JPWO2019160148A5 - - Google Patents
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- JPWO2019160148A5 JPWO2019160148A5 JP2019572319A JP2019572319A JPWO2019160148A5 JP WO2019160148 A5 JPWO2019160148 A5 JP WO2019160148A5 JP 2019572319 A JP2019572319 A JP 2019572319A JP 2019572319 A JP2019572319 A JP 2019572319A JP WO2019160148 A5 JPWO2019160148 A5 JP WO2019160148A5
- Authority
- JP
- Japan
- Prior art keywords
- mixture
- cells
- cell
- production method
- adhesive
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 210000004027 cell Anatomy 0.000 claims 60
- 239000000203 mixture Substances 0.000 claims 27
- 239000000853 adhesive Substances 0.000 claims 23
- 230000001070 adhesive effect Effects 0.000 claims 23
- 238000004519 manufacturing process Methods 0.000 claims 21
- 230000004069 differentiation Effects 0.000 claims 20
- 210000005155 neural progenitor cell Anatomy 0.000 claims 15
- 241000282341 Mustela putorius furo Species 0.000 claims 8
- 238000000034 method Methods 0.000 claims 5
- VUDQSRFCCHQIIU-UHFFFAOYSA-N 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one Chemical compound CCCCCC(=O)C1=C(O)C(Cl)=C(OC)C(Cl)=C1O VUDQSRFCCHQIIU-UHFFFAOYSA-N 0.000 claims 4
- 101000942967 Homo sapiens Leukemia inhibitory factor Proteins 0.000 claims 4
- 102100032352 Leukemia inhibitory factor Human genes 0.000 claims 4
- 238000012258 culturing Methods 0.000 claims 4
- 239000007788 liquid Substances 0.000 claims 4
- 210000000653 nervous system Anatomy 0.000 claims 4
- 102100029284 Hepatocyte nuclear factor 3-beta Human genes 0.000 claims 3
- 101001062347 Homo sapiens Hepatocyte nuclear factor 3-beta Proteins 0.000 claims 3
- 230000030833 cell death Effects 0.000 claims 3
- 210000000130 stem cell Anatomy 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 230000001939 inductive effect Effects 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 102100037293 Atrial natriuretic peptide-converting enzyme Human genes 0.000 claims 1
- 101710133555 Atrial natriuretic peptide-converting enzyme Proteins 0.000 claims 1
- 102100021239 G protein-activated inward rectifier potassium channel 2 Human genes 0.000 claims 1
- 102100030634 Homeobox protein OTX2 Human genes 0.000 claims 1
- 102100027694 Homeobox protein engrailed-1 Human genes 0.000 claims 1
- 101000614714 Homo sapiens G protein-activated inward rectifier potassium channel 2 Proteins 0.000 claims 1
- 101000584400 Homo sapiens Homeobox protein OTX2 Proteins 0.000 claims 1
- 101001081126 Homo sapiens Homeobox protein engrailed-1 Proteins 0.000 claims 1
- 101001038339 Homo sapiens LIM homeobox transcription factor 1-alpha Proteins 0.000 claims 1
- 101000984044 Homo sapiens LIM homeobox transcription factor 1-beta Proteins 0.000 claims 1
- 101000595674 Homo sapiens Pituitary homeobox 3 Proteins 0.000 claims 1
- 102100040290 LIM homeobox transcription factor 1-alpha Human genes 0.000 claims 1
- 102100025457 LIM homeobox transcription factor 1-beta Human genes 0.000 claims 1
- 101150026563 NR4A2 gene Proteins 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 102100036088 Pituitary homeobox 3 Human genes 0.000 claims 1
- 230000001464 adherent effect Effects 0.000 claims 1
- 229960003638 dopamine Drugs 0.000 claims 1
- 210000001259 mesencephalon Anatomy 0.000 claims 1
- 210000005036 nerve Anatomy 0.000 claims 1
- 210000003061 neural cell Anatomy 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 210000001778 pluripotent stem cell Anatomy 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023166389A JP7797028B2 (ja) | 2018-02-19 | 2023-09-27 | 細胞凝集体、細胞凝集体の混合物及びそれらの製造方法 |
| JP2025259834A JP2026042046A (ja) | 2018-02-19 | 2025-12-17 | 細胞凝集体、細胞凝集体の混合物及びそれらの製造方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2018027455 | 2018-02-19 | ||
| JP2018027455 | 2018-02-19 | ||
| PCT/JP2019/005914 WO2019160148A1 (ja) | 2018-02-19 | 2019-02-18 | 細胞凝集体、細胞凝集体の混合物及びそれらの製造方法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023166389A Division JP7797028B2 (ja) | 2018-02-19 | 2023-09-27 | 細胞凝集体、細胞凝集体の混合物及びそれらの製造方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JPWO2019160148A1 JPWO2019160148A1 (ja) | 2021-02-04 |
| JPWO2019160148A5 true JPWO2019160148A5 (https=) | 2022-02-16 |
| JP7414530B2 JP7414530B2 (ja) | 2024-01-16 |
Family
ID=67618694
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019572319A Active JP7414530B2 (ja) | 2018-02-19 | 2019-02-18 | 細胞凝集体、細胞凝集体の混合物及びそれらの製造方法 |
| JP2023166389A Active JP7797028B2 (ja) | 2018-02-19 | 2023-09-27 | 細胞凝集体、細胞凝集体の混合物及びそれらの製造方法 |
| JP2025259834A Pending JP2026042046A (ja) | 2018-02-19 | 2025-12-17 | 細胞凝集体、細胞凝集体の混合物及びそれらの製造方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023166389A Active JP7797028B2 (ja) | 2018-02-19 | 2023-09-27 | 細胞凝集体、細胞凝集体の混合物及びそれらの製造方法 |
| JP2025259834A Pending JP2026042046A (ja) | 2018-02-19 | 2025-12-17 | 細胞凝集体、細胞凝集体の混合物及びそれらの製造方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20200405768A1 (https=) |
| EP (1) | EP3757208A4 (https=) |
| JP (3) | JP7414530B2 (https=) |
| CN (1) | CN111788303B (https=) |
| CA (1) | CA3096870A1 (https=) |
| TW (1) | TW202000902A (https=) |
| WO (1) | WO2019160148A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2020387259A1 (en) * | 2019-11-20 | 2022-06-09 | Kyoto University | Method for freezing neural cells |
| WO2021100830A1 (ja) * | 2019-11-20 | 2021-05-27 | 大日本住友製薬株式会社 | 細胞凝集体の凍結方法 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5843780A (en) | 1995-01-20 | 1998-12-01 | Wisconsin Alumni Research Foundation | Primate embryonic stem cells |
| CA2277278A1 (en) | 1997-01-10 | 1998-07-16 | Life Technologies, Inc. | Embryonic stem cell serum replacement |
| US6280718B1 (en) | 1999-11-08 | 2001-08-28 | Wisconsin Alumni Reasearch Foundation | Hematopoietic differentiation of human pluripotent embryonic stem cells |
| UY27224A1 (es) | 2001-03-23 | 2002-10-31 | Bayer Corp | Inhibidores de la rho-quinasa |
| PE20020958A1 (es) | 2001-03-23 | 2002-11-14 | Bayer Corp | Inhibidores de la rho-quinasa |
| WO2002101057A1 (fr) | 2001-06-08 | 2002-12-19 | Dnavec Research Inc. | Transfert genique dans des cellules souches embryonnaires de primate a l'aide d'un virus de l'immunodeficience simienne de pseudo type vsv-g utilise comme vecteur |
| JP4505228B2 (ja) | 2002-01-10 | 2010-07-21 | バイエル・シェーリング・ファルマ・アクチェンゲゼルシャフト | Ｒｈｏ−キナーゼ阻害剤 |
| MXPA04007196A (es) | 2002-01-23 | 2005-06-08 | Bayer Pharmaceuticals Corp | Inhibidores de rho-quinasa. |
| EP1470121B1 (en) | 2002-01-23 | 2012-07-11 | Bayer HealthCare LLC | Pyrimidine derivatives as rho-kinase inhibitors |
| ES2273047T3 (es) | 2002-10-28 | 2007-05-01 | Bayer Healthcare Ag | Fenilaminopirimidinas sustituidas con heteroariloxi como inhibidores de rho-cinasa. |
| JP4573332B2 (ja) | 2003-01-24 | 2010-11-04 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | Ｌｒｐ４／Ｃｏｒｉｎドーパミン産生ニューロン増殖前駆細胞マーカー |
| US20050289257A1 (en) | 2004-06-24 | 2005-12-29 | Fink Thomas M | Self-powered USB device with USB power line reset and related USB host and USB system |
| JP2009050194A (ja) * | 2007-08-27 | 2009-03-12 | Sumitomo Bakelite Co Ltd | 細胞凝集塊形成培養用容器 |
| US20100087486A1 (en) | 2008-05-30 | 2010-04-08 | Hiroshi Nakamura | Methods for using tgf-b receptor inhibitors or activin-like kinase (alk) 5 inhibitors a-83-01 and sb-431542 to treat eye disease and wound healing conditions |
| JP5590646B2 (ja) | 2009-10-08 | 2014-09-17 | 国立大学法人大阪大学 | ヒト多能性幹細胞用培養基材およびその利用 |
| JP6090937B2 (ja) | 2011-07-27 | 2017-03-08 | 国立大学法人京都大学 | 新規ドーパミン産生神経前駆細胞マーカー |
| CA2912345C (en) * | 2013-05-16 | 2020-10-06 | Sumitomo Dainippon Pharma Co., Ltd. | Transplantation adjuvant in cell therapy using neural progenitor cells |
| AU2014316100B2 (en) * | 2013-09-05 | 2020-11-05 | Eisai R&D Management Co., Ltd. | New method for inducing dopamine-producing neural precursor cells |
| US9619881B2 (en) * | 2013-09-26 | 2017-04-11 | Cellogy, Inc. | Method and system for characterizing cell populations |
| ES2939807T3 (es) * | 2014-03-21 | 2023-04-27 | Fujifilm Cellular Dynamics Inc | Producción de neuronas dopaminérgicas del mesencéfalo y métodos para su utilización |
| JP7011260B2 (ja) | 2016-04-22 | 2022-02-10 | 国立大学法人京都大学 | ドーパミン産生神経前駆細胞の製造方法 |
-
2019
- 2019-02-18 US US16/970,087 patent/US20200405768A1/en active Pending
- 2019-02-18 EP EP19754255.8A patent/EP3757208A4/en active Pending
- 2019-02-18 WO PCT/JP2019/005914 patent/WO2019160148A1/ja not_active Ceased
- 2019-02-18 CA CA3096870A patent/CA3096870A1/en active Pending
- 2019-02-18 CN CN201980013902.XA patent/CN111788303B/zh active Active
- 2019-02-18 JP JP2019572319A patent/JP7414530B2/ja active Active
- 2019-02-19 TW TW108105458A patent/TW202000902A/zh unknown
-
2023
- 2023-09-27 JP JP2023166389A patent/JP7797028B2/ja active Active
-
2025
- 2025-12-17 JP JP2025259834A patent/JP2026042046A/ja active Pending
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