JPWO2019183201A5 - - Google Patents
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- Publication number
- JPWO2019183201A5 JPWO2019183201A5 JP2020550177A JP2020550177A JPWO2019183201A5 JP WO2019183201 A5 JPWO2019183201 A5 JP WO2019183201A5 JP 2020550177 A JP2020550177 A JP 2020550177A JP 2020550177 A JP2020550177 A JP 2020550177A JP WO2019183201 A5 JPWO2019183201 A5 JP WO2019183201A5
- Authority
- JP
- Japan
- Prior art keywords
- scaffold
- hydrogel scaffold
- hydrogel
- root canal
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000000017 hydrogel Substances 0.000 claims description 31
- 239000000463 material Substances 0.000 claims description 24
- 238000000034 method Methods 0.000 claims description 19
- 210000004262 dental pulp cavity Anatomy 0.000 claims description 16
- 230000008595 infiltration Effects 0.000 claims description 8
- 238000001764 infiltration Methods 0.000 claims description 8
- 230000002519 immonomodulatory effect Effects 0.000 claims description 7
- 230000002491 angiogenic effect Effects 0.000 claims description 6
- 230000001272 neurogenic effect Effects 0.000 claims description 6
- 230000003399 chemotactic effect Effects 0.000 claims description 5
- 108010010803 Gelatin Proteins 0.000 claims description 4
- 206010061218 Inflammation Diseases 0.000 claims description 4
- 239000003246 corticosteroid Substances 0.000 claims description 4
- 229940079593 drug Drugs 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 4
- 239000008273 gelatin Substances 0.000 claims description 4
- 229920000159 gelatin Polymers 0.000 claims description 4
- 235000019322 gelatine Nutrition 0.000 claims description 4
- 235000011852 gelatine desserts Nutrition 0.000 claims description 4
- 238000011065 in-situ storage Methods 0.000 claims description 4
- 230000004054 inflammatory process Effects 0.000 claims description 4
- 102000019034 Chemokines Human genes 0.000 claims description 2
- 108010012236 Chemokines Proteins 0.000 claims description 2
- 108090000695 Cytokines Proteins 0.000 claims description 2
- 102000004127 Cytokines Human genes 0.000 claims description 2
- 108010074604 Epoetin Alfa Proteins 0.000 claims description 2
- 108010029961 Filgrastim Proteins 0.000 claims description 2
- 102100039619 Granulocyte colony-stimulating factor Human genes 0.000 claims description 2
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims description 2
- 230000001154 acute effect Effects 0.000 claims description 2
- 239000000556 agonist Substances 0.000 claims description 2
- 239000002260 anti-inflammatory agent Substances 0.000 claims description 2
- 230000003110 anti-inflammatory effect Effects 0.000 claims description 2
- 239000003181 biological factor Substances 0.000 claims description 2
- 229960003388 epoetin alfa Drugs 0.000 claims description 2
- 229960004177 filgrastim Drugs 0.000 claims description 2
- 239000003102 growth factor Substances 0.000 claims description 2
- 229960002897 heparin Drugs 0.000 claims description 2
- 229920000669 heparin Polymers 0.000 claims description 2
- 239000002858 neurotransmitter agent Substances 0.000 claims description 2
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 claims description 2
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims description 2
- 239000000126 substance Substances 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 11
- 229940124599 anti-inflammatory drug Drugs 0.000 claims 1
- 230000035605 chemotaxis Effects 0.000 claims 1
- 229940121363 anti-inflammatory agent Drugs 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023196673A JP2024009130A (ja) | 2018-03-20 | 2023-11-20 | 活力のある歯髄の再生 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862645364P | 2018-03-20 | 2018-03-20 | |
| US62/645,364 | 2018-03-20 | ||
| PCT/US2019/023132 WO2019183201A1 (en) | 2018-03-20 | 2019-03-20 | Regeneration of vital tooth pulp |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023196673A Division JP2024009130A (ja) | 2018-03-20 | 2023-11-20 | 活力のある歯髄の再生 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2021518203A JP2021518203A (ja) | 2021-08-02 |
| JP2021518203A5 JP2021518203A5 (https=) | 2022-03-09 |
| JPWO2019183201A5 true JPWO2019183201A5 (https=) | 2022-03-09 |
| JP7406809B2 JP7406809B2 (ja) | 2023-12-28 |
Family
ID=67988017
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020550177A Active JP7406809B2 (ja) | 2018-03-20 | 2019-03-20 | 活力のある歯髄の再生 |
| JP2023196673A Pending JP2024009130A (ja) | 2018-03-20 | 2023-11-20 | 活力のある歯髄の再生 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023196673A Pending JP2024009130A (ja) | 2018-03-20 | 2023-11-20 | 活力のある歯髄の再生 |
Country Status (4)
| Country | Link |
|---|---|
| US (2) | US12285545B2 (https=) |
| EP (1) | EP3768222B1 (https=) |
| JP (2) | JP7406809B2 (https=) |
| WO (1) | WO2019183201A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019183201A1 (en) * | 2018-03-20 | 2019-09-26 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Regeneration of vital tooth pulp |
| WO2019241577A1 (en) | 2018-06-13 | 2019-12-19 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Bone regeneration in compromised wounds |
| US20220347347A1 (en) * | 2021-04-28 | 2022-11-03 | Worcester Polytechnic Institute | Ligament Repair Scaffold |
| US11890154B2 (en) * | 2021-06-30 | 2024-02-06 | Khalid AL HEZAIMI | Pulp capping methods |
| US20230166006A1 (en) * | 2021-12-01 | 2023-06-01 | Khalid Alhezaimi | Methods and compositions for periapical tissue regeneration |
Family Cites Families (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6632457B1 (en) | 1998-08-14 | 2003-10-14 | Incept Llc | Composite hydrogel drug delivery systems |
| US7206638B2 (en) | 2002-11-20 | 2007-04-17 | The Nemours Foundation | Electrical current induced inhibition of bone growth |
| CN1871024B (zh) * | 2003-09-09 | 2012-03-28 | 智再如股份有限公司 | 牙周病和牙髓疾病的治疗剂以及治疗方法 |
| US7901461B2 (en) | 2003-12-05 | 2011-03-08 | Ethicon, Inc. | Viable tissue repair implants and methods of use |
| AU2004309083B2 (en) * | 2003-12-30 | 2010-11-11 | Augustinus Bader | Tissue regeneration method |
| JP2005211477A (ja) | 2004-01-30 | 2005-08-11 | Gunze Ltd | 再生医療用支持体 |
| JP2005213449A (ja) | 2004-01-30 | 2005-08-11 | Gunze Ltd | ゼラチンスポンジ |
| US7680542B2 (en) | 2004-05-17 | 2010-03-16 | New York Society For The Ruptured And Crippled Maintaining The Hospital For Special Surgery | Radiofrequency ablation epiphysiodesis |
| JP2008517660A (ja) | 2004-10-22 | 2008-05-29 | ザ ボード オブ トラスティーズ オブ ザ ユニバーシティ オブ イリノイ | 生物剤を送達する中空かつ多孔質の整形外科用または歯科用のインプラント |
| US8268344B2 (en) | 2005-04-27 | 2012-09-18 | The Regents Of The University Of Michigan | Particle-containing complex porous materials |
| US20090148486A1 (en) | 2005-04-28 | 2009-06-11 | Helen Lu | Compositions and methods for treating pulp inflammations caused by infection or trauma |
| US20070286880A1 (en) | 2006-06-08 | 2007-12-13 | Andrey Vasiliev | Inoculated spongiform scaffold for transplantation and tissue regeneration |
| US20140302111A1 (en) * | 2007-10-25 | 2014-10-09 | The Trustees Of Columbia University In The City Of New York | Compositions and methods for dental tissue regeneration |
| EP2268254A4 (en) * | 2007-12-14 | 2013-12-11 | Univ Nova Southeastern | METHOD AND KIT FOR THE ADMINISTRATION OF REGENERATIVE ENDODONTIC TREATMENT |
| FR2926024B1 (fr) | 2008-01-07 | 2010-04-09 | Teknimed | Biomateriau pour osteosynthese |
| US8920791B2 (en) | 2008-03-12 | 2014-12-30 | Japan Health Sciences Foundation | Root canal filler and dental tissue regeneration method |
| ES2658609T3 (es) * | 2008-09-02 | 2018-03-12 | Tautona Group Lp | Hilos de ácido hialurónico y/o derivados de los mismos, métodos para fabricar los mismos, y usos de los mismos |
| EP2442834A2 (en) | 2009-06-15 | 2012-04-25 | Technion Research and Development Foundation, Ltd. | Reinforced surgical adhesives and sealants and their in-situ application |
| WO2010148229A1 (en) | 2009-06-17 | 2010-12-23 | The Trustees Of Columbia University In The City Of New York | Tooth scaffolds |
| US20120164604A1 (en) * | 2009-09-11 | 2012-06-28 | National Center For Geriatrics And Gerontology | Unextracted tooth root canal filler and dental tissue regeneration method for unextracted tooth |
| US9040070B2 (en) | 2009-10-20 | 2015-05-26 | Nitto Denko Corporation | Material for induction of hard tissue regeneration |
| US9327015B2 (en) | 2009-10-23 | 2016-05-03 | DePuy Synthes Products, Inc. | Methods and devices for correcting spinal deformity with pharmaceutical-eluting pedicle screws |
| US20130052155A1 (en) | 2009-11-09 | 2013-02-28 | Drexel University | Compositions and Methods for Treating a Disorder or Defect in Soft Tissue |
| US9180166B2 (en) | 2010-03-12 | 2015-11-10 | New Jersey Institute Of Technology | Cartilage repair systems and applications utilizing a glycosaminoglycan mimic |
| WO2011158245A1 (en) | 2010-06-16 | 2011-12-22 | Department Of Biotechnology | Sealbio: a novel non-obturation regenerative technique of endodontic treatment. |
| US20140050773A1 (en) | 2010-11-26 | 2014-02-20 | Universite De Strasbourg | Compound comprising alpha-msh for use in endodontic regeneration |
| US9051549B2 (en) * | 2011-02-22 | 2015-06-09 | Scripps Health | In situ tissue engineering using magnetically guided three dimensional cell patterning |
| EP2801377B1 (en) | 2011-03-04 | 2019-08-07 | The Regents of The University of California | Hydrogel comprising cells for local release of growth factors to mediate motor recovery after stroke |
| EP2508212A1 (en) | 2011-04-05 | 2012-10-10 | Universitätsklinikum Freiburg | Biocompatible and biodegradable gradient layer system for regenerative medicine and for tissue support |
| DK2854883T3 (da) | 2012-05-17 | 2019-07-15 | Cartiheal 2009 Ltd | Biomatrix-hydrogeler og fremgangsmåder til anvendelse deraf |
| EP2983643A4 (en) * | 2013-04-12 | 2016-12-28 | Univ Columbia | PROCESS FOR HOST CELL HOMING AND TOOTH MARK GENERATION |
| WO2014169236A1 (en) | 2013-04-12 | 2014-10-16 | The Trustees Of Columbia University In The City Of New York | Scaffolds for promoting calcified cartilage and/or bone formation |
| WO2015002707A1 (en) | 2013-05-28 | 2015-01-08 | The Johns Hopkins University | Bone regeneration using stromal vascular fraction. platelet-derived growth factor-rich hydrogel, three dimensional printed poly-epsilon-caprolactone scaffolds |
| US10335515B2 (en) | 2013-09-25 | 2019-07-02 | The University Of Kansas | Hydrogel precursors having nanoparticles |
| JP6644709B2 (ja) | 2014-04-29 | 2020-02-12 | デンツプライ シロナ インコーポレーテッド | 長期間薬物送達システムによる歯内療法 |
| WO2016011039A1 (en) | 2014-07-14 | 2016-01-21 | Temple University-Of The Commonwealth System Of Higher Education | Biomimetic scaffold for regenerative dentistry |
| CN104307049B (zh) | 2014-09-29 | 2016-04-13 | 四川大学华西医院 | 一种仿细胞外基质可注射的原位水凝胶及其制备方法与应用 |
| CN104548212B (zh) * | 2014-12-31 | 2018-05-11 | 新科沃再生医学（苏州）有限公司 | 一种促进牙髓及牙本质再生的组合物 |
| US11583613B2 (en) | 2016-03-03 | 2023-02-21 | University of Pittsburgh—of the Commonwealth System of Higher Education | Hydrogel systems for skeletal interfacial tissue regeneration applied to epiphyseal growth plate repair |
| US11278474B2 (en) * | 2016-12-01 | 2022-03-22 | Trustees Of Tufts College | Pulp regeneration compositions and methods of forming and using the same |
| US11701453B2 (en) * | 2017-05-30 | 2023-07-18 | Oregon Health & Science University | Dental pulp construct |
| TWI644801B (zh) | 2017-08-10 | 2018-12-21 | 國立清華大學 | 可積層製造的生物可降解光聚合高分子複合材料及其應用 |
| CL2017002194A1 (es) | 2017-08-29 | 2019-04-22 | Univ Pontificia Catolica Chile | Biomaterial particulado que contiene partículas con formas geodésicas, método de obtención y uso para relleno o substitución de tejido óseo |
| US11298441B2 (en) | 2017-11-08 | 2022-04-12 | The Regents Of The University Of Colorado, A Body Corporate | Biodegradable biomimetics of growth plate cartilage for the treatment of physeal injuries |
| WO2019183201A1 (en) | 2018-03-20 | 2019-09-26 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Regeneration of vital tooth pulp |
| WO2019241577A1 (en) | 2018-06-13 | 2019-12-19 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Bone regeneration in compromised wounds |
-
2019
- 2019-03-20 WO PCT/US2019/023132 patent/WO2019183201A1/en not_active Ceased
- 2019-03-20 US US16/979,038 patent/US12285545B2/en active Active
- 2019-03-20 EP EP19771745.7A patent/EP3768222B1/en active Active
- 2019-03-20 JP JP2020550177A patent/JP7406809B2/ja active Active
-
2023
- 2023-11-20 JP JP2023196673A patent/JP2024009130A/ja active Pending
-
2025
- 2025-03-19 US US19/084,682 patent/US20250242082A1/en active Pending
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