JPWO2019168203A5 - - Google Patents
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- Publication number
- JPWO2019168203A5 JPWO2019168203A5 JP2020503673A JP2020503673A JPWO2019168203A5 JP WO2019168203 A5 JPWO2019168203 A5 JP WO2019168203A5 JP 2020503673 A JP2020503673 A JP 2020503673A JP 2020503673 A JP2020503673 A JP 2020503673A JP WO2019168203 A5 JPWO2019168203 A5 JP WO2019168203A5
- Authority
- JP
- Japan
- Prior art keywords
- acid
- nitrophenylalanine
- host cell
- enzyme
- conversion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 22
- 210000004027 cell Anatomy 0.000 claims 14
- GTVVZTAFGPQSPC-UHFFFAOYSA-N 4-nitrophenylalanine Chemical compound OC(=O)C(N)CC1=CC=C([N+]([O-])=O)C=C1 GTVVZTAFGPQSPC-UHFFFAOYSA-N 0.000 claims 9
- 238000006243 chemical reaction Methods 0.000 claims 9
- 150000001413 amino acids Chemical group 0.000 claims 8
- JOLPMPPNHIACPD-ZZXKWVIFSA-N (e)-3-(4-aminophenyl)prop-2-enoic acid Chemical compound NC1=CC=C(\C=C\C(O)=O)C=C1 JOLPMPPNHIACPD-ZZXKWVIFSA-N 0.000 claims 7
- 102000004190 Enzymes Human genes 0.000 claims 7
- 108090000790 Enzymes Proteins 0.000 claims 7
- SCJHPUGWYHCYAZ-UHFFFAOYSA-N 3,5-diethyl-2-propylpyridine Chemical compound CCCC1=NC=C(CC)C=C1CC SCJHPUGWYHCYAZ-UHFFFAOYSA-N 0.000 claims 5
- 239000002253 acid Substances 0.000 claims 5
- 238000004519 manufacturing process Methods 0.000 claims 5
- 230000000284 resting effect Effects 0.000 claims 5
- 241000894006 Bacteria Species 0.000 claims 4
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 4
- 230000000694 effects Effects 0.000 claims 4
- 244000005700 microbiome Species 0.000 claims 4
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims 4
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 2
- 239000008103 glucose Substances 0.000 claims 2
- 230000036647 reaction Effects 0.000 claims 2
- 210000004748 cultured cell Anatomy 0.000 claims 1
- 210000001822 immobilized cell Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2018037794 | 2018-03-02 | ||
| JP2018037794 | 2018-03-02 | ||
| PCT/JP2019/008482 WO2019168203A1 (ja) | 2018-03-02 | 2019-03-04 | ４－アミノ桂皮酸を製造する方法、並びに、それに用いられるベクター及び宿主細胞 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JPWO2019168203A1 JPWO2019168203A1 (ja) | 2021-02-18 |
| JPWO2019168203A5 true JPWO2019168203A5 (https=) | 2022-01-17 |
| JP7228914B2 JP7228914B2 (ja) | 2023-02-27 |
Family
ID=67805416
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020503673A Active JP7228914B2 (ja) | 2018-03-02 | 2019-03-04 | ４－アミノ桂皮酸を製造する方法、並びに、それに用いられるベクター及び宿主細胞 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US11352652B2 (https=) |
| EP (1) | EP3760723A4 (https=) |
| JP (1) | JP7228914B2 (https=) |
| CN (1) | CN111801420B (https=) |
| WO (1) | WO2019168203A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111801420B (zh) * | 2018-03-02 | 2023-10-24 | 国立研究开发法人科学技术振兴机构 | 制造4-氨基肉桂酸的方法、以及用于其的载体及宿主细胞 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2202607C2 (ru) | 2000-03-03 | 2003-04-20 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" | Штамм бактерий methylophilus methylotrophus - продуцент l-фенилаланина (варианты), способ получения l-фенилаланина |
| US20030166645A1 (en) | 2001-06-25 | 2003-09-04 | Ala Paul J. | Novel nitrofuran-containing heterocyclic compounds and uses thereof |
| EP2090662A3 (en) * | 2006-04-05 | 2012-10-31 | Metanomics GmbH | Process for the production of a fine chemical |
| CA2780079A1 (en) | 2009-11-18 | 2011-05-26 | Basf Plant Science Company Gmbh | Process for the production of fine chemicals |
| CN105884641A (zh) | 2011-11-17 | 2016-08-24 | 国立研究开发法人科学技术振兴机构 | 化合物及其制造方法 |
| CN103146773B (zh) * | 2013-03-08 | 2014-08-27 | 江南大学 | 一种增强大肠杆菌l-苯丙氨酸胞外分泌的方法 |
| CN106133144B (zh) | 2014-02-06 | 2020-02-14 | 国立研究开发法人科学技术振兴机构 | 使用酶的4-氨基肉桂酸的制备方法 |
| EP3121275A4 (en) | 2014-03-20 | 2017-11-22 | Japan Science and Technology Agency | Method for producing aniline derivative by fermentation from carbon source |
| CN111801420B (zh) * | 2018-03-02 | 2023-10-24 | 国立研究开发法人科学技术振兴机构 | 制造4-氨基肉桂酸的方法、以及用于其的载体及宿主细胞 |
-
2019
- 2019-03-04 CN CN201980016395.5A patent/CN111801420B/zh active Active
- 2019-03-04 EP EP19761067.8A patent/EP3760723A4/en active Pending
- 2019-03-04 US US16/976,222 patent/US11352652B2/en active Active
- 2019-03-04 WO PCT/JP2019/008482 patent/WO2019168203A1/ja not_active Ceased
- 2019-03-04 JP JP2020503673A patent/JP7228914B2/ja active Active
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