AU2019265699B2 - Bispecific antibodies with cleavable C-terminal charge-paired tags - Google Patents

Bispecific antibodies with cleavable C-terminal charge-paired tags

Info

Publication number
AU2019265699B2
AU2019265699B2 AU2019265699A AU2019265699A AU2019265699B2 AU 2019265699 B2 AU2019265699 B2 AU 2019265699B2 AU 2019265699 A AU2019265699 A AU 2019265699A AU 2019265699 A AU2019265699 A AU 2019265699A AU 2019265699 B2 AU2019265699 B2 AU 2019265699B2
Authority
AU
Australia
Prior art keywords
amino acid
domain
polypeptide
seq
tag
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2019265699A
Other languages
English (en)
Other versions
AU2019265699A1 (en
Inventor
Neeraj J AGRAWAL
Kevin Graham
Alex W JACOBITZ
John K KAWOOYA
Ray Lieh Yoon LOW
Christopher MOHR
Dante ROMANINI
Stephen Smith
Oliver Thiel
Victoria WAGNER
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amgen Inc
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of AU2019265699A1 publication Critical patent/AU2019265699A1/en
Priority to AU2026201242A priority Critical patent/AU2026201242A1/en
Application granted granted Critical
Publication of AU2019265699B2 publication Critical patent/AU2019265699B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2875—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AU2019265699A 2018-05-08 2019-05-08 Bispecific antibodies with cleavable C-terminal charge-paired tags Active AU2019265699B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2026201242A AU2026201242A1 (en) 2018-05-08 2026-02-19 Bispecific antibodies with cleavable C-terminal charge-paired tags

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862668626P 2018-05-08 2018-05-08
US62/668,626 2018-05-08
PCT/US2019/031379 WO2019217587A1 (en) 2018-05-08 2019-05-08 Bispecific antibodies with cleavable c-terminal charge-paired tags

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2026201242A Division AU2026201242A1 (en) 2018-05-08 2026-02-19 Bispecific antibodies with cleavable C-terminal charge-paired tags

Publications (2)

Publication Number Publication Date
AU2019265699A1 AU2019265699A1 (en) 2021-01-07
AU2019265699B2 true AU2019265699B2 (en) 2026-03-12

Family

ID=66676901

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2019265699A Active AU2019265699B2 (en) 2018-05-08 2019-05-08 Bispecific antibodies with cleavable C-terminal charge-paired tags
AU2026201242A Pending AU2026201242A1 (en) 2018-05-08 2026-02-19 Bispecific antibodies with cleavable C-terminal charge-paired tags

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2026201242A Pending AU2026201242A1 (en) 2018-05-08 2026-02-19 Bispecific antibodies with cleavable C-terminal charge-paired tags

Country Status (8)

Country Link
US (2) US12384849B2 (https=)
EP (1) EP3790904A1 (https=)
JP (3) JP2021523101A (https=)
AU (2) AU2019265699B2 (https=)
CA (1) CA3099450A1 (https=)
MA (1) MA52571A (https=)
MX (2) MX2020011844A (https=)
WO (1) WO2019217587A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2020304671A1 (en) * 2019-06-28 2022-01-20 Amgen Inc. Anti-CGRP receptor/anti-PAC1 receptor bispecific antigen binding proteins
EP4466020A4 (en) * 2022-01-21 2026-04-15 Lyvgen Biopharma Holdings Ltd Multi-specific antibodies and their uses in avidity receptor cross-linking and immune modulation

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017034770A1 (en) * 2015-08-26 2017-03-02 Bison Therapeutics Inc. Multispecific antibody platform and related methods

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US5260203A (en) 1986-09-02 1993-11-09 Enzon, Inc. Single polypeptide chain binding molecules
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
ATE87659T1 (de) 1986-09-02 1993-04-15 Enzon Lab Inc Bindungsmolekuele mit einzelpolypeptidkette.
DE3920358A1 (de) 1989-06-22 1991-01-17 Behringwerke Ag Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
US5932448A (en) 1991-11-29 1999-08-03 Protein Design Labs., Inc. Bispecific antibody heterodimers
US6096871A (en) 1995-04-14 2000-08-01 Genentech, Inc. Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life
JP4046354B2 (ja) 1996-03-18 2008-02-13 ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム 増大した半減期を有する免疫グロブリン様ドメイン
DE19819846B4 (de) 1998-05-05 2016-11-24 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Multivalente Antikörper-Konstrukte
US7101692B2 (en) * 1999-04-15 2006-09-05 The Regents Of The University Of California Identification of sortase gene
WO2001000814A2 (en) * 1999-06-25 2001-01-04 Universität Zürich Hetero-associating coiled-coil peptides and screenign method therefor
US6833441B2 (en) 2001-08-01 2004-12-21 Abmaxis, Inc. Compositions and methods for generating chimeric heteromultimers
US20050214300A1 (en) * 2002-11-25 2005-09-29 Chiron Corporation Methods for treating cancer using Porimin as a target
EP3050963B1 (en) 2005-03-31 2019-09-18 Chugai Seiyaku Kabushiki Kaisha Process for production of polypeptide by regulation of assembly
US8703132B2 (en) 2009-06-18 2014-04-22 Hoffmann-La Roche, Inc. Bispecific, tetravalent antigen binding proteins
KR20120108967A (ko) 2009-09-16 2012-10-05 제넨테크, 인크. 코일드 코일 및/또는 테더 함유 단백질 복합체 및 그의 용도
EP2824111B1 (en) * 2010-04-30 2017-03-22 Alexion Pharmaceuticals, Inc. Anti-C5A Antibodies and Methods for Using the Antibodies
US10851178B2 (en) * 2011-10-10 2020-12-01 Xencor, Inc. Heterodimeric human IgG1 polypeptides with isoelectric point modifications
JO3519B1 (ar) * 2013-01-25 2020-07-05 Amgen Inc تركيبات أجسام مضادة لأجل cdh19 و cd3
SG11201508732PA (en) * 2013-04-25 2015-11-27 Scripps Korea Antibody Inst Method for refining protein including self-cutting cassette and use thereof
RS61907B1 (sr) 2015-04-06 2021-06-30 Subdomain Llc Polipeptidi koji sadrže de novo vezujući domen i njihova primena

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017034770A1 (en) * 2015-08-26 2017-03-02 Bison Therapeutics Inc. Multispecific antibody platform and related methods

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BEERLI R R, HELL T, MERKEL A S, GRAWUNDER U: "Sortase Enzyme-Mediated Generation of Site-Specifically Conjugated Antibody Drug Conjugates with High In Vitro and In Vivo Potency.", PLOS ONE, PUBLIC LIBRARY OF SCIENCE, US, vol. 10, no. 7, 1 July 2015 (2015-07-01), US, pages e0131177 - e0131177-17, XP002756397, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0131177 *
KOEN WAGNER, MARK J. KWAKKENBOS, YVONNE B. CLAASSEN, KELLY MAIJOOR, MARTINO BÖHNE, KOENRAAD F. VAN DER SLUIJS, MARTIN D. WITTE, DI: "Bispecific antibody generated with sortase and click chemistry has broad antiinfluenza virus activity", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, vol. 111, no. 47, 25 November 2014 (2014-11-25), pages 16820 - 16825, XP055205415, ISSN: 00278424, DOI: 10.1073/pnas.1408605111 *

Also Published As

Publication number Publication date
JP2024023264A (ja) 2024-02-21
AU2019265699A1 (en) 2021-01-07
MX2020011844A (es) 2021-04-13
US20220089756A1 (en) 2022-03-24
EP3790904A1 (en) 2021-03-17
JP7785734B2 (ja) 2025-12-15
AU2026201242A1 (en) 2026-04-23
JP2021523101A (ja) 2021-09-02
CA3099450A1 (en) 2019-11-14
MX2025001939A (es) 2025-04-02
US12384849B2 (en) 2025-08-12
MA52571A (fr) 2021-03-17
US20250197518A1 (en) 2025-06-19
WO2019217587A1 (en) 2019-11-14
JP2026035775A (ja) 2026-03-04

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