JPWO2019165067A5 - - Google Patents
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- Publication number
- JPWO2019165067A5 JPWO2019165067A5 JP2020544270A JP2020544270A JPWO2019165067A5 JP WO2019165067 A5 JPWO2019165067 A5 JP WO2019165067A5 JP 2020544270 A JP2020544270 A JP 2020544270A JP 2020544270 A JP2020544270 A JP 2020544270A JP WO2019165067 A5 JPWO2019165067 A5 JP WO2019165067A5
- Authority
- JP
- Japan
- Prior art keywords
- aso
- seq
- camk2d
- nucleotides
- conjugate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000002773 nucleotide Substances 0.000 claims 12
- 125000003729 nucleotide group Chemical group 0.000 claims 12
- 239000002777 nucleoside Substances 0.000 claims 9
- 150000003833 nucleoside derivatives Chemical class 0.000 claims 7
- 239000008194 pharmaceutical composition Substances 0.000 claims 7
- 208000024172 Cardiovascular disease Diseases 0.000 claims 6
- 108090000623 proteins and genes Proteins 0.000 claims 5
- 102000004169 proteins and genes Human genes 0.000 claims 5
- 210000004027 cell Anatomy 0.000 claims 3
- 150000007523 nucleic acids Chemical group 0.000 claims 3
- 108020000948 Antisense Oligonucleotides Proteins 0.000 claims 2
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
- 239000000074 antisense oligonucleotide Substances 0.000 claims 2
- 238000012230 antisense oligonucleotides Methods 0.000 claims 2
- -1 bicyclic nucleoside Chemical class 0.000 claims 2
- 230000000295 complement effect Effects 0.000 claims 2
- 108020004999 messenger RNA Proteins 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- YIMATHOGWXZHFX-WCTZXXKLSA-N (2r,3r,4r,5r)-5-(hydroxymethyl)-3-(2-methoxyethoxy)oxolane-2,4-diol Chemical compound COCCO[C@H]1[C@H](O)O[C@H](CO)[C@H]1O YIMATHOGWXZHFX-WCTZXXKLSA-N 0.000 claims 1
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 1
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 101710086875 Calcium/calmodulin-dependent protein kinase type II Proteins 0.000 claims 1
- 208000002330 Congenital Heart Defects Diseases 0.000 claims 1
- 239000005977 Ethylene Substances 0.000 claims 1
- 206010019280 Heart failures Diseases 0.000 claims 1
- 208000006011 Stroke Diseases 0.000 claims 1
- 208000001435 Thromboembolism Diseases 0.000 claims 1
- 206010047249 Venous thrombosis Diseases 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 208000007474 aortic aneurysm Diseases 0.000 claims 1
- 206010003119 arrhythmia Diseases 0.000 claims 1
- 210000001367 artery Anatomy 0.000 claims 1
- 208000028831 congenital heart disease Diseases 0.000 claims 1
- 208000029078 coronary artery disease Diseases 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 208000018578 heart valve disease Diseases 0.000 claims 1
- 210000005260 human cell Anatomy 0.000 claims 1
- 208000015210 hypertensive heart disease Diseases 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 210000004165 myocardium Anatomy 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 230000002093 peripheral effect Effects 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 229940127557 pharmaceutical product Drugs 0.000 claims 1
- 108091033319 polynucleotide Proteins 0.000 claims 1
- 102000040430 polynucleotide Human genes 0.000 claims 1
- 239000002157 polynucleotide Substances 0.000 claims 1
- 208000004124 rheumatic heart disease Diseases 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862633502P | 2018-02-21 | 2018-02-21 | |
| US62/633,502 | 2018-02-21 | ||
| US201862635954P | 2018-02-27 | 2018-02-27 | |
| US62/635,954 | 2018-02-27 | ||
| US201862665998P | 2018-05-02 | 2018-05-02 | |
| US62/665,998 | 2018-05-02 | ||
| US201862778679P | 2018-12-12 | 2018-12-12 | |
| US62/778,679 | 2018-12-12 | ||
| PCT/US2019/018947 WO2019165067A1 (en) | 2018-02-21 | 2019-02-21 | Camk2d antisense oligonucleotides and uses thereof |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2021513861A JP2021513861A (ja) | 2021-06-03 |
| JPWO2019165067A5 true JPWO2019165067A5 (https=) | 2022-03-01 |
| JP2021513861A5 JP2021513861A5 (https=) | 2022-03-01 |
| JP7500426B2 JP7500426B2 (ja) | 2024-06-17 |
Family
ID=65729436
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020544270A Active JP7500426B2 (ja) | 2018-02-21 | 2019-02-21 | Ｃａｍｋ２ｄアンチセンスオリゴヌクレオチドおよびその使用 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US11083444B2 (https=) |
| EP (1) | EP3755800A1 (https=) |
| JP (1) | JP7500426B2 (https=) |
| KR (1) | KR20200140805A (https=) |
| CN (1) | CN112020559A (https=) |
| AU (1) | AU2019226001B2 (https=) |
| BR (1) | BR112020016347A2 (https=) |
| CA (1) | CA3091789A1 (https=) |
| IL (2) | IL320427A (https=) |
| MX (1) | MX2020008581A (https=) |
| SG (1) | SG11202007652UA (https=) |
| WO (1) | WO2019165067A1 (https=) |
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| US9198767B2 (en) | 2012-08-28 | 2015-12-01 | Samy Abdou | Devices and methods for spinal stabilization and instrumentation |
| US9320617B2 (en) | 2012-10-22 | 2016-04-26 | Cogent Spine, LLC | Devices and methods for spinal stabilization and instrumentation |
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