JPWO2019148293A5 - - Google Patents
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- JPWO2019148293A5 JPWO2019148293A5 JP2020538791A JP2020538791A JPWO2019148293A5 JP WO2019148293 A5 JPWO2019148293 A5 JP WO2019148293A5 JP 2020538791 A JP2020538791 A JP 2020538791A JP 2020538791 A JP2020538791 A JP 2020538791A JP WO2019148293 A5 JPWO2019148293 A5 JP WO2019148293A5
- Authority
- JP
- Japan
- Prior art keywords
- article
- coating according
- compound
- coating
- disease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000011248 coating agent Substances 0.000 claims 46
- 238000000576 coating method Methods 0.000 claims 46
- 150000001875 compounds Chemical class 0.000 claims 23
- 201000010099 disease Diseases 0.000 claims 15
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 15
- 150000003431 steroids Chemical class 0.000 claims 11
- 150000003839 salts Chemical class 0.000 claims 10
- 239000012453 solvate Substances 0.000 claims 10
- 239000007943 implant Substances 0.000 claims 6
- -1 progestin steroids Chemical class 0.000 claims 6
- 208000027866 inflammatory disease Diseases 0.000 claims 4
- 125000005647 linker group Chemical group 0.000 claims 3
- 206010012688 Diabetic retinal oedema Diseases 0.000 claims 2
- 241001653121 Glenoides Species 0.000 claims 2
- 125000002947 alkylene group Chemical group 0.000 claims 2
- 229960003957 dexamethasone Drugs 0.000 claims 2
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 claims 2
- 201000011190 diabetic macular edema Diseases 0.000 claims 2
- 125000004474 heteroalkylene group Chemical group 0.000 claims 2
- 230000004410 intraocular pressure Effects 0.000 claims 2
- 239000000583 progesterone congener Substances 0.000 claims 2
- 208000004644 retinal vein occlusion Diseases 0.000 claims 2
- 206010061218 Inflammation Diseases 0.000 claims 1
- 208000001344 Macular Edema Diseases 0.000 claims 1
- 206010025415 Macular oedema Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 206010046851 Uveitis Diseases 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 125000004450 alkenylene group Chemical group 0.000 claims 1
- 125000004419 alkynylene group Chemical group 0.000 claims 1
- 239000003263 anabolic agent Substances 0.000 claims 1
- 229940070021 anabolic steroids Drugs 0.000 claims 1
- 239000003098 androgen Substances 0.000 claims 1
- 230000001772 anti-angiogenic effect Effects 0.000 claims 1
- 239000003613 bile acid Substances 0.000 claims 1
- 230000003115 biocidal effect Effects 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 150000001841 cholesterols Chemical class 0.000 claims 1
- 239000003246 corticosteroid Substances 0.000 claims 1
- 229960001334 corticosteroids Drugs 0.000 claims 1
- 239000000539 dimer Substances 0.000 claims 1
- 239000000262 estrogen Substances 0.000 claims 1
- 229940011871 estrogen Drugs 0.000 claims 1
- 208000030533 eye disease Diseases 0.000 claims 1
- 239000003862 glucocorticoid Substances 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 201000010230 macular retinal edema Diseases 0.000 claims 1
- 239000002207 metabolite Substances 0.000 claims 1
- 239000002858 neurotransmitter agent Substances 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 239000003016 pheromone Chemical class 0.000 claims 1
- 229960005205 prednisolone Drugs 0.000 claims 1
- OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 238000011200 topical administration Methods 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862625460P | 2018-02-02 | 2018-02-02 | |
| US62/625,460 | 2018-02-02 | ||
| US201862627608P | 2018-02-07 | 2018-02-07 | |
| US62/627,608 | 2018-02-07 | ||
| US201862758234P | 2018-11-09 | 2018-11-09 | |
| US62/758,234 | 2018-11-09 | ||
| PCT/CA2019/050135 WO2019148293A1 (en) | 2018-02-02 | 2019-02-01 | Glass formulations comprising steroid dimers and uses thereof |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2021512852A JP2021512852A (ja) | 2021-05-20 |
| JP2021512852A5 JP2021512852A5 (https=) | 2022-01-31 |
| JPWO2019148293A5 true JPWO2019148293A5 (https=) | 2022-01-31 |
| JP7502186B2 JP7502186B2 (ja) | 2024-06-18 |
Family
ID=67479137
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020538791A Active JP7502186B2 (ja) | 2018-02-02 | 2019-02-01 | ステロイド二量体を含むガラス製剤およびその使用 |
Country Status (9)
| Country | Link |
|---|---|
| US (9) | US11612567B2 (https=) |
| EP (1) | EP3740494A4 (https=) |
| JP (1) | JP7502186B2 (https=) |
| KR (1) | KR102952719B1 (https=) |
| CN (1) | CN111971292B (https=) |
| AU (1) | AU2019214347B2 (https=) |
| CA (1) | CA3087898A1 (https=) |
| MX (1) | MX2020008017A (https=) |
| WO (3) | WO2019148291A1 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111971292B (zh) | 2018-02-02 | 2024-12-13 | 波纹疗法公司 | 包含类固醇二聚体的玻璃制剂及其用途 |
| WO2020154815A1 (en) | 2019-02-01 | 2020-08-06 | Ripple Therapeutics Corporation | Crystalline forms of dexamethasone dimers and uses thereof |
| CN114599406A (zh) * | 2019-07-10 | 2022-06-07 | 波纹疗法公司 | 包含二聚类固醇前药的表面涂层和可植入装置及其用途 |
| JP2022541341A (ja) * | 2019-07-25 | 2022-09-22 | リップル セラピューティクス コーポレーション | ステロイド二量体を含む物品と治療剤の送達におけるそれらの使用 |
| WO2021024041A1 (en) | 2019-08-07 | 2021-02-11 | Ripple Therapeutics Corporation | Controlled release drug dimers |
| CN111485325A (zh) * | 2020-04-16 | 2020-08-04 | 青岛科技大学 | 一种耐高温的抗菌纳米纤维无纺布及其制备方法和用途 |
| MX2022013665A (es) | 2020-05-01 | 2022-11-30 | Ripple Therapeutics Corp | Composiciones y metodos heterodimeros para el tratamiento de trastornos oculares. |
| EP4108231A1 (en) | 2021-06-25 | 2022-12-28 | Johann-Wolfgang-Goethe-Universität Frankfurt am Main | In-situ dissolving electrospun polymer fibers for ocular drug delivery |
| WO2023079362A1 (en) * | 2021-11-03 | 2023-05-11 | Ripple Therapeutics Corporation | Processable compositions and use for the same |
| US20260007686A1 (en) * | 2022-07-12 | 2026-01-08 | Ripple Therapeutics Corporation | Compositions and methods for improving vision |
| AU2024238803A1 (en) * | 2023-03-23 | 2025-10-09 | Praesidia Biotherapeutics Inc. | Prodrugs, prodrug compositions and related methods |
| TR2024002978A1 (tr) * | 2024-03-12 | 2025-09-22 | İstanbul Tekni̇k Üni̇versi̇tesi̇ | Elektroeği̇rme yöntemi̇yle elde edi̇len ve i̇laç yüklü bi̇yopoli̇mer nanoli̇flerle kaplanan göz i̇mplanti üreti̇m yöntemi̇ |
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| US5965590A (en) | 1994-09-08 | 1999-10-12 | Romark Lab Lc | Method for treatment of opportunistic infections with pharmaceutical compositions of tizoxanide and nitazoxanide |
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| US5856348A (en) | 1994-09-08 | 1999-01-05 | Romark Laboratories, L.C. | Method for treatment of trematodes with pharmaceutical compositions of tizoxanide and nitazoxanide |
| DE19521642C2 (de) | 1995-06-14 | 2000-11-09 | Aesculap Ag & Co Kg | Implantat, seine Verwendung in der Chirurgie und Verfahren zu seiner Herstellung |
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| EP3374369B1 (en) * | 2015-11-12 | 2020-03-18 | Board of Regents of the University of Nebraska | Polyethylene glycol-conjugated glucocorticoid prodrugs and compositions and methods thereof |
| CN111971292B (zh) | 2018-02-02 | 2024-12-13 | 波纹疗法公司 | 包含类固醇二聚体的玻璃制剂及其用途 |
| WO2020154815A1 (en) | 2019-02-01 | 2020-08-06 | Ripple Therapeutics Corporation | Crystalline forms of dexamethasone dimers and uses thereof |
| CN114599406A (zh) | 2019-07-10 | 2022-06-07 | 波纹疗法公司 | 包含二聚类固醇前药的表面涂层和可植入装置及其用途 |
| JP2022541341A (ja) | 2019-07-25 | 2022-09-22 | リップル セラピューティクス コーポレーション | ステロイド二量体を含む物品と治療剤の送達におけるそれらの使用 |
-
2019
- 2019-02-01 CN CN201980024377.1A patent/CN111971292B/zh active Active
- 2019-02-01 US US16/966,453 patent/US11612567B2/en active Active
- 2019-02-01 KR KR1020207024684A patent/KR102952719B1/ko active Active
- 2019-02-01 CA CA3087898A patent/CA3087898A1/en active Pending
- 2019-02-01 US US16/966,452 patent/US20210113457A1/en not_active Abandoned
- 2019-02-01 WO PCT/CA2019/050133 patent/WO2019148291A1/en not_active Ceased
- 2019-02-01 JP JP2020538791A patent/JP7502186B2/ja active Active
- 2019-02-01 EP EP19747412.5A patent/EP3740494A4/en active Pending
- 2019-02-01 WO PCT/CA2019/050135 patent/WO2019148293A1/en not_active Ceased
- 2019-02-01 WO PCT/CA2019/050136 patent/WO2019148294A1/en not_active Ceased
- 2019-02-01 MX MX2020008017A patent/MX2020008017A/es unknown
- 2019-02-01 AU AU2019214347A patent/AU2019214347B2/en active Active
- 2019-04-26 US US16/396,400 patent/US10588862B2/en active Active
- 2019-04-26 US US16/396,135 patent/US10632075B2/en active Active
- 2019-11-27 US US16/698,372 patent/US10959954B2/en active Active
- 2019-11-29 US US16/699,305 patent/US10945958B2/en active Active
-
2021
- 2021-01-08 US US17/145,093 patent/US20210205222A1/en not_active Abandoned
-
2023
- 2023-02-16 US US18/170,403 patent/US20230225975A1/en not_active Abandoned
-
2024
- 2024-06-10 US US18/738,907 patent/US20250049719A1/en active Pending
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