JPWO2019217587A5 - - Google Patents

Download PDF

Info

Publication number
JPWO2019217587A5
JPWO2019217587A5 JP2020560761A JP2020560761A JPWO2019217587A5 JP WO2019217587 A5 JPWO2019217587 A5 JP WO2019217587A5 JP 2020560761 A JP2020560761 A JP 2020560761A JP 2020560761 A JP2020560761 A JP 2020560761A JP WO2019217587 A5 JPWO2019217587 A5 JP WO2019217587A5
Authority
JP
Japan
Prior art keywords
amino acid
domain
tag
multispecific antibody
polypeptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2020560761A
Other languages
English (en)
Japanese (ja)
Other versions
JP2021523101A5 (https=
JP2021523101A (ja
Publication date
Application filed filed Critical
Priority claimed from PCT/US2019/031379 external-priority patent/WO2019217587A1/en
Publication of JP2021523101A publication Critical patent/JP2021523101A/ja
Publication of JP2021523101A5 publication Critical patent/JP2021523101A5/ja
Publication of JPWO2019217587A5 publication Critical patent/JPWO2019217587A5/ja
Priority to JP2023191593A priority Critical patent/JP7785734B2/ja
Priority to JP2025219116A priority patent/JP2026035775A/ja
Pending legal-status Critical Current

Links

JP2020560761A 2018-05-08 2019-05-08 切断可能なｃ末端電荷対タグを有する二重特異性抗体 Pending JP2021523101A (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2023191593A JP7785734B2 (ja) 2018-05-08 2023-11-09 切断可能なｃ末端電荷対タグを有する二重特異性抗体
JP2025219116A JP2026035775A (ja) 2018-05-08 2025-12-02 切断可能なｃ末端電荷対タグを有する二重特異性抗体

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862668626P 2018-05-08 2018-05-08
US62/668,626 2018-05-08
PCT/US2019/031379 WO2019217587A1 (en) 2018-05-08 2019-05-08 Bispecific antibodies with cleavable c-terminal charge-paired tags

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2023191593A Division JP7785734B2 (ja) 2018-05-08 2023-11-09 切断可能なｃ末端電荷対タグを有する二重特異性抗体

Publications (3)

Publication Number Publication Date
JP2021523101A JP2021523101A (ja) 2021-09-02
JP2021523101A5 JP2021523101A5 (https=) 2022-05-16
JPWO2019217587A5 true JPWO2019217587A5 (https=) 2022-05-16

Family

ID=66676901

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2020560761A Pending JP2021523101A (ja) 2018-05-08 2019-05-08 切断可能なｃ末端電荷対タグを有する二重特異性抗体
JP2023191593A Active JP7785734B2 (ja) 2018-05-08 2023-11-09 切断可能なｃ末端電荷対タグを有する二重特異性抗体
JP2025219116A Pending JP2026035775A (ja) 2018-05-08 2025-12-02 切断可能なｃ末端電荷対タグを有する二重特異性抗体

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2023191593A Active JP7785734B2 (ja) 2018-05-08 2023-11-09 切断可能なｃ末端電荷対タグを有する二重特異性抗体
JP2025219116A Pending JP2026035775A (ja) 2018-05-08 2025-12-02 切断可能なｃ末端電荷対タグを有する二重特異性抗体

Country Status (8)

Country Link
US (2) US12384849B2 (https=)
EP (1) EP3790904A1 (https=)
JP (3) JP2021523101A (https=)
AU (2) AU2019265699B2 (https=)
CA (1) CA3099450A1 (https=)
MA (1) MA52571A (https=)
MX (2) MX2020011844A (https=)
WO (1) WO2019217587A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2020304671A1 (en) * 2019-06-28 2022-01-20 Amgen Inc. Anti-CGRP receptor/anti-PAC1 receptor bispecific antigen binding proteins
EP4466020A4 (en) * 2022-01-21 2026-04-15 Lyvgen Biopharma Holdings Ltd Multi-specific antibodies and their uses in avidity receptor cross-linking and immune modulation

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5260203A (en) 1986-09-02 1993-11-09 Enzon, Inc. Single polypeptide chain binding molecules
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
ATE87659T1 (de) 1986-09-02 1993-04-15 Enzon Lab Inc Bindungsmolekuele mit einzelpolypeptidkette.
DE3920358A1 (de) 1989-06-22 1991-01-17 Behringwerke Ag Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
US5932448A (en) 1991-11-29 1999-08-03 Protein Design Labs., Inc. Bispecific antibody heterodimers
US6096871A (en) 1995-04-14 2000-08-01 Genentech, Inc. Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life
JP4046354B2 (ja) 1996-03-18 2008-02-13 ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム 増大した半減期を有する免疫グロブリン様ドメイン
DE19819846B4 (de) 1998-05-05 2016-11-24 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Multivalente Antikörper-Konstrukte
US7101692B2 (en) * 1999-04-15 2006-09-05 The Regents Of The University Of California Identification of sortase gene
WO2001000814A2 (en) * 1999-06-25 2001-01-04 Universität Zürich Hetero-associating coiled-coil peptides and screenign method therefor
US6833441B2 (en) 2001-08-01 2004-12-21 Abmaxis, Inc. Compositions and methods for generating chimeric heteromultimers
US20050214300A1 (en) * 2002-11-25 2005-09-29 Chiron Corporation Methods for treating cancer using Porimin as a target
EP3050963B1 (en) 2005-03-31 2019-09-18 Chugai Seiyaku Kabushiki Kaisha Process for production of polypeptide by regulation of assembly
US8703132B2 (en) 2009-06-18 2014-04-22 Hoffmann-La Roche, Inc. Bispecific, tetravalent antigen binding proteins
KR20120108967A (ko) 2009-09-16 2012-10-05 제넨테크, 인크. 코일드 코일 및/또는 테더 함유 단백질 복합체 및 그의 용도
EP2824111B1 (en) * 2010-04-30 2017-03-22 Alexion Pharmaceuticals, Inc. Anti-C5A Antibodies and Methods for Using the Antibodies
US10851178B2 (en) * 2011-10-10 2020-12-01 Xencor, Inc. Heterodimeric human IgG1 polypeptides with isoelectric point modifications
JO3519B1 (ar) * 2013-01-25 2020-07-05 Amgen Inc تركيبات أجسام مضادة لأجل cdh19 و cd3
SG11201508732PA (en) * 2013-04-25 2015-11-27 Scripps Korea Antibody Inst Method for refining protein including self-cutting cassette and use thereof
RS61907B1 (sr) 2015-04-06 2021-06-30 Subdomain Llc Polipeptidi koji sadrže de novo vezujući domen i njihova primena
KR102095096B1 (ko) * 2015-08-26 2020-03-30 바이슨 테라퓨틱스 인크. 다중특이적 항체 플랫폼 및 관련 방법

Similar Documents

Publication Publication Date Title
US5525491A (en) Serine-rich peptide linkers
Berdichevsky et al. Matrix-assisted refolding of single-chain Fv–cellulose binding domain fusion proteins
CN101704879A (zh) 具有改进的特异性的新型免疫球蛋白结合蛋白
Nilsson et al. Multiple affinity domains for the detection, purification and immobilization of recombinant proteins
JP6382826B2 (ja) アルブミン結合ポリペプチド
CA2477270A1 (en) Nanostructures containing antibody assembly units
CN104640983A (zh) 亲和分离基质用蛋白质配体
US9481715B2 (en) Peptides capable of forming a convalent complex, and uses thereof
JP2019163270A (ja) 親和性タンパク質及びその使用
CN101970456B (zh) 标签肽及其应用
JP2021523101A5 (https=)
CN105636976A (zh) 新型肽标签以及其用途
JPWO2019217587A5 (https=)
CN117659145B (zh) 链霉亲和素第27位丝氨酸突变的突变蛋白s27v及其应用
WO2010123013A1 (ja) プロテアーゼ認識配列を有するタグペプチドおよびその利用
CN104812773A (zh) 表位标记用抗体、杂交瘤细胞株以及其用途
JP4471721B2 (ja) 抗インターロイキン２１受容体（ｉｌ−２１ｒ）抗体および本抗体を産生するハイブリドーマ
CN113087807B (zh) 用于检测糖类抗原的基于志贺毒素b亚基重组蛋白的探针、制备方法
WO2017132395A1 (en) Methods and compositions to increase the rate of ligation reactions catalyzed by a sortase
WO2005121178A2 (en) Immunoaffinity chromatography polyol-responsive monoclonal antibodies
CN120842417A (zh) Strep-tag II特异性抗体及其应用
JP2023513802A (ja) 構造研究の促進のためのｐｒｏ－マクロボディ
Mersich et al. Identification of a ligand for IgG‐Fc derived from a soluble peptide library based on fusion proteins secreted by S. cerevisiae
EP3875472A1 (en) Novel immunoglobulin binding polypeptides
CN117836313A (zh) 嵌合IgG-Fc结合配体多肽及其用于IgG亲和纯化的用途