16 | 2006-08-08 | Allergan, Inc. | Titration/compliance pack with increasing doses |
| TWI293715B (en) | 2002-10-10 | 2008-02-21 | Sipix Imaging Inc | A method for inducing or enhancing the threshold of an electrophoretic display, an electrophoretic fluid and an electrophoretic display |
| CN101723891A (zh) | 2003-02-10 | 2010-06-09 | 沃泰克斯药物股份有限公司 | 通过使n-芳基氨基甲酸酯与卤代杂芳基反应制备n-杂芳基-n-芳基胺的方法和类似方法 |
| JP4402413B2 (ja) | 2003-09-29 | 2010-01-20 | 財団法人２１あおもり産業総合支援センター | Ｕ字型化合物およびこれを含む液晶組成物 |
| DE102004006785A1 (de) | 2004-02-11 | 2005-09-08 | Mayr, Herbert, Prof. Dr. | Verfahren zur CC-Bindungsknüpfung zwischen elektrophilen Substraten und TT-Verbindungen in neutralen bis basischen wässrigen oder alkoholischen Lösungsmitteln ohne den Einsatz einer Lewis- oder Protonensäure |
| US20060063930A1 (en) | 2004-08-20 | 2006-03-23 | Agoston Gregory E | Compositions and methods comprising proteinase activated receptor antagonists |
| JP2006083085A (ja) | 2004-09-15 | 2006-03-30 | Kyowa Hakko Kogyo Co Ltd | 二環性ピリミジン誘導体の製造法およびその合成中間体 |
| JP4792731B2 (ja) | 2004-11-12 | 2011-10-12 | Ｄｉｃ株式会社 | 重合性液晶組成物及び当該組成物の硬化物 |
| WO2007051255A1 (en) | 2005-11-04 | 2007-05-10 | The University Of Sydney | Process for the preparation of compounds containing an azacyclic ring system |
| JP2007161867A (ja) | 2005-12-14 | 2007-06-28 | Toyo Ink Mfg Co Ltd | インキ組成物 |
| CN101489544A (zh) | 2006-05-09 | 2009-07-22 | 海玛奎斯特医药公司 | 治疗血液病的方法 |
| US20110086916A1 (en) | 2007-09-12 | 2011-04-14 | Merz Pharma Gmbh & Co. Kgaa | Interval therapy for the treatment of tinnitus |
| KR20230085944A (ko) | 2008-03-18 | 2023-06-14 | 아레나 파마슈티칼스, 인크. | 프로스타시클린 （ｐｇｉ２） 수용체와 관련된 장애의 치료에 유용한 상기 수용체의 조절제 |
| JP5603343B2 (ja) | 2008-11-26 | 2014-10-08 | アリーナ ファーマシューティカルズ， インコーポレイテッド | 関連する障害を処置するために有用なプロスタサイクリン（ｐｇｉ２）受容体モジュレーターとしてのピラゾリル置換炭酸誘導体 |
| PT2370413E (pt) | 2008-12-08 | 2015-10-23 | Arena Pharm Inc | Moduladores do recetor da prostaciclina (pgi2) úteis para o tratamento de distúrbios relacionados com o mesmo |
| EP2480526A1 (en) | 2009-09-23 | 2012-08-01 | Arena Pharmaceuticals, Inc. | Crystalline forms and processes for the preparation of pgi2 receptor agonists |
| WO2016065103A1 (en) | 2014-10-23 | 2016-04-28 | Arena Pharmaceuticals, Inc. | Method of treating conditions related to the pgi2 receptor |
| KR20260020212A (ko) * | 2016-11-10 | 2026-02-10 | 아레나 파마슈티칼스, 인크. | 라리네팍 및 다른 제제의 조합에 의한 pah의 치료 방법 |
| EP3977985B1 (en) | 2017-03-01 | 2023-09-06 | Arena Pharmaceuticals, Inc. | Compositions comprising pgi2-receptor agonists and processes for the preparation thereof |
-
2019
- 2019-05-23 WO PCT/US2019/033727 patent/WO2019222764A1/en not_active Ceased
- 2019-05-23 KR KR1020207036346A patent/KR20210040837A/ko not_active Ceased
- 2019-05-23 JP JP2020563751A patent/JP7519909B2/ja active Active
- 2019-05-23 US US17/055,065 patent/US12433865B2/en active Active
- 2019-05-23 EP EP19755451.2A patent/EP3796902A1/en active Pending
-
2024
- 2024-07-08 JP JP2024109855A patent/JP2025011059A/ja active Pending
-
2025
- 2025-08-28 US US19/313,204 patent/US20250375408A1/en active Pending
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